GREMLIN Database
Q7LXL0 - GTP binding protein
UniProt: Q7LXL0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 408 (378)
Sequences: 509 (379)
Seq/√Len: 19.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_I231_A5.4741.00
364_N371_A5.0021.00
357_S361_D4.5611.00
392_L398_I4.5041.00
329_V350_A3.8991.00
319_T323_D3.7101.00
92_G95_E3.4661.00
24_F28_A3.3561.00
361_D371_A3.2951.00
43_I87_A3.2941.00
115_H140_D3.1960.99
231_A257_T2.9080.99
293_Q297_L2.7140.98
134_S139_E2.6890.98
33_V46_N2.6770.98
276_Y279_G2.6120.98
124_N128_V2.6040.98
68_K348_P2.5960.98
305_L310_S2.5670.98
353_L357_S2.5580.97
258_S262_E2.5200.97
141_I231_A2.5050.97
262_E272_G2.4240.96
364_N372_K2.4020.96
298_E301_R2.3920.96
210_T213_D2.3610.96
262_E265_L2.2840.95
12_G23_T2.2690.95
86_V107_L2.2620.95
258_S261_S2.2500.95
376_Y385_R2.2320.94
362_L392_L2.1630.93
273_I279_G2.1520.93
105_D108_R2.1290.93
326_N355_K2.0800.92
12_G359_P2.0530.91
296_A299_Y2.0210.91
70_S77_R2.0160.91
355_K393_Q1.9920.90
11_I112_A1.9770.90
17_T38_R1.9520.89
91_P144_I1.9210.88
373_G402_S1.9190.88
240_A243_N1.9120.88
15_G20_G1.9100.88
15_G21_K1.9100.88
262_E273_I1.9000.88
231_A316_A1.8990.88
17_T22_S1.8690.87
262_E279_G1.8470.86
359_P374_F1.8110.85
390_Y396_D1.7870.84
258_S273_I1.7840.84
374_F377_A1.7580.83
135_R140_D1.7370.82
370_L402_S1.7160.82
12_G25_F1.7140.82
275_S279_G1.6620.80
23_T27_A1.6480.79
93_A98_G1.6340.78
18_N113_L1.6330.78
353_L361_D1.6300.78
38_R41_V1.6300.78
59_T397_V1.6290.78
290_N293_Q1.6240.78
330_T335_D1.6060.77
353_L365_A1.5840.76
272_G279_G1.5750.76
162_K252_K1.5630.75
26_A35_I1.5290.73
34_E41_V1.5270.73
368_T371_A1.5170.73
27_A48_G1.5130.73
114_I257_T1.5000.72
111_D227_P1.4940.72
258_S265_L1.4800.71
294_K297_L1.4660.70
272_G276_Y1.4660.70
52_V317_I1.4640.70
149_D222_R1.4570.70
264_A268_A1.4440.69
106_D113_L1.4370.69
157_N211_E1.4330.68
26_A32_D1.4290.68
159_D181_K1.4220.68
291_E294_K1.4210.68
293_Q296_A1.4010.67
269_A279_G1.3840.66
275_S284_T1.3830.66
61_F64_K1.3800.65
329_V394_N1.3680.65
18_N42_T1.3650.65
14_I19_V1.3620.64
385_R401_V1.3600.64
100_G103_F1.3590.64
87_A106_D1.3580.64
266_R279_G1.3560.64
273_I276_Y1.3400.63
22_S43_I1.3390.63
265_L279_G1.3330.63
265_L276_Y1.3110.61
24_F316_A1.2700.59
117_I141_I1.2690.59
149_D219_K1.2630.58
328_I355_K1.2620.58
39_P43_I1.2430.57
40_F43_I1.2400.57
268_A293_Q1.2330.56
262_E269_A1.2260.56
24_F112_A1.2160.55
