GREMLIN Database
Q7LXN3 - Molybdopterin-guanine dinucleotide biosynthesis protein A (MobA)
UniProt: Q7LXN3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (172)
Sequences: 3318 (2642)
Seq/√Len: 201.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_K40_E5.1291.00
10_I77_G3.1941.00
33_T36_D3.1121.00
25_C91_C3.0391.00
87_F101_V2.9261.00
95_F181_R2.9201.00
20_F27_F2.8541.00
8_D83_R2.6661.00
81_V86_V2.4811.00
79_K135_I2.2161.00
143_E146_E2.1911.00
27_F178_L2.0651.00
9_V42_F1.9581.00
8_D44_N1.9421.00
75_R135_I1.8531.00
174_S177_D1.8271.00
10_I86_V1.7991.00
32_K36_D1.7791.00
74_V88_I1.7661.00
75_R79_K1.7591.00
68_E142_V1.7251.00
13_A47_V1.7171.00
8_D81_V1.6741.00
85_R127_S1.6681.00
110_D127_S1.6521.00
93_F123_L1.6441.00
96_L123_L1.6151.00
22_A27_F1.5791.00
46_I61_V1.5611.00
78_L86_V1.5591.00
44_N59_I1.5551.00
85_R125_C1.5471.00
48_V77_G1.5261.00
137_K141_L1.5191.00
17_S25_C1.4981.00
20_F175_I1.4961.00
39_L45_P1.4931.00
135_I139_N1.4841.00
32_K37_R1.4841.00
17_S22_A1.4791.00
17_S20_F1.4671.00
89_T96_L1.4481.00
28_E31_S1.3961.00
116_D120_Q1.3961.00
34_M38_L1.3811.00
100_L168_S1.3761.00
72_K76_E1.3741.00
39_L58_G1.3161.00
144_L147_L1.3151.00
90_G93_F1.3121.00
49_S60_L1.3021.00
87_F125_C1.2991.00
36_D40_E1.2931.00
179_I182_P1.2741.00
110_D155_G1.2731.00
10_I48_V1.2641.00
111_I148_S1.2431.00
141_L146_E1.2201.00
119_P158_E1.2141.00
178_L182_P1.2141.00
74_V144_L1.2121.00
90_G123_L1.2091.00
97_I168_S1.2001.00
137_K147_L1.1881.00
11_I35_L1.1721.00
134_N147_L1.1621.00
145_I149_S1.1471.00
110_D129_E1.1321.00
64_K79_K1.1301.00
81_V128_T1.1131.00
48_V61_V1.1071.00
172_I181_R1.1041.00
170_I181_R1.1041.00
9_V38_L1.0961.00
90_G126_Y1.0871.00
172_I178_L1.0741.00
29_V34_M1.0741.00
65_G68_E1.0711.00
61_V76_E1.0671.00
113_I119_P1.0641.00
10_I88_I1.0521.00
97_I100_L1.0411.00
11_I39_L1.0301.00
22_A175_I1.0201.00
38_L41_Q1.0021.00
111_I154_I0.9981.00
34_M172_I0.9941.00
42_F87_F0.9901.00
38_L89_T0.9831.00
28_E33_T0.9821.00
79_K131_L0.9781.00
176_I179_I0.9771.00
105_C125_C0.9741.00
155_G159_L0.9731.00
77_G86_V0.9731.00
16_L67_Y0.9700.99
27_F175_I0.9690.99
115_F119_P0.9610.99
84_D128_T0.9600.99
23_D26_C0.9570.99
7_Y105_C0.9570.99
136_D140_G0.9550.99
37_R41_Q0.9540.99
88_I126_Y0.9510.99
8_D46_I0.9400.99
95_F170_I0.9310.99
111_I114_P0.9160.99
133_K147_L0.9130.99
111_I156_T0.9030.99
140_G150_S0.9000.99
133_K150_S0.8950.99
7_Y42_F0.8910.99
115_F158_E0.8880.99
145_I148_S0.8860.99
51_S54_R0.8860.99
71_V134_N0.8820.99
30_N37_R0.8660.99
86_V128_T0.8610.99
113_I124_A0.8580.99
102_D106_S0.8580.99
71_V138_I0.8570.99
104_V112_V0.8470.99
115_F160_L0.8460.99
68_E138_I0.8450.99
69_G72_K0.8420.99
146_E149_S0.8370.99
136_D139_N0.8360.98
33_T37_R0.8360.98
130_L133_K0.8350.98
65_G75_R0.8310.98
15_G19_R0.8290.98
156_T159_L0.8280.98
68_E72_K0.8190.98
133_K137_K0.8180.98
176_I180_Y0.8080.98
46_I80_Y0.8030.98
