Q7LXK7 - SULSO - GREMLIN Contacts

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Q7LXK7 - Uncharacterized protein

UniProt:	Q7LXK7	Sequences: MASVRIIEFRGIRLCLNDQTYEPSDDTDILLSLLRVGKGDKVLDMGSGSGILGIWSLMMGGKVVFVDINPYATLSTLCSLKVNNLYNTPNYYGVLNCDLLSCLRKYDFDVAIFNPPYLPVEEYNEWIEYSWSGGNDGSKVLIDFLKTVKANRIYTLYSSLSDEEKIVYAINKWRFKISQKYEKVIGYERLIGLELVKEYDKGSISGA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	207 (187)
Sequences:	7550 (5377)
Seq/√Len:	393.2

ECOLI - PRMC PRMB TRMN6 RSMC
BACSU - PRMC YABB YBXB
HALSA - Q9HQH3
SULSO - Q7LXK7 Q980C4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
6_I	13_R	3.708	1.00
15_C	78_C	3.705	1.00
53_G	65_F	3.029	1.00
70_P	96_N	2.521	1.00
19_Q	71_Y	2.473	1.00
97_C	102_C	2.462	1.00
68_I	129_Y	2.383	1.00
182_E	188_E	2.370	1.00
64_V	95_L	2.353	1.00
53_G	63_V	2.345	1.00
109_D	149_K	2.241	1.00
43_L	108_F	2.218	1.00
64_V	108_F	2.184	1.00
10_R	59_M	2.150	1.00
8_E	13_R	2.134	1.00
120_V	132_S	2.132	1.00
12_I	58_M	2.021	1.00
80_L	94_V	1.940	1.00
33_L	181_Y	1.934	1.00
47_S	76_T	1.930	1.00
134_G	139_K	1.929	1.00
145_L	170_I	1.891	1.00
17_N	75_S	1.888	1.00
2_A	126_W	1.866	1.00
148_V	154_Y	1.804	1.00
15_C	82_V	1.794	1.00
5_R	15_C	1.704	1.00
128_E	132_S	1.703	1.00
34_L	155_T	1.655	1.00
73_T	94_V	1.650	1.00
156_L	170_I	1.649	1.00
12_I	59_M	1.632	1.00
26_D	29_I	1.627	1.00
136_D	142_I	1.625	1.00
57_L	63_V	1.621	1.00
14_L	55_W	1.611	1.00
35_R	60_G	1.601	1.00
56_S	112_I	1.599	1.00
99_L	140_V	1.584	1.00
163_E	180_K	1.577	1.00
12_I	55_W	1.515	1.00
98_D	143_D	1.497	1.00
54_I	85_L	1.477	1.00
73_T	96_N	1.475	1.00
8_E	11_G	1.475	1.00
170_I	193_L	1.459	1.00
54_I	80_L	1.448	1.00
160_L	187_Y	1.448	1.00
163_E	188_E	1.430	1.00
20_T	49_S	1.410	1.00
10_R	32_S	1.405	1.00
47_S	53_G	1.401	1.00
143_D	147_T	1.386	1.00
168_Y	172_K	1.382	1.00
30_L	155_T	1.358	1.00
119_P	161_S	1.358	1.00
155_T	192_G	1.266	1.00
167_V	171_N	1.254	1.00
107_D	149_K	1.248	1.00
98_D	101_S	1.242	1.00
34_L	112_I	1.235	1.00
31_L	55_W	1.210	1.00
181_Y	192_G	1.201	1.00
76_T	94_V	1.191	1.00
66_V	103_L	1.190	1.00
34_L	110_V	1.188	1.00
29_I	184_V	1.177	1.00
69_N	129_Y	1.168	1.00
158_S	191_I	1.168	1.00
29_I	190_L	1.166	1.00
66_V	97_C	1.164	1.00
100_L	147_T	1.163	1.00
67_D	73_T	1.161	1.00
146_K	173_W	1.160	1.00
27_T	52_L	1.159	1.00
42_V	56_S	1.157	1.00
65_F	92_Y	1.144	1.00
167_V	180_K	1.142	1.00
35_R	59_M	1.139	1.00
69_N	72_A	1.138	1.00
41_K	108_F	1.130	1.00
135_N	142_I	1.130	1.00
13_R	82_V	1.128	1.00
