GREMLIN Database
Q7LXK5 - Uncharacterized protein
UniProt: Q7LXK5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 208 (176)
Sequences: 183 (131)
Seq/√Len: 9.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_K147_E7.2831.00
107_V152_I4.5100.99
39_V183_V3.8860.98
41_E63_K3.7890.98
38_A49_L3.5380.97
12_V116_L2.7440.89
95_L99_V2.7200.88
108_E112_K2.5490.84
102_K105_V2.4880.83
150_K154_S2.4200.81
18_M21_G2.3790.80
144_K148_S2.3610.79
115_P138_L2.1920.74
138_L167_E2.0040.67
35_L139_E1.8590.61
65_E71_S1.8350.60
11_V41_E1.8320.59
148_S152_I1.8220.59
36_I51_P1.7720.57
104_K108_E1.6500.51
17_Y99_V1.6310.50
21_G34_P1.6250.50
100_F165_L1.6200.50
103_E107_V1.5790.48
90_N93_K1.5680.48
92_P110_F1.5650.47
117_T157_G1.5610.47
23_P30_H1.4800.44
45_L74_V1.4760.43
115_P157_G1.4630.43
31_R176_G1.4570.43
113_A156_I1.4560.43
20_E45_L1.4350.42
51_P110_F1.4330.41
120_L179_Y1.4320.41
99_V152_I1.4310.41
74_V165_L1.3890.40
138_L150_K1.3700.39
34_P84_T1.3590.38
37_Q84_T1.3510.38
99_V166_V1.3420.38
110_F124_E1.3270.37
74_V171_K1.3180.37
117_T140_E1.3020.36
116_L179_Y1.2880.35
13_Y41_E1.2720.35
8_R68_S1.2620.34
64_I137_I1.2580.34
145_P149_F1.2530.34
31_R175_G1.2510.34
118_L134_L1.2330.33
113_A163_S1.2280.33
157_G177_E1.2180.32
21_G127_P1.2090.32
67_D71_S1.2090.32
51_P58_F1.1960.32
50_T157_G1.1940.31
118_L135_R1.1870.31
9_E40_G1.1820.31
95_L118_L1.1690.30
66_L71_S1.1670.30
166_V170_I1.1670.30
127_P178_K1.1650.30
65_E77_H1.1580.30
60_P140_E1.1370.29
39_V95_L1.1260.29
79_S91_L1.1260.29
37_Q78_I1.1100.28
60_P86_V1.1060.28
64_I165_L1.1000.28
162_A173_M1.0850.27
125_L148_S1.0760.27
124_E132_K1.0670.27
153_E160_D1.0610.26
49_L74_V1.0600.26
92_P143_K1.0380.26
10_R28_K1.0370.26
120_L156_I1.0340.26
138_L166_V1.0290.25
15_L138_L1.0270.25
140_E143_K1.0260.25
21_G178_K1.0260.25
149_F166_V1.0200.25
106_F115_P1.0090.25
52_L65_E0.9980.24
104_K112_K0.9980.24
52_L64_I0.9970.24
25_D30_H0.9890.24
110_F132_K0.9870.24
63_K181_L0.9860.24
160_D173_M0.9810.24
59_L62_D0.9810.24
115_P148_S0.9800.24
67_D72_V0.9720.23
13_Y174_Q0.9650.23
71_S74_V0.9610.23
106_F181_L0.9610.23
60_P120_L0.9560.23
17_Y127_P0.9520.23
14_V26_K0.9510.23
21_G35_L0.9440.23
89_D97_K0.9210.22
69_N72_V0.9180.22
47_L67_D0.9080.21
70_S73_K0.9010.21
48_E134_L0.9010.21
116_L163_S0.8980.21
124_E133_T0.8980.21
35_L126_L0.8940.21
47_L77_H0.8920.21
35_L137_I0.8910.21
52_L71_S0.8910.21
81_E115_P0.8890.21
7_V119_R0.8820.21
58_F175_G0.8760.20
18_M34_P0.8710.20
80_Y88_R0.8710.20
17_Y178_K0.8710.20
82_D104_K0.8700.20
96_Y180_Y0.8660.20
105_V158_V0.8630.20
41_E153_E0.8550.20
120_L170_I0.8490.20
63_K137_I0.8470.20
80_Y83_L0.8440.20
14_V181_L0.8420.19
118_L142_K0.8400.19
113_A161_V0.8390.19
58_F137_I0.8380.19
17_Y171_K0.8350.19
14_V144_K0.8320.19
98_I102_K0.8270.19
153_E159_K0.8250.19
33_K47_L0.8250.19
49_L152_I0.8240.19
96_Y163_S0.8240.19
8_R74_V0.8130.19
116_L169_I0.8010.18
64_I85_S0.7990.18
