Q7LXK9 - SULSO - GREMLIN Contacts

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Q7LXK9 - Sugar phosphate nucleotydyl transferase

UniProt:	Q7LXK9	Sequences: MKAVVLAAGKGERLEPITHTRPKPFVPVLETPLILRHIRILKKYINKIIIVINSNHKDYFKTIEGVSLVEQTEGKGTAAALRAAEKYLEGDEEFLVIYGDLLFEEDALDKIVNTEGEAILARESEDPRKFGVIVKDSENRLVRIVEKPENPPSNIINAGIYKFTYDIFSYIDKISLSSRGEFELTDAVNLIGNKVKVVTYNGIWLDIGRPWDLIEANKVLLDKEKDRNLGVIEENVKIKGKVVIEDGVIIKSGTYIEGPVYIGKNSVIGPNAYIRPYSVIGSNVKVGAFNEIKESVIMENAKIPHLSYVGDSVICEGVNFGAGTITANLRFDEEEVKVNIKNERVSSGRKKLGAIVGAHVRTGINVSILPGVKIGAYAWIYPGAVVDRDVEKGEKYVPYYLRRSSGT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	407 (324)
Sequences:	5862 (3784)
Seq/√Len:	210.2

ECOLI - GLMU GLGC
BACSU - GLMU GLGC GLGD
HALSA - Q9HSZ8 Q9HSZ9 Q9HS61
SULSO - Q7LXK9 Q97ZD1 Q980D4 Q980H9 Q7LXE7 Q97XG0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
309_V	312_S	4.042	1.00
292_I	295_S	3.458	1.00
293_K	310_G	3.399	1.00
297_I	303_I	3.073	1.00
274_I	278_S	3.037	1.00
304_P	322_A	3.000	1.00
287_G	305_H	2.983	1.00
111_I	118_A	2.942	1.00
275_R	293_K	2.932	1.00
123_E	154_N	2.825	1.00
294_E	311_D	2.742	1.00
305_H	322_A	2.733	1.00
288_A	305_H	2.655	1.00
109_D	113_N	2.588	1.00
280_I	286_V	2.582	1.00
117_E	164_T	2.442	1.00
110_K	114_T	2.440	1.00
136_D	140_R	2.399	1.00
278_S	292_I	2.357	1.00
276_P	294_E	2.325	1.00
283_N	300_N	2.232	1.00
273_Y	291_E	2.212	1.00
108_L	162_K	2.208	1.00
282_S	299_E	2.144	1.00
290_N	307_S	2.108	1.00
38_I	48_I	2.106	1.00
249_I	267_V	2.069	1.00
93_E	112_V	2.066	1.00
123_E	199_T	2.043	1.00
266_S	280_I	2.020	1.00
114_T	196_K	2.009	1.00
3_A	45_I	1.974	1.00
145_V	152_P	1.932	1.00
269_G	288_A	1.919	1.00
285_K	302_K	1.893	1.00
314_I	320_F	1.877	1.00
265_N	283_N	1.874	1.00
257_E	275_R	1.870	1.00
280_I	284_V	1.867	1.00
307_S	324_T	1.846	1.00
134_V	143_R	1.844	1.00
93_E	164_T	1.823	1.00
121_A	197_V	1.823	1.00
248_V	266_S	1.774	1.00
301_A	318_V	1.772	1.00
3_A	41_L	1.766	1.00
71_Q	74_G	1.764	1.00
308_Y	325_I	1.724	1.00
289_F	306_L	1.722	1.00
110_K	198_V	1.715	1.00
264_K	282_S	1.712	1.00
31_T	39_R	1.704	1.00
267_V	285_K	1.692	1.00
255_Y	273_Y	1.684	1.00
85_E	172_D	1.674	1.00
140_R	196_K	1.671	1.00
302_K	319_N	1.639	1.00
245_E	248_V	1.638	1.00
136_D	142_V	1.624	1.00
291_E	308_Y	1.621	1.00
287_G	304_P	1.608	1.00
140_R	194_K	1.599	1.00
35_L	62_T	1.595	1.00
169_S	173_K	1.591	1.00
95_L	162_K	1.591	1.00
281_G	299_E	1.576	1.00
183_E	186_D	1.575	1.00
203_I	219_V	1.569	1.00
121_A	133_I	1.567	1.00
184_L	189_N	1.562	1.00
297_I	301_A	1.538	1.00
