Q7LXK8 - SULSO - GREMLIN Contacts

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Q7LXK8 - Uncharacterized protein

UniProt:	Q7LXK8	Sequences: MIRVVLVEPEGEYNIGFVARLCKNFLVDELYIVNPRANISEAFRFSAGGREILEKAKIVNTFDKAINDVDIKIATSSIADNNGDILRKSIRPWEILPLIQGKKIALIFGRESVGLTREEIFKCDFLLYIPANPSYPVLNLSHAVGIVLYEIWKNRELLTNPQTSTISDQSIKLIDKYTEILYKLLKRSDDDYKMYIALKRAIIKGVKDEEEARVIVHFLRKLYTRIIHNEKEMNNVS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	237 (224)
Sequences:	1795 (1193)
Seq/√Len:	79.7

ECOLI - TRMJ LAST TRMH
HALSA - Q9HQ36
SULSO - Q7LXK8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
61_T	64_K	4.840	1.00
63_D	122_K	4.437	1.00
23_K	51_E	3.876	1.00
127_L	147_V	3.561	1.00
29_E	57_K	3.314	1.00
17_F	45_F	3.299	1.00
69_V	105_A	3.154	1.00
31_Y	59_V	2.983	1.00
89_S	153_K	2.930	1.00
8_E	110_R	2.909	1.00
8_E	34_N	2.794	1.00
60_N	64_K	2.743	1.00
74_A	123_C	2.738	1.00
6_L	140_L	2.543	1.00
29_E	103_K	2.389	1.00
62_F	107_I	2.376	1.00
166_I	171_I	2.366	1.00
110_R	119_E	2.317	1.00
74_A	120_I	2.258	1.00
4_V	148_L	2.252	1.00
176_K	216_V	2.207	1.00
3_R	31_Y	2.197	1.00
66_I	72_K	2.195	1.00
108_F	144_V	2.147	1.00
106_L	147_V	2.095	1.00
34_N	60_N	2.062	1.00
43_F	54_E	2.055	1.00
31_Y	57_K	2.042	1.00
5_V	105_A	1.963	1.00
173_L	202_I	1.911	1.00
42_A	53_L	1.872	1.00
21_L	145_G	1.868	1.00
4_V	22_C	1.821	1.00
183_K	223_Y	1.799	1.00
72_K	107_I	1.787	1.00
140_L	144_V	1.775	1.00
174_I	203_I	1.741	1.00
172_K	216_V	1.678	1.00
27_V	148_L	1.628	1.00
180_I	223_Y	1.623	1.00
13_Y	41_E	1.618	1.00
170_S	209_E	1.616	1.00
179_E	223_Y	1.601	1.00
25_F	145_G	1.549	0.99
71_I	125_F	1.526	0.99
116_T	119_E	1.503	0.99
37_A	40_S	1.491	0.99
22_C	27_V	1.483	0.99
6_L	144_V	1.458	0.99
166_I	170_S	1.440	0.99
33_V	65_A	1.418	0.99
7_V	115_L	1.407	0.99
5_V	69_V	1.405	0.99
212_A	216_V	1.392	0.99
180_I	222_L	1.385	0.99
18_V	144_V	1.371	0.99
184_L	222_L	1.354	0.99
173_L	212_A	1.351	0.99
167_S	170_S	1.350	0.99
32_I	35_P	1.344	0.98
184_L	221_K	1.334	0.98
10_E	112_S	1.329	0.98
165_T	171_I	1.321	0.98
181_L	218_F	1.312	0.98
23_K	49_G	1.300	0.98
108_F	140_L	1.296	0.98
77_S	80_D	1.291	0.98
201_A	207_K	1.291	0.98
107_I	123_C	1.289	0.98
73_I	91_R	1.265	0.98
86_L	94_E	1.258	0.98
62_F	66_I	1.256	0.98
50_R	54_E	1.253	0.98
70_D	102_K	1.252	0.98
31_Y	68_D	1.240	0.97
98_L	206_V	1.214	0.97
180_I	219_L	1.205	0.97
89_S	150_E	1.200	0.97
3_R	29_E	1.200	0.97
43_F	50_R	1.200	0.97
34_N	61_T	1.200	0.97
66_I	69_V	1.173	0.96
152_W	156_E	1.170	0.96
70_D	103_K	1.163	0.96
73_I	127_L	1.139	0.96
17_F	24_N	1.131	0.96
45_F	142_H	1.122	0.95
113_V	116_T	1.121	0.95
94_E	125_F	1.119	0.95
167_S	171_I	1.116	0.95
198_L	218_F	1.109	0.95
69_V	72_K	1.098	0.95
173_L	177_Y	1.098	0.95
76_S	126_L	1.081	0.94
13_Y	45_F	1.081	0.94
7_V	110_R	1.070	0.94
131_A	135_Y	1.054	0.94
90_I	93_W	1.050	0.93
184_L	218_F	1.039	0.93
110_R	116_T	1.034	0.93
3_R	59_V	1.030	0.93
221_K	224_T	1.024	0.93
