GREMLIN Database
Q7LXN4 - Molybdopterin biosynthesis protein (MoeA-1)
UniProt: Q7LXN4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 389 (381)
Sequences: 5344 (4058)
Seq/√Len: 207.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_T238_S3.6271.00
25_K35_K3.5291.00
154_T157_Y3.1261.00
228_T261_K3.0901.00
161_L169_V3.0901.00
39_E170_K3.0681.00
101_L133_I3.0411.00
323_K384_E2.9821.00
26_Y168_H2.9071.00
72_R91_E2.8591.00
151_T157_Y2.7871.00
323_K382_E2.7381.00
88_K91_E2.6721.00
51_S135_E2.6671.00
378_K381_E2.5781.00
46_S136_E2.4591.00
337_D370_I2.4161.00
329_D378_K2.3531.00
61_K64_D2.3481.00
192_Q195_K2.2851.00
40_D148_Q2.2821.00
146_I164_Q2.2601.00
329_D379_K2.2281.00
40_D145_I2.2191.00
46_S142_I2.2091.00
51_S136_E2.1941.00
42_L145_I2.1871.00
289_L306_G2.1691.00
326_L377_Y2.1041.00
40_D149_K2.0971.00
29_I162_I2.0601.00
337_D373_R2.0591.00
26_Y170_K2.0511.00
24_E170_K2.0331.00
324_S385_L2.0201.00
115_R122_I2.0101.00
264_E282_R1.9541.00
46_S141_N1.9411.00
37_A147_I1.9291.00
321_F384_E1.9081.00
342_F367_G1.9031.00
345_K350_F1.8871.00
11_K15_N1.8611.00
186_T195_K1.8581.00
367_G385_L1.8471.00
215_K238_S1.8421.00
240_V310_L1.8141.00
342_F369_A1.8041.00
59_A105_A1.8011.00
147_I157_Y1.8011.00
141_N144_Q1.7811.00
159_G203_I1.7581.00
224_L258_A1.7361.00
27_V35_K1.7321.00
6_V339_V1.7311.00
233_K237_I1.7301.00
325_T382_E1.7241.00
75_G93_Y1.6991.00
110_P113_N1.6911.00
289_L309_V1.6831.00
173_D213_S1.6671.00
211_F302_F1.6641.00
114_S121_V1.6631.00
302_F306_G1.6611.00
17_N309_V1.6591.00
224_L257_K1.6581.00
242_I306_G1.6381.00
307_L311_S1.6331.00
327_V350_F1.6251.00
86_E103_L1.6241.00
60_I107_S1.6211.00
145_I148_Q1.6191.00
270_V305_F1.6161.00
208_L214_V1.5891.00
74_V91_E1.5871.00
62_Y107_S1.5811.00
52_L134_R1.5631.00
324_S349_A1.5571.00
62_Y106_D1.5551.00
175_K213_S1.5521.00
31_Q209_E1.5481.00
78_Y252_K1.5391.00
28_E31_Q1.4961.00
203_I299_I1.4961.00
343_N350_F1.4931.00
178_V205_I1.4881.00
115_R124_K1.4851.00
221_K226_D1.4821.00
50_R100_P1.4821.00
153_I157_Y1.4621.00
299_I362_L1.4561.00
324_S344_V1.4431.00
224_L261_K1.4111.00
109_V123_F1.4041.00
87_L105_A1.3881.00
259_V288_I1.3861.00
223_D226_D1.3691.00
14_S312_N1.3581.00
369_A383_V1.3521.00
44_V166_I1.3441.00
109_V114_S1.3411.00
148_Q151_T1.3401.00
311_S316_T1.3351.00
228_T232_E1.3341.00
5_P8_E1.3331.00
158_L206_K1.3241.00
177_T217_M1.3231.00
375_L381_E1.3211.00
108_V132_N1.3211.00