66_V	73_E	1.519	1.00
117_E	194_K	1.495	1.00
34_I	63_I	1.472	1.00
70_E	74_G	1.448	1.00
66_V	70_E	1.445	1.00
41_L	97_I	1.435	1.00
179_R	185_T	1.435	1.00
287_G	302_K	1.429	1.00
262_I	266_S	1.427	1.00
307_S	322_A	1.426	1.00
185_T	189_N	1.423	1.00
68_L	71_Q	1.423	1.00
284_V	301_A	1.415	1.00
301_A	314_I	1.407	1.00
166_D	169_S	1.399	1.00
314_I	318_V	1.397	1.00
245_E	264_K	1.389	1.00
266_S	284_V	1.380	1.00
295_S	309_V	1.375	1.00
49_I	69_V	1.365	1.00
139_N	199_T	1.362	1.00
132_V	156_I	1.360	1.00
141_L	195_V	1.358	1.00
245_E	282_S	1.357	1.00
254_T	258_G	1.355	1.00
66_V	69_V	1.353	1.00
251_K	270_P	1.347	1.00
117_E	193_N	1.342	1.00
116_G	196_K	1.339	1.00
263_G	282_S	1.323	1.00
306_L	323_G	1.316	1.00
70_E	73_E	1.312	1.00
134_V	145_V	1.308	1.00
256_I	259_P	1.298	1.00
180_G	186_D	1.294	1.00
287_G	290_N	1.283	1.00
292_I	297_I	1.270	1.00
66_V	71_Q	1.253	1.00
180_G	185_T	1.249	1.00
270_P	288_A	1.239	1.00
69_V	73_E	1.231	1.00
244_I	248_V	1.229	1.00
233_E	236_V	1.228	1.00
82_R	85_E	1.225	1.00
67_S	71_Q	1.224	1.00
79_A	82_R	1.220	1.00
89_E	172_D	1.213	1.00
182_F	185_T	1.213	1.00
33_L	207_I	1.204	1.00
248_V	282_S	1.202	1.00
11_G	23_K	1.198	1.00
246_D	264_K	1.196	1.00
181_E	186_D	1.190	1.00
21_R	27_P	1.190	1.00
141_L	197_V	1.182	1.00
66_V	74_G	1.156	1.00
186_D	190_L	1.155	1.00
135_K	197_V	1.153	1.00
239_K	257_E	1.153	1.00
35_L	39_R	1.151	1.00
56_H	60_F	1.144	1.00
173_K	190_L	1.142	1.00
258_G	276_P	1.137	1.00
306_L	322_A	1.136	1.00
310_G	327_A	1.098	1.00
134_V	142_V	1.096	1.00
126_D	129_K	1.093	1.00
321_G	324_T	1.092	1.00
25_F	62_T	1.087	1.00
268_I	272_A	1.084	1.00
179_R	183_E	1.082	1.00
47_K	67_S	1.077	1.00
183_E	189_N	1.076	1.00
284_V	298_M	1.075	1.00
35_L	63_I	1.072	1.00
180_G	184_L	1.071	1.00
290_N	304_P	1.070	1.00
50_I	63_I	1.067	1.00
141_L	144_I	1.067	1.00
67_S	70_E	1.062	1.00
127_P	151_P	1.058	1.00
247_G	265_N	1.058	1.00
143_R	152_P	1.055	1.00
304_P	319_N	1.052	1.00
300_N	317_G	1.051	1.00
254_T	257_E	1.047	1.00
110_K	196_K	1.042	1.00
211_W	215_E	1.027	1.00
298_M	313_V	1.016	1.00
119_I	133_I	1.015	1.00
45_I	108_L	1.011	1.00
303_I	309_V	1.010	1.00
265_N	282_S	1.009	1.00
135_K	155_I	1.008	1.00
21_R	58_D	1.001	1.00
119_I	141_L	0.997	1.00
69_V	74_G	0.989	1.00
94_F	165_Y	0.983	1.00
179_R	184_L	0.977	1.00
272_A	288_A	0.977	1.00
150_N	153_S	0.975	1.00
34_I	59_Y	0.973	1.00
69_V	72_T	0.964	1.00
115_E	164_T	0.961	1.00
22_P	58_D	0.956	1.00
96_V	163_F	0.953	1.00
110_K	113_N	0.953	1.00
131_G	146_E	0.951	1.00
92_E	164_T	0.948	0.99