4_V	106_L	1.021	0.92
42_A	56_A	1.015	0.92
178_T	195_Y	1.014	0.92
94_E	98_L	1.012	0.92
86_L	125_F	1.012	0.92
220_R	224_T	0.998	0.92
68_D	103_K	0.989	0.91
173_L	219_L	0.984	0.91
9_P	32_I	0.980	0.91
181_L	184_L	0.973	0.91
76_S	83_G	0.972	0.91
25_F	131_A	0.963	0.90
28_D	55_K	0.954	0.90
77_S	136_P	0.949	0.89
3_R	69_V	0.941	0.89
35_P	58_I	0.938	0.89
94_E	97_P	0.936	0.89
207_K	215_I	0.930	0.88
209_E	213_R	0.930	0.88
165_T	168_D	0.927	0.88
6_L	18_V	0.917	0.88
98_L	102_K	0.914	0.88
4_V	27_V	0.914	0.88
175_D	179_E	0.908	0.87
46_S	50_R	0.906	0.87
201_A	215_I	0.902	0.87
12_E	38_N	0.899	0.87
75_T	147_V	0.880	0.86
24_N	45_F	0.877	0.85
16_G	20_R	0.873	0.85
76_S	81_N	0.870	0.85
7_V	33_V	0.868	0.85
11_G	45_F	0.865	0.85
178_T	182_Y	0.853	0.84
138_L	145_G	0.845	0.83
207_K	212_A	0.844	0.83
17_F	141_S	0.843	0.83
93_W	97_P	0.840	0.83
77_S	117_R	0.839	0.83
12_E	15_I	0.838	0.83
59_V	64_K	0.833	0.82
91_R	127_L	0.830	0.82
15_I	38_N	0.821	0.81
13_Y	145_G	0.820	0.81
18_V	141_S	0.816	0.81
200_R	208_D	0.816	0.81
172_K	176_K	0.810	0.80
38_N	43_F	0.803	0.80
85_I	126_L	0.802	0.80
73_I	125_F	0.798	0.79
131_A	136_P	0.794	0.79
12_E	39_I	0.791	0.79
121_F	196_I	0.790	0.79
12_E	40_S	0.783	0.78
202_I	222_L	0.781	0.78
14_N	20_R	0.779	0.78
8_E	116_T	0.776	0.78
205_G	211_E	0.771	0.77
193_K	196_I	0.768	0.77
65_A	68_D	0.766	0.77
19_A	42_A	0.764	0.76
124_D	199_K	0.763	0.76
124_D	171_I	0.760	0.76
124_D	203_I	0.758	0.76
72_K	123_C	0.752	0.75
118_E	121_F	0.751	0.75
49_G	135_Y	0.747	0.75
27_V	141_S	0.746	0.75
180_I	226_I	0.745	0.75
165_T	170_S	0.744	0.75
173_L	215_I	0.742	0.74
5_V	59_V	0.739	0.74
3_R	103_K	0.738	0.74
24_N	145_G	0.731	0.73
57_K	64_K	0.731	0.73
72_K	168_D	0.726	0.73
12_E	43_F	0.725	0.73
89_S	154_N	0.725	0.73
83_G	120_I	0.725	0.73
7_V	69_V	0.724	0.73
88_K	91_R	0.723	0.72
23_K	28_D	0.722	0.72
23_K	52_I	0.722	0.72
96_L	154_N	0.721	0.72
76_S	80_D	0.718	0.72
172_K	175_D	0.712	0.71
129_I	146_I	0.711	0.71
73_I	95_I	0.710	0.71
73_I	94_E	0.710	0.71
48_G	132_N	0.706	0.71
62_F	122_K	0.702	0.70
113_V	208_D	0.699	0.70
19_A	117_R	0.696	0.70
19_A	53_L	0.695	0.69
23_K	132_N	0.694	0.69
91_R	95_I	0.691	0.69
59_V	68_D	0.686	0.68
194_M	197_A	0.682	0.68
96_L	155_R	0.677	0.67
135_Y	142_H	0.676	0.67
15_I	18_V	0.676	0.67
150_E	153_K	0.673	0.67
21_L	25_F	0.672	0.67
75_T	149_Y	0.672	0.67
22_C	52_I	0.670	0.67
32_I	205_G	0.670	0.67
32_I	58_I	0.668	0.66
90_I	94_E	0.668	0.66
164_S	209_E	0.667	0.66
211_E	216_V	0.667	0.66
93_W	157_L	0.665	0.66
132_N	135_Y	0.665	0.66
192_Y	196_I	0.662	0.66
24_N	131_A	0.658	0.65
92_P	151_I	0.657	0.65
72_K	124_D	0.657	0.65
67_N	169_Q	0.656	0.65
10_E	137_V	0.656	0.65
39_I	43_F	0.655	0.65
196_I	203_I	0.655	0.65
68_D	169_Q	0.655	0.65
87_R	90_I	0.648	0.64
12_E	37_A	0.646	0.64
23_K	135_Y	0.644	0.64
25_F	152_W	0.640	0.63
5_V	65_A	0.639	0.63
28_D	134_S	0.638	0.63
164_S	168_D	0.638	0.63
48_G	135_Y	0.634	0.62