220_A230_K1.3161.00
41_I161_L1.3131.00
335_S374_G1.3101.00
6_V305_F1.3101.00
343_N366_N1.3061.00
60_I65_Y1.3061.00
322_I387_Q1.3051.00
45_K197_I1.3011.00
61_K106_D1.2911.00
207_I302_F1.2861.00
33_L209_E1.2801.00
272_V305_F1.2761.00
44_V164_Q1.2731.00
278_G305_F1.2711.00
232_E262_L1.2681.00
240_V289_L1.2671.00
300_T368_F1.2641.00
32_A169_V1.2571.00
235_L286_K1.2551.00
78_Y81_T1.2521.00
111_V249_V1.2511.00
8_E11_K1.2451.00
72_R120_Y1.2441.00
75_G83_N1.2401.00
128_K131_K1.2371.00
158_L202_P1.2341.00
95_V99_S1.2241.00
243_S288_I1.2151.00
94_Y111_V1.2041.00
188_F202_P1.2041.00
116_L119_E1.2011.00
224_L228_T1.1981.00
76_K251_E1.1951.00
229_E233_K1.1941.00
279_S290_I1.1871.00
342_F349_A1.1841.00
178_V208_L1.1821.00
51_S103_L1.1821.00
328_E351_P1.1801.00
344_V366_N1.1771.00
107_S127_V1.1731.00
135_E138_E1.1711.00
321_F386_Q1.1711.00
6_V272_V1.1631.00
110_P132_N1.1621.00
217_M238_S1.1581.00
217_M234_S1.1501.00
24_E38_V1.1491.00
63_D106_D1.1471.00
114_S123_F1.1421.00
27_V32_A1.1391.00
201_S216_Y1.1381.00
76_K252_K1.1371.00
13_I280_V1.1351.00
176_F208_L1.1331.00
207_I303_H1.1321.00
16_T280_V1.1281.00
175_K215_K1.1271.00
304_E386_Q1.1201.00
12_I266_L1.1201.00
211_F307_L1.1201.00
28_E168_H1.1181.00
7_E337_D1.1151.00
77_L93_Y1.1141.00
144_Q360_S1.1101.00
241_I286_K1.1071.00
344_V349_A1.1061.00
152_E316_T1.1031.00
326_L330_I1.1011.00
339_V370_I1.0991.00
153_I158_L1.0951.00
179_F220_A1.0951.00
72_R119_E1.0911.00
228_T262_L1.0901.00
280_V289_L1.0791.00
94_Y251_E1.0701.00
159_G359_Y1.0681.00
36_I316_T1.0591.00
62_Y129_K1.0511.00
371_L377_Y1.0501.00
36_I152_E1.0471.00
208_L302_F1.0461.00
189_E197_I1.0451.00
180_A244_V1.0431.00
178_V214_V1.0401.00
344_V385_L1.0391.00
349_A367_G1.0391.00
81_T183_D1.0381.00
33_L158_L1.0361.00
77_L82_S1.0321.00
101_L108_V1.0321.00
349_A385_L1.0311.00
32_A153_I1.0311.00
226_D229_E1.0191.00
303_H307_L1.0141.00
55_M132_N1.0131.00
344_V367_G1.0111.00
303_H319_K1.0091.00
273_N338_S1.0051.00
266_L282_R1.0051.00
215_K237_I1.0031.00
257_K260_N0.9981.00
96_T252_K0.9971.00
155_P210_K0.9941.00
54_A134_R0.9931.00
117_E120_Y0.9931.00
77_L83_N0.9881.00
33_L206_K0.9871.00
225_N229_E0.9851.00
205_I209_E0.9841.00
217_M237_I0.9831.00
54_A132_N0.9751.00
38_V172_S0.9681.00
341_L354_W0.9671.00
228_T258_A0.9651.00
181_N255_V0.9571.00
230_K233_K0.9540.99
351_P369_A0.9530.99
177_T234_S0.9480.99
272_V301_A0.9430.99
226_D230_K0.9400.99
24_E39_E0.9340.99