304_P	321_G	0.947	0.99
75_K	79_A	0.943	0.99
13_R	23_K	0.941	0.99
289_F	305_H	0.938	0.99
23_K	100_D	0.937	0.99
271_N	289_F	0.935	0.99
250_I	256_I	0.933	0.99
25_F	58_D	0.931	0.99
79_A	83_A	0.931	0.99
145_V	150_N	0.930	0.99
28_V	217_N	0.927	0.99
49_I	87_Y	0.914	0.99
281_G	284_V	0.911	0.99
4_V	49_I	0.909	0.99
281_G	298_M	0.906	0.99
186_D	189_N	0.905	0.99
68_L	74_G	0.902	0.99
290_N	322_A	0.902	0.99
269_G	287_G	0.900	0.99
307_S	321_G	0.897	0.99
92_E	166_D	0.895	0.99
109_D	112_V	0.893	0.99
253_G	271_N	0.884	0.99
174_I	179_R	0.884	0.99
170_Y	191_I	0.878	0.99
307_S	320_F	0.867	0.99
309_V	314_I	0.866	0.99
270_P	287_G	0.855	0.99
272_A	290_N	0.854	0.99
275_R	291_E	0.850	0.99
5_V	38_I	0.850	0.99
157_N	161_Y	0.848	0.99
181_E	185_T	0.848	0.99
245_E	263_G	0.848	0.99
284_V	297_I	0.847	0.99
36_R	39_R	0.846	0.99
32_P	35_L	0.845	0.99
256_I	262_I	0.845	0.99
97_I	107_A	0.845	0.99
271_N	288_A	0.844	0.99
253_G	257_E	0.844	0.99
205_L	219_V	0.843	0.99
183_E	187_A	0.839	0.99
82_R	172_D	0.836	0.99
252_S	257_E	0.835	0.99
21_R	315_C	0.832	0.99
64_E	68_L	0.828	0.99
177_S	183_E	0.828	0.99
5_V	41_L	0.825	0.99
259_P	276_P	0.824	0.99
286_V	290_N	0.819	0.99
188_V	195_V	0.819	0.99
18_T	26_V	0.818	0.98
272_A	286_V	0.817	0.98
184_L	187_A	0.812	0.98
116_G	194_K	0.810	0.98
134_V	152_P	0.808	0.98
98_Y	101_L	0.807	0.98
286_V	292_I	0.805	0.98
243_V	261_Y	0.801	0.98
133_I	141_L	0.799	0.98
253_G	258_G	0.797	0.98
213_L	298_M	0.796	0.98
245_E	261_Y	0.795	0.98
178_S	185_T	0.794	0.98
37_H	97_I	0.793	0.98
225_K	228_N	0.791	0.98
39_R	42_K	0.789	0.98
82_R	175_S	0.789	0.98
51_V	80_A	0.788	0.98
34_I	50_I	0.785	0.98
180_G	183_E	0.783	0.98
121_A	155_I	0.780	0.98
298_M	316_E	0.779	0.98
24_P	99_G	0.779	0.98
117_E	167_I	0.768	0.98
257_E	273_Y	0.768	0.98
179_R	182_F	0.765	0.98
179_R	186_D	0.764	0.98
217_N	279_V	0.764	0.98
30_E	261_Y	0.760	0.98
233_E	252_S	0.757	0.98
294_E	310_G	0.756	0.97
292_I	309_V	0.754	0.97
170_Y	190_L	0.754	0.97
266_S	281_G	0.753	0.97
111_I	115_E	0.752	0.97
36_R	220_L	0.751	0.97
167_I	170_Y	0.750	0.97
49_I	88_L	0.749	0.97
247_G	264_K	0.745	0.97
115_E	194_K	0.743	0.97
7_A	50_I	0.743	0.97
7_A	59_Y	0.741	0.97
255_Y	258_G	0.740	0.97
322_A	328_N	0.736	0.97
224_E	228_N	0.735	0.97
254_T	274_I	0.734	0.97
13_R	24_P	0.734	0.97
209_R	212_D	0.732	0.97
52_I	56_H	0.731	0.97
251_K	267_V	0.726	0.97
254_T	259_P	0.725	0.97
29_L	220_L	0.723	0.97
275_R	278_S	0.722	0.97
232_I	236_V	0.722	0.97
100_D	206_D	0.721	0.97
28_V	33_L	0.720	0.97
290_N	305_H	0.719	0.97
78_A	174_I	0.716	0.97
