GREMLIN Database
Q7LXN2 - Uncharacterized protein
UniProt: Q7LXN2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 222 (205)
Sequences: 1151 (875)
Seq/√Len: 61.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_K159_E3.5531.00
20_A94_V3.4421.00
50_Y189_F3.3691.00
158_K167_K3.0991.00
130_Y134_L2.9041.00
19_W125_K2.8621.00
181_F186_A2.8511.00
3_I27_V2.8041.00
52_K64_T2.7551.00
101_D105_L2.7451.00
31_I81_A2.6401.00
104_R108_S2.6051.00
143_I164_D2.4771.00
18_H139_F2.4681.00
79_K113_E2.3051.00
140_K199_Q2.2241.00
131_M160_I2.1511.00
125_K133_W2.1461.00
134_L139_F2.0001.00
146_A151_F1.9831.00
128_E132_R1.9611.00
125_K129_E1.9051.00
59_D197_K1.8811.00
92_G119_Y1.8761.00
95_S118_T1.8691.00
140_K192_Y1.7881.00
15_Y134_L1.7740.99
95_S120_T1.7300.99
65_F84_Q1.7250.99
3_I94_V1.7220.99
7_Y14_T1.7200.99
3_I92_G1.7160.99
84_Q88_E1.7140.99
36_K66_G1.7070.99
128_E169_I1.6740.99
53_Y200_L1.6560.99
58_M195_L1.6540.99
4_C31_I1.6300.99
189_F200_L1.6210.99
5_V17_L1.6170.99
19_W133_W1.6030.99
83_L87_N1.5810.99
161_T164_D1.5610.99
101_D124_R1.5410.99
7_Y54_Q1.5310.98
21_V195_L1.5190.98
17_L27_V1.4910.98
108_S120_T1.4530.98
25_F119_Y1.4440.98
158_K161_T1.4140.97
136_K162_T1.3970.97
99_L127_Q1.3780.97
164_D168_I1.3710.97
93_I111_A1.3700.97
192_Y199_Q1.3620.97
82_L93_I1.3620.97
132_R165_V1.3530.97
4_C85_A1.3490.97
147_S150_G1.3440.96
57_A198_T1.3430.96
15_Y137_E1.3380.96
33_L67_T1.3240.96
153_F207_K1.3240.96
132_R162_T1.3070.96
182_E185_E1.2690.95
48_V64_T1.2690.95
97_A106_N1.2680.95
140_K191_T1.2570.95
56_E198_T1.2560.95
103_Q106_N1.2520.95
55_A60_F1.2510.95
155_L167_K1.2440.94
82_L116_L1.2370.94
168_I177_F1.2320.94
105_L109_I1.2100.94
55_A62_L1.2080.94
102_Y106_N1.1990.93
160_I186_A1.1970.93
152_P155_L1.1870.93
159_E191_T1.1820.93
33_L65_F1.1520.92
65_F81_A1.1390.91
139_F195_L1.1350.91
79_K114_L1.1290.91
31_I85_A1.1270.91
53_Y56_E1.1260.91
58_M193_A1.1240.91
134_L137_E1.1220.91
4_C29_C1.1150.91
14_T54_Q1.1050.90
65_F80_K1.1030.90
42_M69_G1.1020.90
16_A94_V1.1010.90
63_I84_Q1.0980.90
99_L124_R1.0970.90
20_A27_V1.0690.89
4_C90_A1.0580.88
100_S103_Q1.0490.88
108_S118_T1.0460.87
131_M186_A1.0450.87
15_Y133_W1.0380.87
146_A152_P1.0290.87
97_A187_E1.0090.86
16_A20_A1.0010.85
97_A102_Y1.0000.85
18_H22_F0.9910.84
202_V205_K0.9890.84
97_A100_S0.9870.84
18_H21_V0.9790.84
40_S45_Y0.9780.84
135_V160_I0.9770.84
127_Q178_N0.9760.84
28_V90_A0.9690.83
160_I164_D0.9640.83
111_A118_T0.9630.83
17_L60_F0.9590.82
17_L21_V0.9560.82
63_I85_A0.9550.82
162_T166_E0.9420.81
6_L103_Q0.9290.80
27_V60_F0.9290.80
53_Y57_A0.9190.80
19_W22_F0.9170.80
7_Y30_L0.9070.79
151_F155_L0.9060.79
132_R136_K0.8920.78
161_T167_K0.8870.77
178_N187_E0.8850.77
142_I202_V0.8770.76
130_Y181_F0.8740.76
15_Y19_W0.8740.76
3_I20_A0.8710.76
8_S11_K0.8680.76
42_M107_I0.8650.75
40_S47_N0.8630.75
5_V13_S0.8620.75
139_F194_P0.8520.74
35_P67_T0.8520.74
98_L130_Y0.8520.74
183_G187_E0.8490.74
54_Q196_F0.8440.74
100_S106_N0.8420.73
15_Y130_Y0.8410.73
107_I120_T0.8360.73
80_K83_L0.8310.72
27_V30_L0.8250.72
78_L106_N0.8160.71
155_L164_D0.8150.71
93_I116_L0.8130.71
95_S107_I0.8120.71
3_I25_F0.8110.71
97_A107_I0.8090.70
15_Y139_F0.8090.70
106_N111_A0.8040.70
39_D48_V0.8030.70
3_I17_L0.8010.70
18_H137_E0.8010.70
29_C63_I0.7980.69
125_K130_Y0.7880.68
80_K199_Q0.7840.68
142_I191_T0.7820.68
