Q7LXN2 - SULSO - GREMLIN Contacts

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Q7LXN2 - Uncharacterized protein

UniProt:	Q7LXN2	Sequences: MKICVLYSGGKDSTYALHWAVFKGFEVVCLITLIPKREDSWMFQYPNVIYTKYQAEAMDFKLITFGTSGEKDKELEDLKKALLQAKNEGADGIVSGALLSDYQRLNISIIAEELGLKTYTPLWRKSQEEYMRWLVKEGFKFIITSASAYGFPFDLVGKEITTEDVEKIIERARRYGFNPAFEGGEAETFVTYAPLFKTQLRVNGKLKRISEYECRYEITDIH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	222 (205)
Sequences:	1151 (875)
Seq/√Len:	61.1

HALSA - Q9HS60
SULSO - Q7LXN2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
140_K	159_E	3.553	1.00
20_A	94_V	3.442	1.00
50_Y	189_F	3.369	1.00
158_K	167_K	3.099	1.00
130_Y	134_L	2.904	1.00
19_W	125_K	2.862	1.00
181_F	186_A	2.851	1.00
3_I	27_V	2.804	1.00
52_K	64_T	2.755	1.00
101_D	105_L	2.745	1.00
31_I	81_A	2.640	1.00
104_R	108_S	2.605	1.00
143_I	164_D	2.477	1.00
18_H	139_F	2.468	1.00
79_K	113_E	2.305	1.00
140_K	199_Q	2.224	1.00
131_M	160_I	2.151	1.00
125_K	133_W	2.146	1.00
134_L	139_F	2.000	1.00
146_A	151_F	1.983	1.00
128_E	132_R	1.961	1.00
125_K	129_E	1.905	1.00
59_D	197_K	1.881	1.00
92_G	119_Y	1.876	1.00
95_S	118_T	1.869	1.00
140_K	192_Y	1.788	1.00
15_Y	134_L	1.774	0.99
95_S	120_T	1.730	0.99
65_F	84_Q	1.725	0.99
3_I	94_V	1.722	0.99
7_Y	14_T	1.720	0.99
3_I	92_G	1.716	0.99
84_Q	88_E	1.714	0.99
36_K	66_G	1.707	0.99
128_E	169_I	1.674	0.99
53_Y	200_L	1.656	0.99
58_M	195_L	1.654	0.99
4_C	31_I	1.630	0.99
189_F	200_L	1.621	0.99
5_V	17_L	1.617	0.99
19_W	133_W	1.603	0.99
83_L	87_N	1.581	0.99
161_T	164_D	1.561	0.99
101_D	124_R	1.541	0.99
7_Y	54_Q	1.531	0.98
21_V	195_L	1.519	0.98
17_L	27_V	1.491	0.98
108_S	120_T	1.453	0.98
25_F	119_Y	1.444	0.98
158_K	161_T	1.414	0.97
136_K	162_T	1.397	0.97
99_L	127_Q	1.378	0.97
164_D	168_I	1.371	0.97
93_I	111_A	1.370	0.97
192_Y	199_Q	1.362	0.97
82_L	93_I	1.362	0.97
132_R	165_V	1.353	0.97
4_C	85_A	1.349	0.97
147_S	150_G	1.344	0.96
57_A	198_T	1.343	0.96
15_Y	137_E	1.338	0.96
33_L	67_T	1.324	0.96
153_F	207_K	1.324	0.96
132_R	162_T	1.307	0.96
182_E	185_E	1.269	0.95
48_V	64_T	1.269	0.95
97_A	106_N	1.268	0.95
140_K	191_T	1.257	0.95
56_E	198_T	1.256	0.95
103_Q	106_N	1.252	0.95
55_A	60_F	1.251	0.95
155_L	167_K	1.244	0.94
82_L	116_L	1.237	0.94
168_I	177_F	1.232	0.94
105_L	109_I	1.210	0.94
55_A	62_L	1.208	0.94
102_Y	106_N	1.199	0.93
160_I	186_A	1.197	0.93
152_P	155_L	1.187	0.93
159_E	191_T	1.182	0.93
33_L	65_F	1.152	0.92
65_F	81_A	1.139	0.91
139_F	195_L	1.135	0.91
79_K	114_L	1.129	0.91
31_I	85_A	1.127	0.91
53_Y	56_E	1.126	0.91
58_M	193_A	1.124	0.91
134_L	137_E	1.122	0.91
4_C	29_C	1.115	0.91
14_T	54_Q	1.105	0.90
65_F	80_K	1.103	0.90
42_M	69_G	1.102	0.90
16_A	94_V	1.101	0.90
