GREMLIN Database
Q7LXL4 - Uncharacterized protein
UniProt: Q7LXL4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (227)
Sequences: 503 (332)
Seq/√Len: 22.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_M149_I6.6381.00
71_D74_T4.4721.00
134_I149_I3.5691.00
99_K142_V3.4321.00
31_F80_L3.3921.00
217_L225_V2.9420.99
104_I129_M2.7040.99
152_E155_K2.6480.99
129_M134_I2.5590.98
114_P120_I2.5450.98
63_L75_I2.5250.98
104_I122_P2.5120.98
166_L205_I2.4820.98
121_P124_R2.4810.98
77_K81_L2.4620.98
214_I227_V2.4330.98
38_S41_D2.3270.97
78_E82_K2.2970.97
129_M153_I2.2380.96
25_P87_V2.1880.96
13_E18_R2.1330.95
17_E62_S2.0760.94
182_L222_K2.0600.94
74_T77_K1.9660.92
168_I213_V1.9160.91
122_P129_M1.8920.91
103_I136_I1.8720.90
46_D73_E1.8620.90
112_V215_D1.8580.90
114_P125_L1.8330.89
214_I218_N1.8210.89
8_V30_A1.8210.89
117_N221_T1.8180.89
45_S49_Y1.7410.86
31_F39_L1.6840.85
157_I217_L1.6720.84
40_S46_D1.6220.82
21_I80_L1.6190.82
152_E166_L1.6130.82
202_E230_L1.6060.82
14_S66_V1.5880.81
111_A159_I1.5700.80
54_K58_A1.5660.80
11_K21_I1.5550.79
193_W205_I1.5520.79
103_I149_I1.5470.79
42_V80_L1.5300.78
53_K62_S1.4930.76
43_V72_F1.4840.76
7_Y22_L1.4760.76
147_M150_V1.4750.76
177_K193_W1.4670.75
111_A162_A1.4360.74
164_A210_Q1.4350.73
43_V76_V1.4190.73
74_T78_E1.4140.72
140_K144_A1.4090.72
11_K86_P1.3750.70
136_I188_V1.3730.70
89_A112_V1.3680.70
21_I39_L1.3500.69
185_L213_V1.3410.68
48_I63_L1.3300.68
209_A212_D1.3240.67
103_I150_V1.3110.66
7_Y10_V1.2870.65
104_I136_I1.2810.65
106_F142_V1.2630.63
193_W197_G1.2550.63
8_V76_V1.2500.63
153_I227_V1.2440.62
49_Y189_K1.2400.62
80_L166_L1.2250.61
163_R204_E1.2180.61
112_V171_P1.2180.61
21_I137_D1.2160.60
186_G203_L1.2110.60
16_G119_P1.2050.60
182_L187_E1.1970.59
182_L199_L1.1790.58
106_F110_N1.1660.57
53_K63_L1.1600.57
31_F42_V1.1590.57
13_E62_S1.1580.57
167_S200_L1.1500.56
34_G100_R1.1450.56
107_I149_I1.1350.55
5_R24_K1.1320.55
49_Y191_A1.1300.55
5_R10_V1.1250.54
154_S157_I1.1190.54
16_G154_S1.1160.54
14_S82_K1.1130.54
168_I186_G1.1090.53
12_Y37_I1.0910.52
165_L189_K1.0900.52
208_G217_L1.0880.52
7_Y24_K1.0800.51
207_A210_Q1.0760.51
88_T204_E1.0700.51
166_L213_V1.0670.50
149_I157_I1.0660.50
120_I125_L1.0650.50
170_V174_Y1.0620.50
119_P208_G1.0410.49
12_Y140_K1.0340.48
124_R158_P1.0320.48
171_P225_V1.0310.48
123_T127_M1.0240.48
107_I151_K1.0230.47
24_K44_V1.0130.47
65_K82_K1.0000.46
174_Y224_E0.9960.46
48_I216_K0.9960.46
