GREMLIN Database
Q7LXM0 - Uncharacterized protein
UniProt: Q7LXM0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 265 (239)
Sequences: 437 (283)
Seq/√Len: 18.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_I165_F9.5061.00
162_Y165_F6.6571.00
161_D165_F6.2661.00
29_V56_T5.8621.00
49_L80_I5.8471.00
238_F256_S3.9581.00
56_T64_I3.8561.00
63_K173_E3.5501.00
242_Q252_A3.0910.99
160_I164_G3.0450.99
214_L260_L2.9190.99
159_Y165_F2.8980.99
60_R243_G2.6960.98
160_I163_R2.6730.98
56_T253_L2.5630.97
189_A242_Q2.5010.96
31_L66_W2.4520.96
239_V247_I2.1680.92
29_V253_L2.1540.92
67_I222_N2.1490.92
25_K209_K2.0260.89
34_S69_D2.0260.89
79_I89_L1.9940.89
46_T109_M1.9350.87
134_G214_L1.9090.86
45_V89_L1.8860.86
237_N242_Q1.8830.85
88_L168_T1.8470.84
242_Q246_D1.8290.84
66_W170_V1.8140.83
47_L110_S1.6900.78
82_D100_S1.6850.78
161_D164_G1.6840.78
28_N65_Y1.6810.78
113_G119_I1.6780.78
57_T114_I1.6370.76
46_T50_S1.5990.74
189_A246_D1.5640.73
36_F79_I1.5600.72
26_P211_G1.5580.72
31_L56_T1.5340.71
239_V255_Y1.5270.71
50_S109_M1.5190.70
28_N63_K1.5040.70
107_G111_P1.5000.69
191_R223_L1.4910.69
81_T85_K1.4850.69
113_G245_S1.4790.68
44_E91_P1.4520.67
87_A148_T1.4250.65
107_G248_R1.4140.65
91_P111_P1.3790.63
65_Y213_T1.3670.62
82_D102_N1.3560.61
77_E89_L1.2840.57
37_D52_I1.2770.57
126_G148_T1.2720.56
36_F123_A1.2520.55
189_A252_A1.2520.55
246_D252_A1.2270.54
228_G235_S1.2260.53
37_D112_L1.2010.52
30_V168_T1.1900.51
92_Y124_V1.1760.50
37_D159_Y1.1750.50
116_Y168_T1.1720.50
36_F89_L1.1550.49
63_K183_F1.1500.49
88_L147_K1.1450.48
137_G142_L1.1350.48
89_L97_V1.1160.47
35_I67_I1.0990.46
88_L149_I1.0960.45
177_F226_R1.0930.45
79_I83_I1.0900.45
61_V214_L1.0890.45
84_T170_V1.0750.44
94_K168_T1.0640.43
39_E48_K1.0630.43
148_T172_N1.0580.43
50_S243_G1.0540.43
188_I221_G1.0500.43
116_Y170_V1.0460.42
42_L89_L1.0330.42
29_V226_R1.0290.41
60_R85_K1.0270.41
59_F134_G1.0260.41
127_E147_K1.0140.40
49_L64_I1.0100.40
134_G180_V1.0090.40
108_L111_P1.0060.40
31_L77_E1.0050.40
46_T256_S1.0020.40
91_P168_T0.9970.39
29_V139_N0.9970.39
68_T176_D0.9870.39
173_E255_Y0.9830.39
93_L106_V0.9780.38
111_P256_S0.9780.38
38_V53_L0.9710.38
78_K82_D0.9670.38
50_S79_I0.9630.37
236_Y256_S0.9570.37
191_R222_N0.9560.37
55_V254_A0.9500.37
53_L170_V0.9500.37
88_L116_Y0.9480.37
237_N248_R0.9440.36
22_P69_D0.9400.36
84_T172_N0.9400.36
222_N228_G0.9340.36
57_T191_R0.9320.36
26_P209_K0.9320.36
54_R248_R0.9270.35
135_D141_K0.9240.35
136_F140_K0.9130.35
45_V76_L0.9120.35
215_M232_L0.9070.34
28_N211_G0.9050.34
83_I108_L0.9020.34
50_S110_S0.8980.34
