GREMLIN Database
Q7LXK9 - Sugar phosphate nucleotydyl transferase
UniProt: Q7LXK9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 407 (324)
Sequences: 5862 (3784)
Seq/√Len: 210.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
309_V312_S4.0421.00
292_I295_S3.4581.00
293_K310_G3.3991.00
297_I303_I3.0731.00
274_I278_S3.0371.00
304_P322_A3.0001.00
287_G305_H2.9831.00
111_I118_A2.9421.00
275_R293_K2.9321.00
123_E154_N2.8251.00
294_E311_D2.7421.00
305_H322_A2.7331.00
288_A305_H2.6551.00
109_D113_N2.5881.00
280_I286_V2.5821.00
117_E164_T2.4421.00
110_K114_T2.4401.00
136_D140_R2.3991.00
278_S292_I2.3571.00
276_P294_E2.3251.00
283_N300_N2.2321.00
273_Y291_E2.2121.00
108_L162_K2.2081.00
282_S299_E2.1441.00
290_N307_S2.1081.00
38_I48_I2.1061.00
249_I267_V2.0691.00
93_E112_V2.0661.00
123_E199_T2.0431.00
266_S280_I2.0201.00
114_T196_K2.0091.00
3_A45_I1.9741.00
145_V152_P1.9321.00
269_G288_A1.9191.00
285_K302_K1.8931.00
314_I320_F1.8771.00
265_N283_N1.8741.00
257_E275_R1.8701.00
280_I284_V1.8671.00
307_S324_T1.8461.00
134_V143_R1.8441.00
93_E164_T1.8231.00
121_A197_V1.8231.00
248_V266_S1.7741.00
301_A318_V1.7721.00
3_A41_L1.7661.00
71_Q74_G1.7641.00
308_Y325_I1.7241.00
289_F306_L1.7221.00
110_K198_V1.7151.00
264_K282_S1.7121.00
31_T39_R1.7041.00
267_V285_K1.6921.00
255_Y273_Y1.6841.00
85_E172_D1.6741.00
140_R196_K1.6711.00
302_K319_N1.6391.00
245_E248_V1.6381.00
136_D142_V1.6241.00
291_E308_Y1.6211.00
287_G304_P1.6081.00
140_R194_K1.5991.00
35_L62_T1.5951.00
169_S173_K1.5911.00
95_L162_K1.5911.00
281_G299_E1.5761.00
183_E186_D1.5751.00
203_I219_V1.5691.00
121_A133_I1.5671.00
184_L189_N1.5621.00
297_I301_A1.5381.00
66_V73_E1.5191.00
117_E194_K1.4951.00
34_I63_I1.4721.00
70_E74_G1.4481.00
66_V70_E1.4451.00
41_L97_I1.4351.00
179_R185_T1.4351.00
287_G302_K1.4291.00
262_I266_S1.4271.00
307_S322_A1.4261.00
185_T189_N1.4231.00
68_L71_Q1.4231.00
284_V301_A1.4151.00
301_A314_I1.4071.00
166_D169_S1.3991.00
314_I318_V1.3971.00
245_E264_K1.3891.00
266_S284_V1.3801.00
295_S309_V1.3751.00
49_I69_V1.3651.00
139_N199_T1.3621.00
132_V156_I1.3601.00
141_L195_V1.3581.00
245_E282_S1.3571.00
254_T258_G1.3551.00
66_V69_V1.3531.00
251_K270_P1.3471.00
117_E193_N1.3421.00
116_G196_K1.3391.00
263_G282_S1.3231.00
306_L323_G1.3161.00
70_E73_E1.3121.00
134_V145_V1.3081.00
256_I259_P1.2981.00
180_G186_D1.2941.00
287_G290_N1.2831.00
292_I297_I1.2701.00
66_V71_Q1.2531.00
180_G185_T1.2491.00
270_P288_A1.2391.00
69_V73_E1.2311.00
244_I248_V1.2291.00
233_E236_V1.2281.00
82_R85_E1.2251.00
67_S71_Q1.2241.00
79_A82_R1.2201.00
89_E172_D1.2131.00
