Q7LXM0 - SULSO - GREMLIN Contacts

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Q7LXM0 - Uncharacterized protein

UniProt:	Q7LXM0	Sequences: MGYRRGILYNRDKEVYMMFPFPRYKPLNVVLFLSIFDVENSLLEVTLKLSFILRVTTTFRVNKIYWITDSLNSRKLEKIITDITKYALLPPYLKKYVPISRNLKKVGLMSPLGIPYHFIFKQAVEGEIRLGYKGDFGLNKKLNSSSKTILITDSLKAGYIDYRGFYYTGVKNEFIDFKKVFNFDNLIIASRSGKNPLQAKEQLTNLYNKYGLTLMIGPPTGNLLQRLGKQYLDKSYNFVIKQGVSDIRAEEALAYSLSILNLLLS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	265 (239)
Sequences:	437 (283)
Seq/√Len:	18.3

HALSA - Y1688
SULSO - Q7LXM0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
160_I	165_F	9.506	1.00
162_Y	165_F	6.657	1.00
161_D	165_F	6.266	1.00
29_V	56_T	5.862	1.00
49_L	80_I	5.847	1.00
238_F	256_S	3.958	1.00
56_T	64_I	3.856	1.00
63_K	173_E	3.550	1.00
242_Q	252_A	3.091	0.99
160_I	164_G	3.045	0.99
214_L	260_L	2.919	0.99
159_Y	165_F	2.898	0.99
60_R	243_G	2.696	0.98
160_I	163_R	2.673	0.98
56_T	253_L	2.563	0.97
189_A	242_Q	2.501	0.96
31_L	66_W	2.452	0.96
239_V	247_I	2.168	0.92
29_V	253_L	2.154	0.92
67_I	222_N	2.149	0.92
25_K	209_K	2.026	0.89
34_S	69_D	2.026	0.89
79_I	89_L	1.994	0.89
46_T	109_M	1.935	0.87
134_G	214_L	1.909	0.86
45_V	89_L	1.886	0.86
237_N	242_Q	1.883	0.85
88_L	168_T	1.847	0.84
242_Q	246_D	1.829	0.84
66_W	170_V	1.814	0.83
47_L	110_S	1.690	0.78
82_D	100_S	1.685	0.78
161_D	164_G	1.684	0.78
28_N	65_Y	1.681	0.78
113_G	119_I	1.678	0.78
57_T	114_I	1.637	0.76
46_T	50_S	1.599	0.74
189_A	246_D	1.564	0.73
36_F	79_I	1.560	0.72
26_P	211_G	1.558	0.72
31_L	56_T	1.534	0.71
239_V	255_Y	1.527	0.71
50_S	109_M	1.519	0.70
28_N	63_K	1.504	0.70
107_G	111_P	1.500	0.69
191_R	223_L	1.491	0.69
81_T	85_K	1.485	0.69
113_G	245_S	1.479	0.68
44_E	91_P	1.452	0.67
87_A	148_T	1.425	0.65
107_G	248_R	1.414	0.65
91_P	111_P	1.379	0.63
65_Y	213_T	1.367	0.62
82_D	102_N	1.356	0.61
77_E	89_L	1.284	0.57
37_D	52_I	1.277	0.57
126_G	148_T	1.272	0.56
36_F	123_A	1.252	0.55
189_A	252_A	1.252	0.55
246_D	252_A	1.227	0.54
228_G	235_S	1.226	0.53
37_D	112_L	1.201	0.52
30_V	168_T	1.190	0.51
92_Y	124_V	1.176	0.50
37_D	159_Y	1.175	0.50
116_Y	168_T	1.172	0.50
36_F	89_L	1.155	0.49
63_K	183_F	1.150	0.49
88_L	147_K	1.145	0.48
137_G	142_L	1.135	0.48
89_L	97_V	1.116	0.47
35_I	67_I	1.099	0.46
88_L	149_I	1.096	0.45
177_F	226_R	1.093	0.45
79_I	83_I	1.090	0.45