41_K	64_V	1.125	1.00
141_L	156_L	1.123	1.00
108_F	111_A	1.113	1.00
65_F	94_V	1.106	1.00
138_S	165_K	1.102	1.00
113_F	156_L	1.101	1.00
45_M	99_L	1.100	1.00
41_K	106_Y	1.097	1.00
133_G	141_L	1.091	1.00
93_G	106_Y	1.081	1.00
44_D	53_G	1.053	1.00
45_M	144_F	1.049	1.00
64_V	93_G	1.047	1.00
52_L	112_I	1.044	1.00
80_L	92_Y	1.034	1.00
99_L	143_D	1.031	1.00
77_L	81_K	1.031	1.00
42_V	63_V	1.030	1.00
10_R	55_W	1.025	1.00
145_L	169_A	1.016	1.00
53_G	57_L	1.013	1.00
19_Q	75_S	1.009	1.00
14_L	51_I	0.996	1.00
14_L	54_I	0.990	1.00
54_I	83_N	0.973	1.00
42_V	60_G	0.966	1.00
33_L	190_L	0.958	1.00
78_C	82_V	0.955	1.00
16_L	75_S	0.947	1.00
180_K	191_I	0.940	1.00
33_L	192_G	0.936	1.00
53_G	92_Y	0.929	1.00
159_S	162_D	0.927	1.00
58_M	83_N	0.926	1.00
17_N	78_C	0.924	1.00
121_E	125_E	0.923	1.00
138_S	142_I	0.920	1.00
80_L	85_L	0.914	1.00
148_V	175_F	0.913	1.00
16_L	20_T	0.904	1.00
163_E	167_V	0.900	1.00
181_Y	190_L	0.900	1.00
138_S	169_A	0.893	1.00
179_Q	192_G	0.893	1.00
133_G	140_V	0.892	1.00
164_E	168_Y	0.891	1.00
122_E	125_E	0.882	1.00
168_Y	171_N	0.872	1.00
47_S	67_D	0.865	1.00
41_K	149_K	0.857	1.00
158_S	163_E	0.849	1.00
182_E	186_G	0.840	1.00
64_V	106_Y	0.825	1.00
55_W	59_M	0.812	1.00
44_D	47_S	0.810	1.00
12_I	83_N	0.806	1.00
144_F	154_Y	0.801	1.00
58_M	85_L	0.798	1.00
42_V	110_V	0.794	1.00
2_A	22_E	0.787	1.00
113_F	144_F	0.787	1.00
175_F	193_L	0.784	1.00
170_I	191_I	0.782	1.00
81_K	86_Y	0.781	1.00
40_D	60_G	0.781	1.00
78_C	81_K	0.777	1.00
180_K	188_E	0.766	1.00
47_S	65_F	0.766	1.00
6_I	82_V	0.764	1.00
77_L	80_L	0.763	1.00
11_G	58_M	0.760	1.00
118_L	131_W	0.757	1.00
149_K	152_R	0.750	1.00
141_L	166_I	0.747	1.00
146_K	169_A	0.737	1.00
6_I	15_C	0.732	1.00
33_L	155_T	0.729	1.00
100_L	111_A	0.728	1.00
142_I	169_A	0.728	1.00
57_L	92_Y	0.727	1.00
120_V	133_G	0.726	1.00
66_V	95_L	0.724	1.00
11_G	59_M	0.723	1.00
95_L	106_Y	0.720	1.00
178_S	193_L	0.714	1.00
141_L	158_S	0.713	1.00
46_G	140_V	0.711	1.00
136_D	139_K	0.708	1.00
46_G	99_L	0.707	1.00
2_A	19_Q	0.704	1.00
119_P	133_G	0.703	1.00
97_C	103_L	0.698	1.00
133_G	139_K	0.698	1.00
57_L	86_Y	0.696	1.00
29_I	33_L	0.694	1.00
37_G	40_D	0.689	0.99
41_K	109_D	0.689	0.99
20_T	75_S	0.687	0.99
45_M	100_L	0.686	0.99
31_L	35_R	0.682	0.99
162_D	165_K	0.678	0.99
56_S	60_G	0.677	0.99
133_G	137_G	0.674	0.99
57_L	80_L	0.674	0.99
167_V	178_S	0.673	0.99
163_E	187_Y	0.673	0.99
26_D	190_L	0.672	0.99
158_S	180_K	0.670	0.99
143_D	146_K	0.666	0.99
31_L	52_L	0.665	0.99
162_D	166_I	0.665	0.99