96_T251_E0.9310.99
179_F230_K0.9310.99
256_K268_D0.9300.99
113_N125_G0.9260.99
240_V287_P0.9240.99
35_K173_D0.9240.99
328_E350_F0.9220.99
343_N364_K0.9170.99
12_I15_N0.9120.99
198_D201_S0.9100.99
87_L93_Y0.9090.99
179_F241_I0.9090.99
157_Y363_A0.9070.99
328_E379_K0.9060.99
61_K89_E0.9050.99
62_Y65_Y0.8980.99
65_Y68_Y0.8980.99
33_L210_K0.8970.99
39_E166_I0.8910.99
165_K197_I0.8900.99
4_I12_I0.8830.99
138_E355_G0.8820.99
225_N228_T0.8810.99
83_N93_Y0.8800.99
220_A226_D0.8790.99
172_S314_L0.8750.99
296_V341_L0.8730.99
234_S241_I0.8730.99
43_A164_Q0.8720.99
177_T241_I0.8710.99
58_Y114_S0.8710.99
58_Y116_L0.8640.99
55_M110_P0.8620.99
153_I161_L0.8610.99
49_E196_I0.8590.99
208_L211_F0.8590.99
187_S190_N0.8570.99
24_E172_S0.8570.99
58_Y111_V0.8570.99
7_E11_K0.8570.99
180_A218_G0.8560.99
106_D129_K0.8530.99
276_K297_S0.8480.99
180_A201_S0.8460.99
234_S238_S0.8430.99
370_I384_E0.8350.99
282_R285_G0.8300.99
204_L302_F0.8290.99
372_K375_L0.8280.99
187_S198_D0.8250.99
34_G210_K0.8250.99
224_L227_V0.8240.99
60_I109_V0.8240.99
73_V121_V0.8230.98
147_I151_T0.8230.98
232_E284_Q0.8210.98
72_R88_K0.8180.98
75_G85_P0.8120.98
161_L166_I0.8060.98
186_T190_N0.8020.98
270_V278_G0.8010.98
51_S101_L0.7970.98
301_A305_F0.7970.98
14_S308_S0.7960.98
231_I241_I0.7940.98
280_V287_P0.7930.98
345_K348_S0.7870.98
304_E339_V0.7860.98
209_E214_V0.7840.98
96_T111_V0.7820.98
54_A138_E0.7820.98
82_S194_N0.7800.98
227_V258_A0.7770.98
65_Y71_L0.7750.98
8_E12_I0.7730.98
65_Y107_S0.7730.98
149_K172_S0.7700.98
340_Y351_P0.7700.98
209_E213_S0.7670.98
35_K171_V0.7670.98
248_S277_R0.7660.98
321_F370_I0.7640.98
178_V204_L0.7640.98
291_L306_G0.7630.98
187_S202_P0.7630.98
186_T192_Q0.7620.98
358_L361_E0.7620.98
205_I214_V0.7600.97
20_V313_I0.7600.97
236_E284_Q0.7590.97
207_I299_I0.7580.97
41_I170_K0.7580.97
100_P193_K0.7580.97
240_V313_I0.7560.97
58_Y121_V0.7530.97
259_V281_G0.7520.97
64_D71_L0.7510.97
282_R287_P0.7500.97
198_D202_P0.7500.97
26_Y39_E0.7490.97
183_D221_K0.7450.97
111_V114_S0.7420.97
139_D296_V0.7420.97
184_E222_D0.7380.97
235_L241_I0.7370.97
377_Y381_E0.7360.97
74_V87_L0.7350.97
62_Y127_V0.7340.97
327_V345_K0.7320.97
68_Y126_E0.7310.97
139_D358_L0.7310.97
303_H368_F0.7310.97
74_V88_K0.7270.97
4_I9_A0.7240.97
13_I309_V0.7210.97
267_F280_V0.7180.96
77_L95_V0.7180.96
85_P93_Y0.7160.96
180_A219_V0.7120.96
73_V92_T0.7110.96
70_K122_I0.7110.96
41_I166_I0.7100.96
