GREMLIN Database
Q7LXP0 - Iron-dependent repressor
UniProt: Q7LXP0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (206)
Sequences: 1599 (1136)
Seq/√Len: 79.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_I152_Y5.4431.00
134_N138_V3.6971.00
180_E192_K3.5091.00
96_R111_D3.3461.00
19_E69_K3.2881.00
154_V208_V3.1871.00
151_K180_E3.1121.00
15_M54_V2.9951.00
84_R88_D2.9111.00
152_Y210_V2.7591.00
117_D122_Y2.6791.00
151_K178_V2.6421.00
114_E135_R2.6381.00
108_W113_L2.5061.00
94_W165_L2.4471.00
82_S108_W2.3761.00
100_L109_P2.2371.00
164_I204_I2.1581.00
147_N150_G2.1231.00
13_K102_H2.1221.00
120_L123_P2.1201.00
13_K126_C2.0881.00
118_R122_Y2.0781.00
152_Y179_L2.0131.00
85_L90_V1.9971.00
45_L54_V1.9551.00
7_P40_T1.8861.00
89_I119_L1.8601.00
95_I166_R1.8511.00
10_N13_K1.8461.00
190_K197_I1.7861.00
153_K178_V1.7571.00
56_R59_D1.7411.00
167_E187_T1.7211.00
40_T44_A1.6731.00
79_H98_H1.6651.00
154_V179_L1.6121.00
8_L51_L1.6011.00
144_S206_D1.5811.00
154_V173_L1.5721.00
85_L89_I1.5640.99
130_H156_M1.5470.99
174_K177_V1.5430.99
36_I41_I1.5390.99
189_I205_G1.5330.99
9_E106_H1.5220.99
10_N102_H1.4990.99
202_K206_D1.4710.99
123_P132_I1.4630.99
126_C130_H1.4490.99
146_I181_V1.4330.99
116_I119_L1.4200.99
83_E98_H1.3900.99
192_K197_I1.3820.99
85_L119_L1.3820.99
82_S112_I1.3590.99
200_V205_G1.3590.99
14_E30_L1.3530.99
77_K133_G1.3320.98
135_R138_V1.3240.98
146_I210_V1.3230.98
92_V112_I1.3030.98
15_M41_I1.2830.98
9_E75_L1.2700.98
29_E32_S1.2680.98
34_F44_A1.2480.97
27_V42_S1.2470.97
115_R118_R1.2340.97
27_V38_P1.2170.97
15_M30_L1.2030.97
182_I192_K1.2020.97
67_E70_R1.1990.97
183_E190_K1.1850.97
80_R132_I1.1830.97
30_L41_I1.1620.96
9_E105_E1.1480.96
100_L103_R1.1410.96
108_W112_I1.1290.95
93_D96_R1.1130.95
74_R78_S1.0910.95
66_E69_K1.0840.94
192_K195_E1.0630.94
55_E63_K1.0320.93
34_F38_P1.0290.93
19_E25_A1.0270.93
156_M209_L1.0260.93
183_E196_E1.0230.92
87_T97_A0.9970.91
81_L117_D0.9910.91
148_I183_E0.9840.91
146_I150_G0.9830.91
49_E56_R0.9820.91
123_P133_G0.9700.90
129_G133_G0.9700.90
78_S113_L0.9690.90
129_G132_I0.9650.90
179_L191_I0.9580.90
83_E129_G0.9580.90
162_E166_R0.9480.89
11_Y40_T0.9410.89
80_R83_E0.9400.89
191_I200_V0.9380.89
27_V41_I0.9370.89
37_S43_K0.9340.89
100_L108_W0.9190.88
168_A173_L0.9180.88
85_L116_I0.9130.87
86_L97_A0.9130.87
80_R133_G0.9130.87
69_K73_E0.9100.87
140_G155_V0.9030.87
11_Y41_I0.9020.87
37_S44_A0.9010.87
172_G208_V0.9010.87
125_T149_A0.8990.87
49_E52_G0.8990.87
172_G177_V0.8970.86
45_L62_I0.8940.86
92_V96_R0.8880.86
6_E25_A0.8760.85
182_I197_I0.8740.85
14_E34_F0.8740.85
77_K132_I0.8720.85
182_I190_K0.8710.85
67_E71_I0.8630.84
111_D115_R0.8620.84
102_H106_H0.8570.84
102_H105_E0.8550.84
27_V44_A0.8540.84
82_S116_I0.8540.84
79_H128_H0.8540.84
16_Y44_A0.8530.84
41_I45_L0.8490.83
16_Y76_I0.8470.83
37_S40_T0.8350.82
79_H83_E0.8290.82
36_I40_T0.8250.81
185_N188_D0.8250.81
78_S110_D0.8240.81
140_G209_L0.8210.81
124_T153_K0.8190.81
52_G67_E0.8120.80
91_G115_R0.8110.80
55_E93_D0.8090.80
90_V116_I0.8080.80
93_D115_R0.8040.80
54_V57_T0.8010.79
94_W128_H0.7960.79
83_E128_H0.7960.79
75_L78_S0.7920.79
120_L132_I0.7920.79
79_H106_H0.7880.78
78_S107_I0.7860.78
7_P10_N0.7860.78
83_E132_I0.7850.78
100_L107_I0.7800.78
128_H132_I0.7740.77
112_I116_I0.7640.76
66_E70_R0.7640.76
187_T202_K0.7630.76
185_N190_K0.7580.76
52_G150_G0.7560.75