255_I262_E1.2090.55
262_E276_Y1.2040.55
390_Y393_Q1.2040.55
63_V71_I1.2030.55
17_T90_I1.2000.54
15_G22_S1.1950.54
93_A96_G1.1880.54
291_E297_L1.1760.53
37_N43_I1.1760.53
344_G347_L1.1740.53
270_K273_I1.1730.53
269_A273_I1.1700.52
242_N245_R1.1700.52
89_L101_N1.1700.52
359_P375_L1.1610.52
271_A279_G1.1610.52
57_A60_E1.1590.52
76_Y317_I1.1510.51
112_A320_A1.1470.51
101_N115_H1.1420.51
60_E397_V1.1400.51
98_G101_N1.1390.50
22_S87_A1.1390.50
198_V224_V1.1370.50
26_A267_K1.1360.50
262_E266_R1.1340.50
116_V257_T1.1310.50
23_T48_G1.1290.50
319_T324_A1.1280.50
379_D390_Y1.1250.50
376_Y401_V1.1220.49
234_K247_L1.1130.49
274_I305_L1.1120.49
296_A300_I1.1110.49
92_G98_G1.1100.49
12_G15_G1.1070.48
39_P42_T1.1060.48
359_P388_E1.1040.48
260_A268_A1.1040.48
22_S42_T1.1030.48
297_L300_I1.0970.48
289_L293_Q1.0940.48
97_R323_D1.0900.47
81_V110_A1.0870.47
295_S298_E1.0860.47
18_N37_N1.0840.47
100_G104_L1.0830.47
211_E369_E1.0820.47
131_E143_F1.0810.47
328_I356_G1.0790.47
265_L269_A1.0750.46
96_G101_N1.0740.46
273_I296_A1.0690.46
311_T314_Q1.0650.46
255_I265_L1.0630.46
229_I324_A1.0610.45
112_A229_I1.0590.45
11_I320_A1.0570.45
371_A400_I1.0550.45
44_N82_K1.0530.45
98_G103_F1.0490.45
44_N277_I1.0490.45
268_A336_E1.0460.45
12_G397_V1.0450.44
387_G390_Y1.0420.44
28_A83_L1.0400.44
299_Y302_T1.0370.44
266_R278_P1.0330.44
59_T78_F1.0310.44
178_L192_I1.0310.44
213_D241_R1.0300.44
288_P291_E1.0290.43
266_R269_A1.0230.43
17_T144_I1.0160.43
363_A377_A1.0120.42
33_V116_V1.0080.42
17_T41_V0.9990.42
359_P364_N0.9950.41
379_D382_R0.9950.41
36_A39_P0.9930.41
26_A33_V0.9930.41
57_A65_C0.9900.41
87_A99_L0.9890.41
238_P243_N0.9870.41
55_K76_Y0.9830.41
17_T26_A0.9830.41
48_G350_A0.9810.40
56_C65_C0.9800.40
40_F45_P0.9780.40
344_G377_A0.9780.40
18_N22_S0.9760.40
11_I24_F0.9640.39
33_V159_D0.9580.39
90_I163_F0.9530.39
138_E141_I0.9460.38
99_L115_H0.9430.38
43_I86_V0.9390.38
273_I277_I0.9380.38
359_P387_G0.9340.38
145_E149_D0.9320.37
33_V324_A0.9320.37
98_G147_E0.9240.37
37_N129_P0.9240.37
90_I97_R0.9210.37
104_L140_D0.9200.37
140_D150_E0.9180.37
290_N294_K0.9150.36
256_P262_E0.9140.36
29_T151_W0.9130.36
328_I392_L0.9120.36
355_K391_Q0.9040.36
93_A101_N0.9040.36
96_G147_E0.9000.36
14_I113_L0.8970.35
117_I156_I0.8950.35
22_S36_A0.8920.35
193_I197_K0.8890.35
274_I279_G0.8880.35
262_E267_K0.8870.35
213_D280_D0.8840.35
154_S324_A0.8840.35