87_R	93_W	0.631	0.62
22_C	149_Y	0.627	0.62
219_L	222_L	0.626	0.61
182_Y	187_R	0.625	0.61
4_V	144_V	0.623	0.61
163_T	166_I	0.622	0.61
41_E	45_F	0.619	0.61
159_T	162_Q	0.617	0.60
63_D	107_I	0.617	0.60
121_F	126_L	0.615	0.60
221_K	225_R	0.614	0.60
99_I	102_K	0.613	0.60
25_F	138_L	0.611	0.60
95_I	151_I	0.609	0.59
8_E	113_V	0.608	0.59
161_P	164_S	0.603	0.59
3_R	68_D	0.598	0.58
38_N	58_I	0.593	0.57
184_L	226_I	0.593	0.57
19_A	77_S	0.592	0.57
164_S	167_S	0.588	0.57
99_I	104_I	0.587	0.57
30_L	129_I	0.585	0.56
124_D	168_D	0.582	0.56
33_V	59_V	0.582	0.56
132_N	146_I	0.581	0.56
162_Q	165_T	0.581	0.56
174_I	199_K	0.579	0.56
85_I	146_I	0.579	0.56
175_D	178_T	0.579	0.56
100_Q	159_T	0.578	0.55
137_V	140_L	0.576	0.55
197_A	210_E	0.575	0.55
76_S	122_K	0.572	0.55
150_E	217_H	0.572	0.55
7_V	118_E	0.568	0.54
60_N	63_D	0.566	0.54
169_Q	172_K	0.565	0.54
76_S	192_Y	0.565	0.54
22_C	148_L	0.562	0.53
89_S	93_W	0.562	0.53
31_Y	69_V	0.562	0.53
18_V	148_L	0.561	0.53
182_Y	185_L	0.561	0.53
53_L	56_A	0.558	0.53
76_S	120_I	0.556	0.53
11_G	47_A	0.555	0.52
179_E	183_K	0.555	0.52
53_L	74_A	0.554	0.52
23_K	129_I	0.552	0.52
55_K	93_W	0.550	0.52
88_K	147_V	0.548	0.52
26_L	132_N	0.548	0.52
131_A	138_L	0.547	0.51
201_A	205_G	0.545	0.51
5_V	56_A	0.544	0.51
18_V	24_N	0.542	0.51
174_I	195_Y	0.542	0.51
101_G	175_D	0.541	0.51
18_V	209_E	0.538	0.50
21_L	49_G	0.536	0.50
95_I	107_I	0.534	0.50
201_A	218_F	0.533	0.50
28_D	132_N	0.533	0.50
168_D	171_I	0.531	0.49
127_L	198_L	0.531	0.49
64_K	118_E	0.530	0.49
72_K	75_T	0.530	0.49
7_V	119_E	0.530	0.49
128_Y	131_A	0.528	0.49
176_K	180_I	0.527	0.49
24_N	220_R	0.526	0.49
45_F	141_S	0.523	0.48
186_K	214_V	0.523	0.48
78_I	138_L	0.523	0.48
68_D	105_A	0.523	0.48
188_S	192_Y	0.521	0.48
112_S	116_T	0.521	0.48
10_E	140_L	0.519	0.48
60_N	226_I	0.519	0.48
186_K	194_M	0.519	0.48
28_D	52_I	0.518	0.48
131_A	152_W	0.518	0.48
27_V	149_Y	0.517	0.48
189_D	192_Y	0.516	0.47
18_V	48_G	0.513	0.47
88_K	149_Y	0.512	0.47
194_M	213_R	0.509	0.46
26_L	152_W	0.509	0.46
202_I	207_K	0.507	0.46
8_E	140_L	0.507	0.46
47_A	135_Y	0.506	0.46
137_V	194_M	0.506	0.46
117_R	217_H	0.505	0.46
11_G	17_F	0.505	0.46
166_I	212_A	0.504	0.46
190_D	193_K	0.503	0.46
81_N	85_I	0.502	0.46
62_F	119_E	0.502	0.46
17_F	142_H	0.502	0.46
186_K	217_H	0.501	0.45
120_I	128_Y	0.501	0.45
25_F	148_L	0.501	0.45
104_I	175_D	0.500	0.45
10_E	36_R	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cngA	2	0.6498	100	0.346	Contact Map
3ilkA	2	0.9536	100	0.356	Contact Map
4cndA	2	0.6709	100	0.358	Contact Map
3onpA	2	0.6498	100	0.359	Contact Map
3ic6A	2	0.7426	100	0.552	Contact Map
3ktyA	2	0.6582	100	0.58	Contact Map
3dcmX	2	0.6371	100	0.62	Contact Map
1v2xA	2	0.6962	100	0.626	Contact Map
1zjrA	2	0.7257	100	0.629	Contact Map
3l8uA	2	0.6245	100	0.642	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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