GREMLIN Database
Q7LXK7 - Uncharacterized protein
UniProt: Q7LXK7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 207 (187)
Sequences: 7550 (5377)
Seq/√Len: 393.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_I13_R3.7081.00
15_C78_C3.7051.00
53_G65_F3.0291.00
70_P96_N2.5211.00
19_Q71_Y2.4731.00
97_C102_C2.4621.00
68_I129_Y2.3831.00
182_E188_E2.3701.00
64_V95_L2.3531.00
53_G63_V2.3451.00
109_D149_K2.2411.00
43_L108_F2.2181.00
64_V108_F2.1841.00
10_R59_M2.1501.00
8_E13_R2.1341.00
120_V132_S2.1321.00
12_I58_M2.0211.00
80_L94_V1.9401.00
33_L181_Y1.9341.00
47_S76_T1.9301.00
134_G139_K1.9291.00
145_L170_I1.8911.00
17_N75_S1.8881.00
2_A126_W1.8661.00
148_V154_Y1.8041.00
15_C82_V1.7941.00
5_R15_C1.7041.00
128_E132_S1.7031.00
34_L155_T1.6551.00
73_T94_V1.6501.00
156_L170_I1.6491.00
12_I59_M1.6321.00
26_D29_I1.6271.00
136_D142_I1.6251.00
57_L63_V1.6211.00
14_L55_W1.6111.00
35_R60_G1.6011.00
56_S112_I1.5991.00
99_L140_V1.5841.00
163_E180_K1.5771.00
12_I55_W1.5151.00
98_D143_D1.4971.00
54_I85_L1.4771.00
73_T96_N1.4751.00
8_E11_G1.4751.00
170_I193_L1.4591.00
54_I80_L1.4481.00
160_L187_Y1.4481.00
163_E188_E1.4301.00
20_T49_S1.4101.00
10_R32_S1.4051.00
47_S53_G1.4011.00
143_D147_T1.3861.00
168_Y172_K1.3821.00
30_L155_T1.3581.00
119_P161_S1.3581.00
155_T192_G1.2661.00
167_V171_N1.2541.00
107_D149_K1.2481.00
98_D101_S1.2421.00
34_L112_I1.2351.00
31_L55_W1.2101.00
181_Y192_G1.2011.00
76_T94_V1.1911.00
66_V103_L1.1901.00
34_L110_V1.1881.00
29_I184_V1.1771.00
69_N129_Y1.1681.00
158_S191_I1.1681.00
29_I190_L1.1661.00
66_V97_C1.1641.00
100_L147_T1.1631.00
67_D73_T1.1611.00
146_K173_W1.1601.00
27_T52_L1.1591.00
42_V56_S1.1571.00
65_F92_Y1.1441.00
167_V180_K1.1421.00
35_R59_M1.1391.00
69_N72_A1.1381.00
41_K108_F1.1301.00
135_N142_I1.1301.00
13_R82_V1.1281.00
41_K64_V1.1251.00
141_L156_L1.1231.00
108_F111_A1.1131.00
65_F94_V1.1061.00
138_S165_K1.1021.00
113_F156_L1.1011.00
45_M99_L1.1001.00
41_K106_Y1.0971.00
133_G141_L1.0911.00
93_G106_Y1.0811.00
44_D53_G1.0531.00
45_M144_F1.0491.00
64_V93_G1.0471.00
52_L112_I1.0441.00
80_L92_Y1.0341.00
99_L143_D1.0311.00
77_L81_K1.0311.00
42_V63_V1.0301.00
10_R55_W1.0251.00
145_L169_A1.0161.00
53_G57_L1.0131.00
19_Q75_S1.0091.00
14_L51_I0.9961.00
14_L54_I0.9901.00
54_I83_N0.9731.00
42_V60_G0.9661.00
33_L190_L0.9581.00
78_C82_V0.9551.00
16_L75_S0.9471.00
180_K191_I0.9401.00
33_L192_G0.9361.00
53_G92_Y0.9291.00
159_S162_D0.9271.00
58_M83_N0.9261.00
17_N78_C0.9241.00
121_E125_E0.9231.00
138_S142_I0.9201.00
80_L85_L0.9141.00
148_V175_F0.9131.00
16_L20_T0.9041.00
163_E167_V0.9001.00
181_Y190_L0.9001.00
138_S169_A0.8931.00
179_Q192_G0.8931.00
133_G140_V0.8921.00
164_E168_Y0.8911.00
122_E125_E0.8821.00
168_Y171_N0.8721.00
47_S67_D0.8651.00
41_K149_K0.8571.00
158_S163_E0.8491.00
182_E186_G0.8401.00
64_V106_Y0.8251.00
55_W59_M0.8121.00
44_D47_S0.8101.00
12_I83_N0.8061.00
144_F154_Y0.8011.00
58_M85_L0.7981.00
42_V110_V0.7941.00
2_A22_E0.7871.00
113_F144_F0.7871.00
175_F193_L0.7841.00
170_I191_I0.7821.00
81_K86_Y0.7811.00
40_D60_G0.7811.00