32_R48_I0.9910.45
23_A26_K0.9910.45
166_L229_V0.9910.45
148_Q227_V0.9850.45
141_D192_N0.9830.45
69_T101_K0.9760.44
102_Q130_E0.9620.43
119_P126_E0.9490.42
3_K8_V0.9480.42
22_L26_K0.9470.42
104_I126_E0.9360.42
14_S40_S0.9200.41
188_V191_A0.9180.40
64_K70_T0.9070.40
19_F66_V0.9010.39
9_I16_G0.8940.39
100_R130_E0.8920.39
137_D156_I0.8890.39
18_R164_A0.8880.38
99_K137_D0.8770.38
47_T72_F0.8750.38
172_S217_L0.8700.37
39_L52_V0.8650.37
103_I181_Q0.8620.37
112_V167_S0.8610.37
168_I215_D0.8560.36
101_K136_I0.8540.36
153_I182_L0.8540.36
61_A93_K0.8530.36
37_I42_V0.8480.36
155_K176_S0.8460.36
9_I155_K0.8270.35
69_T159_I0.8220.34
103_I145_Q0.8170.34
108_H134_I0.8090.34
184_N200_L0.8080.33
140_K151_K0.8060.33
133_R144_A0.8050.33
29_L121_P0.8050.33
10_V23_A0.8030.33
100_R104_I0.8030.33
117_N178_V0.7970.33
69_T136_I0.7930.33
7_Y44_V0.7920.32
97_E101_K0.7910.32
16_G133_R0.7870.32
62_S110_N0.7840.32
193_W196_D0.7830.32
71_D134_I0.7830.32
39_L66_V0.7820.32
78_E123_T0.7780.32
208_G223_G0.7750.31
150_V180_S0.7730.31
208_G221_T0.7720.31
53_K216_K0.7680.31
101_K105_D0.7680.31
132_A156_I0.7680.31
31_F77_K0.7650.31
168_I201_A0.7640.31
27_E30_A0.7630.31
215_D230_L0.7620.31
39_L46_D0.7610.31
168_I222_K0.7590.31
5_R103_I0.7550.30
132_A137_D0.7530.30
26_K31_F0.7530.30
16_G102_Q0.7450.30
108_H157_I0.7430.30
59_S95_M0.7420.30
97_E108_H0.7410.30
10_V80_L0.7400.29
16_G135_Q0.7380.29
32_R51_D0.7370.29
31_F59_S0.7370.29
112_V184_N0.7340.29
98_T104_I0.7310.29
23_A27_E0.7230.29
110_N211_Q0.7230.29
48_I72_F0.7230.29
97_E103_I0.7210.28
25_P89_A0.7210.28
75_I93_K0.7200.28
11_K18_R0.7160.28
25_P29_L0.7150.28
27_E42_V0.7150.28
81_L94_E0.7130.28
9_I87_V0.7080.28
187_E218_N0.7070.28
156_I197_G0.7050.28
147_M153_I0.6980.27
17_E65_K0.6920.27
37_I230_L0.6910.27
163_R171_P0.6880.27
30_A88_T0.6860.27
118_L136_I0.6840.26
74_T188_V0.6840.26
10_V28_A0.6830.26
17_E89_A0.6800.26
65_K205_I0.6800.26
170_V175_S0.6790.26
25_P30_A0.6780.26
166_L203_L0.6770.26
175_S220_L0.6740.26
86_P106_F0.6730.26
60_P197_G0.6690.26
49_Y143_E0.6670.26
8_V14_S0.6660.25
100_R126_E0.6640.25
13_E17_E0.6590.25
104_I133_R0.6570.25
203_L213_V0.6570.25
36_S77_K0.6550.25
59_S138_L0.6540.25
19_F82_K0.6530.25
38_S54_K0.6500.25
145_Q149_I0.6490.25
40_S120_I0.6480.25
141_D144_A0.6420.24
39_L110_N0.6420.24
159_I162_A0.6410.24
87_V145_Q0.6380.24
166_L227_V0.6370.24
94_E229_V0.6370.24
39_L175_S0.6350.24
107_I155_K0.6300.24
49_Y128_A0.6290.24