182_F185_T1.2131.00
33_L207_I1.2041.00
248_V282_S1.2021.00
11_G23_K1.1981.00
246_D264_K1.1961.00
181_E186_D1.1901.00
21_R27_P1.1901.00
141_L197_V1.1821.00
66_V74_G1.1561.00
186_D190_L1.1551.00
135_K197_V1.1531.00
239_K257_E1.1531.00
35_L39_R1.1511.00
56_H60_F1.1441.00
173_K190_L1.1421.00
258_G276_P1.1371.00
306_L322_A1.1361.00
310_G327_A1.0981.00
134_V142_V1.0961.00
126_D129_K1.0931.00
321_G324_T1.0921.00
25_F62_T1.0871.00
268_I272_A1.0841.00
179_R183_E1.0821.00
47_K67_S1.0771.00
183_E189_N1.0761.00
284_V298_M1.0751.00
35_L63_I1.0721.00
180_G184_L1.0711.00
290_N304_P1.0701.00
50_I63_I1.0671.00
141_L144_I1.0671.00
67_S70_E1.0621.00
127_P151_P1.0581.00
247_G265_N1.0581.00
143_R152_P1.0551.00
304_P319_N1.0521.00
300_N317_G1.0511.00
254_T257_E1.0471.00
110_K196_K1.0421.00
211_W215_E1.0271.00
298_M313_V1.0161.00
119_I133_I1.0151.00
45_I108_L1.0111.00
303_I309_V1.0101.00
265_N282_S1.0091.00
135_K155_I1.0081.00
21_R58_D1.0011.00
119_I141_L0.9971.00
69_V74_G0.9891.00
94_F165_Y0.9831.00
179_R184_L0.9771.00
272_A288_A0.9771.00
150_N153_S0.9751.00
34_I59_Y0.9731.00
69_V72_T0.9641.00
115_E164_T0.9611.00
22_P58_D0.9561.00
96_V163_F0.9531.00
110_K113_N0.9531.00
131_G146_E0.9511.00
92_E164_T0.9480.99
304_P321_G0.9470.99
75_K79_A0.9430.99
13_R23_K0.9410.99
289_F305_H0.9380.99
23_K100_D0.9370.99
271_N289_F0.9350.99
250_I256_I0.9330.99
25_F58_D0.9310.99
79_A83_A0.9310.99
145_V150_N0.9300.99
28_V217_N0.9270.99
49_I87_Y0.9140.99
281_G284_V0.9110.99
4_V49_I0.9090.99
281_G298_M0.9060.99
186_D189_N0.9050.99
68_L74_G0.9020.99
290_N322_A0.9020.99
269_G287_G0.9000.99
307_S321_G0.8970.99
92_E166_D0.8950.99
109_D112_V0.8930.99
253_G271_N0.8840.99
174_I179_R0.8840.99
170_Y191_I0.8780.99
307_S320_F0.8670.99
309_V314_I0.8660.99
270_P287_G0.8550.99
272_A290_N0.8540.99
275_R291_E0.8500.99
5_V38_I0.8500.99
157_N161_Y0.8480.99
181_E185_T0.8480.99
245_E263_G0.8480.99
284_V297_I0.8470.99
36_R39_R0.8460.99
32_P35_L0.8450.99
256_I262_I0.8450.99
97_I107_A0.8450.99
271_N288_A0.8440.99
253_G257_E0.8440.99
205_L219_V0.8430.99
183_E187_A0.8390.99
82_R172_D0.8360.99
252_S257_E0.8350.99
21_R315_C0.8320.99
64_E68_L0.8280.99
177_S183_E0.8280.99
5_V41_L0.8250.99
259_P276_P0.8240.99
286_V290_N0.8190.99
188_V195_V0.8190.99
18_T26_V0.8180.98
272_A286_V0.8170.98
184_L187_A0.8120.98
116_G194_K0.8100.98
134_V152_P0.8080.98
98_Y101_L0.8070.98
286_V292_I0.8050.98
243_V261_Y0.8010.98
133_I141_L0.7990.98
253_G258_G0.7970.98
213_L298_M0.7960.98
245_E261_Y0.7950.98
178_S185_T0.7940.98
37_H97_I0.7930.98
225_K228_N0.7910.98
39_R42_K0.7890.98
82_R175_S0.7890.98
51_V80_A0.7880.98
