GREMLIN Database
Q7LXL1 - Uncharacterized protein
UniProt: Q7LXL1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 149 (130)
Sequences: 171 (139)
Seq/√Len: 12.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_H49_N3.9600.99
91_D94_K3.3340.98
21_I104_L3.3040.98
39_N44_Q2.9590.95
74_I99_F2.7570.93
15_T102_Q2.5090.89
100_D103_Y2.3560.86
6_A70_I2.2310.83
57_R99_F2.1770.81
29_F97_L2.1190.79
85_T89_H1.9770.74
82_I95_L1.9640.74
100_D113_K1.9580.74
63_G91_D1.9320.73
25_I38_K1.8990.71
13_H130_E1.7940.67
5_Q8_I1.7440.64
66_F70_I1.7370.64
19_N82_I1.6640.61
9_S126_N1.6560.60
91_D95_L1.6100.58
124_S129_L1.5390.54
49_N102_Q1.4880.52
24_T106_A1.4870.52
4_N127_T1.4740.51
83_L119_I1.4560.50
87_D109_R1.4470.50
63_G115_G1.4430.50
66_F119_I1.4330.49
75_E109_R1.4230.49
25_I29_F1.4130.48
38_K56_Y1.4030.48
41_T56_Y1.4010.47
6_A30_S1.3840.47
82_I97_L1.3810.46
103_Y109_R1.3740.46
94_K122_I1.2980.42
21_I106_A1.2920.42
29_F55_E1.2890.42
17_D65_Q1.2860.42
92_G95_L1.2320.39
56_Y136_I1.2290.39
124_S135_E1.2180.38
21_I24_T1.1730.36
95_L112_L1.1480.35
9_S104_L1.1470.35
94_K124_S1.1460.35
39_N85_T1.1400.35
6_A84_T1.1350.35
60_R75_E1.0950.33
63_G75_E1.0850.32
129_L135_E1.0760.32
44_Q91_D1.0760.32
98_R136_I1.0760.32
16_E101_K1.0720.32
18_Y100_D1.0680.32
36_S114_E1.0670.31
128_S135_E1.0640.31
27_S119_I1.0610.31
24_T121_C1.0510.31
38_K88_S1.0500.31
74_I108_H1.0470.31
118_V128_S1.0410.30
28_F67_F1.0310.30
9_S25_I1.0150.29
84_T100_D1.0070.29
75_E115_G0.9980.29
11_F52_I0.9970.29
51_I63_G0.9970.29
8_I121_C0.9830.28
8_I38_K0.9820.28
4_N124_S0.9810.28
7_I122_I0.9660.27
131_N138_K0.9660.27
132_I136_I0.9470.26
43_A127_T0.9440.26
48_G75_E0.9430.26
47_Y88_S0.9330.26
30_S104_L0.9290.26
12_I54_L0.9210.25
104_L129_L0.9160.25
81_L85_T0.9160.25
29_F49_N0.9100.25
4_N126_N0.9010.25
98_R112_L0.8960.25
125_F135_E0.8910.24
45_G117_D0.8890.24
17_D92_G0.8890.24
87_D115_G0.8880.24
37_K109_R0.8830.24
4_N95_L0.8790.24
15_T49_N0.8720.24
19_N26_E0.8640.23
65_Q68_K0.8630.23
25_I67_F0.8590.23
60_R128_S0.8570.23
114_E120_K0.8550.23
7_I57_R0.8480.23
18_Y40_V0.8400.22
87_D95_L0.8360.22
20_K50_K0.8350.22
107_E133_K0.8330.22
90_I136_I0.8300.22
82_I98_R0.8170.22
108_H118_V0.8080.21
38_K74_I0.8060.21
72_E112_L0.8000.21
43_A47_Y0.7980.21
77_S98_R0.7970.21
43_A65_Q0.7950.21
5_Q57_R0.7900.21
54_L135_E0.7900.21
78_E81_L0.7840.21
77_S112_L0.7740.20
79_L94_K0.7710.20
18_Y47_Y0.7700.20
17_D57_R0.7550.20
127_T130_E0.7530.20
54_L112_L0.7330.19
46_H139_L0.7290.19
96_Y99_F0.7190.19
90_I96_Y0.7140.18
82_I138_K0.7120.18
92_G124_S0.7100.18
10_V131_N0.7090.18
53_I61_K0.7070.18
40_V119_I0.7020.18
78_E119_I0.7010.18
134_E137_K0.6990.18
48_G118_V0.6810.17
48_G51_I0.6790.17
60_R126_N0.6710.17
59_D63_G0.6690.17
86_I108_H0.6680.17
119_I131_N0.6650.17
70_I82_I0.6610.17
24_T96_Y0.6600.17
9_S125_F0.6570.17
38_K89_H0.6510.17
19_N76_T0.6480.16
37_K75_E0.6450.16
42_T72_E0.6440.16
36_S72_E0.6410.16
10_V40_V0.6340.16
79_L91_D0.6300.16
9_S106_A0.6300.16
14_E82_I0.6280.16
72_E82_I0.6230.16
11_F127_T0.6220.16
26_E30_S0.6210.16
99_F110_L0.6200.16
8_I90_I0.6140.16
132_I137_K0.6110.15
9_S55_E0.6080.15
30_S111_V0.6080.15
28_F79_L0.6070.15
9_S53_I0.6020.15
66_F97_L0.6000.15
53_I86_I0.5970.15
46_H49_N0.5960.15
14_E43_A0.5960.15
45_G101_K0.5910.15
16_E45_G0.5910.15
15_T46_H0.5910.15
58_F79_L0.5900.15
5_Q120_K0.5890.15
88_S114_E0.5870.15
38_K78_E0.5750.15
21_I135_E0.5750.15
11_F123_I0.5730.14
43_A46_H0.5670.14
21_I30_S0.5670.14
15_T101_K0.5670.14
125_F129_L0.5580.14
86_I90_I0.5560.14
50_K68_K0.5560.14
15_T100_D0.5530.14
51_I75_E0.5530.14
9_S135_E0.5500.14
13_H68_K0.5480.14
27_S131_N0.5470.14
104_L133_K0.5450.14
37_K62_S0.5440.14
66_F73_K0.5330.13
8_I69_I0.5210.13
17_D58_F0.5210.13
84_T95_L0.5140.13
27_S104_L0.5140.13
24_T76_T0.5130.13
93_S106_A0.5120.13
20_K112_L0.5100.13
48_G89_H0.5100.13
21_I93_S0.5090.13
46_H102_Q0.5000.13
110_L119_I0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nrqA 1 0.9128 100 0.274 Contact Map
2wnyA 1 0.8993 100 0.345 Contact Map
2ogkA 4 0.9262 100 0.348 Contact Map
2nwuA 2 0.8322 99.9 0.536 Contact Map
2pzzA 2 0.8658 99.9 0.539 Contact Map
3d7aA 2 0.8725 99.9 0.546 Contact Map
3c9gA 2 0.8456 99.9 0.554 Contact Map
4clfA 3 0.8658 19.3 0.944 Contact Map
2pt7G 2 0.5638 18.2 0.945 Contact Map
3cskA 1 0.8523 17.5 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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