GREMLIN Database
Q7LXL6 - 2-haloalkanoic acid dehalogenase, putative
UniProt: Q7LXL6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 242 (207)
Sequences: 29103 (22838)
Seq/√Len: 1587.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_K190_S4.1911.00
179_I183_K2.8571.00
149_R154_I2.8151.00
169_R173_N2.7251.00
195_G201_D2.6821.00
205_A212_S2.5991.00
141_G145_S2.5901.00
13_A186_V2.5091.00
118_K122_E2.3711.00
122_E156_K2.3671.00
11_V211_I2.3371.00
130_K158_D2.2981.00
179_I182_E2.2021.00
132_G159_L2.1601.00
134_V176_P2.1261.00
181_C191_C2.1211.00
16_F131_L2.1201.00
169_R175_E2.0821.00
206_K229_D2.0201.00
233_S237_Q2.0041.00
202_C212_S1.9861.00
159_L183_K1.8981.00
187_E190_S1.8931.00
135_T144_K1.8821.00
203_L207_K1.8521.00
53_N56_I1.7881.00
14_V129_Y1.7761.00
125_D156_K1.7701.00
211_I229_D1.7651.00
15_L193_F1.7391.00
192_V213_V1.6801.00
181_C210_M1.6491.00
141_G166_G1.6311.00
123_Y127_K1.6281.00
125_D158_D1.6191.00
117_A235_L1.5981.00
193_F205_A1.5931.00
123_Y239_E1.5901.00
11_V192_V1.5851.00
39_D99_D1.5841.00
145_S154_I1.5491.00
15_L180_S1.5261.00
131_L157_F1.5221.00
13_A184_L1.5151.00
15_L134_V1.4981.00
181_C188_P1.4881.00
35_A103_L1.4801.00
216_D233_S1.4641.00
186_V191_C1.4611.00
114_Y217_R1.4301.00
132_G184_L1.4161.00
14_V124_L1.3931.00
14_V194_V1.3651.00
39_D103_L1.3651.00
213_V232_L1.3601.00
120_I235_L1.3491.00
103_L106_S1.3201.00
123_Y126_S1.3101.00
216_D231_V1.3081.00
21_T194_V1.2721.00
174_L178_I1.2661.00
234_S237_Q1.2661.00
99_D103_L1.2601.00
18_F133_L1.2551.00
78_K81_E1.2521.00
18_F23_V1.2491.00
35_A39_D1.2451.00
18_F144_K1.2421.00
199_V203_L1.2331.00
100_W104_Y1.2301.00
145_S149_R1.2291.00
116_D119_E1.2261.00
213_V230_F1.2181.00
74_Y78_K1.2171.00
101_T105_W1.2041.00
120_I239_E1.1991.00
22_L117_A1.1981.00
15_L191_C1.1871.00
40_I99_D1.1781.00
98_Y102_S1.1561.00
177_F193_F1.1411.00
95_S99_D1.1351.00
92_I95_S1.1291.00
113_P153_L1.1191.00
177_F204_A1.1151.00
93_D96_Q1.1061.00
191_C210_M1.1021.00
54_I58_R1.1001.00
119_E236_K1.0891.00
99_D102_S1.0891.00
58_R61_V1.0791.00
13_A130_K1.0741.00
35_A38_K1.0721.00
36_V40_I1.0711.00
96_Q100_W1.0641.00
177_F210_M1.0621.00
178_I182_E1.0571.00
19_D25_F1.0521.00
13_A191_C1.0521.00
141_G165_E1.0511.00
125_D131_L1.0391.00
122_E126_S1.0341.00
77_N81_E1.0301.00
206_K212_S1.0261.00
78_K82_N1.0221.00
175_E179_I1.0211.00
152_P155_D1.0191.00
134_V180_S1.0101.00
118_K156_K1.0011.00
31_E35_A1.0001.00
81_E85_K0.9971.00
121_I157_F0.9821.00
75_N79_W0.9771.00
175_E178_I0.9731.00
13_A132_G0.9661.00
133_L157_F0.9661.00
146_S150_T0.9621.00
18_F139_G0.9591.00
161_L183_K0.9581.00
180_S184_L0.9511.00
178_I208_A0.9481.00
193_F210_M0.9361.00
202_C228_A0.9321.00
19_D139_G0.9291.00
119_E122_E0.9221.00
146_S149_R0.9141.00
82_N85_K0.9071.00
34_D38_K0.9051.00
56_I60_L0.9001.00
15_L210_M0.8991.00
57_I60_L0.8971.00
31_E34_D0.8961.00
211_I230_F0.8951.00
200_K203_L0.8901.00
97_L101_T0.8861.00
15_L184_L0.8831.00
166_G183_K0.8831.00
144_K147_R0.8821.00
178_I188_P0.8791.00
122_E155_D0.8741.00
177_F195_G0.8721.00
204_A208_A0.8721.00
206_K227_Y0.8661.00
31_E110_Q0.8661.00
94_K98_Y0.8581.00
19_D135_T0.8551.00
113_P118_K0.8431.00
159_L184_L0.8391.00
116_D234_S0.8321.00
232_L238_L0.8311.00
124_L129_Y0.8271.00
192_V211_I0.8271.00
37_S42_T0.8251.00
85_K88_N0.8251.00
197_E200_K0.8241.00
188_P210_M0.8211.00
92_I96_Q0.8181.00
114_Y215_I0.8111.00
11_V129_Y0.8081.00
132_G180_S0.8081.00
34_D54_I0.8021.00