61_V	214_L	1.089	0.45
84_T	170_V	1.075	0.44
94_K	168_T	1.064	0.43
39_E	48_K	1.063	0.43
148_T	172_N	1.058	0.43
50_S	243_G	1.054	0.43
188_I	221_G	1.050	0.43
116_Y	170_V	1.046	0.42
42_L	89_L	1.033	0.42
29_V	226_R	1.029	0.41
60_R	85_K	1.027	0.41
59_F	134_G	1.026	0.41
127_E	147_K	1.014	0.40
49_L	64_I	1.010	0.40
134_G	180_V	1.009	0.40
108_L	111_P	1.006	0.40
31_L	77_E	1.005	0.40
46_T	256_S	1.002	0.40
91_P	168_T	0.997	0.39
29_V	139_N	0.997	0.39
68_T	176_D	0.987	0.39
173_E	255_Y	0.983	0.39
93_L	106_V	0.978	0.38
111_P	256_S	0.978	0.38
38_V	53_L	0.971	0.38
78_K	82_D	0.967	0.38
50_S	79_I	0.963	0.37
236_Y	256_S	0.957	0.37
191_R	222_N	0.956	0.37
55_V	254_A	0.950	0.37
53_L	170_V	0.950	0.37
88_L	116_Y	0.948	0.37
237_N	248_R	0.944	0.36
22_P	69_D	0.940	0.36
84_T	172_N	0.940	0.36
222_N	228_G	0.934	0.36
57_T	191_R	0.932	0.36
26_P	209_K	0.932	0.36
54_R	248_R	0.927	0.35
135_D	141_K	0.924	0.35
136_F	140_K	0.913	0.35
45_V	76_L	0.912	0.35
215_M	232_L	0.907	0.34
28_N	211_G	0.905	0.34
83_I	108_L	0.902	0.34
50_S	110_S	0.898	0.34
136_F	142_L	0.897	0.34
52_I	56_T	0.891	0.33
233_D	253_L	0.886	0.33
110_S	135_D	0.886	0.33
194_K	241_K	0.879	0.33
58_T	242_Q	0.878	0.33
22_P	25_K	0.872	0.32
93_L	250_E	0.870	0.32
109_M	134_G	0.870	0.32
190_S	193_G	0.868	0.32
106_V	118_F	0.868	0.32
37_D	141_K	0.867	0.32
32_F	97_V	0.866	0.32
68_T	221_G	0.866	0.32
40_N	91_P	0.864	0.32
189_A	237_N	0.863	0.32
38_V	113_G	0.857	0.32
55_V	215_M	0.856	0.31
35_I	52_I	0.855	0.31
139_N	206_L	0.848	0.31
32_F	67_I	0.848	0.31
147_K	168_T	0.846	0.31
56_T	101_R	0.835	0.30
83_I	109_M	0.830	0.30
188_I	191_R	0.823	0.30
40_N	44_E	0.820	0.30
76_L	79_I	0.818	0.29
27_L	33_L	0.814	0.29
36_F	220_T	0.813	0.29
39_E	50_S	0.812	0.29
108_L	256_S	0.811	0.29
60_R	241_K	0.807	0.29
61_V	227_L	0.806	0.29
242_Q	249_A	0.804	0.29
202_Q	206_L	0.800	0.29
38_V	255_Y	0.798	0.28
176_D	179_K	0.797	0.28
30_V	213_T	0.797	0.28
183_F	211_G	0.797	0.28
173_E	183_F	0.790	0.28
217_G	237_N	0.788	0.28
85_K	174_F	0.788	0.28
159_Y	162_Y	0.788	0.28
52_I	64_I	0.786	0.28
47_L	97_V	0.780	0.28
22_P	59_F	0.779	0.27
87_A	108_L	0.778	0.27
213_T	231_Y	0.771	0.27
129_R	141_K	0.765	0.27
242_Q	247_I	0.758	0.26
24_Y	72_N	0.749	0.26
189_A	193_G	0.739	0.26
76_L	235_S	0.737	0.25
177_F	180_V	0.736	0.25
128_I	147_K	0.736	0.25
83_I	87_A	0.728	0.25
135_D	150_L	0.727	0.25