342_F385_L0.7090.96
17_N313_I0.7070.96
332_V371_L0.7060.96
12_I16_T0.7040.96
97_T112_E0.6990.96
242_I302_F0.6990.96
278_G301_A0.6990.96
247_S290_I0.6960.96
256_K260_N0.6950.96
255_V288_I0.6930.96
180_A198_D0.6920.96
43_A46_S0.6920.96
134_R292_P0.6910.96
355_G358_L0.6890.96
271_S373_R0.6870.95
227_V254_Y0.6840.95
73_V116_L0.6840.95
37_A169_V0.6830.95
276_K336_M0.6820.95
30_F205_I0.6810.95
167_F188_F0.6800.95
70_K120_Y0.6770.95
233_K236_E0.6760.95
68_Y124_K0.6750.95
360_S364_K0.6730.95
51_S133_I0.6730.95
268_D279_S0.6700.95
292_P297_S0.6700.95
64_D89_E0.6690.95
265_V281_G0.6660.95
10_R14_S0.6640.95
79_P99_S0.6630.95
63_D129_K0.6600.94
232_E236_E0.6600.94
224_L254_Y0.6540.94
243_S255_V0.6540.94
138_E357_G0.6520.94
258_A261_K0.6490.94
243_S247_S0.6470.94
40_D151_T0.6470.94
47_M140_I0.6450.94
208_L213_S0.6450.94
140_I146_I0.6450.94
325_T380_G0.6450.94
205_I216_Y0.6430.94
265_V279_S0.6430.94
45_K49_E0.6420.94
107_S129_K0.6410.93
109_V127_V0.6410.93
342_F366_N0.6410.93
101_L104_Y0.6410.93
30_F209_E0.6400.93
256_K279_S0.6390.93
17_N287_P0.6390.93
76_K94_Y0.6370.93
92_T121_V0.6360.93
82_S100_P0.6340.93
207_I211_F0.6330.93
330_I369_A0.6330.93
258_A262_L0.6330.93
191_P197_I0.6330.93
309_V313_I0.6300.93
78_Y96_T0.6300.93
185_I198_D0.6290.93
283_I287_P0.6280.93
230_K234_S0.6270.93
332_V338_S0.6260.93
277_R356_V0.6250.93
156_Y299_I0.6250.93
352_L365_A0.6240.93
266_L280_V0.6240.93
21_K24_E0.6220.92
273_N336_M0.6220.92
179_F218_G0.6200.92
147_I161_L0.6190.92
114_S124_K0.6170.92
65_Y70_K0.6160.92
349_A369_A0.6160.92
97_T277_R0.6120.92
208_L310_L0.6110.92
52_L357_G0.6100.92
96_T247_S0.6100.92
96_T99_S0.6100.92
4_I267_F0.6090.92
20_V172_S0.6080.92
218_G230_K0.6080.92
5_P271_S0.6080.92
47_M139_D0.6080.92
146_I160_I0.6070.92
198_D219_V0.6070.92
19_E312_N0.6040.91
71_L121_V0.6040.91
200_I244_V0.6030.91
204_L242_I0.6010.91
37_A40_D0.5990.91
177_T237_I0.5980.91
183_D219_V0.5970.91
16_T282_R0.5940.91
65_Y127_V0.5920.90
49_E137_G0.5920.90
241_I288_I0.5910.90
254_Y257_K0.5910.90
77_L81_T0.5900.90
177_T218_G0.5880.90
177_T215_K0.5880.90
63_D89_E0.5880.90
322_I385_L0.5860.90
61_K105_A0.5860.90
203_I298_A0.5850.90
19_E313_I0.5850.90
179_F217_M0.5820.90
175_K238_S0.5820.90
74_V93_Y0.5810.90
187_S219_V0.5810.90
311_S314_L0.5800.90
342_F383_V0.5800.90
249_V269_G0.5800.90
296_V362_L0.5780.89
58_Y73_V0.5770.89
107_S131_K0.5760.89
205_I208_L0.5750.89
220_A227_V0.5750.89
