GREMLIN Database
Q7LXK8 - Uncharacterized protein
UniProt: Q7LXK8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (224)
Sequences: 1795 (1193)
Seq/√Len: 79.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_T64_K4.8401.00
63_D122_K4.4371.00
23_K51_E3.8761.00
127_L147_V3.5611.00
29_E57_K3.3141.00
17_F45_F3.2991.00
69_V105_A3.1541.00
31_Y59_V2.9831.00
89_S153_K2.9301.00
8_E110_R2.9091.00
8_E34_N2.7941.00
60_N64_K2.7431.00
74_A123_C2.7381.00
6_L140_L2.5431.00
29_E103_K2.3891.00
62_F107_I2.3761.00
166_I171_I2.3661.00
110_R119_E2.3171.00
74_A120_I2.2581.00
4_V148_L2.2521.00
176_K216_V2.2071.00
3_R31_Y2.1971.00
66_I72_K2.1951.00
108_F144_V2.1471.00
106_L147_V2.0951.00
34_N60_N2.0621.00
43_F54_E2.0551.00
31_Y57_K2.0421.00
5_V105_A1.9631.00
173_L202_I1.9111.00
42_A53_L1.8721.00
21_L145_G1.8681.00
4_V22_C1.8211.00
183_K223_Y1.7991.00
72_K107_I1.7871.00
140_L144_V1.7751.00
174_I203_I1.7411.00
172_K216_V1.6781.00
27_V148_L1.6281.00
180_I223_Y1.6231.00
13_Y41_E1.6181.00
170_S209_E1.6161.00
179_E223_Y1.6011.00
25_F145_G1.5490.99
71_I125_F1.5260.99
116_T119_E1.5030.99
37_A40_S1.4910.99
22_C27_V1.4830.99
6_L144_V1.4580.99
166_I170_S1.4400.99
33_V65_A1.4180.99
7_V115_L1.4070.99
5_V69_V1.4050.99
212_A216_V1.3920.99
180_I222_L1.3850.99
18_V144_V1.3710.99
184_L222_L1.3540.99
173_L212_A1.3510.99
167_S170_S1.3500.99
32_I35_P1.3440.98
184_L221_K1.3340.98
10_E112_S1.3290.98
165_T171_I1.3210.98
181_L218_F1.3120.98
23_K49_G1.3000.98
108_F140_L1.2960.98
77_S80_D1.2910.98
201_A207_K1.2910.98
107_I123_C1.2890.98
73_I91_R1.2650.98
86_L94_E1.2580.98
62_F66_I1.2560.98
50_R54_E1.2530.98
70_D102_K1.2520.98
31_Y68_D1.2400.97
98_L206_V1.2140.97
180_I219_L1.2050.97
89_S150_E1.2000.97
3_R29_E1.2000.97
43_F50_R1.2000.97
34_N61_T1.2000.97
66_I69_V1.1730.96
152_W156_E1.1700.96
70_D103_K1.1630.96
73_I127_L1.1390.96
17_F24_N1.1310.96
45_F142_H1.1220.95
113_V116_T1.1210.95
94_E125_F1.1190.95
167_S171_I1.1160.95
198_L218_F1.1090.95
69_V72_K1.0980.95
173_L177_Y1.0980.95
76_S126_L1.0810.94
13_Y45_F1.0810.94
7_V110_R1.0700.94
131_A135_Y1.0540.94
90_I93_W1.0500.93
184_L218_F1.0390.93
110_R116_T1.0340.93
3_R59_V1.0300.93
221_K224_T1.0240.93
4_V106_L1.0210.92
42_A56_A1.0150.92
178_T195_Y1.0140.92
94_E98_L1.0120.92
86_L125_F1.0120.92
220_R224_T0.9980.92
68_D103_K0.9890.91
173_L219_L0.9840.91
9_P32_I0.9800.91
181_L184_L0.9730.91
76_S83_G0.9720.91
25_F131_A0.9630.90