34_I50_I0.7850.98
180_G183_E0.7830.98
121_A155_I0.7800.98
298_M316_E0.7790.98
24_P99_G0.7790.98
117_E167_I0.7680.98
257_E273_Y0.7680.98
179_R182_F0.7650.98
179_R186_D0.7640.98
217_N279_V0.7640.98
30_E261_Y0.7600.98
233_E252_S0.7570.98
294_E310_G0.7560.97
292_I309_V0.7540.97
170_Y190_L0.7540.97
266_S281_G0.7530.97
111_I115_E0.7520.97
36_R220_L0.7510.97
167_I170_Y0.7500.97
49_I88_L0.7490.97
247_G264_K0.7450.97
115_E194_K0.7430.97
7_A50_I0.7430.97
7_A59_Y0.7410.97
255_Y258_G0.7400.97
322_A328_N0.7360.97
224_E228_N0.7350.97
254_T274_I0.7340.97
13_R24_P0.7340.97
209_R212_D0.7320.97
52_I56_H0.7310.97
251_K267_V0.7260.97
254_T259_P0.7250.97
29_L220_L0.7230.97
275_R278_S0.7220.97
232_I236_V0.7220.97
100_D206_D0.7210.97
28_V33_L0.7200.97
290_N305_H0.7190.97
78_A174_I0.7160.97
67_S74_G0.7150.96
268_I280_I0.7120.96
284_V316_E0.7100.96
33_L37_H0.7100.96
252_S256_I0.7080.96
251_K258_G0.7080.96
9_G23_K0.7070.96
5_V37_H0.7070.96
53_N79_A0.7050.96
185_T188_V0.7020.96
57_K61_K0.7010.96
71_Q75_K0.6990.96
178_S181_E0.6990.96
290_N306_L0.6990.96
15_E19_H0.6980.96
129_K147_K0.6960.96
124_S154_N0.6950.96
120_L160_I0.6950.96
14_L26_V0.6950.96
77_T100_D0.6930.96
251_K254_T0.6920.96
244_I250_I0.6900.96
68_L73_E0.6900.96
4_V94_F0.6890.96
207_I216_A0.6860.96
284_V299_E0.6850.96
252_S258_G0.6850.96
174_I187_A0.6830.95
248_V262_I0.6810.95
32_P36_R0.6790.95
145_V151_P0.6780.95
242_V258_G0.6770.95
97_I160_I0.6740.95
262_I268_I0.6700.95
6_L80_A0.6700.95
30_E263_G0.6690.95
283_N299_E0.6690.95
250_I254_T0.6680.95
11_G24_P0.6660.95
67_S73_E0.6660.95
273_Y293_K0.6650.95
184_L191_I0.6640.95
38_I66_V0.6620.95
155_I199_T0.6590.95
163_F167_I0.6560.94
183_E188_V0.6560.94
308_Y328_N0.6540.94
308_Y323_G0.6540.94
67_S72_T0.6530.94
179_R189_N0.6530.94
248_V263_G0.6520.94
142_V145_V0.6500.94
85_E168_F0.6500.94
272_A305_H0.6490.94
49_I84_A0.6480.94
81_L96_V0.6480.94
275_R310_G0.6460.94
310_G323_G0.6440.94
85_E89_E0.6430.94
325_I328_N0.6420.94
82_R171_I0.6400.94
309_V326_T0.6390.94
266_S282_S0.6360.93
92_E165_Y0.6360.93
234_E237_K0.6360.93
296_V313_V0.6350.93
147_K208_G0.6350.93
210_P214_I0.6340.93
170_Y193_N0.6340.93
315_C318_V0.6320.93
32_P62_T0.6320.93
248_V264_K0.6310.93
310_G328_N0.6300.93
11_G206_D0.6300.93
151_P154_N0.6290.93
101_L158_A0.6290.93
299_E316_E0.6260.93
251_K257_E0.6260.93
319_N322_A0.6250.93
253_G256_I0.6240.93
305_H323_G0.6220.93
41_L45_I0.6210.93
158_A200_Y0.6210.93
66_V72_T0.6160.92
240_G247_G0.6130.92
252_S255_Y0.6120.92
131_G147_K0.6110.92
27_P32_P0.6070.92
102_L207_I0.6060.92
155_I197_V0.6040.92
43_K107_A0.6040.92
