GREMLIN Database
Q7LXK6 - rRNA adenine N-6-methyltransferase (Erm/ksgA)
UniProt: Q7LXK6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (187)
Sequences: 4416 (2651)
Seq/√Len: 193.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_L180_E3.7101.00
23_E41_F3.2751.00
176_L185_Q3.0841.00
182_K185_Q2.8961.00
92_V132_I2.6471.00
185_Q188_E2.5581.00
35_I45_I2.5271.00
64_Y131_S2.3321.00
111_N137_N2.2991.00
21_F24_P2.2231.00
120_P130_Y2.2151.00
89_K117_I2.2041.00
93_D114_I2.2031.00
119_P122_C2.1511.00
113_Q137_N2.1511.00
153_I186_V2.1411.00
113_Q135_I2.1311.00
111_N139_I2.0861.00
6_R57_Q2.0471.00
32_D45_I2.0101.00
110_Y136_F1.9961.00
13_C27_C1.9761.00
149_I190_L1.9521.00
22_L59_V1.9511.00
160_T175_D1.9261.00
96_F112_I1.8891.00
115_K135_I1.8491.00
181_F185_Q1.8121.00
103_S107_N1.8061.00
86_I118_I1.7921.00
114_I117_I1.7251.00
28_I51_L1.7211.00
117_I132_I1.7131.00
114_I132_I1.6791.00
139_I143_D1.6651.00
57_Q82_K1.6611.00
72_K105_L1.6371.00
48_A53_V1.6161.00
89_K93_D1.5741.00
82_K135_I1.5671.00
39_K45_I1.5511.00
84_T135_I1.5511.00
28_I48_A1.5481.00
188_E191_N1.5391.00
71_F87_L1.5381.00
73_E77_L1.5151.00
95_I106_L1.5061.00
104_F150_L1.5041.00
48_A70_F1.4911.00
145_E190_L1.4891.00
44_V51_L1.4311.00
106_L112_I1.4301.00
35_I39_K1.4231.00
104_F183_P1.4051.00
160_T163_K1.3931.00
58_L74_V1.3401.00
67_T87_L1.3381.00
118_I133_I1.3261.00
84_T133_I1.3221.00
153_I178_V1.3191.00
89_K130_Y1.3171.00
108_Y146_V1.3171.00
55_R81_R1.3121.00
27_C43_L1.3101.00
87_L92_V1.2881.00
110_Y138_R1.2831.00
158_N179_R1.2831.00
146_V150_L1.2781.00
120_P128_K1.2771.00
62_L85_L1.2701.00
121_S126_R1.2351.00
95_I134_T1.2331.00
47_D50_Y1.2271.00
67_T91_F1.2201.00
116_D133_I1.2201.00
117_I130_Y1.2171.00
170_F173_N1.2011.00
15_K37_Y1.1891.00
155_R164_A1.1831.00
27_C41_F1.1781.00
153_I161_L1.1541.00
107_N112_I1.1331.00
93_D100_T1.1321.00
60_S85_L1.1301.00
153_I164_A1.1201.00
82_K137_N1.1191.00
15_K34_M1.1131.00
75_I110_Y1.1051.00
187_L191_N1.0941.00
46_A51_L1.0921.00
9_L28_I1.0881.00
96_F114_I1.0791.00
11_I58_L1.0531.00
110_Y139_I1.0391.00
13_C38_L1.0201.00
89_K132_I1.0171.00
108_Y183_P1.0161.00
46_A50_Y1.0061.00
109_I147_D1.0031.00
8_I26_I0.9860.99
164_A178_V0.9850.99
62_L70_F0.9630.99
35_I43_L0.9600.99
95_I112_I0.9470.99
66_I70_F0.9430.99
139_I142_Y0.9370.99
120_P126_R0.9340.99
76_K147_D0.9310.99
49_R66_I0.9120.99
184_W188_E0.9110.99
36_E39_K0.9070.99
37_Y40_N0.9060.99
21_F25_D0.8970.99
178_V186_V0.8940.99
145_E149_I0.8870.99
27_C38_L0.8800.99
142_Y187_L0.8800.99
71_F95_I0.8650.99
38_L43_L0.8600.99
89_K114_I0.8520.98
149_I153_I0.8500.98
119_P130_Y0.8490.98
104_F186_V0.8450.98
9_L56_G0.8420.98
48_A62_L0.8370.98
36_E40_N0.8330.98
64_Y86_I0.8300.98
57_Q84_T0.8230.98
169_G172_S0.8210.98
57_Q81_R0.8210.98
105_L147_D0.8150.98
56_G80_I0.8080.98
83_L138_R0.8040.98
145_E148_S0.7970.98
146_V190_L0.7920.98
54_L77_L0.7880.97
140_R143_D0.7850.97
17_N21_F0.7840.97
48_A66_I0.7780.97
148_S152_C0.7710.97
152_C178_V0.7710.97
96_F132_I0.7690.97
71_F106_L0.7670.97
29_E35_I0.7630.97
15_K124_S0.7590.97
156_Y164_A0.7580.97
