Q7LXN6 - SULSO - GREMLIN Contacts

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Q7LXN6 - Uncharacterized protein

UniProt:	Q7LXN6	Sequences: MSVQINGAEIISLDPNAYVTDALFFMRRNNVRRLVVSNSSNIIGVFTIENAIRQILENRLEVRLNELKLRRPVYVEDNYIKSIVGTMIGESSDFVLYRGKYIITEKDVVRSFNWSSVKGSVEGISKDAIVVQPFTKISTCIETMLKNNIRHLPIVNGIALGIVSARDIAYSYDSVTGNTIVEKIMNVNLVTADDNSELSYAINLMIGRNVGSLIVKTRVKNKVKILTNRDLIKLIFSYIL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	240 (188)
Sequences:	2944 (1560)
Seq/√Len:	113.8

ECOLI - IMDH
BACSU - MGTE IMDH
HALSA - IMDH
SULSO - Q7LXN6 Q97V95

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
217_T	221_N	5.479	1.00
192_A	215_V	4.425	1.00
131_V	154_I	3.929	1.00
179_T	183_K	3.863	1.00
68_K	74_Y	3.537	1.00
135_T	139_T	3.201	1.00
138_S	142_E	3.082	1.00
193_D	218_R	2.793	1.00
114_W	117_V	2.668	1.00
107_D	110_R	2.643	1.00
133_P	160_L	2.522	1.00
90_E	114_W	2.445	1.00
131_V	140_C	2.444	1.00
138_S	178_N	2.400	1.00
194_D	223_V	2.303	1.00
132_Q	135_T	2.291	1.00
180_I	183_K	2.261	1.00
197_E	200_Y	2.234	1.00
133_P	182_E	2.179	1.00
158_I	221_N	2.178	1.00
200_Y	203_N	2.147	1.00
134_F	182_E	2.139	1.00
196_S	200_Y	2.094	1.00
131_V	181_V	2.042	1.00
68_K	76_E	1.967	1.00
198_L	202_I	1.959	1.00
142_E	146_K	1.915	1.00
163_V	184_I	1.907	1.00
131_V	135_T	1.871	1.00
134_F	180_I	1.833	1.00
203_N	207_G	1.818	1.00
192_A	196_S	1.815	1.00
190_V	208_R	1.783	1.00
188_N	220_K	1.760	1.00
154_I	181_V	1.749	1.00
171_S	179_T	1.695	1.00
136_K	139_T	1.692	1.00
120_S	123_G	1.671	1.00
216_K	220_K	1.631	1.00
171_S	175_V	1.592	1.00
176_T	179_T	1.576	1.00
175_V	203_N	1.543	1.00
140_C	144_M	1.509	1.00
141_I	145_L	1.504	1.00
194_D	218_R	1.501	1.00
124_I	215_V	1.491	1.00
138_S	177_G	1.488	1.00
110_R	113_N	1.457	1.00
139_T	142_E	1.399	1.00
140_C	163_V	1.395	1.00
206_I	209_N	1.394	1.00
141_I	177_G	1.391	1.00
137_I	171_S	1.358	1.00
201_A	213_L	1.330	1.00
148_N	165_A	1.329	1.00
144_M	152_L	1.298	0.99
205_M	213_L	1.284	0.99
110_R	114_W	1.261	0.99
193_D	196_S	1.254	0.99
132_Q	160_L	1.250	0.99
52_I	58_N	1.216	0.99
90_E	117_V	1.216	0.99
193_D	200_Y	1.206	0.99
132_Q	156_N	1.191	0.99
113_N	116_S	1.190	0.99
113_N	117_V	1.167	0.99
119_G	123_G	1.154	0.99
157_G	221_N	1.152	0.99
129_I	152_L	1.148	0.99
149_I	152_L	1.129	0.99
124_I	130_V	1.123	0.99
193_D	219_V	1.122	0.99
129_I	149_I	1.122	0.99
156_N	160_L	1.116	0.98
133_P	155_V	1.088	0.98
144_M	168_I	1.076	0.98
116_S	120_S	1.053	0.98
124_I	129_I	1.052	0.98
54_Q	58_N	1.038	0.98
220_K	223_V	1.031	0.97
63_R	67_L	1.022	0.97
137_I	179_T	1.012	0.97
