GREMLIN Database
Q7LXL7 - Uncharacterized protein
UniProt: Q7LXL7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 488 (438)
Sequences: 1243 (883)
Seq/√Len: 42.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_L116_C7.4041.00
88_C93_L5.2981.00
118_G167_I4.2791.00
30_R34_E4.1381.00
267_L358_I3.8301.00
81_V161_I3.6201.00
260_K314_A3.5691.00
197_I355_N3.4951.00
256_L310_S3.4851.00
32_I35_D3.3171.00
256_L314_A3.2831.00
80_D91_R3.2641.00
88_C116_C3.2311.00
45_I258_N3.1661.00
271_M351_L3.1371.00
345_S349_T3.1341.00
201_H232_S3.1031.00
220_Q223_S3.0791.00
198_T268_N3.0611.00
76_E166_R2.8151.00
190_N225_I2.7691.00
236_E329_Y2.7281.00
193_K427_H2.6381.00
381_P395_L2.6051.00
69_L150_A2.5861.00
174_N177_A2.5581.00
159_P163_G2.4271.00
6_L10_S2.3791.00
90_G117_L2.3711.00
82_V88_C2.3121.00
210_D236_E2.2831.00
33_L219_R2.2711.00
235_A241_F2.2611.00
65_D69_L2.2521.00
236_E330_H2.2221.00
22_E180_Y2.1731.00
66_A69_L2.1280.99
445_L454_D2.1110.99
210_D330_H2.1100.99
192_N423_V2.0960.99
337_E341_P2.0250.99
273_N276_E2.0220.99
103_E236_E2.0180.99
200_H210_D2.0070.99
96_V119_I2.0060.99
64_I68_S1.9940.99
254_E257_K1.9780.99
65_D68_S1.9550.99
81_V94_I1.9370.99
44_P178_T1.9370.99
222_R230_L1.8900.99
19_S51_E1.8860.99
210_D329_Y1.8800.99
96_V121_F1.8790.99
120_I165_C1.8760.99
5_Y28_E1.8250.98
58_E166_R1.8070.98
78_E166_R1.8040.98
237_E329_Y1.7830.98
80_D164_K1.7680.98
373_L452_R1.7680.98
103_E329_Y1.7630.98
109_I113_E1.7450.98
199_A211_N1.7420.98
153_V158_F1.7230.97
29_I215_V1.7220.97
196_H229_H1.7160.97
22_E234_T1.7090.97
30_R40_I1.6990.97
197_I351_L1.6750.97
23_T180_Y1.6720.97
16_I19_S1.6640.97
183_E231_I1.6540.97
269_I355_N1.6520.97
79_A117_L1.6410.97
98_I123_L1.6380.97
136_D139_S1.6190.96
394_I398_N1.6180.96
27_K31_K1.6060.96
29_I201_H1.5930.96
442_I445_L1.5740.96
137_L140_H1.5720.96
189_R225_I1.5690.96
281_L291_S1.5630.96
200_H329_Y1.5600.95
205_F332_E1.5440.95
194_I229_H1.5260.95
50_W150_A1.5020.94
409_L413_I1.4930.94
64_I69_L1.4890.94
185_I229_H1.4860.94
160_Y163_G1.4800.94
77_I167_I1.4770.94
253_R257_K1.4650.94
133_K137_L1.4630.94
43_I259_Y1.4580.93
112_V147_P1.4450.93
26_V42_L1.4420.93
228_T359_N1.4330.93
200_H236_E1.4320.93
187_N191_E1.4310.93
200_H330_H1.4290.93
412_G416_F1.4260.93
272_D306_S1.4220.93
8_T11_N1.4190.93
269_I351_L1.4140.92
304_I309_Y1.4110.92
81_V165_C1.4070.92
195_I358_I1.4060.92
20_K24_K1.3910.92
198_T233_F1.3860.92
99_Q106_K1.3830.92
15_I203_H1.3750.91
131_M135_G1.3700.91
200_H237_E1.3650.91
442_I454_D1.3600.91
31_K34_E1.3560.91
33_L222_R1.3500.91
134_Y137_L1.3310.90
79_A88_C1.3310.90
306_S329_Y1.3290.90
47_V179_G1.3270.90
37_S40_I1.3230.90
286_G366_T1.3230.90
150_A169_L1.3220.90
133_K136_D1.3190.89
92_N118_G1.3160.89
78_E164_K1.3160.89
136_D140_H1.3140.89
