GREMLIN Database
Q7LXN6 - Uncharacterized protein
UniProt: Q7LXN6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (188)
Sequences: 2944 (1560)
Seq/√Len: 113.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
217_T221_N5.4791.00
192_A215_V4.4251.00
131_V154_I3.9291.00
179_T183_K3.8631.00
68_K74_Y3.5371.00
135_T139_T3.2011.00
138_S142_E3.0821.00
193_D218_R2.7931.00
114_W117_V2.6681.00
107_D110_R2.6431.00
133_P160_L2.5221.00
90_E114_W2.4451.00
131_V140_C2.4441.00
138_S178_N2.4001.00
194_D223_V2.3031.00
132_Q135_T2.2911.00
180_I183_K2.2611.00
197_E200_Y2.2341.00
133_P182_E2.1791.00
158_I221_N2.1781.00
200_Y203_N2.1471.00
134_F182_E2.1391.00
196_S200_Y2.0941.00
131_V181_V2.0421.00
68_K76_E1.9671.00
198_L202_I1.9591.00
142_E146_K1.9151.00
163_V184_I1.9071.00
131_V135_T1.8711.00
134_F180_I1.8331.00
203_N207_G1.8181.00
192_A196_S1.8151.00
190_V208_R1.7831.00
188_N220_K1.7601.00
154_I181_V1.7491.00
171_S179_T1.6951.00
136_K139_T1.6921.00
120_S123_G1.6711.00
216_K220_K1.6311.00
171_S175_V1.5921.00
176_T179_T1.5761.00
175_V203_N1.5431.00
140_C144_M1.5091.00
141_I145_L1.5041.00
194_D218_R1.5011.00
124_I215_V1.4911.00
138_S177_G1.4881.00
110_R113_N1.4571.00
139_T142_E1.3991.00
140_C163_V1.3951.00
206_I209_N1.3941.00
141_I177_G1.3911.00
137_I171_S1.3581.00
201_A213_L1.3301.00
148_N165_A1.3291.00
144_M152_L1.2980.99
205_M213_L1.2840.99
110_R114_W1.2610.99
193_D196_S1.2540.99
132_Q160_L1.2500.99
52_I58_N1.2160.99
90_E117_V1.2160.99
193_D200_Y1.2060.99
132_Q156_N1.1910.99
113_N116_S1.1900.99
113_N117_V1.1670.99
119_G123_G1.1540.99
157_G221_N1.1520.99
129_I152_L1.1480.99
149_I152_L1.1290.99
124_I130_V1.1230.99
193_D219_V1.1220.99
129_I149_I1.1220.99
156_N160_L1.1160.98
133_P155_V1.0880.98
144_M168_I1.0760.98
116_S120_S1.0530.98
124_I129_I1.0520.98
54_Q58_N1.0380.98
220_K223_V1.0310.97
63_R67_L1.0220.97
137_I179_T1.0120.97
43_I57_E0.9950.97
132_Q155_V0.9870.97
194_D217_T0.9780.96
60_L67_L0.9780.96
63_R66_E0.9730.96
132_Q182_E0.9700.96
214_I222_K0.9700.96
116_S223_V0.9630.96
198_L231_L0.9620.96
70_R73_V0.9570.96
98_R121_V0.9420.96
66_E74_Y0.9400.96
202_I209_N0.9110.95
192_A228_N0.9080.95
92_S96_L0.9050.95
113_N146_K0.9000.94
204_L231_L0.8900.94
179_T184_I0.8860.94
81_K88_I0.8740.93
66_E69_L0.8700.93
202_I231_L0.8620.93
50_N85_G0.8600.93
158_I220_K0.8560.93
141_I168_I0.8530.93
62_V153_P0.8420.92
159_A212_S0.8360.92
137_I181_V0.8320.92
156_N214_I0.8320.92
156_N221_N0.8300.92
182_E187_V0.8260.91
144_M149_I0.8250.91
136_K180_I0.8240.91
62_V105_E0.8190.91
135_T181_V0.8150.91
135_T152_L0.8100.91
151_H211_G0.8060.90
127_D222_K0.8050.90
147_N152_L0.7920.90
129_I154_I0.7880.89
151_H212_S0.7850.89
62_V69_L0.7830.89
43_I54_Q0.7640.88
102_I115_S0.7600.88
136_K141_I0.7580.87
171_S176_T0.7560.87
192_A214_I0.7560.87
47_T50_N0.7510.87
43_I67_L0.7500.87
143_T152_L0.7490.87
124_I159_A0.7480.87
97_Y100_K0.7480.87
203_N206_I0.7470.87
134_F156_N0.7370.86
131_V192_A0.7370.86
105_E153_P0.7360.86
169_A229_R0.7340.86
60_L64_L0.7310.86
121_V147_N0.7270.85
79_Y96_L0.7270.85
121_V124_I0.7240.85
131_V198_L0.7210.85
69_L75_V0.7200.85
201_A209_N0.7160.84
121_V215_V0.7120.84
129_I143_T0.7070.84