28_D55_K0.9540.90
77_S136_P0.9490.89
3_R69_V0.9410.89
35_P58_I0.9380.89
94_E97_P0.9360.89
207_K215_I0.9300.88
209_E213_R0.9300.88
165_T168_D0.9270.88
6_L18_V0.9170.88
98_L102_K0.9140.88
4_V27_V0.9140.88
175_D179_E0.9080.87
46_S50_R0.9060.87
201_A215_I0.9020.87
12_E38_N0.8990.87
75_T147_V0.8800.86
24_N45_F0.8770.85
16_G20_R0.8730.85
76_S81_N0.8700.85
7_V33_V0.8680.85
11_G45_F0.8650.85
178_T182_Y0.8530.84
138_L145_G0.8450.83
207_K212_A0.8440.83
17_F141_S0.8430.83
93_W97_P0.8400.83
77_S117_R0.8390.83
12_E15_I0.8380.83
59_V64_K0.8330.82
91_R127_L0.8300.82
15_I38_N0.8210.81
13_Y145_G0.8200.81
18_V141_S0.8160.81
200_R208_D0.8160.81
172_K176_K0.8100.80
38_N43_F0.8030.80
85_I126_L0.8020.80
73_I125_F0.7980.79
131_A136_P0.7940.79
12_E39_I0.7910.79
121_F196_I0.7900.79
12_E40_S0.7830.78
202_I222_L0.7810.78
14_N20_R0.7790.78
8_E116_T0.7760.78
205_G211_E0.7710.77
193_K196_I0.7680.77
65_A68_D0.7660.77
19_A42_A0.7640.76
124_D199_K0.7630.76
124_D171_I0.7600.76
124_D203_I0.7580.76
72_K123_C0.7520.75
118_E121_F0.7510.75
49_G135_Y0.7470.75
27_V141_S0.7460.75
180_I226_I0.7450.75
165_T170_S0.7440.75
173_L215_I0.7420.74
5_V59_V0.7390.74
3_R103_K0.7380.74
24_N145_G0.7310.73
57_K64_K0.7310.73
72_K168_D0.7260.73
12_E43_F0.7250.73
89_S154_N0.7250.73
83_G120_I0.7250.73
7_V69_V0.7240.73
88_K91_R0.7230.72
23_K28_D0.7220.72
23_K52_I0.7220.72
96_L154_N0.7210.72
76_S80_D0.7180.72
172_K175_D0.7120.71
129_I146_I0.7110.71
73_I95_I0.7100.71
73_I94_E0.7100.71
48_G132_N0.7060.71
62_F122_K0.7020.70
113_V208_D0.6990.70
19_A117_R0.6960.70
19_A53_L0.6950.69
23_K132_N0.6940.69
91_R95_I0.6910.69
59_V68_D0.6860.68
194_M197_A0.6820.68
96_L155_R0.6770.67
135_Y142_H0.6760.67
15_I18_V0.6760.67
150_E153_K0.6730.67
21_L25_F0.6720.67
75_T149_Y0.6720.67
22_C52_I0.6700.67
32_I205_G0.6700.67
32_I58_I0.6680.66
90_I94_E0.6680.66
164_S209_E0.6670.66
211_E216_V0.6670.66
93_W157_L0.6650.66
132_N135_Y0.6650.66
192_Y196_I0.6620.66
24_N131_A0.6580.65
92_P151_I0.6570.65
72_K124_D0.6570.65
67_N169_Q0.6560.65
10_E137_V0.6560.65
39_I43_F0.6550.65
196_I203_I0.6550.65
68_D169_Q0.6550.65
87_R90_I0.6480.64
12_E37_A0.6460.64
23_K135_Y0.6440.64
25_F152_W0.6400.63
5_V65_A0.6390.63
28_D134_S0.6380.63
164_S168_D0.6380.63
48_G135_Y0.6340.62
87_R93_W0.6310.62
22_C149_Y0.6270.62
219_L222_L0.6260.61
182_Y187_R0.6250.61
4_V144_V0.6230.61
163_T166_I0.6220.61
41_E45_F0.6190.61
159_T162_Q0.6170.60