136_F142_L0.8970.34
52_I56_T0.8910.33
233_D253_L0.8860.33
110_S135_D0.8860.33
194_K241_K0.8790.33
58_T242_Q0.8780.33
22_P25_K0.8720.32
93_L250_E0.8700.32
109_M134_G0.8700.32
190_S193_G0.8680.32
106_V118_F0.8680.32
37_D141_K0.8670.32
32_F97_V0.8660.32
68_T221_G0.8660.32
40_N91_P0.8640.32
189_A237_N0.8630.32
38_V113_G0.8570.32
55_V215_M0.8560.31
35_I52_I0.8550.31
139_N206_L0.8480.31
32_F67_I0.8480.31
147_K168_T0.8460.31
56_T101_R0.8350.30
83_I109_M0.8300.30
188_I191_R0.8230.30
40_N44_E0.8200.30
76_L79_I0.8180.29
27_L33_L0.8140.29
36_F220_T0.8130.29
39_E50_S0.8120.29
108_L256_S0.8110.29
60_R241_K0.8070.29
61_V227_L0.8060.29
242_Q249_A0.8040.29
202_Q206_L0.8000.29
38_V255_Y0.7980.28
176_D179_K0.7970.28
30_V213_T0.7970.28
183_F211_G0.7970.28
173_E183_F0.7900.28
217_G237_N0.7880.28
85_K174_F0.7880.28
159_Y162_Y0.7880.28
52_I64_I0.7860.28
47_L97_V0.7800.28
22_P59_F0.7790.27
87_A108_L0.7780.27
213_T231_Y0.7710.27
129_R141_K0.7650.27
242_Q247_I0.7580.26
24_Y72_N0.7490.26
189_A193_G0.7390.26
76_L235_S0.7370.25
177_F180_V0.7360.25
128_I147_K0.7360.25
83_I87_A0.7280.25
135_D150_L0.7270.25
135_D225_Q0.7270.25
184_D218_P0.7250.25
48_K219_P0.7240.25
223_L242_Q0.7200.25
27_L209_K0.7200.25
63_K160_I0.7180.25
143_N162_Y0.7170.25
88_L91_P0.7160.24
29_V146_S0.7160.24
121_K129_R0.7130.24
26_P63_K0.7120.24
107_G217_G0.7120.24
48_K112_L0.7120.24
49_L112_L0.7070.24
237_N240_I0.7070.24
89_L104_K0.7070.24
94_K216_I0.7060.24
46_T49_L0.7020.24
193_G221_G0.7010.24
28_N173_E0.7000.24
92_Y95_K0.6990.24
94_K249_A0.6950.24
28_N109_M0.6920.23
221_G245_S0.6910.23
83_I101_R0.6910.23
86_Y107_G0.6910.23
42_L46_T0.6910.23
122_Q247_I0.6900.23
35_I58_T0.6890.23
249_A252_A0.6890.23
253_L256_S0.6870.23
252_A257_L0.6800.23
196_P214_L0.6800.23
35_I214_L0.6790.23
58_T91_P0.6760.23
98_P240_I0.6750.23
236_Y254_A0.6750.23
117_H168_T0.6750.23
255_Y258_S0.6730.23
50_S117_H0.6710.22
190_S237_N0.6700.22
91_P98_P0.6680.22
42_L79_I0.6660.22
35_I48_K0.6660.22
126_G136_F0.6650.22
67_I246_D0.6650.22
58_T244_V0.6620.22
44_E51_F0.6620.22
106_V121_K0.6600.22
63_K149_I0.6600.22
56_T151_I0.6570.22
247_I252_A0.6540.22
197_L233_D0.6490.22
130_L145_S0.6450.21
27_L214_L0.6440.21
193_G252_A0.6410.21
66_W248_R0.6400.21
28_N81_T0.6400.21
156_K215_M0.6380.21
32_F236_Y0.6360.21
80_I196_P0.6350.21
223_L245_S0.6340.21
99_I144_S0.6320.21
69_D83_I0.6300.21
140_K163_R0.6290.21
225_Q229_K0.6280.21
124_V137_G0.6270.21
171_K202_Q0.6260.21
106_V214_L0.6250.21
103_L111_P0.6240.21
138_L225_Q0.6180.20
86_Y255_Y0.6170.20
44_E108_L0.6160.20
193_G242_Q0.6160.20
58_T187_I0.6150.20