128_T131_L0.7980.98
74_V126_Y0.7940.98
50_R69_G0.7940.98
84_D127_S0.7940.98
25_C35_L0.7830.98
133_K136_D0.7820.98
93_F122_L0.7800.98
99_N103_Y0.7760.98
59_I80_Y0.7760.98
156_T161_K0.7760.98
170_I180_Y0.7750.98
14_G70_P0.7710.97
28_E32_K0.7670.97
70_P73_G0.7590.97
72_K75_R0.7460.97
42_F101_V0.7450.97
108_P112_V0.7360.97
113_I156_T0.7320.97
89_T101_V0.7320.97
50_R62_I0.7280.96
11_I45_P0.7280.96
28_E182_P0.7230.96
35_L47_V0.7160.96
61_V77_G0.7110.96
14_G19_R0.7100.96
114_P161_K0.7050.96
84_D129_E0.7020.96
46_I81_V0.7000.96
118_R145_I0.6980.95
177_D180_Y0.6940.95
63_E173_N0.6910.95
17_S23_D0.6880.95
30_N182_P0.6880.95
63_E73_G0.6860.95
43_D83_R0.6840.95
163_D168_S0.6800.95
29_V37_R0.6800.95
137_K146_E0.6800.95
64_K75_R0.6740.95
113_I148_S0.6730.94
133_K154_I0.6710.94
41_Q96_L0.6670.94
14_G73_G0.6660.94
108_P127_S0.6630.94
35_L39_L0.6620.94
122_L126_Y0.6590.94
144_L148_S0.6530.94
107_K112_V0.6520.94
41_Q98_K0.6500.93
61_V80_Y0.6450.93
51_S55_I0.6430.93
78_L81_V0.6410.93
156_T160_L0.6360.93
20_F172_I0.6330.92
44_N83_R0.6310.92
131_L135_I0.6300.92
121_P145_I0.6290.92
124_A148_S0.6270.92
132_N135_I0.6230.92
7_Y101_V0.6210.92
53_R62_I0.6190.92
157_E160_L0.6150.91
155_G158_E0.6140.91
23_D51_S0.6130.91
175_I179_I0.6110.91
71_V147_L0.6100.91
38_L96_L0.6090.91
95_F167_Y0.6020.91
20_F23_D0.5980.90
112_V125_C0.5980.90
98_K102_D0.5980.90
38_L178_L0.5960.90
163_D166_L0.5950.90
104_V125_C0.5930.90
65_G72_K0.5900.90
23_D52_P0.5890.90
43_D46_I0.5880.89
77_G81_V0.5870.89
132_N136_D0.5860.89
48_V76_E0.5850.89
24_K92_D0.5840.89
154_I162_I0.5820.89
103_Y107_K0.5810.89
99_N102_D0.5780.89
49_S53_R0.5780.89
34_M91_C0.5770.89
100_L104_V0.5750.88
93_F120_Q0.5720.88
100_L114_P0.5700.88
107_K157_E0.5690.88
17_S178_L0.5680.88
143_E147_L0.5660.88
102_D105_C0.5640.87
73_G76_E0.5630.87
10_I81_V0.5560.87
9_V89_T0.5500.86
157_E180_Y0.5480.86
7_Y125_C0.5470.86
17_S21_G0.5460.86
14_G63_E0.5450.86
73_G77_G0.5430.85
158_E162_I0.5430.85
113_I121_P0.5430.85
8_D86_V0.5350.85
75_R138_I0.5350.85
146_E150_S0.5340.84
134_N137_K0.5310.84
12_L19_R0.5290.84
17_S175_I0.5290.84
12_L15_G0.5290.84
10_I46_I0.5270.84
109_Y114_P0.5230.83
121_P126_Y0.5180.83
154_I161_K0.5170.83
26_C35_L0.5140.82
69_G142_V0.5140.82
29_V181_R0.5130.82
154_I157_E0.5070.81
89_T123_L0.5060.81
136_D150_S0.5050.81
103_Y162_I0.5040.81
141_L147_L0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e5kA 1 0.9021 100 0.388 Contact Map
2e8bA 1 0.8711 100 0.4 Contact Map
3ngwA 2 0.9124 100 0.413 Contact Map
2weeA 1 0.9072 100 0.448 Contact Map
2wawA 1 0.9278 100 0.455 Contact Map
3d5nA 2 0.8608 100 0.464 Contact Map
2px7A 2 0.8608 99.9 0.543 Contact Map
3rsbA 1 0.799 99.9 0.548 Contact Map
1vpaA 2 0.9175 99.9 0.568 Contact Map
2xmeA 3 0.8505 99.9 0.574 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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