27_K30_R1.3020.89
199_A215_V1.2960.89
441_C445_L1.2950.89
76_E168_S1.2930.89
43_I258_N1.2870.88
37_S184_A1.2870.88
23_T27_K1.2820.88
305_Y329_Y1.2790.88
233_F311_Y1.2690.88
290_L294_Y1.2650.87
50_W69_L1.2630.87
423_V427_H1.2620.87
292_R295_F1.2620.87
26_V182_V1.2590.87
31_K35_D1.2560.87
56_I168_S1.2550.87
64_I67_I1.2350.86
25_L201_H1.2320.86
110_E114_N1.2300.86
50_W70_P1.2270.86
289_E368_E1.2240.86
10_S336_I1.2190.85
287_L317_P1.2180.85
120_I153_V1.2170.85
279_L321_I1.2150.85
194_I227_E1.2150.85
374_K403_Y1.2150.85
390_N393_D1.2120.85
441_C449_K1.2110.85
236_E306_S1.2110.85
103_E306_S1.2040.85
384_L391_V1.1850.84
281_L350_I1.1820.84
290_L357_I1.1800.83
9_L219_R1.1540.82
336_I340_K1.1420.81
402_V406_I1.1420.81
294_Y354_I1.1390.81
240_S329_Y1.1340.81
179_G235_A1.1320.81
57_F151_F1.1320.81
441_C447_C1.1300.81
103_E237_E1.1280.81
72_S75_T1.1210.80
93_L119_I1.1200.80
94_I150_A1.1190.80
103_E305_Y1.1160.80
184_A230_L1.1070.79
103_E121_F1.1030.79
76_E79_A1.1020.79
78_E235_A1.1010.79
357_I361_N1.0950.78
207_G334_D1.0930.78
98_I305_Y1.0860.78
418_Q421_S1.0840.78
445_L455_E1.0840.78
15_I212_L1.0780.77
145_P151_F1.0750.77
238_S322_E1.0690.77
410_Y414_L1.0690.77
63_L68_S1.0640.76
208_E334_D1.0590.76
179_G234_T1.0510.76
221_F352_D1.0470.75
190_N193_K1.0450.75
116_C317_P1.0330.74
282_K300_E1.0320.74
456_I459_R1.0260.74
213_L344_F1.0200.73
411_G414_L1.0190.73
152_Y234_T1.0160.73
302_P306_S1.0160.73
108_Y119_I1.0120.73
240_S308_G1.0110.73
233_F268_N1.0090.73
193_K264_D0.9990.72
221_F241_F0.9990.72
352_D356_K0.9970.72
268_N318_S0.9900.71
131_M136_D0.9890.71
195_I266_L0.9880.71
89_N117_L0.9860.71
206_I331_G0.9800.70
103_E210_D0.9790.70
98_I103_E0.9750.70
381_P396_D0.9680.69
406_I413_I0.9650.69
409_L425_L0.9620.69
94_I120_I0.9610.69
420_Y427_H0.9590.69
294_Y353_T0.9500.68
192_N449_K0.9500.68
87_D91_R0.9490.68
45_I254_E0.9430.67
392_K396_D0.9430.67
118_G166_R0.9370.67
38_D187_N0.9350.67
303_E307_D0.9290.66
255_F265_I0.9290.66
302_P308_G0.9280.66
188_S224_N0.9250.66
317_P409_L0.9250.66
22_E201_H0.9220.66
290_L354_I0.9220.66
97_R101_L0.9210.65
26_V180_Y0.9200.65
53_K170_K0.9190.65
212_L376_N0.9180.65
10_S212_L0.9110.65
46_R178_T0.9080.64
444_D455_E0.9070.64
317_P366_T0.9040.64
110_E113_E0.9040.64
236_E240_S0.9010.64
204_W330_H0.9010.64
419_P423_V0.8980.63
398_N406_I0.8960.63
295_F350_I0.8930.63
94_I161_I0.8910.63
54_E170_K0.8910.63
202_D334_D0.8900.63
414_L417_N0.8840.62
94_I216_A0.8830.62
200_H270_N0.8820.62
433_N447_C0.8810.62
210_D270_N0.8800.62
91_R428_K0.8790.62
356_K360_E0.8790.62
372_Q375_N0.8770.62
400_T404_R0.8760.62
409_L412_G0.8760.62
288_L368_E0.8750.61
183_E255_F0.8750.61
299_V302_P0.8750.61
203_H212_L0.8720.61
413_I437_K0.8670.61
290_L358_I0.8600.60
236_E305_Y0.8560.60