78_C81_K0.7771.00
180_K188_E0.7661.00
47_S65_F0.7661.00
6_I82_V0.7641.00
77_L80_L0.7631.00
11_G58_M0.7601.00
118_L131_W0.7571.00
149_K152_R0.7501.00
141_L166_I0.7471.00
146_K169_A0.7371.00
6_I15_C0.7321.00
33_L155_T0.7291.00
100_L111_A0.7281.00
142_I169_A0.7281.00
57_L92_Y0.7271.00
120_V133_G0.7261.00
66_V95_L0.7241.00
11_G59_M0.7231.00
95_L106_Y0.7201.00
178_S193_L0.7141.00
141_L158_S0.7131.00
46_G140_V0.7111.00
136_D139_K0.7081.00
46_G99_L0.7071.00
2_A19_Q0.7041.00
119_P133_G0.7031.00
97_C103_L0.6981.00
133_G139_K0.6981.00
57_L86_Y0.6961.00
29_I33_L0.6941.00
37_G40_D0.6890.99
41_K109_D0.6890.99
20_T75_S0.6870.99
45_M100_L0.6860.99
31_L35_R0.6820.99
162_D165_K0.6780.99
56_S60_G0.6770.99
133_G137_G0.6740.99
57_L80_L0.6740.99
167_V178_S0.6730.99
163_E187_Y0.6730.99
26_D190_L0.6720.99
158_S180_K0.6700.99
143_D146_K0.6660.99
31_L52_L0.6650.99
162_D166_I0.6650.99
40_D109_D0.6650.99
142_I146_K0.6640.99
100_L103_L0.6630.99
165_K168_Y0.6630.99
43_L100_L0.6580.99
153_I192_G0.6550.99
70_P74_L0.6460.99
71_Y74_L0.6460.99
54_I58_M0.6430.99
161_S187_Y0.6370.99
154_Y193_L0.6360.99
144_F148_V0.6360.99
145_L193_L0.6300.99
63_V92_Y0.6260.99
30_L112_I0.6250.99
115_P166_I0.6190.99
120_V134_G0.6170.99
22_E130_S0.6160.99
77_L94_V0.6130.99
40_D62_K0.6080.99
4_V7_I0.6080.99
31_L56_S0.6020.99
22_E126_W0.6010.99
139_K142_I0.5990.99
17_N71_Y0.5980.99
39_G62_K0.5970.99
26_D185_I0.5970.99
165_K169_A0.5960.99
166_I169_A0.5950.99
164_E188_E0.5910.98
120_V128_E0.5900.98
45_M66_V0.5870.98
110_V153_I0.5870.98
74_L77_L0.5850.98
5_R78_C0.5840.98
140_V143_D0.5820.98
145_L173_W0.5800.98
73_T77_L0.5780.98
47_S94_V0.5740.98
34_L56_S0.5710.98
134_G137_G0.5700.98
95_L102_C0.5670.98
169_A173_W0.5660.98
142_I172_K0.5640.98
156_L166_I0.5640.98
43_L103_L0.5630.98
80_L83_N0.5610.98
148_V152_R0.5610.98
43_L66_V0.5590.98
145_L156_L0.5570.98
121_E124_N0.5570.98
38_K62_K0.5570.98
46_G113_F0.5550.98
55_W58_M0.5520.98
110_V155_T0.5510.98
36_V39_G0.5420.97
16_L49_S0.5420.97
25_D28_D0.5400.97
139_K143_D0.5390.97
17_N74_L0.5370.97
167_V188_E0.5360.97
69_N73_T0.5340.97
111_A148_V0.5300.97
137_G162_D0.5290.97
41_K107_D0.5270.97
119_P132_S0.5260.97
145_L148_V0.5250.97
119_P159_S0.5230.97
14_L83_N0.5210.97
57_L85_L0.5170.96
7_I13_R0.5170.96
164_E167_V0.5160.96
155_T190_L0.5160.96
133_G136_D0.5150.96
29_I32_S0.5140.96
171_N178_S0.5110.96
182_E187_Y0.5090.96
2_A16_L0.5090.96
119_P160_L0.5080.96
97_C100_L0.5070.96
95_L104_R0.5060.96
17_N20_T0.5060.96
68_I96_N0.5050.96
158_S166_I0.5020.96
66_V102_C0.5020.96
57_L61_G0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nv8A 1 0.9034 100 0.354 Contact Map
2b3tA 1 0.9275 100 0.373 Contact Map
4dzrA 2 0.6908 100 0.537 Contact Map
3evzA 1 0.8599 100 0.547 Contact Map
3lpmA 2 0.8986 99.9 0.575 Contact Map
1uwvA 1 0.8357 99.9 0.577 Contact Map
3tm4A 1 0.8792 99.9 0.588 Contact Map
3c6kA 2 0.8937 99.9 0.592 Contact Map
4dcmA 1 0.8164 99.9 0.597 Contact Map
3v97A 1 0.8744 99.9 0.608 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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