67_S	74_G	0.715	0.96
268_I	280_I	0.712	0.96
284_V	316_E	0.710	0.96
33_L	37_H	0.710	0.96
252_S	256_I	0.708	0.96
251_K	258_G	0.708	0.96
9_G	23_K	0.707	0.96
5_V	37_H	0.707	0.96
53_N	79_A	0.705	0.96
185_T	188_V	0.702	0.96
57_K	61_K	0.701	0.96
71_Q	75_K	0.699	0.96
178_S	181_E	0.699	0.96
290_N	306_L	0.699	0.96
15_E	19_H	0.698	0.96
129_K	147_K	0.696	0.96
124_S	154_N	0.695	0.96
120_L	160_I	0.695	0.96
14_L	26_V	0.695	0.96
77_T	100_D	0.693	0.96
251_K	254_T	0.692	0.96
244_I	250_I	0.690	0.96
68_L	73_E	0.690	0.96
4_V	94_F	0.689	0.96
207_I	216_A	0.686	0.96
284_V	299_E	0.685	0.96
252_S	258_G	0.685	0.96
174_I	187_A	0.683	0.95
248_V	262_I	0.681	0.95
32_P	36_R	0.679	0.95
145_V	151_P	0.678	0.95
242_V	258_G	0.677	0.95
97_I	160_I	0.674	0.95
262_I	268_I	0.670	0.95
6_L	80_A	0.670	0.95
30_E	263_G	0.669	0.95
283_N	299_E	0.669	0.95
250_I	254_T	0.668	0.95
11_G	24_P	0.666	0.95
67_S	73_E	0.666	0.95
273_Y	293_K	0.665	0.95
184_L	191_I	0.664	0.95
38_I	66_V	0.662	0.95
155_I	199_T	0.659	0.95
163_F	167_I	0.656	0.94
183_E	188_V	0.656	0.94
308_Y	328_N	0.654	0.94
308_Y	323_G	0.654	0.94
67_S	72_T	0.653	0.94
179_R	189_N	0.653	0.94
248_V	263_G	0.652	0.94
142_V	145_V	0.650	0.94
85_E	168_F	0.650	0.94
272_A	305_H	0.649	0.94
49_I	84_A	0.648	0.94
81_L	96_V	0.648	0.94
275_R	310_G	0.646	0.94
310_G	323_G	0.644	0.94
85_E	89_E	0.643	0.94
325_I	328_N	0.642	0.94
82_R	171_I	0.640	0.94
309_V	326_T	0.639	0.94
266_S	282_S	0.636	0.93
92_E	165_Y	0.636	0.93
234_E	237_K	0.636	0.93
296_V	313_V	0.635	0.93
147_K	208_G	0.635	0.93
210_P	214_I	0.634	0.93
170_Y	193_N	0.634	0.93
315_C	318_V	0.632	0.93
32_P	62_T	0.632	0.93
248_V	264_K	0.631	0.93
310_G	328_N	0.630	0.93
11_G	206_D	0.630	0.93
151_P	154_N	0.629	0.93
101_L	158_A	0.629	0.93
299_E	316_E	0.626	0.93
251_K	257_E	0.626	0.93
319_N	322_A	0.625	0.93
253_G	256_I	0.624	0.93
305_H	323_G	0.622	0.93
41_L	45_I	0.621	0.93
158_A	200_Y	0.621	0.93
66_V	72_T	0.616	0.92
240_G	247_G	0.613	0.92
252_S	255_Y	0.612	0.92
131_G	147_K	0.611	0.92
27_P	32_P	0.607	0.92
102_L	207_I	0.606	0.92
155_I	197_V	0.604	0.92
43_K	107_A	0.604	0.92
63_I	66_V	0.603	0.91
255_Y	259_P	0.601	0.91
205_L	215_E	0.600	0.91
53_N	74_G	0.600	0.91
290_N	303_I	0.600	0.91
181_E	184_L	0.599	0.91
111_I	117_E	0.598	0.91
103_F	160_I	0.597	0.91
327_A	330_R	0.597	0.91
222_D	225_K	0.593	0.91
274_I	280_I	0.591	0.91
241_K	244_I	0.589	0.91
33_L	102_L	0.586	0.90
182_F	189_N	0.585	0.90
27_P	316_E	0.585	0.90
128_R	149_E	0.584	0.90
58_D	61_K	0.583	0.90
248_V	268_I	0.582	0.90