63_I	84_Q	1.098	0.90
99_L	124_R	1.097	0.90
20_A	27_V	1.069	0.89
4_C	90_A	1.058	0.88
100_S	103_Q	1.049	0.88
108_S	118_T	1.046	0.87
131_M	186_A	1.045	0.87
15_Y	133_W	1.038	0.87
146_A	152_P	1.029	0.87
97_A	187_E	1.009	0.86
16_A	20_A	1.001	0.85
97_A	102_Y	1.000	0.85
18_H	22_F	0.991	0.84
202_V	205_K	0.989	0.84
97_A	100_S	0.987	0.84
18_H	21_V	0.979	0.84
40_S	45_Y	0.978	0.84
135_V	160_I	0.977	0.84
127_Q	178_N	0.976	0.84
28_V	90_A	0.969	0.83
160_I	164_D	0.964	0.83
111_A	118_T	0.963	0.83
17_L	60_F	0.959	0.82
17_L	21_V	0.956	0.82
63_I	85_A	0.955	0.82
162_T	166_E	0.942	0.81
6_L	103_Q	0.929	0.80
27_V	60_F	0.929	0.80
53_Y	57_A	0.919	0.80
19_W	22_F	0.917	0.80
7_Y	30_L	0.907	0.79
151_F	155_L	0.906	0.79
132_R	136_K	0.892	0.78
161_T	167_K	0.887	0.77
178_N	187_E	0.885	0.77
142_I	202_V	0.877	0.76
130_Y	181_F	0.874	0.76
15_Y	19_W	0.874	0.76
3_I	20_A	0.871	0.76
8_S	11_K	0.868	0.76
42_M	107_I	0.865	0.75
40_S	47_N	0.863	0.75
5_V	13_S	0.862	0.75
139_F	194_P	0.852	0.74
35_P	67_T	0.852	0.74
98_L	130_Y	0.852	0.74
183_G	187_E	0.849	0.74
54_Q	196_F	0.844	0.74
100_S	106_N	0.842	0.73
15_Y	130_Y	0.841	0.73
107_I	120_T	0.836	0.73
80_K	83_L	0.831	0.72
27_V	30_L	0.825	0.72
78_L	106_N	0.816	0.71
155_L	164_D	0.815	0.71
93_I	116_L	0.813	0.71
95_S	107_I	0.812	0.71
3_I	25_F	0.811	0.71
97_A	107_I	0.809	0.70
15_Y	139_F	0.809	0.70
106_N	111_A	0.804	0.70
39_D	48_V	0.803	0.70
3_I	17_L	0.801	0.70
18_H	137_E	0.801	0.70
29_C	63_I	0.798	0.69
125_K	130_Y	0.788	0.68
80_K	199_Q	0.784	0.68
142_I	191_T	0.782	0.68
142_I	159_E	0.777	0.67
36_K	68_S	0.772	0.67
134_L	141_F	0.760	0.66
3_I	30_L	0.752	0.65
100_S	187_E	0.749	0.65
14_T	196_F	0.747	0.64
16_A	121_P	0.745	0.64
141_F	145_S	0.744	0.64
34_I	66_G	0.742	0.64
110_I	113_E	0.740	0.64
43_F	103_Q	0.737	0.63
20_A	119_Y	0.735	0.63
99_L	106_N	0.728	0.62
126_S	129_E	0.728	0.62
54_Q	59_D	0.725	0.62
85_A	90_A	0.720	0.61
20_A	121_P	0.716	0.61
192_Y	198_T	0.712	0.61
43_F	75_L	0.707	0.60
51_T	62_L	0.706	0.60
27_V	203_N	0.706	0.60
19_W	23_K	0.702	0.59
151_F	177_F	0.701	0.59
67_T	77_D	0.700	0.59
18_H	195_L	0.698	0.59
108_S	112_E	0.689	0.58
79_K	83_L	0.687	0.58
74_E	78_L	0.683	0.57
192_Y	196_F	0.681	0.57
103_Q	187_E	0.680	0.57
30_L	54_Q	0.677	0.57
79_K	110_I	0.676	0.57
14_T	139_F	0.675	0.57
74_E	106_N	0.674	0.56
141_F	190_V	0.668	0.56
16_A	95_S	0.667	0.56
111_A	127_Q	0.665	0.55
106_N	187_E	0.663	0.55
134_L	193_A	0.662	0.55
48_V	51_T	0.660	0.55
18_H	193_A	0.656	0.54
130_Y	133_W	0.653	0.54
8_S	12_D	0.651	0.54
139_F	193_A	0.651	0.54
63_I	198_T	0.650	0.54
32_T	64_T	0.648	0.53
132_R	143_I	0.646	0.53
191_T	202_V	0.642	0.53
22_F	137_E	0.641	0.53
8_S	33_L	0.641	0.53
103_Q	147_S	0.640	0.53
33_L	107_I	0.639	0.52