61_V150_L0.6140.20
105_K148_T0.6130.20
237_N252_A0.6120.20
185_N212_L0.6120.20
107_G237_N0.6100.20
188_I245_S0.6050.20
125_E213_T0.6030.20
135_D151_I0.6020.20
178_K257_L0.6020.20
125_E147_K0.6010.20
139_N142_L0.6000.20
44_E47_L0.5990.20
172_N187_I0.5980.19
131_G138_L0.5950.19
42_L105_K0.5930.19
125_E183_F0.5920.19
251_E257_L0.5890.19
72_N241_K0.5870.19
91_P110_S0.5850.19
66_W69_D0.5850.19
117_H167_Y0.5840.19
246_D250_E0.5800.19
128_I206_L0.5800.19
33_L66_W0.5790.19
215_M253_L0.5790.19
152_T177_F0.5780.19
113_G191_R0.5780.19
91_P166_Y0.5770.19
42_L187_I0.5750.19
61_V64_I0.5750.19
53_L87_A0.5740.19
127_E149_I0.5740.19
54_R167_Y0.5730.19
28_N134_G0.5720.18
69_D103_L0.5710.18
242_Q251_E0.5700.18
55_V68_T0.5690.18
53_L84_T0.5680.18
128_I145_S0.5680.18
38_V250_E0.5670.18
66_W74_R0.5670.18
33_L40_N0.5670.18
125_E137_G0.5650.18
65_Y173_E0.5650.18
75_K79_I0.5640.18
208_N234_K0.5630.18
29_V215_M0.5630.18
107_G251_E0.5620.18
159_Y180_V0.5620.18
124_V168_T0.5620.18
103_L107_G0.5600.18
107_G242_Q0.5600.18
138_L143_N0.5600.18
26_P147_K0.5580.18
215_M223_L0.5560.18
56_T85_K0.5560.18
190_S223_L0.5540.18
154_S158_G0.5540.18
75_K101_R0.5540.18
130_L144_S0.5530.18
23_R114_I0.5530.18
205_N208_N0.5530.18
188_I232_L0.5520.18
56_T236_Y0.5520.18
105_K120_F0.5520.18
217_G242_Q0.5510.18
237_N250_E0.5430.17
99_I121_K0.5430.17
79_I110_S0.5430.17
125_E173_E0.5420.17
24_Y105_K0.5390.17
83_I129_R0.5380.17
218_P221_G0.5370.17
45_V94_K0.5360.17
256_S259_I0.5360.17
66_W81_T0.5320.17
191_R242_Q0.5310.17
236_Y240_I0.5300.17
65_Y178_K0.5290.17
92_Y226_R0.5290.17
27_L172_N0.5260.17
185_N199_A0.5260.17
45_V77_E0.5240.17
187_I219_P0.5240.17
145_S154_S0.5240.17
128_I196_P0.5230.17
41_S255_Y0.5170.17
79_I104_K0.5140.16
135_D139_N0.5140.16
29_V204_T0.5120.16
237_N249_A0.5120.16
142_L164_G0.5120.16
38_V245_S0.5110.16
254_A259_I0.5110.16
187_I236_Y0.5090.16
118_F138_L0.5080.16
117_H170_V0.5080.16
37_D257_L0.5070.16
31_L207_Y0.5070.16
95_K148_T0.5060.16
83_I196_P0.5050.16
62_N218_P0.5040.16
33_L219_P0.5030.16
66_W107_G0.5020.16
43_L183_F0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rg1A 2 0.9019 100 0.145 Contact Map
1k3rA 2 0.8943 100 0.175 Contact Map
4q37A 2 0.4113 54 0.959 Contact Map
2qmmA 2 0.6717 49.3 0.961 Contact Map
3ilkA 2 0.5736 48.3 0.961 Contact Map
3onpA 2 0.5585 40.5 0.963 Contact Map
1to0A 2 0.5019 36.2 0.964 Contact Map
4pzkA 2 0.5472 29.1 0.965 Contact Map
4fakA 2 0.5434 26 0.966 Contact Map
1o6dA 2 0.4491 22.1 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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