33_S142_V0.6290.24
13_E31_F0.6280.24
21_I173_E0.6270.24
29_L85_L0.6270.24
23_A91_Q0.6270.24
144_A179_K0.6270.24
145_Q150_V0.6250.23
180_S218_N0.6240.23
93_K137_D0.6230.23
24_K27_E0.6220.23
49_Y154_S0.6190.23
8_V29_L0.6170.23
50_K54_K0.6160.23
186_G193_W0.6130.23
175_S193_W0.6110.23
115_K206_P0.6100.23
58_A62_S0.6100.23
22_L52_V0.6090.23
37_I178_V0.6090.23
84_E110_N0.6080.23
10_V24_K0.6050.22
40_S90_E0.6010.22
57_K219_S0.6010.22
165_L202_E0.6010.22
195_E220_L0.5970.22
210_Q227_V0.5960.22
120_I210_Q0.5960.22
55_G85_L0.5940.22
121_P186_G0.5930.22
79_I103_I0.5930.22
70_T125_L0.5890.22
49_Y229_V0.5880.22
41_D147_M0.5880.22
160_K230_L0.5860.22
8_V23_A0.5850.22
186_G209_A0.5840.21
213_V223_G0.5800.21
82_K189_K0.5790.21
188_V222_K0.5780.21
63_L178_V0.5770.21
22_L143_E0.5770.21
28_A219_S0.5760.21
40_S43_V0.5750.21
105_D122_P0.5750.21
117_N230_L0.5740.21
74_T125_L0.5720.21
175_S213_V0.5720.21
22_L91_Q0.5680.21
43_V48_I0.5670.21
5_R80_L0.5670.21
112_V159_I0.5570.20
119_P133_R0.5540.20
66_V188_V0.5540.20
113_D163_R0.5510.20
164_A207_A0.5500.20
150_V159_I0.5490.20
107_I150_V0.5480.20
32_R73_E0.5480.20
93_K101_K0.5460.20
103_I203_L0.5450.20
111_A206_P0.5420.20
19_F38_S0.5400.20
124_R210_Q0.5400.20
224_E230_L0.5390.19
3_K34_G0.5390.19
52_V147_M0.5390.19
94_E98_T0.5360.19
19_F54_K0.5360.19
44_V52_V0.5350.19
51_D62_S0.5340.19
26_K40_S0.5340.19
66_V224_E0.5310.19
6_D18_R0.5310.19
185_L227_V0.5300.19
4_E62_S0.5290.19
173_E190_K0.5280.19
6_D41_D0.5260.19
63_L118_L0.5250.19
5_R8_V0.5250.19
42_V53_K0.5230.19
34_G81_L0.5220.19
21_I189_K0.5220.19
6_D13_E0.5210.19
48_I129_M0.5200.19
101_K115_K0.5190.19
25_P164_A0.5190.19
113_D167_S0.5140.18
89_A108_H0.5110.18
189_K217_L0.5100.18
75_I165_L0.5090.18
173_E176_S0.5080.18
121_P198_T0.5050.18
42_V91_Q0.5050.18
85_L173_E0.5040.18
118_L150_V0.5030.18
166_L214_I0.5030.18
27_E35_K0.5030.18
49_Y150_V0.5020.18
125_L157_I0.5010.18
131_Q150_V0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wbmA 1 0.9914 100 0.08 Contact Map
2kdoA 1 0.9914 100 0.093 Contact Map
1t95A 1 0.9828 100 0.095 Contact Map
1nynA 1 0.4335 100 0.631 Contact Map
3lh2S 2 0.2918 91 0.936 Contact Map
2cveA 1 0.7124 70.2 0.95 Contact Map
3e3xA 2 0.5193 58.2 0.954 Contact Map
3j25A 1 0.7811 54.2 0.955 Contact Map
4qjty 1 0.9571 52.3 0.955 Contact Map
1vi7A 1 0.7082 44.6 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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