63_D107_I0.6170.60
121_F126_L0.6150.60
221_K225_R0.6140.60
99_I102_K0.6130.60
25_F138_L0.6110.60
95_I151_I0.6090.59
8_E113_V0.6080.59
161_P164_S0.6030.59
3_R68_D0.5980.58
38_N58_I0.5930.57
184_L226_I0.5930.57
19_A77_S0.5920.57
164_S167_S0.5880.57
99_I104_I0.5870.57
30_L129_I0.5850.56
124_D168_D0.5820.56
33_V59_V0.5820.56
132_N146_I0.5810.56
162_Q165_T0.5810.56
174_I199_K0.5790.56
85_I146_I0.5790.56
175_D178_T0.5790.56
100_Q159_T0.5780.55
137_V140_L0.5760.55
197_A210_E0.5750.55
76_S122_K0.5720.55
150_E217_H0.5720.55
7_V118_E0.5680.54
60_N63_D0.5660.54
169_Q172_K0.5650.54
76_S192_Y0.5650.54
22_C148_L0.5620.53
89_S93_W0.5620.53
31_Y69_V0.5620.53
18_V148_L0.5610.53
182_Y185_L0.5610.53
53_L56_A0.5580.53
76_S120_I0.5560.53
11_G47_A0.5550.52
179_E183_K0.5550.52
53_L74_A0.5540.52
23_K129_I0.5520.52
55_K93_W0.5500.52
88_K147_V0.5480.52
26_L132_N0.5480.52
131_A138_L0.5470.51
201_A205_G0.5450.51
5_V56_A0.5440.51
18_V24_N0.5420.51
174_I195_Y0.5420.51
101_G175_D0.5410.51
18_V209_E0.5380.50
21_L49_G0.5360.50
95_I107_I0.5340.50
201_A218_F0.5330.50
28_D132_N0.5330.50
168_D171_I0.5310.49
127_L198_L0.5310.49
64_K118_E0.5300.49
72_K75_T0.5300.49
7_V119_E0.5300.49
128_Y131_A0.5280.49
176_K180_I0.5270.49
24_N220_R0.5260.49
45_F141_S0.5230.48
186_K214_V0.5230.48
78_I138_L0.5230.48
68_D105_A0.5230.48
188_S192_Y0.5210.48
112_S116_T0.5210.48
10_E140_L0.5190.48
60_N226_I0.5190.48
186_K194_M0.5190.48
28_D52_I0.5180.48
131_A152_W0.5180.48
27_V149_Y0.5170.48
189_D192_Y0.5160.47
18_V48_G0.5130.47
88_K149_Y0.5120.47
194_M213_R0.5090.46
26_L152_W0.5090.46
202_I207_K0.5070.46
8_E140_L0.5070.46
47_A135_Y0.5060.46
137_V194_M0.5060.46
117_R217_H0.5050.46
11_G17_F0.5050.46
166_I212_A0.5040.46
190_D193_K0.5030.46
81_N85_I0.5020.46
62_F119_E0.5020.46
17_F142_H0.5020.46
186_K217_H0.5010.45
120_I128_Y0.5010.45
25_F148_L0.5010.45
104_I175_D0.5000.45
10_E36_R0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cngA 2 0.6498 100 0.346 Contact Map
3ilkA 2 0.9536 100 0.356 Contact Map
4cndA 2 0.6709 100 0.358 Contact Map
3onpA 2 0.6498 100 0.359 Contact Map
3ic6A 2 0.7426 100 0.552 Contact Map
3ktyA 2 0.6582 100 0.58 Contact Map
3dcmX 2 0.6371 100 0.62 Contact Map
1v2xA 2 0.6962 100 0.626 Contact Map
1zjrA 2 0.7257 100 0.629 Contact Map
3l8uA 2 0.6245 100 0.642 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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