142_I159_E0.7770.67
36_K68_S0.7720.67
134_L141_F0.7600.66
3_I30_L0.7520.65
100_S187_E0.7490.65
14_T196_F0.7470.64
16_A121_P0.7450.64
141_F145_S0.7440.64
34_I66_G0.7420.64
110_I113_E0.7400.64
43_F103_Q0.7370.63
20_A119_Y0.7350.63
99_L106_N0.7280.62
126_S129_E0.7280.62
54_Q59_D0.7250.62
85_A90_A0.7200.61
20_A121_P0.7160.61
192_Y198_T0.7120.61
43_F75_L0.7070.60
51_T62_L0.7060.60
27_V203_N0.7060.60
19_W23_K0.7020.59
151_F177_F0.7010.59
67_T77_D0.7000.59
18_H195_L0.6980.59
108_S112_E0.6890.58
79_K83_L0.6870.58
74_E78_L0.6830.57
192_Y196_F0.6810.57
103_Q187_E0.6800.57
30_L54_Q0.6770.57
79_K110_I0.6760.57
14_T139_F0.6750.57
74_E106_N0.6740.56
141_F190_V0.6680.56
16_A95_S0.6670.56
111_A127_Q0.6650.55
106_N187_E0.6630.55
134_L193_A0.6620.55
48_V51_T0.6600.55
18_H193_A0.6560.54
130_Y133_W0.6530.54
8_S12_D0.6510.54
139_F193_A0.6510.54
63_I198_T0.6500.54
32_T64_T0.6480.53
132_R143_I0.6460.53
191_T202_V0.6420.53
22_F137_E0.6410.53
8_S33_L0.6410.53
103_Q147_S0.6400.53
33_L107_I0.6390.52
4_C9_G0.6370.52
158_K164_D0.6370.52
135_V165_V0.6350.52
74_E187_E0.6320.52
5_V20_A0.6310.52
23_K163_E0.6260.51
22_F139_F0.6260.51
55_A170_E0.6250.51
29_C85_A0.6240.51
40_S100_S0.6230.51
99_L178_N0.6220.51
40_S102_Y0.6210.50
209_I212_Y0.6200.50
97_A147_S0.6180.50
102_Y187_E0.6150.50
7_Y32_T0.6150.50
40_S187_E0.6140.50
37_R57_A0.6130.50
104_R123_W0.6130.50
97_A103_Q0.6110.49
191_T199_Q0.6090.49
197_K203_N0.6090.49
132_R163_E0.6070.49
50_Y62_L0.6050.49
74_E97_A0.6020.48
102_Y183_G0.6010.48
87_N112_E0.5980.48
139_F190_V0.5930.47
74_E100_S0.5910.47
124_R160_I0.5890.47
6_L71_K0.5890.47
28_V60_F0.5840.46
4_C93_I0.5820.46
105_L108_S0.5820.46
35_P42_M0.5810.46
161_T168_I0.5790.46
190_V196_F0.5780.46
161_T165_V0.5770.45
46_P189_F0.5750.45
20_A25_F0.5740.45
103_Q150_G0.5740.45
139_F196_F0.5720.45
32_T54_Q0.5690.45
29_C60_F0.5680.44
81_A85_A0.5640.44
4_C46_P0.5640.44
135_V167_K0.5600.44
9_G12_D0.5530.43
69_G77_D0.5520.43
134_L191_T0.5510.43
82_L163_E0.5510.43
3_I119_Y0.5500.42
179_P188_T0.5500.42
146_A156_V0.5470.42
59_D206_L0.5450.42
32_T48_V0.5440.42
141_F159_E0.5420.42
42_M100_S0.5410.41
143_I207_K0.5410.41
26_E154_D0.5400.41
100_S183_G0.5400.41
130_Y180_A0.5400.41
30_L34_I0.5390.41
22_F188_T0.5370.41
148_A177_F0.5340.41
14_T195_L0.5340.41
88_E112_E0.5330.41
41_W106_N0.5320.40
81_A150_G0.5290.40
109_I112_E0.5280.40
73_K77_D0.5280.40
93_I103_Q0.5270.40
120_T187_E0.5270.40
42_M102_Y0.5210.39
43_F69_G0.5200.39
147_S187_E0.5200.39
19_W124_R0.5190.39
35_P43_F0.5170.39
43_F102_Y0.5150.39
50_Y105_L0.5140.39
40_S43_F0.5120.38
56_E59_D0.5120.38
91_D116_L0.5110.38
145_S150_G0.5110.38
17_L58_M0.5090.38
41_W187_E0.5090.38
6_L147_S0.5070.38
35_P40_S0.5060.38
94_V121_P0.5030.37
111_A122_L0.5020.37
9_G98_L0.5020.37
6_L114_L0.5020.37
128_E179_P0.5010.37
129_E203_N0.5010.37
41_W97_A0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rjzA 2 0.9009 100 0.369 Contact Map
2nz2A 4 0.9595 99.7 0.775 Contact Map
1korA 4 0.9009 99.6 0.785 Contact Map
4xfjA 4 0.9505 99.6 0.786 Contact Map
2ywbA 4 0.9324 99.6 0.794 Contact Map
4kr6A 2 0.8468 99.5 0.798 Contact Map
4nzpA 4 0.8919 99.5 0.802 Contact Map
1k92A 4 0.9459 99.5 0.805 Contact Map
2c5sA 2 0.8198 99.5 0.806 Contact Map
2derA 1 0.9595 99.5 0.808 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0077 seconds.