133_G137_K0.7560.75
9_E78_S0.7540.75
8_L16_Y0.7520.75
169_T174_K0.7480.75
18_I107_I0.7480.75
90_V119_L0.7470.75
27_V45_L0.7430.74
18_I44_A0.7420.74
31_I95_I0.7360.73
28_S38_P0.7290.73
17_E75_L0.7280.73
80_R123_P0.7270.73
10_N107_I0.7270.73
141_K145_E0.7260.72
98_H128_H0.7210.72
25_A30_L0.7170.72
8_L44_A0.7170.72
178_V195_E0.7160.71
190_K199_E0.7110.71
152_Y181_V0.7080.71
145_E183_E0.7070.70
141_K150_G0.7050.70
154_V171_L0.7050.70
79_H105_E0.7040.70
201_S204_I0.7040.70
47_K104_L0.7010.70
13_K17_E0.7010.70
7_P44_A0.6990.70
81_L116_I0.6930.69
142_K206_D0.6910.69
127_P132_I0.6870.68
142_K145_E0.6860.68
36_I44_A0.6850.68
104_L112_I0.6770.67
77_K131_P0.6600.65
152_Y191_I0.6600.65
83_E133_G0.6570.65
193_I196_E0.6570.65
58_N63_K0.6570.65
95_I169_T0.6550.65
97_A128_H0.6530.64
14_E33_I0.6530.64
76_I140_G0.6490.64
27_V56_R0.6480.64
195_E200_V0.6470.64
7_P39_G0.6460.64
86_L101_A0.6450.63
57_T63_K0.6440.63
117_D134_N0.6400.63
54_V59_D0.6340.62
141_K147_N0.6320.62
126_C133_G0.6300.62
27_V61_K0.6280.61
56_R62_I0.6260.61
6_E91_G0.6230.61
153_K210_V0.6170.60
83_E123_P0.6160.60
181_V198_E0.6150.60
113_L117_D0.6140.60
86_L98_H0.6140.60
198_E204_I0.6110.59
18_I25_A0.6090.59
127_P133_G0.6070.59
48_L53_L0.6060.59
5_S36_I0.6050.59
92_V100_L0.6040.58
98_H132_I0.6040.58
44_A47_K0.6010.58
80_R127_P0.5990.58
46_N56_R0.5990.58
39_G44_A0.5990.58
10_N105_E0.5970.58
66_E93_D0.5960.57
102_H128_H0.5930.57
78_S100_L0.5910.57
9_E85_L0.5850.56
27_V36_I0.5830.56
43_K46_N0.5810.55
145_E151_K0.5800.55
146_I149_A0.5790.55
15_M64_L0.5780.55
38_P44_A0.5770.55
37_S42_S0.5760.55
61_K90_V0.5740.55
13_K105_E0.5740.55
71_I114_E0.5730.54
5_S8_L0.5710.54
82_S85_L0.5680.54
114_E118_R0.5660.54
76_I80_R0.5650.53
96_R123_P0.5620.53
39_G113_L0.5620.53
12_L24_S0.5610.53
8_L28_S0.5570.52
10_N100_L0.5570.52
78_S108_W0.5570.52
43_K112_I0.5530.52
75_L100_L0.5520.52
128_H165_L0.5510.52
177_V194_G0.5510.52
67_E154_V0.5500.52
30_L45_L0.5500.52
9_E44_A0.5490.51
124_T196_E0.5470.51
114_E122_Y0.5450.51
146_I192_K0.5450.51
148_I174_K0.5450.51
44_A60_R0.5440.51
52_G157_I0.5420.50
194_G199_E0.5420.50
34_F75_L0.5420.50
142_K209_L0.5410.50
154_V210_V0.5410.50
38_P42_S0.5400.50
81_L123_P0.5370.50
42_S61_K0.5360.50
83_E120_L0.5330.49
82_S104_L0.5310.49
173_L193_I0.5310.49
13_K73_E0.5310.49
28_S51_L0.5290.49
77_K137_K0.5290.49
82_S100_L0.5280.49
154_V180_E0.5280.49
41_I205_G0.5270.49
42_S56_R0.5270.49
123_P128_H0.5270.49
148_I184_N0.5240.48
76_I128_H0.5240.48
31_I45_L0.5240.48
86_L127_P0.5210.48
100_L156_M0.5160.47
149_A163_W0.5150.47
22_K99_E0.5140.47
134_N137_K0.5140.47
17_E33_I0.5130.47
27_V62_I0.5110.46
40_T43_K0.5090.46
28_S92_V0.5080.46
82_S113_L0.5070.46
20_E69_K0.5070.46
110_D113_L0.5060.46
164_I208_V0.5060.46
10_N156_M0.5030.45
59_D62_I0.5030.45
43_K130_H0.5020.45
190_K193_I0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fx7A 4 1 100 0.349 Contact Map
2qq9A 2 0.9623 100 0.367 Contact Map
4o5vA 2 0.9811 100 0.374 Contact Map
3hrsA 2 0.9764 100 0.394 Contact Map
2x4hA 3 0.6179 99.9 0.67 Contact Map
1on2A 2 0.6368 99.8 0.694 Contact Map
2p8tA 1 0.783 99.7 0.733 Contact Map
2h09A 2 0.566 99.7 0.735 Contact Map
2k5fA 1 0.3349 99.1 0.805 Contact Map
2k5lA 1 0.3396 99.1 0.806 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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