Q7LXL4 - SULSO - GREMLIN Contacts

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Q7LXL4 - Uncharacterized protein

UniProt:	Q7LXL4	Sequences: MTKERDYVIVKYESHGERFEILAKPKEALAFRSGKSISLSDVVVSDTIYKDVKKGLKASPASLKKVFGTTDFETIVKEILLKGELPVTAEQRKEMLETKRKQIIDFIHRNAVDPKTNLPIPPTRLEMAMEQARIQIDLNKDVEAQAMQIVKEISKIIPIKIARALLSIKVPSEYSSKVKSQLHNLGEVKKANWLEDGTLLAELEIPAGAQQDVIDKLNSLTKGEVEVKVLQVR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	233 (227)
Sequences:	503 (332)
Seq/√Len:	22.0

HALSA - Q9HQ87
SULSO - Q7LXL4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
129_M	149_I	6.638	1.00
71_D	74_T	4.472	1.00
134_I	149_I	3.569	1.00
99_K	142_V	3.432	1.00
31_F	80_L	3.392	1.00
217_L	225_V	2.942	0.99
104_I	129_M	2.704	0.99
152_E	155_K	2.648	0.99
129_M	134_I	2.559	0.98
114_P	120_I	2.545	0.98
63_L	75_I	2.525	0.98
104_I	122_P	2.512	0.98
166_L	205_I	2.482	0.98
121_P	124_R	2.481	0.98
77_K	81_L	2.462	0.98
214_I	227_V	2.433	0.98
38_S	41_D	2.327	0.97
78_E	82_K	2.297	0.97
129_M	153_I	2.238	0.96
25_P	87_V	2.188	0.96
13_E	18_R	2.133	0.95
17_E	62_S	2.076	0.94
182_L	222_K	2.060	0.94
74_T	77_K	1.966	0.92
168_I	213_V	1.916	0.91
122_P	129_M	1.892	0.91
103_I	136_I	1.872	0.90
46_D	73_E	1.862	0.90
112_V	215_D	1.858	0.90
114_P	125_L	1.833	0.89
214_I	218_N	1.821	0.89
8_V	30_A	1.821	0.89
117_N	221_T	1.818	0.89
45_S	49_Y	1.741	0.86
31_F	39_L	1.684	0.85
157_I	217_L	1.672	0.84
40_S	46_D	1.622	0.82
21_I	80_L	1.619	0.82
152_E	166_L	1.613	0.82
202_E	230_L	1.606	0.82
14_S	66_V	1.588	0.81
111_A	159_I	1.570	0.80
54_K	58_A	1.566	0.80
11_K	21_I	1.555	0.79
193_W	205_I	1.552	0.79
103_I	149_I	1.547	0.79
42_V	80_L	1.530	0.78
53_K	62_S	1.493	0.76
43_V	72_F	1.484	0.76
7_Y	22_L	1.476	0.76
147_M	150_V	1.475	0.76
177_K	193_W	1.467	0.75
111_A	162_A	1.436	0.74
164_A	210_Q	1.435	0.73
43_V	76_V	1.419	0.73
74_T	78_E	1.414	0.72
140_K	144_A	1.409	0.72
11_K	86_P	1.375	0.70
136_I	188_V	1.373	0.70
89_A	112_V	1.368	0.70
21_I	39_L	1.350	0.69
185_L	213_V	1.341	0.68
48_I	63_L	1.330	0.68
209_A	212_D	1.324	0.67
103_I	150_V	1.311	0.66
7_Y	10_V	1.287	0.65
104_I	136_I	1.281	0.65
106_F	142_V	1.263	0.63
193_W	197_G	1.255	0.63
8_V	76_V	1.250	0.63
153_I	227_V	1.244	0.62
49_Y	189_K	1.240	0.62
80_L	166_L	1.225	0.61
163_R	204_E	1.218	0.61
112_V	171_P	1.218	0.61
21_I	137_D	1.216	0.60
186_G	203_L	1.211	0.60
16_G	119_P	1.205	0.60
182_L	187_E	1.197	0.59
182_L	199_L	1.179	0.58
106_F	110_N	1.166	0.57
53_K	63_L	1.160	0.57
31_F	42_V	1.159	0.57
13_E	62_S	1.158	0.57
167_S	200_L	1.150	0.56
34_G	100_R	1.145	0.56
107_I	149_I	1.135	0.55
5_R	24_K	1.132	0.55
49_Y	191_A	1.130	0.55
5_R	10_V	1.125	0.54
154_S	157_I	1.119	0.54
16_G	154_S	1.116	0.54
14_S	82_K	1.113	0.54
168_I	186_G	1.109	0.53
12_Y	37_I	1.091	0.52
165_L	189_K	1.090	0.52
208_G	217_L	1.088	0.52
7_Y	24_K	1.080	0.51
207_A	210_Q	1.076	0.51
88_T	204_E	1.070	0.51
166_L	213_V	1.067	0.50
149_I	157_I	1.066	0.50
120_I	125_L	1.065	0.50
170_V	174_Y	1.062	0.50