25_F	63_I	0.580	0.90
243_V	264_K	0.579	0.90
72_T	75_K	0.577	0.90
107_A	203_I	0.576	0.90
56_H	70_E	0.576	0.90
279_V	296_V	0.575	0.89
205_L	216_A	0.575	0.89
218_K	221_L	0.575	0.89
131_G	144_I	0.574	0.89
163_F	187_A	0.573	0.89
291_E	305_H	0.573	0.89
241_K	259_P	0.572	0.89
93_E	162_K	0.570	0.89
281_G	296_V	0.569	0.89
94_F	167_I	0.567	0.89
306_L	310_G	0.567	0.89
263_G	266_S	0.566	0.89
57_K	60_F	0.566	0.89
245_E	266_S	0.563	0.88
242_V	259_P	0.562	0.88
248_V	265_N	0.561	0.88
311_D	328_N	0.558	0.88
9_G	77_T	0.557	0.88
45_I	95_L	0.557	0.88
40_I	43_K	0.555	0.88
325_I	330_R	0.554	0.88
288_A	306_L	0.554	0.88
246_D	249_I	0.554	0.88
301_A	316_E	0.553	0.88
122_R	199_T	0.553	0.88
177_S	185_T	0.551	0.87
74_G	79_A	0.551	0.87
41_L	107_A	0.551	0.87
249_I	252_S	0.547	0.87
254_T	268_I	0.546	0.87
141_L	147_K	0.545	0.87
293_K	308_Y	0.543	0.87
253_G	259_P	0.543	0.87
323_G	327_A	0.541	0.86
131_G	159_G	0.537	0.86
297_I	314_I	0.537	0.86
242_V	245_E	0.537	0.86
251_K	255_Y	0.535	0.86
60_F	70_E	0.533	0.86
124_S	156_I	0.533	0.86
25_F	32_P	0.533	0.86
180_G	189_N	0.532	0.86
5_V	97_I	0.531	0.85
298_M	315_C	0.531	0.85
274_I	286_V	0.531	0.85
129_K	212_D	0.529	0.85
14_L	206_D	0.529	0.85
178_S	184_L	0.529	0.85
312_S	326_T	0.529	0.85
159_G	206_D	0.527	0.85
169_S	172_D	0.526	0.85
169_S	193_N	0.525	0.85
238_I	244_I	0.525	0.85
102_L	205_L	0.524	0.85
128_R	147_K	0.524	0.85
147_K	151_P	0.522	0.84
146_E	157_N	0.522	0.84
79_A	175_S	0.521	0.84
269_G	290_N	0.521	0.84
93_E	115_E	0.520	0.84
17_I	213_L	0.518	0.84
259_P	274_I	0.517	0.84
40_I	105_E	0.517	0.84
302_K	305_H	0.516	0.84
251_K	259_P	0.513	0.83
269_G	272_A	0.512	0.83
135_K	139_N	0.511	0.83
164_T	167_I	0.510	0.83
214_I	218_K	0.510	0.83
118_A	121_A	0.509	0.83
172_D	176_L	0.509	0.83
307_S	323_G	0.508	0.83
287_G	322_A	0.508	0.83
76_G	131_G	0.507	0.83
266_S	301_A	0.506	0.83
13_R	208_G	0.505	0.82
239_K	258_G	0.503	0.82
241_K	258_G	0.502	0.82
38_I	63_I	0.502	0.82
11_G	100_D	0.501	0.82
8_A	51_V	0.501	0.82
177_S	186_D	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ggoA	3	0.9607	100	0.355	Contact Map
4g3qA	3	0.9853	100	0.4	Contact Map
1hm9A	3	0.9877	100	0.401	Contact Map
4fceA	3	0.9779	100	0.417	Contact Map
2v0hA	3	0.9853	100	0.42	Contact Map
1yp2A	4	0.8698	100	0.438	Contact Map
3brkX	2	0.8378	100	0.471	Contact Map
2icyA	1	0.7518	100	0.574	Contact Map
2i5kA	5	0.7125	100	0.589	Contact Map
4r7pA	4	0.7322	100	0.615	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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