GREMLIN Database
Q7LXL8 - Uncharacterized protein
UniProt: Q7LXL8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 195 (172)
Sequences: 279 (224)
Seq/√Len: 17.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_V33_I3.8151.00
20_G28_I3.4981.00
173_S176_T3.2150.99
106_S112_I3.1810.99
101_E116_N3.0540.99
33_I63_H2.9540.98
33_I62_I2.5660.96
100_A145_T2.5460.96
73_L182_E2.5360.96
61_S99_Y2.4910.96
55_E113_F2.3880.94
34_I62_I2.2110.92
102_C115_I2.1510.90
166_W170_K2.1100.90
62_I145_T2.0050.87
143_N161_I1.9910.87
130_Y134_D1.9900.87
72_I183_I1.9860.86
23_G138_V1.8290.81
176_T179_L1.8150.81
173_S179_L1.8130.81
102_C113_F1.7930.80
31_L44_I1.7840.80
64_V98_I1.7630.79
21_T53_N1.6430.74
62_I144_Y1.5980.72
60_C100_A1.5970.72
73_L81_F1.5700.70
98_I117_P1.4850.66
35_V40_L1.4580.64
27_I97_V1.4390.63
63_H145_T1.4080.62
47_S51_Y1.3710.59
65_T135_Y1.3700.59
144_Y187_M1.3610.59
18_L76_L1.3350.57
31_L63_H1.3250.57
75_M140_F1.3200.56
122_I178_S1.2950.55
131_N173_S1.2940.55
18_L156_E1.2890.55
84_D91_V1.2840.54
137_S179_L1.2750.54
71_F96_N1.2720.54
159_V163_E1.2630.53
177_S181_E1.2600.53
121_E156_E1.2590.53
147_L164_Y1.2410.52
68_T134_D1.2340.51
30_P48_T1.2340.51
25_K56_K1.2330.51
169_I180_L1.2280.51
25_K84_D1.2260.51
38_N178_S1.2160.50
50_T53_N1.2100.50
24_I49_L1.2060.50
75_M144_Y1.2040.50
51_Y55_E1.1870.48
159_V184_L1.1850.48
131_N168_V1.1720.48
73_L76_L1.1520.46
22_S57_N1.1470.46
90_P136_I1.1390.46
37_A101_E1.1380.46
58_N138_V1.1320.45
177_S185_N1.1300.45
54_L113_F1.1100.44
19_V26_P1.1000.43
131_N171_R1.0950.43
26_P31_L1.0940.43
114_T184_L1.0730.42
18_L133_G1.0600.41
54_L115_I1.0590.41
33_I64_V1.0510.40
105_T138_V1.0420.40
161_I164_Y1.0390.40
64_V96_N1.0360.40
76_L81_F1.0360.40
14_I172_T1.0160.38
140_F169_I1.0140.38
125_N173_S1.0090.38
60_C115_I1.0060.38
38_N174_Q1.0030.38
131_N176_T0.9980.37
72_I184_L0.9960.37
141_L150_Y0.9960.37
162_L166_W0.9920.37
67_D137_S0.9860.37
16_E21_T0.9820.37
18_L30_P0.9780.36
72_I131_N0.9750.36
15_Y98_I0.9730.36
140_F162_L0.9680.36
80_T142_V0.9650.36
15_Y140_F0.9600.35
109_D112_I0.9580.35
72_I141_L0.9560.35
45_Y82_S0.9510.35
73_L82_S0.9510.35
99_Y119_D0.9500.35
31_L40_L0.9440.34
104_K122_I0.9430.34
155_L160_R0.9410.34
109_D175_Y0.9330.34
43_K112_I0.9300.34
135_Y160_R0.9270.34
61_S86_D0.9260.33
129_A133_G0.9250.33
155_L159_V0.9230.33
65_T138_V0.9200.33
89_V99_Y0.9170.33
58_N102_C0.9170.33
17_V56_K0.9090.33
159_V183_I0.9080.33
54_L170_K0.9060.32
37_A93_K0.9040.32
18_L122_I0.9030.32
97_V147_L0.9020.32
141_L161_I0.8950.32
53_N146_R0.8950.32
15_Y102_C0.8930.32
72_I176_T0.8880.31
33_I42_S0.8850.31
24_I177_S0.8850.31
77_D151_K0.8790.31
16_E32_G0.8700.31
18_L63_H0.8690.31
32_G132_R0.8650.30
39_E65_T0.8610.30
26_P90_P0.8570.30
75_M141_L0.8550.30
33_I145_T0.8520.30
88_N174_Q0.8470.29
54_L57_N0.8460.29
108_T160_R0.8450.29
66_L95_L0.8420.29
139_D168_V0.8420.29