40_D	109_D	0.665	0.99
142_I	146_K	0.664	0.99
100_L	103_L	0.663	0.99
165_K	168_Y	0.663	0.99
43_L	100_L	0.658	0.99
153_I	192_G	0.655	0.99
70_P	74_L	0.646	0.99
71_Y	74_L	0.646	0.99
54_I	58_M	0.643	0.99
161_S	187_Y	0.637	0.99
154_Y	193_L	0.636	0.99
144_F	148_V	0.636	0.99
145_L	193_L	0.630	0.99
63_V	92_Y	0.626	0.99
30_L	112_I	0.625	0.99
115_P	166_I	0.619	0.99
120_V	134_G	0.617	0.99
22_E	130_S	0.616	0.99
77_L	94_V	0.613	0.99
40_D	62_K	0.608	0.99
4_V	7_I	0.608	0.99
31_L	56_S	0.602	0.99
22_E	126_W	0.601	0.99
139_K	142_I	0.599	0.99
17_N	71_Y	0.598	0.99
39_G	62_K	0.597	0.99
26_D	185_I	0.597	0.99
165_K	169_A	0.596	0.99
166_I	169_A	0.595	0.99
164_E	188_E	0.591	0.98
120_V	128_E	0.590	0.98
45_M	66_V	0.587	0.98
110_V	153_I	0.587	0.98
74_L	77_L	0.585	0.98
5_R	78_C	0.584	0.98
140_V	143_D	0.582	0.98
145_L	173_W	0.580	0.98
73_T	77_L	0.578	0.98
47_S	94_V	0.574	0.98
34_L	56_S	0.571	0.98
134_G	137_G	0.570	0.98
95_L	102_C	0.567	0.98
169_A	173_W	0.566	0.98
142_I	172_K	0.564	0.98
156_L	166_I	0.564	0.98
43_L	103_L	0.563	0.98
80_L	83_N	0.561	0.98
148_V	152_R	0.561	0.98
43_L	66_V	0.559	0.98
145_L	156_L	0.557	0.98
121_E	124_N	0.557	0.98
38_K	62_K	0.557	0.98
46_G	113_F	0.555	0.98
55_W	58_M	0.552	0.98
110_V	155_T	0.551	0.98
36_V	39_G	0.542	0.97
16_L	49_S	0.542	0.97
25_D	28_D	0.540	0.97
139_K	143_D	0.539	0.97
17_N	74_L	0.537	0.97
167_V	188_E	0.536	0.97
69_N	73_T	0.534	0.97
111_A	148_V	0.530	0.97
137_G	162_D	0.529	0.97
41_K	107_D	0.527	0.97
119_P	132_S	0.526	0.97
145_L	148_V	0.525	0.97
119_P	159_S	0.523	0.97
14_L	83_N	0.521	0.97
57_L	85_L	0.517	0.96
7_I	13_R	0.517	0.96
164_E	167_V	0.516	0.96
155_T	190_L	0.516	0.96
133_G	136_D	0.515	0.96
29_I	32_S	0.514	0.96
171_N	178_S	0.511	0.96
182_E	187_Y	0.509	0.96
2_A	16_L	0.509	0.96
119_P	160_L	0.508	0.96
97_C	100_L	0.507	0.96
95_L	104_R	0.506	0.96
17_N	20_T	0.506	0.96
68_I	96_N	0.505	0.96
158_S	166_I	0.502	0.96
66_V	102_C	0.502	0.96
57_L	61_G	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nv8A	1	0.9034	100	0.354	Contact Map
2b3tA	1	0.9275	100	0.373	Contact Map
4dzrA	2	0.6908	100	0.537	Contact Map
3evzA	1	0.8599	100	0.547	Contact Map
3lpmA	2	0.8986	99.9	0.575	Contact Map
1uwvA	1	0.8357	99.9	0.577	Contact Map
3tm4A	1	0.8792	99.9	0.588	Contact Map
3c6kA	2	0.8937	99.9	0.592	Contact Map
4dcmA	1	0.8164	99.9	0.597	Contact Map
3v97A	1	0.8744	99.9	0.608	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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