349_A383_V0.5740.89
162_I202_P0.5730.89
64_D90_G0.5720.89
67_K126_E0.5720.89
139_D163_Q0.5710.89
297_S356_V0.5700.89
231_I258_A0.5680.89
79_P134_R0.5680.89
87_L91_E0.5680.89
181_N222_D0.5660.88
341_L358_L0.5650.88
5_P373_R0.5630.88
246_G255_V0.5610.88
53_S294_Q0.5600.88
58_Y92_T0.5590.88
50_R196_I0.5570.88
257_K261_K0.5570.88
60_I71_L0.5560.88
324_S345_K0.5550.87
183_D252_K0.5540.87
139_D360_S0.5520.87
185_I197_I0.5500.87
324_S366_N0.5500.87
44_V142_I0.5490.87
151_T154_T0.5480.87
327_V366_N0.5470.87
244_V298_A0.5460.87
188_F197_I0.5460.87
326_L381_E0.5460.87
167_F189_E0.5460.87
10_R16_T0.5460.87
74_V85_P0.5450.87
235_L283_I0.5430.86
27_V171_V0.5420.86
14_S17_N0.5400.86
294_Q356_V0.5400.86
281_G290_I0.5390.86
37_A151_T0.5380.86
55_M276_K0.5380.86
59_A102_P0.5370.86
341_L361_E0.5360.86
172_S315_G0.5360.86
52_L256_K0.5360.86
6_V337_D0.5350.86
55_M97_T0.5350.86
20_V24_E0.5330.85
334_H374_G0.5320.85
6_V10_R0.5320.85
132_N138_E0.5320.85
231_I235_L0.5310.85
74_V83_N0.5310.85
166_I169_V0.5290.85
134_R256_K0.5280.85
238_S241_I0.5270.85
310_L314_L0.5270.85
7_E10_R0.5270.85
125_G131_K0.5260.85
287_P309_V0.5260.85
37_A148_Q0.5260.85
13_I305_F0.5250.84
370_I373_R0.5240.84
25_K171_V0.5240.84
292_P338_S0.5230.84
176_F240_V0.5230.84
144_Q364_K0.5220.84
283_I286_K0.5220.84
61_K88_K0.5200.84
64_D105_A0.5190.84
30_F33_L0.5190.84
369_A385_L0.5190.84
319_K386_Q0.5180.84
250_G293_G0.5160.83
110_P131_K0.5130.83
259_V283_I0.5130.83
16_T264_E0.5120.83
278_G355_G0.5110.83
53_S95_V0.5100.83
179_F234_S0.5100.83
377_Y383_V0.5100.83
6_V304_E0.5090.83
174_L313_I0.5090.83
10_R305_F0.5090.83
352_L364_K0.5070.82
55_M134_R0.5070.82
29_I41_I0.5060.82
333_N376_T0.5060.82
79_P96_T0.5060.82
308_S311_S0.5060.82
160_I359_Y0.5060.82
121_V124_K0.5050.82
39_E149_K0.5050.82
4_I8_E0.5040.82
304_E368_F0.5030.82
44_V197_I0.5020.82
211_F311_S0.5010.82
16_T287_P0.5000.82
253_D276_K0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g8lA 2 0.9923 100 0.134 Contact Map
1uz5A 1 0.9743 100 0.138 Contact Map
4pd0A 2 0.982 100 0.154 Contact Map
1wu2A 2 0.9537 100 0.161 Contact Map
3rfqA 5 0.365 100 0.684 Contact Map
1jljA 3 0.3856 100 0.686 Contact Map
4lhbA 4 0.3676 100 0.705 Contact Map
3iwtA 4 0.3779 100 0.713 Contact Map
2pbqA 3 0.4062 100 0.715 Contact Map
1y5eA 4 0.3676 100 0.715 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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