57_A217_F0.8820.35
189_R222_R0.8820.35
14_I26_A0.8800.34
265_L273_I0.8780.34
12_G20_G0.8720.34
12_G21_K0.8720.34
229_I308_Y0.8690.34
92_G96_G0.8650.34
38_R319_T0.8650.34
127_G263_M0.8650.34
33_V357_S0.8630.33
335_D348_P0.8590.33
111_D148_L0.8590.33
29_T38_R0.8560.33
81_V320_A0.8540.33
40_F100_G0.8540.33
69_N336_E0.8510.33
176_D315_Q0.8510.33
166_T171_G0.8500.33
66_N399_K0.8490.33
157_N214_L0.8450.32
43_I106_D0.8450.32
27_A40_F0.8420.32
89_L98_G0.8380.32
262_E271_A0.8370.32
368_T399_K0.8340.32
239_Q242_N0.8330.32
261_S272_G0.8320.32
91_P126_E0.8280.31
274_I278_P0.8280.31
156_I189_R0.8260.31
93_A147_E0.8260.31
290_N296_A0.8260.31
353_L360_K0.8240.31
79_I397_V0.8240.31
185_V225_S0.8210.31
24_F125_E0.8200.31
11_I81_V0.8170.31
45_P100_G0.8160.31
282_D301_R0.8160.31
14_I22_S0.8110.31
71_I78_F0.8080.30
261_S276_Y0.8080.30
121_G136_D0.8040.30
15_G18_N0.8040.30
211_E218_A0.8030.30
89_L93_A0.8000.30
89_L96_G0.7950.30
65_C70_S0.7940.30
55_K59_T0.7940.30
379_D392_L0.7930.30
87_A101_N0.7880.29
325_L396_D0.7880.29
138_E246_R0.7880.29
17_T20_G0.7880.29
17_T21_K0.7880.29
122_S126_E0.7810.29
127_G311_T0.7810.29
262_E268_A0.7780.29
54_V394_N0.7770.29
223_S319_T0.7760.29
77_R330_T0.7760.29
367_H377_A0.7700.28
117_I194_E0.7670.28
353_L362_L0.7580.28
358_T389_N0.7520.27
347_L377_A0.7500.27
267_K327_M0.7500.27
93_A100_G0.7440.27
318_N331_Y0.7420.27
18_N40_F0.7410.27
148_L224_V0.7370.27
56_C75_D0.7360.27
20_G23_T0.7350.27
206_L222_R0.7330.26
172_K192_I0.7300.26
230_I378_I0.7290.26
333_V348_P0.7290.26
235_S244_I0.7290.26
258_S276_Y0.7280.26
26_A148_L0.7270.26
129_P395_N0.7270.26
53_K105_D0.7260.26
117_I384_M0.7260.26
116_V231_A0.7260.26
121_G127_G0.7260.26
67_P80_P0.7250.26
25_F47_E0.7210.26
194_E229_I0.7210.26
81_V89_L0.7200.26
102_K186_S0.7190.26
286_L305_L0.7180.26
269_A275_S0.7150.26
76_Y277_I0.7130.26
77_R80_P0.7120.25
67_P70_S0.7120.25
21_K42_T0.7120.25
20_G42_T0.7120.25
53_K280_D0.7120.25
119_A234_K0.7110.25
93_A103_F0.7100.25
10_T24_F0.7090.25
33_V241_R0.7090.25
266_R276_Y0.7090.25
297_L301_R0.7090.25
107_L143_F0.7090.25
275_S278_P0.7080.25
122_S125_E0.7080.25
47_E82_K0.7050.25
44_N295_S0.7040.25
78_F277_I0.7010.25
360_K371_A0.7010.25
54_V327_M0.7000.25
334_E359_P0.7000.25
86_V92_G0.6970.25
108_R374_F0.6970.25
162_K393_Q0.6970.25
47_E225_S0.6970.25
182_L192_I0.6950.25
387_G396_D0.6950.25
88_G98_G0.6940.25
