GREMLIN Database
Q7LXN7 - Uncharacterized protein
UniProt: Q7LXN7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 232 (183)
Sequences: 15264 (10857)
Seq/√Len: 802.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_L103_T3.1081.00
164_S212_L3.0631.00
111_L128_R2.6411.00
162_E165_R2.6051.00
89_G149_V2.4421.00
163_M173_C2.4371.00
90_T106_G2.3941.00
107_I129_A2.2781.00
136_L141_A2.2251.00
96_F104_C2.2091.00
111_L115_M2.1951.00
105_I141_A2.1851.00
142_D168_K2.1711.00
157_S209_E2.1401.00
86_I141_A2.1011.00
167_L171_G2.0891.00
117_M126_A2.0671.00
46_S110_S2.0621.00
114_L126_A2.0571.00
103_T125_I2.0461.00
144_I163_M2.0271.00
88_V163_M2.0141.00
167_L173_C1.9871.00
105_I127_V1.8701.00
116_Y119_R1.8441.00
97_D121_R1.8371.00
162_E166_V1.7671.00
114_L128_R1.7251.00
157_S161_R1.7051.00
121_R126_A1.7051.00
80_I83_D1.7041.00
204_I208_Q1.7031.00
83_D143_G1.7021.00
155_N158_F1.6561.00
199_H202_Y1.6471.00
90_T96_F1.6331.00
156_P206_L1.6221.00
46_S112_R1.5971.00
144_I167_L1.5961.00
88_V131_A1.5831.00
84_L105_I1.5181.00
85_I143_G1.4961.00
129_A135_P1.4751.00
138_S165_R1.4721.00
186_G189_L1.4521.00
153_L159_A1.4071.00
112_R115_M1.3921.00
157_S206_L1.3841.00
149_V153_L1.3831.00
167_L212_L1.3821.00
84_L141_A1.3771.00
108_D114_L1.3761.00
85_I99_L1.3531.00
158_F161_R1.3511.00
109_V130_D1.3061.00
38_D130_D1.2861.00
96_F106_G1.2851.00
151_H177_V1.2831.00
53_E92_T1.2651.00
114_L118_K1.2591.00
66_G69_Y1.2541.00
97_D120_K1.2531.00
84_L168_K1.2421.00
205_N209_E1.2191.00
160_I207_L1.2171.00
127_V136_L1.2161.00
130_D133_N1.1931.00
89_G146_S1.1791.00
105_I125_I1.1751.00
134_L166_V1.1711.00
157_S210_N1.1601.00
131_A149_V1.1551.00
146_S149_V1.1521.00
65_S68_T1.1501.00
137_K140_I1.1341.00
100_N123_R1.1291.00
186_G190_S1.1221.00
106_G126_A1.1141.00
115_M118_K1.0881.00
38_D132_N1.0831.00
144_I166_V1.0791.00
62_L65_S1.0771.00
86_I144_I1.0761.00
205_N208_Q1.0721.00
84_L142_D1.0681.00
190_S193_W1.0671.00
135_P162_E1.0601.00
200_Y219_E1.0591.00
189_L193_W1.0561.00
82_G102_K1.0541.00
188_T192_W1.0431.00
108_D113_F1.0361.00
62_L66_G1.0271.00
204_I217_R1.0251.00
107_I134_L1.0251.00
90_T117_M1.0241.00
131_A153_L1.0211.00
186_G193_W1.0161.00
85_I104_C1.0121.00
84_L140_I1.0111.00
61_L65_S1.0091.00
188_T193_W1.0041.00
71_S75_E0.9991.00
163_M167_L0.9941.00
87_D90_T0.9931.00
42_D46_S0.9901.00
107_I127_V0.9731.00
79_F83_D0.9731.00
148_L151_H0.9711.00
161_R210_N0.9691.00
83_D102_K0.9651.00
183_S186_G0.9641.00
187_K191_R0.9641.00
51_I54_S0.9611.00
191_R194_K0.9451.00
53_E120_K0.9401.00
189_L192_W0.9291.00
133_N158_F0.9081.00
187_K190_S0.8981.00
185_I189_L0.8881.00
202_Y205_N0.8861.00
186_G194_K0.8841.00
148_L176_A0.8711.00
92_T113_F0.8701.00
62_L69_Y0.8621.00
164_S210_N0.8621.00
99_L145_S0.8621.00
95_I147_T0.8611.00
159_A163_M0.8611.00
190_S194_K0.8501.00
72_F76_I0.8491.00
115_M119_R0.8431.00
160_I210_N0.8371.00
93_G126_A0.8341.00
63_I66_G0.8311.00
93_G117_M0.8301.00
63_I69_Y0.8291.00
186_G192_W0.8101.00
86_I166_V0.8081.00
106_G117_M0.8071.00
65_S69_Y0.8051.00
121_R124_V0.8021.00
112_R116_Y0.7961.00
180_N199_H0.7951.00