73_L150_A0.8530.59
269_I319_I0.8510.59
50_W173_L0.8510.59
215_V257_K0.8500.59
38_D230_L0.8490.59
153_V443_E0.8490.59
315_G318_S0.8490.59
200_H272_D0.8490.59
420_Y423_V0.8440.59
28_E32_I0.8440.59
55_L151_F0.8430.59
9_L29_I0.8400.58
237_E240_S0.8360.58
382_A396_D0.8360.58
216_A422_K0.8350.58
290_L295_F0.8350.58
291_S412_G0.8320.58
93_L153_V0.8320.58
432_L435_A0.8310.57
209_R339_D0.8310.57
43_I284_V0.8300.57
41_R259_Y0.8280.57
221_F348_T0.8270.57
413_I417_N0.8270.57
131_M139_S0.8240.57
76_E118_G0.8240.57
285_P369_M0.8210.57
17_T241_F0.8190.56
194_I264_D0.8130.56
201_H274_I0.8120.56
420_Y424_E0.8110.56
402_V453_N0.8080.55
374_K395_L0.8060.55
60_E381_P0.8030.55
7_K336_I0.8010.55
218_L300_E0.7980.54
237_E330_H0.7970.54
302_P305_Y0.7960.54
7_K10_S0.7950.54
33_L167_I0.7910.54
169_L331_G0.7900.54
204_W270_N0.7880.53
36_N39_E0.7850.53
215_V232_S0.7850.53
33_L232_S0.7830.53
262_V434_I0.7800.53
279_L350_I0.7790.53
79_A92_N0.7790.53
433_N450_R0.7770.52
6_L212_L0.7730.52
196_H231_I0.7730.52
367_H382_A0.7720.52
70_P228_T0.7720.52
203_H260_K0.7710.52
262_V314_A0.7710.52
17_T179_G0.7700.52
119_I348_T0.7660.51
441_C455_E0.7650.51
370_R394_I0.7640.51
291_S421_S0.7620.51
401_E405_K0.7620.51
269_I273_N0.7590.51
389_V437_K0.7560.50
80_D392_K0.7530.50
396_D401_E0.7530.50
386_S404_R0.7520.50
200_H307_D0.7480.50
355_N365_K0.7480.50
118_G168_S0.7480.50
358_I369_M0.7480.50
310_S313_K0.7450.49
131_M138_L0.7450.49
24_K31_K0.7440.49
86_K91_R0.7420.49
103_E330_H0.7420.49
307_D329_Y0.7410.49
96_V358_I0.7380.49
37_S274_I0.7370.49
186_R192_N0.7340.48
217_L273_N0.7340.48
319_I354_I0.7320.48
8_T28_E0.7280.48
202_D234_T0.7250.48
203_H237_E0.7230.47
58_E76_E0.7220.47
331_G335_I0.7220.47
367_H410_Y0.7220.47
33_L184_A0.7210.47
224_N228_T0.7210.47
404_R411_G0.7200.47
25_L28_E0.7200.47
252_S307_D0.7180.47
7_K11_N0.7170.47
413_I425_L0.7150.47
29_I35_D0.7150.47
122_S125_N0.7150.47
192_N264_D0.7150.47
377_L398_N0.7150.47
85_F186_R0.7100.46
290_L352_D0.7090.46
134_Y139_S0.7070.46
398_N410_Y0.7030.45
15_I211_N0.7030.45
135_G140_H0.7010.45
391_V415_A0.6950.45
34_E367_H0.6950.45
28_E219_R0.6940.45
442_I447_C0.6940.45
141_K316_I0.6930.45
381_P415_A0.6920.44
193_K430_K0.6910.44
308_G320_T0.6910.44
185_I194_I0.6900.44
413_I416_F0.6900.44
30_R42_L0.6890.44
71_Y97_R0.6870.44
19_S22_E0.6850.44
203_H211_N0.6850.44
236_E270_N0.6840.44
61_S65_D0.6830.44
46_R176_F0.6830.44
103_E240_S0.6830.44
182_V281_L0.6820.44
344_F452_R0.6820.44
434_I437_K0.6800.43
261_N265_I0.6790.43
191_E227_E0.6780.43
210_D306_S0.6770.43
62_K66_A0.6740.43
308_G445_L0.6740.43
125_N155_E0.6740.43
424_E428_K0.6730.43
183_E258_N0.6720.43
304_I308_G0.6710.42
96_V101_L0.6700.42
86_K196_H0.6680.42
200_H252_S0.6680.42
441_C446_G0.6660.42
410_Y413_I0.6660.42