135_D	225_Q	0.727	0.25
184_D	218_P	0.725	0.25
48_K	219_P	0.724	0.25
223_L	242_Q	0.720	0.25
27_L	209_K	0.720	0.25
63_K	160_I	0.718	0.25
143_N	162_Y	0.717	0.25
88_L	91_P	0.716	0.24
29_V	146_S	0.716	0.24
121_K	129_R	0.713	0.24
26_P	63_K	0.712	0.24
107_G	217_G	0.712	0.24
48_K	112_L	0.712	0.24
49_L	112_L	0.707	0.24
237_N	240_I	0.707	0.24
89_L	104_K	0.707	0.24
94_K	216_I	0.706	0.24
46_T	49_L	0.702	0.24
193_G	221_G	0.701	0.24
28_N	173_E	0.700	0.24
92_Y	95_K	0.699	0.24
94_K	249_A	0.695	0.24
28_N	109_M	0.692	0.23
221_G	245_S	0.691	0.23
83_I	101_R	0.691	0.23
86_Y	107_G	0.691	0.23
42_L	46_T	0.691	0.23
122_Q	247_I	0.690	0.23
35_I	58_T	0.689	0.23
249_A	252_A	0.689	0.23
253_L	256_S	0.687	0.23
252_A	257_L	0.680	0.23
196_P	214_L	0.680	0.23
35_I	214_L	0.679	0.23
58_T	91_P	0.676	0.23
98_P	240_I	0.675	0.23
236_Y	254_A	0.675	0.23
117_H	168_T	0.675	0.23
255_Y	258_S	0.673	0.23
50_S	117_H	0.671	0.22
190_S	237_N	0.670	0.22
91_P	98_P	0.668	0.22
42_L	79_I	0.666	0.22
35_I	48_K	0.666	0.22
126_G	136_F	0.665	0.22
67_I	246_D	0.665	0.22
58_T	244_V	0.662	0.22
44_E	51_F	0.662	0.22
106_V	121_K	0.660	0.22
63_K	149_I	0.660	0.22
56_T	151_I	0.657	0.22
247_I	252_A	0.654	0.22
197_L	233_D	0.649	0.22
130_L	145_S	0.645	0.21
27_L	214_L	0.644	0.21
193_G	252_A	0.641	0.21
66_W	248_R	0.640	0.21
28_N	81_T	0.640	0.21
156_K	215_M	0.638	0.21
32_F	236_Y	0.636	0.21
80_I	196_P	0.635	0.21
223_L	245_S	0.634	0.21
99_I	144_S	0.632	0.21
69_D	83_I	0.630	0.21
140_K	163_R	0.629	0.21
225_Q	229_K	0.628	0.21
124_V	137_G	0.627	0.21
171_K	202_Q	0.626	0.21
106_V	214_L	0.625	0.21
103_L	111_P	0.624	0.21
138_L	225_Q	0.618	0.20
86_Y	255_Y	0.617	0.20
44_E	108_L	0.616	0.20
193_G	242_Q	0.616	0.20
58_T	187_I	0.615	0.20
61_V	150_L	0.614	0.20
105_K	148_T	0.613	0.20
237_N	252_A	0.612	0.20
185_N	212_L	0.612	0.20
107_G	237_N	0.610	0.20
188_I	245_S	0.605	0.20
125_E	213_T	0.603	0.20
135_D	151_I	0.602	0.20
178_K	257_L	0.602	0.20
125_E	147_K	0.601	0.20
139_N	142_L	0.600	0.20
44_E	47_L	0.599	0.20
172_N	187_I	0.598	0.19
131_G	138_L	0.595	0.19
42_L	105_K	0.593	0.19
125_E	183_F	0.592	0.19
251_E	257_L	0.589	0.19
72_N	241_K	0.587	0.19
91_P	110_S	0.585	0.19
66_W	69_D	0.585	0.19
117_H	167_Y	0.584	0.19
246_D	250_E	0.580	0.19
128_I	206_L	0.580	0.19
33_L	66_W	0.579	0.19
215_M	253_L	0.579	0.19
152_T	177_F	0.578	0.19