32_D35_I0.7580.97
55_R140_R0.7470.97
58_L85_L0.7460.97
101_Y186_V0.7420.96
148_S168_C0.7390.96
53_V73_E0.7370.96
80_I83_L0.7370.96
58_L80_I0.7370.96
11_I85_L0.7280.96
53_V70_F0.7270.96
146_V149_I0.7270.96
111_N143_D0.7260.96
6_R81_R0.7240.96
93_D117_I0.7240.96
108_Y187_L0.7210.96
54_L79_N0.7190.96
96_F134_T0.7110.95
75_I106_L0.7090.95
77_L80_I0.6970.95
72_K76_K0.6970.95
181_F186_V0.6950.95
108_Y147_D0.6870.94
94_K97_N0.6860.94
175_D180_E0.6860.94
144_K148_S0.6840.94
118_I122_C0.6830.94
86_I133_I0.6790.94
30_L45_I0.6780.94
169_G173_N0.6760.94
152_C168_C0.6750.94
116_D132_I0.6740.94
7_P42_N0.6740.94
149_I168_C0.6720.94
118_I129_V0.6700.94
33_K36_E0.6630.93
160_T164_A0.6590.93
76_K144_K0.6590.93
28_I164_A0.6580.93
68_S72_K0.6570.93
59_V84_T0.6550.93
86_I131_S0.6550.93
184_W187_L0.6520.93
48_A73_E0.6460.93
12_G16_G0.6420.92
68_S83_L0.6410.92
87_L106_L0.6400.92
146_V187_L0.6390.92
162_R166_K0.6380.92
83_L136_F0.6370.92
158_N177_K0.6330.92
161_L165_S0.6280.91
62_L67_T0.6260.91
69_D73_E0.6230.91
8_I57_Q0.6200.91
122_C126_R0.6180.91
146_V183_P0.6160.91
153_I165_S0.6120.90
32_D140_R0.6110.90
17_N60_S0.6100.90
61_S86_I0.6090.90
168_C171_S0.6070.90
149_I189_L0.6070.90
157_R164_A0.6070.90
107_N183_P0.6030.90
120_P129_V0.6030.90
91_F102_I0.6000.89
149_I186_V0.5950.89
16_G23_E0.5910.89
9_L53_V0.5900.89
67_T71_F0.5890.89
53_V77_L0.5860.88
98_D107_N0.5820.88
108_Y139_I0.5770.88
121_S124_S0.5760.88
112_I134_T0.5710.87
66_I69_D0.5710.87
87_L95_I0.5700.87
157_R179_R0.5690.87
161_L176_L0.5690.87
21_F26_I0.5690.87
6_R26_I0.5680.87
99_S182_K0.5680.87
13_C23_E0.5650.87
30_L46_A0.5630.86
19_T27_C0.5630.86
183_P187_L0.5620.86
83_L87_L0.5600.86
94_K157_R0.5590.86
120_P132_I0.5580.86
87_L134_T0.5560.86
117_I120_P0.5540.85
29_E34_M0.5520.85
8_I25_D0.5520.85
88_Q94_K0.5410.84
101_Y104_F0.5400.84
65_Q68_S0.5400.84
123_F131_S0.5400.84
7_P56_G0.5380.84
49_R73_E0.5360.84
67_T72_K0.5360.84
160_T180_E0.5350.83
161_L181_F0.5340.83
95_I103_S0.5340.83
69_D74_V0.5330.83
23_E26_I0.5320.83
163_K179_R0.5300.83
126_R151_S0.5290.83
58_L70_F0.5270.83
15_K20_R0.5270.83
19_T22_L0.5260.82
62_L83_L0.5250.82
48_A51_L0.5230.82
17_N34_M0.5230.82
92_V117_I0.5220.82
5_I26_I0.5210.82
104_F107_N0.5200.82
155_R178_V0.5190.82
19_T41_F0.5180.81
104_F146_V0.5180.81
65_Q128_K0.5170.81
62_L86_I0.5100.80
18_I131_S0.5090.80
68_S91_F0.5090.80
119_P132_I0.5090.80
166_K171_S0.5080.80
155_R168_C0.5070.80
101_Y183_P0.5060.80
88_Q154_S0.5060.80
74_V83_L0.5060.80
42_N137_N0.5050.80
7_P57_Q0.5040.80
178_V187_L0.5040.80
86_I156_Y0.5010.79
95_I102_I0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i4wA 1 1 100 0.279 Contact Map
4gc5A 2 1 100 0.305 Contact Map
4jxjA 1 0.9948 100 0.333 Contact Map
1qyrA 1 1 100 0.34 Contact Map
3tqsA 1 1 100 0.353 Contact Map
3uzuA 1 1 100 0.354 Contact Map
3futA 1 0.9948 100 0.355 Contact Map
3ftdA 1 1 100 0.372 Contact Map
3gruA 1 0.9948 100 0.38 Contact Map
1zq9A 2 1 100 0.43 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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