20_G94_N0.8410.29
135_Y142_V0.8380.29
62_I100_A0.8170.28
126_L167_S0.8170.28
41_R133_G0.8110.28
24_I98_I0.8080.27
118_L123_N0.7990.27
23_G90_P0.7980.27
143_N165_E0.7970.27
72_I143_N0.7920.27
54_L102_C0.7850.26
133_G139_D0.7810.26
141_L183_I0.7810.26
136_I168_V0.7800.26
47_S180_L0.7790.26
129_A172_T0.7780.26
31_L74_S0.7750.26
76_L138_V0.7690.26
15_Y64_V0.7660.26
165_E173_S0.7650.25
15_Y40_L0.7630.25
39_E114_T0.7620.25
104_K114_T0.7600.25
54_L142_V0.7600.25
19_V177_S0.7530.25
145_T170_K0.7480.25
160_R163_E0.7460.25
77_D131_N0.7450.25
24_I148_D0.7410.24
64_V71_F0.7390.24
44_I129_A0.7380.24
26_P119_D0.7370.24
62_I65_T0.7360.24
34_I102_C0.7280.24
42_S49_L0.7280.24
31_L51_Y0.7270.24
58_N177_S0.7240.24
123_N126_L0.7200.23
157_K186_K0.7120.23
130_Y138_V0.7080.23
44_I142_V0.7050.23
136_I176_T0.7020.23
157_K164_Y0.7010.23
110_P133_G0.6980.23
59_K99_Y0.6920.22
75_M186_K0.6920.22
77_D139_D0.6890.22
68_T143_N0.6890.22
184_L188_R0.6850.22
36_E90_P0.6780.22
181_E185_N0.6770.22
79_L87_Y0.6700.21
34_I145_T0.6690.21
21_T177_S0.6680.21
167_S171_R0.6670.21
16_E30_P0.6620.21
59_K94_N0.6610.21
51_Y56_K0.6610.21
43_K142_V0.6600.21
125_N181_E0.6590.21
18_L65_T0.6530.21
31_L142_V0.6510.21
17_V62_I0.6400.20
19_V22_S0.6380.20
40_L138_V0.6370.20
143_N158_L0.6320.20
33_I184_L0.6290.20
76_L183_I0.6250.20
21_T102_C0.6220.20
48_T162_L0.6210.19
38_N173_S0.6150.19
163_E175_Y0.6150.19
174_Q186_K0.6100.19
97_V137_S0.6060.19
62_I84_D0.6060.19
72_I179_L0.6050.19
89_V118_L0.6040.19
91_V133_G0.6030.19
136_I169_I0.6020.19
80_T185_N0.6010.19
72_I147_L0.5940.18
85_S90_P0.5900.18
76_L182_E0.5870.18
37_A70_F0.5850.18
43_K186_K0.5830.18
45_Y112_I0.5810.18
109_D174_Q0.5720.18
48_T171_R0.5670.18
22_S88_N0.5660.18
162_L188_R0.5640.17
97_V179_L0.5630.17
34_I100_A0.5610.17
16_E132_R0.5440.17
38_N71_F0.5440.17
21_T25_K0.5420.17
87_Y101_E0.5390.17
60_C165_E0.5370.17
128_R184_L0.5360.16
132_R146_R0.5340.16
148_D159_V0.5320.16
20_G50_T0.5310.16
143_N176_T0.5290.16
100_A147_L0.5290.16
107_S178_S0.5290.16
84_D93_K0.5280.16
118_L163_E0.5270.16
83_I111_S0.5190.16
17_V135_Y0.5170.16
124_S173_S0.5160.16
31_L43_K0.5150.16
76_L162_L0.5140.16
65_T71_F0.5130.16
62_I169_I0.5120.16
88_N119_D0.5110.16
66_L150_Y0.5110.16
70_F142_V0.5100.16
127_T167_S0.5080.16
144_Y172_T0.5080.16
175_Y178_S0.5030.15
94_N109_D0.5000.15
29_K45_Y0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nr4A 2 0.9282 100 0.503 Contact Map
2imlA 2 0.959 100 0.503 Contact Map
2ptfA 2 0.9436 100 0.524 Contact Map
3b5mA 2 0.9026 100 0.544 Contact Map
4f07A 6 0.6923 98.4 0.843 Contact Map
3fgeA 2 0.8154 98.2 0.852 Contact Map
2d5mA 2 0.8205 98.2 0.852 Contact Map
4l82A 2 0.6872 98.2 0.853 Contact Map
3bnkA 2 0.8205 98.1 0.854 Contact Map
3e4vA 2 0.7846 98.1 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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