424_E431_G0.6650.42
5_Y219_R0.6650.42
135_G139_S0.6650.42
266_L364_Y0.6640.42
51_E238_S0.6630.42
309_Y448_I0.6620.42
79_A165_C0.6610.42
406_I410_Y0.6590.41
319_I350_I0.6590.41
76_E196_H0.6580.41
17_T26_V0.6580.41
210_D305_Y0.6570.41
125_N158_F0.6560.41
132_I136_D0.6550.41
218_L360_E0.6550.41
6_L161_I0.6540.41
88_C368_E0.6540.41
112_V212_L0.6520.41
120_I382_A0.6520.41
374_K407_V0.6500.41
54_E168_S0.6500.41
431_G435_A0.6500.41
292_R296_K0.6490.40
448_I453_N0.6480.40
21_N25_L0.6480.40
378_W395_L0.6470.40
98_I329_Y0.6460.40
202_D272_D0.6450.40
304_I456_I0.6440.40
22_E46_R0.6430.40
188_S226_Y0.6420.40
37_S161_I0.6410.40
449_K452_R0.6400.40
270_N330_H0.6390.40
407_V411_G0.6390.40
86_K119_I0.6380.39
82_V335_I0.6380.39
370_R374_K0.6360.39
77_I119_I0.6350.39
10_S269_I0.6340.39
62_K69_L0.6340.39
382_A407_V0.6330.39
150_A331_G0.6330.39
42_L180_Y0.6330.39
123_L128_R0.6300.39
304_I454_D0.6300.39
73_L118_G0.6290.39
57_F154_K0.6280.39
252_S256_L0.6270.39
269_I278_S0.6260.38
43_I46_R0.6260.38
101_L110_E0.6260.38
273_N325_G0.6250.38
153_V386_S0.6240.38
41_R120_I0.6230.38
9_L215_V0.6220.38
120_I201_H0.6210.38
386_S392_K0.6210.38
227_E255_F0.6210.38
293_K390_N0.6210.38
106_K240_S0.6210.38
288_L292_R0.6190.38
398_N408_K0.6190.38
195_I357_I0.6190.38
342_N345_S0.6180.38
444_D457_Y0.6180.38
161_I402_V0.6180.38
217_L361_N0.6170.38
33_L269_I0.6170.38
323_S347_V0.6160.38
134_Y140_H0.6160.38
292_R368_E0.6160.38
414_L419_P0.6140.37
199_A218_L0.6140.37
204_W210_D0.6120.37
93_L289_E0.6110.37
351_L355_N0.6110.37
19_S321_I0.6110.37
5_Y9_L0.6100.37
98_I104_I0.6100.37
339_D344_F0.6090.37
87_D117_L0.6080.37
254_E258_N0.6080.37
39_E187_N0.6060.37
291_S425_L0.6060.37
396_D414_L0.6050.37
103_E303_E0.6050.37
214_A310_S0.6040.36
87_D94_I0.6020.36
411_G415_A0.6020.36
97_R449_K0.6010.36
408_K415_A0.6000.36
27_K161_I0.6000.36
106_K124_D0.6000.36
19_S429_I0.5990.36
382_A415_A0.5950.36
382_A389_V0.5940.36
236_E272_D0.5940.36
307_D315_G0.5920.35
103_E204_W0.5920.35
235_A438_N0.5910.35
60_E223_S0.5910.35
236_E308_G0.5910.35
209_R275_S0.5890.35
289_E421_S0.5890.35
157_D160_Y0.5880.35
283_T324_L0.5880.35
210_D237_E0.5870.35
32_I86_K0.5860.35
17_T238_S0.5860.35
84_N196_H0.5860.35
297_N353_T0.5860.35
193_K423_V0.5840.35
129_K133_K0.5840.35
198_T201_H0.5840.35
60_E86_K0.5830.35
375_N378_W0.5820.35
153_V229_H0.5820.35
229_H255_F0.5810.34
285_P291_S0.5800.34
153_V454_D0.5800.34
146_P285_P0.5790.34
92_N167_I0.5780.34
270_N307_D0.5780.34
294_Y357_I0.5770.34
401_E417_N0.5770.34
123_L304_I0.5770.34
397_K443_E0.5760.34
448_I455_E0.5760.34
392_K404_R0.5760.34
293_K297_N0.5750.34
309_Y442_I0.5730.34
283_T421_S0.5730.34
37_S230_L0.5730.34
448_I456_I0.5720.34
266_L269_I0.5720.34
86_K316_I0.5710.34
7_K136_D0.5710.34