96_F126_A0.7901.00
138_S162_E0.7871.00
134_L162_E0.7791.00
148_L152_M0.7781.00
161_R165_R0.7781.00
64_T67_K0.7721.00
43_K47_R0.7681.00
61_L64_T0.7671.00
41_V45_L0.7661.00
66_G70_T0.7641.00
39_V43_K0.7621.00
85_I145_S0.7561.00
96_F124_V0.7561.00
188_T194_K0.7541.00
95_I145_S0.7481.00
105_I136_L0.7471.00
173_C207_L0.7341.00
45_L152_M0.7301.00
185_I188_T0.7301.00
96_F100_N0.7231.00
116_Y120_K0.7171.00
72_F218_K0.7171.00
110_S113_F0.7141.00
146_S153_L0.7141.00
183_S187_K0.7111.00
53_E56_W0.7101.00
111_L118_K0.7091.00
92_T120_K0.7071.00
150_L153_L0.7051.00
76_I218_K0.7051.00
186_G191_R0.7041.00
63_I67_K0.7001.00
150_L159_A0.7001.00
42_D128_R0.6961.00
160_I203_Y0.6891.00
147_T176_A0.6811.00
97_D100_N0.6801.00
67_K70_T0.6731.00
143_G171_G0.6701.00
64_T68_T0.6681.00
87_D152_M0.6661.00
118_K125_I0.6641.00
134_L141_A0.6611.00
49_I53_E0.6581.00
45_L151_H0.6581.00
173_C212_L0.6551.00
158_F162_E0.6531.00
151_H178_L0.6531.00
88_V144_I0.6511.00
72_F75_E0.6501.00
87_D106_G0.6501.00
89_G153_L0.6491.00
39_V42_D0.6471.00
46_S111_L0.6461.00
114_L117_M0.6461.00
146_S175_I0.6451.00
206_L210_N0.6431.00
132_N155_N0.6401.00
141_A166_V0.6401.00
42_D109_V0.6391.00
185_I191_R0.6341.00
136_L166_V0.6311.00
195_V198_R0.6281.00
185_I193_W0.6271.00
206_L209_E0.6221.00
183_S190_S0.6131.00
184_I190_S0.6061.00
150_L175_I0.6051.00
76_I216_E0.6031.00
148_L178_L0.6021.00
152_M177_V0.6011.00
140_I165_R0.5991.00
188_T191_R0.5921.00
177_V203_Y0.5921.00
83_D142_D0.5891.00
183_S188_T0.5881.00
71_S98_F0.5871.00
76_I79_F0.5871.00
73_L174_S0.5811.00
185_I190_S0.5811.00
183_S192_W0.5801.00
48_V51_I0.5801.00
150_L160_I0.5781.00
113_F148_L0.5771.00
214_V217_R0.5761.00
139_G169_S0.5751.00
95_I99_L0.5721.00
60_G64_T0.5711.00
140_I168_K0.5701.00
200_Y204_I0.5701.00
62_L70_T0.5681.00
63_I68_T0.5651.00
50_P116_Y0.5631.00
45_L56_W0.5611.00
62_L68_T0.5591.00
50_P53_E0.5591.00
61_L68_T0.5551.00
183_S193_W0.5551.00
100_N124_V0.5541.00
165_R168_K0.5521.00
150_L203_Y0.5501.00
70_T98_F0.5501.00
189_L194_K0.5491.00
156_P198_R0.5471.00
45_L49_I0.5471.00
94_K98_F0.5471.00
184_I191_R0.5471.00
45_L48_V0.5451.00
71_S74_R0.5431.00
139_G168_K0.5431.00
74_R98_F0.5341.00
187_K192_W0.5311.00
49_I113_F0.5291.00
183_S189_L0.5261.00
45_L51_I0.5241.00
37_K41_V0.5231.00
207_L210_N0.5221.00
77_G143_G0.5181.00
88_V134_L0.5151.00
105_I140_I0.5151.00
51_I55_I0.5151.00
49_I112_R0.5131.00
85_I102_K0.5111.00
175_I203_Y0.5111.00
46_S113_F0.5081.00
187_K193_W0.5071.00
88_V107_I0.5071.00
178_L195_V0.5041.00
146_S163_M0.5011.00
144_I171_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4obxA 2 0.7888 100 0.424 Contact Map
4pneA 2 0.875 100 0.433 Contact Map
2o57A 2 0.8578 100 0.436 Contact Map
4kdcA 1 0.7888 100 0.443 Contact Map
3hnrA 1 0.7371 100 0.451 Contact Map
4htfA 2 0.819 100 0.454 Contact Map
4kriA 1 0.9741 100 0.455 Contact Map
3busA 1 0.7629 100 0.456 Contact Map
3dlcA 1 0.8362 100 0.456 Contact Map
4kdrA 1 0.8017 100 0.457 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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