74_Y82_N0.7981.00
76_R79_W0.7981.00
75_N78_K0.7901.00
162_I165_E0.7881.00
56_I59_K0.7851.00
116_D236_K0.7811.00
55_N58_R0.7791.00
139_G144_K0.7781.00
194_V213_V0.7781.00
96_Q99_D0.7751.00
121_I156_K0.7741.00
124_L131_L0.7731.00
212_S229_D0.7731.00
161_L180_S0.7711.00
82_N86_S0.7711.00
14_V192_V0.7711.00
168_I175_E0.7671.00
84_L87_L0.7651.00
214_L231_V0.7631.00
23_V151_F0.7621.00
30_K34_D0.7611.00
114_Y117_A0.7571.00
131_L156_K0.7561.00
19_D196_D0.7511.00
32_A36_V0.7501.00
75_N80_W0.7481.00
81_E93_D0.7481.00
55_N59_K0.7461.00
23_V147_R0.7391.00
167_G179_I0.7361.00
12_K130_K0.7341.00
118_K152_P0.7311.00
12_K129_Y0.7291.00
11_V190_S0.7231.00
193_F201_D0.7201.00
31_E107_I0.7201.00
18_F147_R0.7141.00
136_N172_P0.7141.00
21_T201_D0.7111.00
161_L179_I0.7101.00
186_V190_S0.7091.00
141_G162_I0.7091.00
202_C214_L0.6961.00
53_N57_I0.6951.00
144_K162_I0.6931.00
52_I57_I0.6931.00
118_K155_D0.6921.00
15_L132_G0.6911.00
136_N170_P0.6881.00
203_L206_K0.6881.00
113_P151_F0.6831.00
177_F201_D0.6821.00
213_V238_L0.6821.00
176_P180_S0.6821.00
53_N58_R0.6811.00
98_Y101_T0.6801.00
77_N94_K0.6771.00
174_L207_K0.6701.00
223_D226_L0.6651.00
194_V238_L0.6641.00
119_E123_Y0.6631.00
27_S112_E0.6611.00
52_I56_I0.6601.00
217_R235_L0.6591.00
29_A33_L0.6571.00
12_K186_V0.6571.00
24_D112_E0.6541.00
101_T104_Y0.6541.00
130_K186_V0.6531.00
35_A107_I0.6521.00
74_Y79_W0.6511.00
72_G75_N0.6501.00
20_D26_S0.6481.00
103_L107_I0.6451.00
235_L239_E0.6451.00
76_R80_W0.6401.00
35_A106_S0.6361.00
222_K225_E0.6361.00
223_D227_Y0.6331.00
144_K160_I0.6331.00
167_G176_P0.6291.00
148_L154_I0.6261.00
232_L235_L0.6251.00
136_N200_K0.6231.00
106_S109_S0.6171.00
193_F204_A0.6151.00
100_W105_W0.6141.00
134_V193_F0.6141.00
215_I235_L0.6141.00
159_L180_S0.6111.00
176_P204_A0.6081.00
23_V111_T0.6081.00
181_C208_A0.6071.00
236_K239_E0.6071.00
181_C186_V0.6021.00
24_D27_S0.5991.00
131_L158_D0.5991.00
117_A121_I0.5951.00
72_G79_W0.5951.00
72_G76_R0.5931.00
57_I61_V0.5921.00
125_D128_G0.5901.00
19_D147_R0.5871.00
139_G143_N0.5841.00
21_T215_I0.5801.00
200_K204_A0.5791.00
97_L100_W0.5781.00
145_S160_I0.5761.00
100_W103_L0.5761.00
188_P191_C0.5711.00
142_G146_S0.5701.00
73_E79_W0.5701.00
102_S106_S0.5681.00
178_I181_C0.5681.00
116_D120_I0.5671.00
108_A146_S0.5651.00
120_I194_V0.5651.00
29_A139_G0.5641.00
38_K43_Y0.5631.00
54_I57_I0.5631.00
140_E143_N0.5611.00
24_D114_Y0.5611.00
115_E236_K0.5581.00
120_I124_L0.5571.00
232_L239_E0.5561.00
95_S98_Y0.5551.00
28_K111_T0.5521.00
122_E125_D0.5501.00
116_D217_R0.5481.00
149_R155_D0.5451.00
125_D155_D0.5441.00
84_L89_I0.5441.00
25_F139_G0.5441.00
15_L177_F0.5431.00
16_F120_I0.5431.00
117_A120_I0.5391.00
79_W82_N0.5391.00
139_G195_G0.5341.00
102_S105_W0.5341.00
80_W84_L0.5341.00
144_K148_L0.5311.00
30_K57_I0.5261.00
214_L228_A0.5211.00
214_L223_D0.5201.00
216_D221_V0.5111.00
164_G167_G0.5071.00
27_S31_E0.5011.00
22_L121_I0.5001.00
113_P117_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uw9A 1 0.814 100 0.299 Contact Map
3l5kA 1 0.9091 100 0.308 Contact Map
4eekA 2 0.876 100 0.318 Contact Map
3kbbA 1 0.8636 100 0.323 Contact Map
1te2A 2 0.876 100 0.325 Contact Map
2om6A 2 0.9215 100 0.325 Contact Map
3s6jA 2 0.8678 100 0.326 Contact Map
3dv9A 1 0.8843 100 0.33 Contact Map
2hdoA 1 0.8512 100 0.334 Contact Map
3iruA 4 0.9463 100 0.334 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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