63_I66_V0.6030.91
255_Y259_P0.6010.91
205_L215_E0.6000.91
53_N74_G0.6000.91
290_N303_I0.6000.91
181_E184_L0.5990.91
111_I117_E0.5980.91
103_F160_I0.5970.91
327_A330_R0.5970.91
222_D225_K0.5930.91
274_I280_I0.5910.91
241_K244_I0.5890.91
33_L102_L0.5860.90
182_F189_N0.5850.90
27_P316_E0.5850.90
128_R149_E0.5840.90
58_D61_K0.5830.90
248_V268_I0.5820.90
25_F63_I0.5800.90
243_V264_K0.5790.90
72_T75_K0.5770.90
107_A203_I0.5760.90
56_H70_E0.5760.90
279_V296_V0.5750.89
205_L216_A0.5750.89
218_K221_L0.5750.89
131_G144_I0.5740.89
163_F187_A0.5730.89
291_E305_H0.5730.89
241_K259_P0.5720.89
93_E162_K0.5700.89
281_G296_V0.5690.89
94_F167_I0.5670.89
306_L310_G0.5670.89
263_G266_S0.5660.89
57_K60_F0.5660.89
245_E266_S0.5630.88
242_V259_P0.5620.88
248_V265_N0.5610.88
311_D328_N0.5580.88
9_G77_T0.5570.88
45_I95_L0.5570.88
40_I43_K0.5550.88
325_I330_R0.5540.88
288_A306_L0.5540.88
246_D249_I0.5540.88
301_A316_E0.5530.88
122_R199_T0.5530.88
177_S185_T0.5510.87
74_G79_A0.5510.87
41_L107_A0.5510.87
249_I252_S0.5470.87
254_T268_I0.5460.87
141_L147_K0.5450.87
293_K308_Y0.5430.87
253_G259_P0.5430.87
323_G327_A0.5410.86
131_G159_G0.5370.86
297_I314_I0.5370.86
242_V245_E0.5370.86
251_K255_Y0.5350.86
60_F70_E0.5330.86
124_S156_I0.5330.86
25_F32_P0.5330.86
180_G189_N0.5320.86
5_V97_I0.5310.85
298_M315_C0.5310.85
274_I286_V0.5310.85
129_K212_D0.5290.85
14_L206_D0.5290.85
178_S184_L0.5290.85
312_S326_T0.5290.85
159_G206_D0.5270.85
169_S172_D0.5260.85
169_S193_N0.5250.85
238_I244_I0.5250.85
102_L205_L0.5240.85
128_R147_K0.5240.85
147_K151_P0.5220.84
146_E157_N0.5220.84
79_A175_S0.5210.84
269_G290_N0.5210.84
93_E115_E0.5200.84
17_I213_L0.5180.84
259_P274_I0.5170.84
40_I105_E0.5170.84
302_K305_H0.5160.84
251_K259_P0.5130.83
269_G272_A0.5120.83
135_K139_N0.5110.83
164_T167_I0.5100.83
214_I218_K0.5100.83
118_A121_A0.5090.83
172_D176_L0.5090.83
307_S323_G0.5080.83
287_G322_A0.5080.83
76_G131_G0.5070.83
266_S301_A0.5060.83
13_R208_G0.5050.82
239_K258_G0.5030.82
241_K258_G0.5020.82
38_I63_I0.5020.82
11_G100_D0.5010.82
8_A51_V0.5010.82
177_S186_D0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ggoA 3 0.9607 100 0.355 Contact Map
4g3qA 3 0.9853 100 0.4 Contact Map
1hm9A 3 0.9877 100 0.401 Contact Map
4fceA 3 0.9779 100 0.417 Contact Map
2v0hA 3 0.9853 100 0.42 Contact Map
1yp2A 4 0.8698 100 0.438 Contact Map
3brkX 2 0.8378 100 0.471 Contact Map
2icyA 1 0.7518 100 0.574 Contact Map
2i5kA 5 0.7125 100 0.589 Contact Map
4r7pA 4 0.7322 100 0.615 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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