119_P	208_G	1.041	0.49
12_Y	140_K	1.034	0.48
124_R	158_P	1.032	0.48
171_P	225_V	1.031	0.48
123_T	127_M	1.024	0.48
107_I	151_K	1.023	0.47
24_K	44_V	1.013	0.47
65_K	82_K	1.000	0.46
174_Y	224_E	0.996	0.46
48_I	216_K	0.996	0.46
32_R	48_I	0.991	0.45
23_A	26_K	0.991	0.45
166_L	229_V	0.991	0.45
148_Q	227_V	0.985	0.45
141_D	192_N	0.983	0.45
69_T	101_K	0.976	0.44
102_Q	130_E	0.962	0.43
119_P	126_E	0.949	0.42
3_K	8_V	0.948	0.42
22_L	26_K	0.947	0.42
104_I	126_E	0.936	0.42
14_S	40_S	0.920	0.41
188_V	191_A	0.918	0.40
64_K	70_T	0.907	0.40
19_F	66_V	0.901	0.39
9_I	16_G	0.894	0.39
100_R	130_E	0.892	0.39
137_D	156_I	0.889	0.39
18_R	164_A	0.888	0.38
99_K	137_D	0.877	0.38
47_T	72_F	0.875	0.38
172_S	217_L	0.870	0.37
39_L	52_V	0.865	0.37
103_I	181_Q	0.862	0.37
112_V	167_S	0.861	0.37
168_I	215_D	0.856	0.36
101_K	136_I	0.854	0.36
153_I	182_L	0.854	0.36
61_A	93_K	0.853	0.36
37_I	42_V	0.848	0.36
155_K	176_S	0.846	0.36
9_I	155_K	0.827	0.35
69_T	159_I	0.822	0.34
103_I	145_Q	0.817	0.34
108_H	134_I	0.809	0.34
184_N	200_L	0.808	0.33
140_K	151_K	0.806	0.33
133_R	144_A	0.805	0.33
29_L	121_P	0.805	0.33
10_V	23_A	0.803	0.33
100_R	104_I	0.803	0.33
117_N	178_V	0.797	0.33
69_T	136_I	0.793	0.33
7_Y	44_V	0.792	0.32
97_E	101_K	0.791	0.32
16_G	133_R	0.787	0.32
62_S	110_N	0.784	0.32
193_W	196_D	0.783	0.32
71_D	134_I	0.783	0.32
39_L	66_V	0.782	0.32
78_E	123_T	0.778	0.32
208_G	223_G	0.775	0.31
150_V	180_S	0.773	0.31
208_G	221_T	0.772	0.31
53_K	216_K	0.768	0.31
101_K	105_D	0.768	0.31
132_A	156_I	0.768	0.31
31_F	77_K	0.765	0.31
168_I	201_A	0.764	0.31
27_E	30_A	0.763	0.31
215_D	230_L	0.762	0.31
39_L	46_D	0.761	0.31
168_I	222_K	0.759	0.31
5_R	103_I	0.755	0.30
132_A	137_D	0.753	0.30
26_K	31_F	0.753	0.30
16_G	102_Q	0.745	0.30
108_H	157_I	0.743	0.30
59_S	95_M	0.742	0.30
97_E	108_H	0.741	0.30
10_V	80_L	0.740	0.29
16_G	135_Q	0.738	0.29
32_R	51_D	0.737	0.29
31_F	59_S	0.737	0.29
112_V	184_N	0.734	0.29
98_T	104_I	0.731	0.29
23_A	27_E	0.723	0.29
110_N	211_Q	0.723	0.29
48_I	72_F	0.723	0.29
97_E	103_I	0.721	0.28
25_P	89_A	0.721	0.28
75_I	93_K	0.720	0.28
11_K	18_R	0.716	0.28
25_P	29_L	0.715	0.28
27_E	42_V	0.715	0.28
81_L	94_E	0.713	0.28
9_I	87_V	0.708	0.28
187_E	218_N	0.707	0.28
156_I	197_G	0.705	0.28
147_M	153_I	0.698	0.27
17_E	65_K	0.692	0.27
37_I	230_L	0.691	0.27
163_R	171_P	0.688	0.27
30_A	88_T	0.686	0.27
118_L	136_I	0.684	0.26
74_T	188_V	0.684	0.26
10_V	28_A	0.683	0.26
17_E	89_A	0.680	0.26
65_K	205_I	0.680	0.26
170_V	175_S	0.679	0.26
25_P	30_A	0.678	0.26
166_L	203_L	0.677	0.26
175_S	220_L	0.674	0.26
86_P	106_F	0.673	0.26
60_P	197_G	0.669	0.26
49_Y	143_E	0.667	0.26
8_V	14_S	0.666	0.25
100_R	126_E	0.664	0.25
13_E	17_E	0.659	0.25
104_I	133_R	0.657	0.25
203_L	213_V	0.657	0.25
36_S	77_K	0.655	0.25
59_S	138_L	0.654	0.25
19_F	82_K	0.653	0.25
38_S	54_K	0.650	0.25
145_Q	149_I	0.649	0.25
40_S	120_I	0.648	0.25
141_D	144_A	0.642	0.24
39_L	110_N	0.642	0.24