113_G	191_R	0.578	0.19
91_P	166_Y	0.577	0.19
42_L	187_I	0.575	0.19
61_V	64_I	0.575	0.19
53_L	87_A	0.574	0.19
127_E	149_I	0.574	0.19
54_R	167_Y	0.573	0.19
28_N	134_G	0.572	0.18
69_D	103_L	0.571	0.18
242_Q	251_E	0.570	0.18
55_V	68_T	0.569	0.18
53_L	84_T	0.568	0.18
128_I	145_S	0.568	0.18
38_V	250_E	0.567	0.18
66_W	74_R	0.567	0.18
33_L	40_N	0.567	0.18
125_E	137_G	0.565	0.18
65_Y	173_E	0.565	0.18
75_K	79_I	0.564	0.18
208_N	234_K	0.563	0.18
29_V	215_M	0.563	0.18
107_G	251_E	0.562	0.18
159_Y	180_V	0.562	0.18
124_V	168_T	0.562	0.18
103_L	107_G	0.560	0.18
107_G	242_Q	0.560	0.18
138_L	143_N	0.560	0.18
26_P	147_K	0.558	0.18
215_M	223_L	0.556	0.18
56_T	85_K	0.556	0.18
190_S	223_L	0.554	0.18
154_S	158_G	0.554	0.18
75_K	101_R	0.554	0.18
130_L	144_S	0.553	0.18
23_R	114_I	0.553	0.18
205_N	208_N	0.553	0.18
188_I	232_L	0.552	0.18
56_T	236_Y	0.552	0.18
105_K	120_F	0.552	0.18
217_G	242_Q	0.551	0.18
237_N	250_E	0.543	0.17
99_I	121_K	0.543	0.17
79_I	110_S	0.543	0.17
125_E	173_E	0.542	0.17
24_Y	105_K	0.539	0.17
83_I	129_R	0.538	0.17
218_P	221_G	0.537	0.17
45_V	94_K	0.536	0.17
256_S	259_I	0.536	0.17
66_W	81_T	0.532	0.17
191_R	242_Q	0.531	0.17
236_Y	240_I	0.530	0.17
65_Y	178_K	0.529	0.17
92_Y	226_R	0.529	0.17
27_L	172_N	0.526	0.17
185_N	199_A	0.526	0.17
45_V	77_E	0.524	0.17
187_I	219_P	0.524	0.17
145_S	154_S	0.524	0.17
128_I	196_P	0.523	0.17
41_S	255_Y	0.517	0.17
79_I	104_K	0.514	0.16
135_D	139_N	0.514	0.16
29_V	204_T	0.512	0.16
237_N	249_A	0.512	0.16
142_L	164_G	0.512	0.16
38_V	245_S	0.511	0.16
254_A	259_I	0.511	0.16
187_I	236_Y	0.509	0.16
118_F	138_L	0.508	0.16
117_H	170_V	0.508	0.16
37_D	257_L	0.507	0.16
31_L	207_Y	0.507	0.16
95_K	148_T	0.506	0.16
83_I	196_P	0.505	0.16
62_N	218_P	0.504	0.16
33_L	219_P	0.503	0.16
66_W	107_G	0.502	0.16
43_L	183_F	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rg1A	2	0.9019	100	0.145	Contact Map
1k3rA	2	0.8943	100	0.175	Contact Map
4q37A	2	0.4113	54	0.959	Contact Map
2qmmA	2	0.6717	49.3	0.961	Contact Map
3ilkA	2	0.5736	48.3	0.961	Contact Map
3onpA	2	0.5585	40.5	0.963	Contact Map
1to0A	2	0.5019	36.2	0.964	Contact Map
4pzkA	2	0.5472	29.1	0.965	Contact Map
4fakA	2	0.5434	26	0.966	Contact Map
1o6dA	2	0.4491	22.1	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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