43_I	57_E	0.995	0.97
132_Q	155_V	0.987	0.97
194_D	217_T	0.978	0.96
60_L	67_L	0.978	0.96
63_R	66_E	0.973	0.96
132_Q	182_E	0.970	0.96
214_I	222_K	0.970	0.96
116_S	223_V	0.963	0.96
198_L	231_L	0.962	0.96
70_R	73_V	0.957	0.96
98_R	121_V	0.942	0.96
66_E	74_Y	0.940	0.96
202_I	209_N	0.911	0.95
192_A	228_N	0.908	0.95
92_S	96_L	0.905	0.95
113_N	146_K	0.900	0.94
204_L	231_L	0.890	0.94
179_T	184_I	0.886	0.94
81_K	88_I	0.874	0.93
66_E	69_L	0.870	0.93
202_I	231_L	0.862	0.93
50_N	85_G	0.860	0.93
158_I	220_K	0.856	0.93
141_I	168_I	0.853	0.93
62_V	153_P	0.842	0.92
159_A	212_S	0.836	0.92
137_I	181_V	0.832	0.92
156_N	214_I	0.832	0.92
156_N	221_N	0.830	0.92
182_E	187_V	0.826	0.91
144_M	149_I	0.825	0.91
136_K	180_I	0.824	0.91
62_V	105_E	0.819	0.91
135_T	181_V	0.815	0.91
135_T	152_L	0.810	0.91
151_H	211_G	0.806	0.90
127_D	222_K	0.805	0.90
147_N	152_L	0.792	0.90
129_I	154_I	0.788	0.89
151_H	212_S	0.785	0.89
62_V	69_L	0.783	0.89
43_I	54_Q	0.764	0.88
102_I	115_S	0.760	0.88
136_K	141_I	0.758	0.87
171_S	176_T	0.756	0.87
192_A	214_I	0.756	0.87
47_T	50_N	0.751	0.87
43_I	67_L	0.750	0.87
143_T	152_L	0.749	0.87
124_I	159_A	0.748	0.87
97_Y	100_K	0.748	0.87
203_N	206_I	0.747	0.87
134_F	156_N	0.737	0.86
131_V	192_A	0.737	0.86
105_E	153_P	0.736	0.86
169_A	229_R	0.734	0.86
60_L	64_L	0.731	0.86
121_V	147_N	0.727	0.85
79_Y	96_L	0.727	0.85
121_V	124_I	0.724	0.85
131_V	198_L	0.721	0.85
69_L	75_V	0.720	0.85
201_A	209_N	0.716	0.84
121_V	215_V	0.712	0.84
129_I	143_T	0.707	0.84
137_I	184_I	0.702	0.83
167_D	186_N	0.699	0.83
171_S	177_G	0.698	0.83
116_S	121_V	0.694	0.82
199_S	203_N	0.694	0.82
50_N	55_I	0.689	0.82
55_I	58_N	0.689	0.82
170_Y	206_I	0.688	0.82
80_I	83_I	0.688	0.82
123_G	127_D	0.686	0.82
151_H	162_I	0.684	0.82
135_T	163_V	0.684	0.82
92_S	95_V	0.683	0.81
130_V	152_L	0.682	0.81
96_L	99_G	0.680	0.81
168_I	202_I	0.676	0.81
137_I	168_I	0.673	0.80
201_A	226_L	0.673	0.80
155_V	221_N	0.672	0.80
108_V	112_F	0.672	0.80
140_C	202_I	0.667	0.80
43_I	48_I	0.665	0.80
132_Q	138_S	0.663	0.79
70_R	128_A	0.662	0.79
83_I	105_E	0.662	0.79
218_R	221_N	0.660	0.79
196_S	204_L	0.659	0.79
158_I	219_V	0.657	0.79
130_V	224_K	0.656	0.79
85_G	100_K	0.654	0.79
163_V	232_I	0.651	0.78
159_A	214_I	0.648	0.78
152_L	181_V	0.648	0.78
177_G	180_I	0.639	0.77
97_Y	101_Y	0.636	0.77
132_Q	202_I	0.634	0.76
193_D	197_E	0.633	0.76
166_R	212_S	0.630	0.76
106_K	110_R	0.628	0.76
55_I	100_K	0.627	0.76
159_A	166_R	0.624	0.75
211_G	229_R	0.624	0.75
78_N	84_V	0.624	0.75
144_M	213_L	0.620	0.75
163_V	228_N	0.619	0.75
139_T	181_V	0.618	0.75