398_N402_V0.5700.34
10_S338_T0.5700.34
200_H204_W0.5690.33
53_K94_I0.5680.33
314_A437_K0.5670.33
341_P396_D0.5650.33
79_A318_S0.5650.33
403_Y412_G0.5650.33
283_T288_L0.5630.33
426_F436_R0.5620.33
342_N346_N0.5620.33
135_G138_L0.5610.33
451_L457_Y0.5610.33
382_A400_T0.5600.33
99_Q128_R0.5590.33
152_Y162_K0.5590.33
62_K65_D0.5580.33
27_K42_L0.5580.33
98_I445_L0.5570.32
422_K426_F0.5570.32
204_W237_E0.5560.32
396_D400_T0.5530.32
90_G283_T0.5520.32
184_A451_L0.5520.32
302_P307_D0.5520.32
110_E123_L0.5520.32
412_G421_S0.5510.32
11_N382_A0.5510.32
15_I18_G0.5500.32
159_P391_V0.5490.32
396_D403_Y0.5490.32
23_T43_I0.5490.32
313_K452_R0.5490.32
28_E449_K0.5480.32
34_E168_S0.5480.32
49_N179_G0.5470.32
311_Y315_G0.5460.32
27_K180_Y0.5460.32
240_S330_H0.5460.32
198_T323_S0.5450.31
49_N195_I0.5450.31
358_I373_L0.5440.31
268_N276_E0.5440.31
394_I402_V0.5430.31
405_K408_K0.5420.31
15_I199_A0.5410.31
199_A237_E0.5410.31
234_T254_E0.5410.31
268_N285_P0.5410.31
71_Y173_L0.5410.31
50_W238_S0.5390.31
161_I319_I0.5390.31
24_K231_I0.5380.31
82_V354_I0.5380.31
117_L265_I0.5370.31
358_I366_T0.5370.31
239_G416_F0.5360.31
75_T257_K0.5360.31
233_F252_S0.5360.31
164_K354_I0.5350.31
77_I118_G0.5350.31
210_D240_S0.5340.31
91_R116_C0.5330.31
98_I304_I0.5320.30
103_E200_H0.5310.30
61_S64_I0.5270.30
375_N414_L0.5270.30
15_I215_V0.5260.30
67_I449_K0.5260.30
391_V402_V0.5260.30
403_Y410_Y0.5260.30
151_F334_D0.5250.30
194_I230_L0.5250.30
133_K138_L0.5230.30
335_I435_A0.5230.30
31_K57_F0.5220.30
81_V118_G0.5220.30
404_R407_V0.5220.30
49_N52_Q0.5220.30
103_E272_D0.5210.30
291_S319_I0.5200.29
382_A385_K0.5190.29
58_E135_G0.5190.29
271_M274_I0.5180.29
59_C273_N0.5170.29
53_K372_Q0.5170.29
76_E170_K0.5160.29
306_S330_H0.5150.29
403_Y416_F0.5150.29
82_V120_I0.5140.29
151_F331_G0.5140.29
55_L196_H0.5130.29
111_A270_N0.5110.29
293_K296_K0.5110.29
92_N140_H0.5110.29
400_T405_K0.5100.29
186_R197_I0.5100.29
312_I317_P0.5090.29
290_L395_L0.5070.28
108_Y269_I0.5070.28
57_F165_C0.5070.28
30_R218_L0.5060.28
442_I455_E0.5050.28
96_V407_V0.5050.28
386_S401_E0.5040.28
42_L203_H0.5040.28
98_I102_Y0.5030.28
151_F171_T0.5030.28
200_H240_S0.5010.28
263_D360_E0.5010.28
31_K178_T0.5010.28
50_W73_L0.5000.28
410_Y416_F0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tweA 2 0.9693 100 0.325 Contact Map
3fedA 2 0.9693 100 0.338 Contact Map
3kasA 2 0.9693 100 0.355 Contact Map
2ek8A 2 0.7254 100 0.544 Contact Map
3iibA 2 0.7316 100 0.557 Contact Map
4r12A 1 0.8422 100 0.682 Contact Map
3k9tA 3 0.75 100 0.721 Contact Map
4mhpA 1 0.4631 100 0.761 Contact Map
1tkjA 1 0.459 100 0.763 Contact Map
4f9uA 1 0.4816 100 0.767 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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