4_C	9_G	0.637	0.52
158_K	164_D	0.637	0.52
135_V	165_V	0.635	0.52
74_E	187_E	0.632	0.52
5_V	20_A	0.631	0.52
23_K	163_E	0.626	0.51
22_F	139_F	0.626	0.51
55_A	170_E	0.625	0.51
29_C	85_A	0.624	0.51
40_S	100_S	0.623	0.51
99_L	178_N	0.622	0.51
40_S	102_Y	0.621	0.50
209_I	212_Y	0.620	0.50
97_A	147_S	0.618	0.50
102_Y	187_E	0.615	0.50
7_Y	32_T	0.615	0.50
40_S	187_E	0.614	0.50
37_R	57_A	0.613	0.50
104_R	123_W	0.613	0.50
97_A	103_Q	0.611	0.49
191_T	199_Q	0.609	0.49
197_K	203_N	0.609	0.49
132_R	163_E	0.607	0.49
50_Y	62_L	0.605	0.49
74_E	97_A	0.602	0.48
102_Y	183_G	0.601	0.48
87_N	112_E	0.598	0.48
139_F	190_V	0.593	0.47
74_E	100_S	0.591	0.47
124_R	160_I	0.589	0.47
6_L	71_K	0.589	0.47
28_V	60_F	0.584	0.46
4_C	93_I	0.582	0.46
105_L	108_S	0.582	0.46
35_P	42_M	0.581	0.46
161_T	168_I	0.579	0.46
190_V	196_F	0.578	0.46
161_T	165_V	0.577	0.45
46_P	189_F	0.575	0.45
20_A	25_F	0.574	0.45
103_Q	150_G	0.574	0.45
139_F	196_F	0.572	0.45
32_T	54_Q	0.569	0.45
29_C	60_F	0.568	0.44
81_A	85_A	0.564	0.44
4_C	46_P	0.564	0.44
135_V	167_K	0.560	0.44
9_G	12_D	0.553	0.43
69_G	77_D	0.552	0.43
134_L	191_T	0.551	0.43
82_L	163_E	0.551	0.43
3_I	119_Y	0.550	0.42
179_P	188_T	0.550	0.42
146_A	156_V	0.547	0.42
59_D	206_L	0.545	0.42
32_T	48_V	0.544	0.42
141_F	159_E	0.542	0.42
42_M	100_S	0.541	0.41
143_I	207_K	0.541	0.41
26_E	154_D	0.540	0.41
100_S	183_G	0.540	0.41
130_Y	180_A	0.540	0.41
30_L	34_I	0.539	0.41
22_F	188_T	0.537	0.41
148_A	177_F	0.534	0.41
14_T	195_L	0.534	0.41
88_E	112_E	0.533	0.41
41_W	106_N	0.532	0.40
81_A	150_G	0.529	0.40
109_I	112_E	0.528	0.40
73_K	77_D	0.528	0.40
93_I	103_Q	0.527	0.40
120_T	187_E	0.527	0.40
42_M	102_Y	0.521	0.39
43_F	69_G	0.520	0.39
147_S	187_E	0.520	0.39
19_W	124_R	0.519	0.39
35_P	43_F	0.517	0.39
43_F	102_Y	0.515	0.39
50_Y	105_L	0.514	0.39
40_S	43_F	0.512	0.38
56_E	59_D	0.512	0.38
91_D	116_L	0.511	0.38
145_S	150_G	0.511	0.38
17_L	58_M	0.509	0.38
41_W	187_E	0.509	0.38
6_L	147_S	0.507	0.38
35_P	40_S	0.506	0.38
94_V	121_P	0.503	0.37
111_A	122_L	0.502	0.37
9_G	98_L	0.502	0.37
6_L	114_L	0.502	0.37
128_E	179_P	0.501	0.37
129_E	203_N	0.501	0.37
41_W	97_A	0.500	0.37

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rjzA	2	0.9009	100	0.369	Contact Map
2nz2A	4	0.9595	99.7	0.775	Contact Map
1korA	4	0.9009	99.6	0.785	Contact Map
4xfjA	4	0.9505	99.6	0.786	Contact Map
2ywbA	4	0.9324	99.6	0.794	Contact Map
4kr6A	2	0.8468	99.5	0.798	Contact Map
4nzpA	4	0.8919	99.5	0.802	Contact Map
1k92A	4	0.9459	99.5	0.805	Contact Map
2c5sA	2	0.8198	99.5	0.806	Contact Map
2derA	1	0.9595	99.5	0.808	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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