159_I	162_A	0.641	0.24
87_V	145_Q	0.638	0.24
166_L	227_V	0.637	0.24
94_E	229_V	0.637	0.24
39_L	175_S	0.635	0.24
107_I	155_K	0.630	0.24
49_Y	128_A	0.629	0.24
33_S	142_V	0.629	0.24
13_E	31_F	0.628	0.24
21_I	173_E	0.627	0.24
29_L	85_L	0.627	0.24
23_A	91_Q	0.627	0.24
144_A	179_K	0.627	0.24
145_Q	150_V	0.625	0.23
180_S	218_N	0.624	0.23
93_K	137_D	0.623	0.23
24_K	27_E	0.622	0.23
49_Y	154_S	0.619	0.23
8_V	29_L	0.617	0.23
50_K	54_K	0.616	0.23
186_G	193_W	0.613	0.23
175_S	193_W	0.611	0.23
115_K	206_P	0.610	0.23
58_A	62_S	0.610	0.23
22_L	52_V	0.609	0.23
37_I	178_V	0.609	0.23
84_E	110_N	0.608	0.23
10_V	24_K	0.605	0.22
40_S	90_E	0.601	0.22
57_K	219_S	0.601	0.22
165_L	202_E	0.601	0.22
195_E	220_L	0.597	0.22
210_Q	227_V	0.596	0.22
120_I	210_Q	0.596	0.22
55_G	85_L	0.594	0.22
121_P	186_G	0.593	0.22
79_I	103_I	0.593	0.22
70_T	125_L	0.589	0.22
49_Y	229_V	0.588	0.22
41_D	147_M	0.588	0.22
160_K	230_L	0.586	0.22
8_V	23_A	0.585	0.22
186_G	209_A	0.584	0.21
213_V	223_G	0.580	0.21
82_K	189_K	0.579	0.21
188_V	222_K	0.578	0.21
63_L	178_V	0.577	0.21
22_L	143_E	0.577	0.21
28_A	219_S	0.576	0.21
40_S	43_V	0.575	0.21
105_D	122_P	0.575	0.21
117_N	230_L	0.574	0.21
74_T	125_L	0.572	0.21
175_S	213_V	0.572	0.21
22_L	91_Q	0.568	0.21
43_V	48_I	0.567	0.21
5_R	80_L	0.567	0.21
112_V	159_I	0.557	0.20
119_P	133_R	0.554	0.20
66_V	188_V	0.554	0.20
113_D	163_R	0.551	0.20
164_A	207_A	0.550	0.20
150_V	159_I	0.549	0.20
107_I	150_V	0.548	0.20
32_R	73_E	0.548	0.20
93_K	101_K	0.546	0.20
103_I	203_L	0.545	0.20
111_A	206_P	0.542	0.20
19_F	38_S	0.540	0.20
124_R	210_Q	0.540	0.20
224_E	230_L	0.539	0.19
3_K	34_G	0.539	0.19
52_V	147_M	0.539	0.19
94_E	98_T	0.536	0.19
19_F	54_K	0.536	0.19
44_V	52_V	0.535	0.19
51_D	62_S	0.534	0.19
26_K	40_S	0.534	0.19
66_V	224_E	0.531	0.19
6_D	18_R	0.531	0.19
185_L	227_V	0.530	0.19
4_E	62_S	0.529	0.19
173_E	190_K	0.528	0.19
6_D	41_D	0.526	0.19
63_L	118_L	0.525	0.19
5_R	8_V	0.525	0.19
42_V	53_K	0.523	0.19
34_G	81_L	0.522	0.19
21_I	189_K	0.522	0.19
6_D	13_E	0.521	0.19
48_I	129_M	0.520	0.19
101_K	115_K	0.519	0.19
25_P	164_A	0.519	0.19
113_D	167_S	0.514	0.18
89_A	108_H	0.511	0.18
189_K	217_L	0.510	0.18
75_I	165_L	0.509	0.18
173_E	176_S	0.508	0.18
121_P	198_T	0.505	0.18
42_V	91_Q	0.505	0.18
85_L	173_E	0.504	0.18
118_L	150_V	0.503	0.18
166_L	214_I	0.503	0.18
27_E	35_K	0.503	0.18
49_Y	150_V	0.502	0.18
125_L	157_I	0.501	0.18
131_Q	150_V	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2wbmA	1	0.9914	100	0.08	Contact Map
2kdoA	1	0.9914	100	0.093	Contact Map
1t95A	1	0.9828	100	0.095	Contact Map
1nynA	1	0.4335	100	0.631	Contact Map
3lh2S	2	0.2918	91	0.936	Contact Map
2cveA	1	0.7124	70.2	0.95	Contact Map
3e3xA	2	0.5193	58.2	0.954	Contact Map
3j25A	1	0.7811	54.2	0.955	Contact Map
4qjty	1	0.9571	52.3	0.955	Contact Map
1vi7A	1	0.7082	44.6	0.957	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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