119_A380_V0.6930.25
22_S40_F0.6920.24
375_L385_R0.6920.24
262_E274_I0.6910.24
212_Q216_V0.6900.24
37_N40_F0.6890.24
80_P105_D0.6890.24
353_L375_L0.6860.24
366_I369_E0.6850.24
112_A116_V0.6840.24
41_V75_D0.6840.24
22_S37_N0.6830.24
156_I178_L0.6830.24
81_V114_I0.6810.24
381_K384_M0.6800.24
91_P121_G0.6780.24
128_V135_R0.6780.24
152_F222_R0.6770.24
40_F103_F0.6750.24
122_S366_I0.6730.24
88_G103_F0.6730.24
39_P103_F0.6710.24
98_G140_D0.6690.23
136_D139_E0.6650.23
318_N385_R0.6650.23
195_T355_K0.6640.23
281_S284_T0.6640.23
110_A309_G0.6640.23
18_N130_V0.6610.23
122_S133_G0.6600.23
11_I357_S0.6600.23
164_A190_S0.6590.23
24_F116_V0.6590.23
107_L113_L0.6580.23
108_R158_K0.6580.23
136_D246_R0.6570.23
26_A113_L0.6570.23
331_Y392_L0.6570.23
385_R388_E0.6560.23
48_G225_S0.6550.23
96_G100_G0.6540.23
372_K391_Q0.6530.23
46_N87_A0.6530.23
137_P140_D0.6520.23
67_P113_L0.6520.23
14_I36_A0.6510.23
364_N368_T0.6510.23
327_M343_N0.6510.23
213_D216_V0.6510.23
286_L302_T0.6500.23
146_S150_E0.6480.22
23_T29_T0.6480.22
64_K370_L0.6470.22
91_P110_A0.6460.22
22_S88_G0.6430.22
55_K343_N0.6430.22
84_V167_S0.6420.22
113_L218_A0.6410.22
358_T361_D0.6400.22
325_L369_E0.6380.22
262_E277_I0.6380.22
317_I376_Y0.6370.22
15_G23_T0.6350.22
189_R193_I0.6340.22
19_V299_Y0.6330.22
96_G103_F0.6330.22
282_D285_I0.6330.22
81_V328_I0.6310.22
47_E358_T0.6310.22
15_G42_T0.6310.22
39_P100_G0.6270.22
200_K278_P0.6270.22
13_I23_T0.6270.22
61_F380_V0.6240.21
169_L389_N0.6240.21
152_F395_N0.6230.21
38_R104_L0.6230.21
10_T110_A0.6230.21
266_R273_I0.6230.21
258_S269_A0.6230.21
44_N49_I0.6210.21
168_D317_I0.6210.21
209_W214_L0.6200.21
75_D186_S0.6200.21
359_P371_A0.6200.21
179_L192_I0.6180.21
117_I359_P0.6180.21
374_F388_E0.6170.21
136_D210_T0.6150.21
92_G185_V0.6150.21
69_N335_D0.6140.21
295_S300_I0.6100.21
205_K231_A0.6090.21
35_I41_V0.6090.21
91_P316_A0.6080.21
87_A90_I0.6070.21
155_I314_Q0.6060.21
37_N86_V0.6060.21
26_A31_K0.6030.21
90_I154_S0.6010.20
360_K370_L0.6000.20
311_T328_I0.5990.20
200_K354_K0.5980.20
164_A331_Y0.5960.20
379_D385_R0.5950.20
379_D398_I0.5950.20
19_V183_S0.5930.20
378_I401_V0.5920.20
27_A384_M0.5920.20
14_I67_P0.5910.20
102_K246_R0.5890.20
384_M393_Q0.5890.20
255_I258_S0.5880.20
38_R328_I0.5880.20
245_R248_K0.5860.20
269_A276_Y0.5840.20
57_A309_G0.5820.20
148_L284_T0.5820.20
291_E301_R0.5820.20
76_Y343_N0.5810.20
37_N94_H0.5800.20