151_D154_S0.7930.18
118_L177_E0.7860.18
107_V148_S0.7820.18
129_I133_T0.7730.18
36_I122_A0.7720.18
64_I164_I0.7660.17
34_P109_I0.7640.17
120_L178_K0.7640.17
37_Q88_R0.7630.17
74_V77_H0.7610.17
60_P94_I0.7610.17
14_V58_F0.7560.17
13_Y68_S0.7540.17
138_L174_Q0.7530.17
158_V177_E0.7520.17
35_L87_S0.7520.17
38_A112_K0.7510.17
10_R57_D0.7420.17
28_K90_N0.7370.17
12_V38_A0.7320.16
24_L55_N0.7270.16
37_Q45_L0.7240.16
135_R165_L0.7180.16
73_K152_I0.7160.16
109_I178_K0.7160.16
19_R116_L0.7150.16
85_S169_I0.7120.16
65_E72_V0.7100.16
28_K171_K0.7080.16
20_E47_L0.7040.16
112_K119_R0.6990.16
12_V90_N0.6960.16
35_L142_K0.6950.16
11_V67_D0.6940.16
69_N79_S0.6940.16
134_L163_S0.6920.16
63_K95_L0.6870.15
112_K152_I0.6820.15
62_D122_A0.6810.15
104_K139_E0.6750.15
14_V36_I0.6740.15
9_E66_L0.6730.15
27_H171_K0.6720.15
47_L112_K0.6690.15
40_G173_M0.6690.15
16_D48_E0.6670.15
150_K173_M0.6660.15
97_K101_E0.6640.15
123_L169_I0.6610.15
148_S156_I0.6570.15
95_L183_V0.6480.14
44_F148_S0.6410.14
63_K115_P0.6400.14
63_K101_E0.6390.14
7_V66_L0.6360.14
74_V143_K0.6320.14
11_V47_L0.6300.14
25_D127_P0.6260.14
10_R32_D0.6230.14
104_K149_F0.6210.14
99_V175_G0.6200.14
52_L66_L0.6190.14
44_F132_K0.6110.14
14_V64_I0.6100.14
21_G126_L0.6080.14
152_I181_L0.6050.14
41_E101_E0.6000.13
68_S134_L0.5990.13
77_H98_I0.5980.13
13_Y26_K0.5980.13
13_Y63_K0.5980.13
47_L144_K0.5970.13
37_Q129_I0.5950.13
36_I97_K0.5940.13
107_V125_L0.5930.13
32_D135_R0.5890.13
30_H164_I0.5880.13
90_N134_L0.5860.13
45_L78_I0.5860.13
126_L149_F0.5820.13
9_E73_K0.5810.13
61_E138_L0.5780.13
19_R96_Y0.5770.13
133_T157_G0.5730.13
128_N171_K0.5670.13
173_M176_G0.5660.13
19_R181_L0.5660.13
40_G73_K0.5640.13
42_D88_R0.5630.13
62_D175_G0.5610.13
110_F161_V0.5590.13
110_F118_L0.5540.12
43_Y124_E0.5540.12
22_N59_L0.5520.12
160_D175_G0.5510.12
82_D170_I0.5460.12
30_H51_P0.5450.12
152_I156_I0.5440.12
115_P171_K0.5430.12
10_R67_D0.5420.12
60_P93_K0.5420.12
45_L65_E0.5420.12
117_T131_K0.5410.12
28_K107_V0.5400.12
150_K153_E0.5380.12
160_D166_V0.5370.12
127_P132_K0.5360.12
36_I98_I0.5350.12
165_L171_K0.5340.12
11_V74_V0.5340.12
17_Y42_D0.5320.12
173_M183_V0.5280.12
74_V89_D0.5280.12
10_R42_D0.5270.12
82_D157_G0.5250.12
18_M126_L0.5180.12
132_K179_Y0.5160.12
14_V25_D0.5160.12
31_R47_L0.5130.12
94_I180_Y0.5080.12
87_S141_R0.5070.12
41_E98_I0.5070.12
37_Q135_R0.5020.11
12_V55_N0.5000.11
11_V77_H0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i5hA 1 0.8317 100 0.398 Contact Map
2eduA 1 0.4567 95.8 0.927 Contact Map
3wu2U 1 0.4519 95.1 0.93 Contact Map
3f2bA 1 0.6779 91.8 0.939 Contact Map
2duyA 1 0.3125 90.6 0.941 Contact Map
2hnhA 1 0.6971 82.2 0.948 Contact Map
2lyhA 1 0.3221 79.2 0.949 Contact Map
2hpiA 2 0.7548 72.3 0.952 Contact Map
4pj0U 1 0.4231 69.6 0.953 Contact Map
3b0xA 1 0.8269 63.3 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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