137_I184_I0.7020.83
167_D186_N0.6990.83
171_S177_G0.6980.83
116_S121_V0.6940.82
199_S203_N0.6940.82
50_N55_I0.6890.82
55_I58_N0.6890.82
170_Y206_I0.6880.82
80_I83_I0.6880.82
123_G127_D0.6860.82
151_H162_I0.6840.82
135_T163_V0.6840.82
92_S95_V0.6830.81
130_V152_L0.6820.81
96_L99_G0.6800.81
168_I202_I0.6760.81
137_I168_I0.6730.80
201_A226_L0.6730.80
155_V221_N0.6720.80
108_V112_F0.6720.80
140_C202_I0.6670.80
43_I48_I0.6650.80
132_Q138_S0.6630.79
70_R128_A0.6620.79
83_I105_E0.6620.79
218_R221_N0.6600.79
196_S204_L0.6590.79
158_I219_V0.6570.79
130_V224_K0.6560.79
85_G100_K0.6540.79
163_V232_I0.6510.78
159_A214_I0.6480.78
152_L181_V0.6480.78
177_G180_I0.6390.77
97_Y101_Y0.6360.77
132_Q202_I0.6340.76
193_D197_E0.6330.76
166_R212_S0.6300.76
106_K110_R0.6280.76
55_I100_K0.6270.76
159_A166_R0.6240.75
211_G229_R0.6240.75
78_N84_V0.6240.75
144_M213_L0.6200.75
163_V228_N0.6190.75
139_T181_V0.6180.75
84_V101_Y0.6150.74
198_L228_N0.6140.74
141_I163_V0.6120.74
60_L65_N0.6090.74
217_T223_V0.6070.73
60_L63_R0.6050.73
198_L204_L0.6010.73
82_S85_G0.6000.72
126_K228_N0.6000.72
212_S225_I0.6000.72
46_F54_Q0.6000.72
206_I215_V0.5980.72
191_T220_K0.5980.72
214_I220_K0.5980.72
93_D101_Y0.5960.72
124_I224_K0.5950.72
193_D223_V0.5940.72
142_E145_L0.5940.72
125_S198_L0.5930.72
56_L59_R0.5910.71
166_R211_G0.5910.71
86_T89_G0.5860.71
112_F116_S0.5850.71
50_N111_S0.5850.71
43_I46_F0.5820.70
98_R214_I0.5820.70
85_G88_I0.5800.70
95_V99_G0.5750.69
204_L213_L0.5740.69
131_V168_I0.5710.69
140_C147_N0.5680.68
55_I84_V0.5660.68
50_N89_G0.5610.67
55_I87_M0.5610.67
166_R230_D0.5600.67
78_N82_S0.5580.67
148_N228_N0.5570.67
163_V169_A0.5560.67
164_S229_R0.5550.67
44_G49_E0.5520.66
165_A225_I0.5510.66
120_S165_A0.5510.66
46_F56_L0.5500.66
44_G205_M0.5490.66
84_V100_K0.5480.66
171_S206_I0.5480.66
116_S154_I0.5470.65
141_I152_L0.5470.65
83_I124_I0.5450.65
228_N231_L0.5420.65
116_S123_G0.5420.65
85_G94_F0.5410.65
63_R168_I0.5410.65
150_R211_G0.5390.64
116_S119_G0.5380.64
189_L214_I0.5370.64
141_I144_M0.5370.64
87_M100_K0.5340.64
121_V148_N0.5340.64
66_E143_T0.5330.63
84_V93_D0.5320.63
83_I153_P0.5310.63
176_T180_I0.5310.63
149_I228_N0.5310.63
137_I163_V0.5310.63
140_C181_V0.5300.63
164_S167_D0.5270.63
98_R125_S0.5260.62
47_T55_I0.5240.62
67_L77_D0.5200.62
138_S171_S0.5190.61
177_G188_N0.5190.61
204_L207_G0.5180.61
47_T51_A0.5170.61
162_I186_N0.5140.61
115_S119_G0.5140.61
120_S206_I0.5130.61
228_N232_I0.5120.60
78_N81_K0.5100.60
175_V207_G0.5090.60
192_A204_L0.5080.60
78_N93_D0.5080.60
71_R80_I0.5060.59
93_D97_Y0.5060.59
62_V83_I0.5040.59
71_R158_I0.5030.59
43_I71_R0.5020.59
150_R228_N0.5010.59
60_L69_L0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ouxA 2 0.9458 100 0.428 Contact Map
2zy9A 2 0.9042 100 0.457 Contact Map
2yvyA 2 0.9375 100 0.513 Contact Map
3kxrA 3 0.6917 100 0.517 Contact Map
1vrdA 3 0.35 99.9 0.566 Contact Map
4af0A 3 0.4583 99.9 0.576 Contact Map
3l2bA 2 0.4792 99.9 0.593 Contact Map
3kh5A 1 0.975 99.9 0.597 Contact Map
1vr9A 1 0.4958 99.9 0.598 Contact Map
3usbA 4 0.8333 99.9 0.599 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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