257_T305_L0.5790.20
43_I90_I0.5790.20
97_R313_V0.5770.19
87_A103_F0.5770.19
24_F48_G0.5750.19
89_L147_E0.5740.19
151_W279_G0.5740.19
18_N21_K0.5730.19
375_L396_D0.5730.19
101_N147_E0.5720.19
258_S279_G0.5700.19
92_G101_N0.5690.19
180_S364_N0.5680.19
144_I181_K0.5670.19
36_A134_S0.5670.19
373_G377_A0.5660.19
358_T371_A0.5640.19
84_V170_S0.5630.19
344_G348_P0.5590.19
27_A46_N0.5580.19
41_V234_K0.5550.19
232_A254_A0.5550.19
66_N70_S0.5540.19
84_V163_F0.5540.19
269_A272_G0.5530.19
118_D234_K0.5500.18
325_L363_A0.5490.18
93_A104_L0.5490.18
112_A324_A0.5490.18
141_I250_K0.5440.18
392_L396_D0.5420.18
86_V370_L0.5410.18
363_A367_H0.5410.18
31_K68_K0.5400.18
87_A91_P0.5400.18
124_N284_T0.5390.18
219_K316_A0.5390.18
82_K254_A0.5390.18
187_V226_K0.5390.18
270_K279_G0.5380.18
131_E134_S0.5380.18
19_V22_S0.5370.18
220_T224_V0.5370.18
81_V247_L0.5370.18
282_D302_T0.5360.18
92_G100_G0.5360.18
211_E271_A0.5350.18
130_V133_G0.5350.18
373_G395_N0.5340.18
70_S256_P0.5340.18
77_R122_S0.5320.18
91_P143_F0.5320.18
81_V248_K0.5310.18
213_D291_E0.5290.18
386_V400_I0.5290.18
344_G363_A0.5270.18
178_L231_A0.5270.18
390_Y398_I0.5260.18
327_M344_G0.5250.17
299_Y398_I0.5240.17
287_K360_K0.5230.17
91_P131_E0.5230.17
80_P106_D0.5190.17
262_E270_K0.5190.17
135_R143_F0.5190.17
187_V281_S0.5170.17
370_L400_I0.5170.17
25_F374_F0.5170.17
265_L272_G0.5170.17
349_D352_L0.5150.17
25_F31_K0.5140.17
97_R126_E0.5130.17
84_V135_R0.5120.17
111_D373_G0.5120.17
198_V294_K0.5110.17
115_H135_R0.5110.17
77_R399_K0.5100.17
381_K399_K0.5090.17
106_D140_D0.5090.17
273_I395_N0.5090.17
90_I165_R0.5070.17
41_V89_L0.5060.17
156_I171_G0.5060.17
214_L245_R0.5050.17
268_A297_L0.5040.17
292_K302_T0.5040.17
226_K367_H0.5030.17
45_P87_A0.5020.17
258_S271_A0.5020.17
163_F185_V0.5010.17
215_R361_D0.5010.17
116_V312_G0.5010.17
198_V323_D0.5010.17
379_D395_N0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wxqA 1 0.8358 100 0.356 Contact Map
2dbyA 1 0.8088 100 0.453 Contact Map
1jalA 1 0.799 100 0.454 Contact Map
1ni3A 1 0.8456 100 0.49 Contact Map
2ohfA 1 0.7353 100 0.555 Contact Map
4a9aA 1 0.7304 100 0.651 Contact Map
1lnzA 1 0.4632 100 0.781 Contact Map
4csu9 1 0.4387 100 0.794 Contact Map
1udxA 1 0.6054 99.9 0.814 Contact Map
3ievA 1 0.6985 99.9 0.819 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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