84_V	101_Y	0.615	0.74
198_L	228_N	0.614	0.74
141_I	163_V	0.612	0.74
60_L	65_N	0.609	0.74
217_T	223_V	0.607	0.73
60_L	63_R	0.605	0.73
198_L	204_L	0.601	0.73
82_S	85_G	0.600	0.72
126_K	228_N	0.600	0.72
212_S	225_I	0.600	0.72
46_F	54_Q	0.600	0.72
206_I	215_V	0.598	0.72
191_T	220_K	0.598	0.72
214_I	220_K	0.598	0.72
93_D	101_Y	0.596	0.72
124_I	224_K	0.595	0.72
193_D	223_V	0.594	0.72
142_E	145_L	0.594	0.72
125_S	198_L	0.593	0.72
56_L	59_R	0.591	0.71
166_R	211_G	0.591	0.71
86_T	89_G	0.586	0.71
112_F	116_S	0.585	0.71
50_N	111_S	0.585	0.71
43_I	46_F	0.582	0.70
98_R	214_I	0.582	0.70
85_G	88_I	0.580	0.70
95_V	99_G	0.575	0.69
204_L	213_L	0.574	0.69
131_V	168_I	0.571	0.69
140_C	147_N	0.568	0.68
55_I	84_V	0.566	0.68
50_N	89_G	0.561	0.67
55_I	87_M	0.561	0.67
166_R	230_D	0.560	0.67
78_N	82_S	0.558	0.67
148_N	228_N	0.557	0.67
163_V	169_A	0.556	0.67
164_S	229_R	0.555	0.67
44_G	49_E	0.552	0.66
165_A	225_I	0.551	0.66
120_S	165_A	0.551	0.66
46_F	56_L	0.550	0.66
44_G	205_M	0.549	0.66
84_V	100_K	0.548	0.66
171_S	206_I	0.548	0.66
116_S	154_I	0.547	0.65
141_I	152_L	0.547	0.65
83_I	124_I	0.545	0.65
228_N	231_L	0.542	0.65
116_S	123_G	0.542	0.65
85_G	94_F	0.541	0.65
63_R	168_I	0.541	0.65
150_R	211_G	0.539	0.64
116_S	119_G	0.538	0.64
189_L	214_I	0.537	0.64
141_I	144_M	0.537	0.64
87_M	100_K	0.534	0.64
121_V	148_N	0.534	0.64
66_E	143_T	0.533	0.63
84_V	93_D	0.532	0.63
83_I	153_P	0.531	0.63
176_T	180_I	0.531	0.63
149_I	228_N	0.531	0.63
137_I	163_V	0.531	0.63
140_C	181_V	0.530	0.63
164_S	167_D	0.527	0.63
98_R	125_S	0.526	0.62
47_T	55_I	0.524	0.62
67_L	77_D	0.520	0.62
138_S	171_S	0.519	0.61
177_G	188_N	0.519	0.61
204_L	207_G	0.518	0.61
47_T	51_A	0.517	0.61
162_I	186_N	0.514	0.61
115_S	119_G	0.514	0.61
120_S	206_I	0.513	0.61
228_N	232_I	0.512	0.60
78_N	81_K	0.510	0.60
175_V	207_G	0.509	0.60
192_A	204_L	0.508	0.60
78_N	93_D	0.508	0.60
71_R	80_I	0.506	0.59
93_D	97_Y	0.506	0.59
62_V	83_I	0.504	0.59
71_R	158_I	0.503	0.59
43_I	71_R	0.502	0.59
150_R	228_N	0.501	0.59
60_L	69_L	0.500	0.59

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ouxA	2	0.9458	100	0.428	Contact Map
2zy9A	2	0.9042	100	0.457	Contact Map
2yvyA	2	0.9375	100	0.513	Contact Map
3kxrA	3	0.6917	100	0.517	Contact Map
1vrdA	3	0.35	99.9	0.566	Contact Map
4af0A	3	0.4583	99.9	0.576	Contact Map
3l2bA	2	0.4792	99.9	0.593	Contact Map
3kh5A	1	0.975	99.9	0.597	Contact Map
1vr9A	1	0.4958	99.9	0.598	Contact Map
3usbA	4	0.8333	99.9	0.599	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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