Q7LXK1 - SULSO - GREMLIN Contacts

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Q7LXK1 - Alcohol dehydrogenase (Zn containing) (Adh-2)

UniProt:	Q7LXK1	Sequences: MKAVVVPGKQKGYRIEEVSDPIPGKDEVVIRVNRAALCYRDLLQLQGFYPRMKYPVILGHEVVGTIEQIGENAKGFKEGDKVISLLYAPDGTCHYCQMGEEAYCHSRVGYSEELDGFFAEKAKVKVTSIVKVGTNVPDEGAVLVPCVTGMVYRSLRRAKLQKGETVLVTGASGGVGIHAIQVAKALGAKVIGVTTSEEKAAFIRKFADHVIVGSKFSEEAKKIGDVNVVIDTVGTPTIDESLKSLWMGGRLVQIGNVDPTQIYQLRLGYVILKDIAIIGHASATKRDAEETLKLTGEGKINPVIAATVGLDEIDKGYEILKDKHKIGKVLVKP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	333 (299)
Sequences:	52804 (36406)
Seq/√Len:	2105.4

ECOLI - YBDR GATD YAHK AHR FRMA RSPB ADHP YDJL YGGP YPHC TDH YDJJ YJJN IDND QOR1 ACUI YCJQ CURA
BACSU - ADHB ADHA YJMD TDH YOGA DHSO YYCR BDHA YHFP YFMJ
HALSA - Q9HP38 Q9HMB6 GLCDH Q9HR85 Q9HQS8
SULSO - Q7LXK1 ADH Q97VW0 Q97YT7 Q97XR4 Q97V32 Q97VV5 Q97ZV3 Q97YM2 Q97WA1 GLCD2 GLCD1 GLCD3 Q97TZ4 Q97W06 Q97UW5 Q97VB8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
312_E	315_K	2.946	1.00
33_N	138_D	2.889	1.00
31_R	67_E	2.812	1.00
33_N	65_T	2.735	1.00
7_P	16_E	2.679	1.00
29_V	67_E	2.653	1.00
28_V	129_I	2.588	1.00
165_T	189_K	2.536	1.00
184_K	209_H	2.508	1.00
137_P	140_G	2.493	1.00
81_K	132_V	2.411	1.00
77_K	80_D	2.384	1.00
80_D	131_K	2.377	1.00
308_V	319_I	2.357	1.00
201_A	205_K	2.301	1.00
62_V	117_F	2.290	1.00
31_R	65_T	2.245	1.00
171_A	192_G	2.195	1.00
20_D	121_K	2.183	1.00
139_E	307_T	2.158	1.00
31_R	121_K	2.154	1.00
189_K	210_V	2.146	1.00
7_P	14_R	2.096	1.00
166_V	183_A	2.088	1.00
200_A	204_R	2.082	1.00
293_K	297_E	2.076	1.00
75_G	126_V	2.043	1.00
309_G	312_E	2.029	1.00
5_V	16_E	1.998	1.00
24_G	27_E	1.981	1.00
25_K	71_E	1.980	1.00
161_Q	164_E	1.976	1.00
26_D	72_N	1.963	1.00
180_I	208_D	1.963	1.00
306_A	319_I	1.962	1.00
135_N	296_G	1.948	1.00
63_V	138_D	1.908	1.00
25_K	72_N	1.905	1.00
62_V	84_S	1.902	1.00
81_K	138_D	1.899	1.00
318_E	322_D	1.863	1.00
22_I	68_Q	1.852	1.00
164_E	250_R	1.806	1.00
29_V	123_K	1.774	1.00
216_F	219_E	1.770	1.00
67_E	121_K	1.768	1.00
167_L	193_V	1.768	1.00
46_Q	321_K	1.757	1.00
201_A	204_R	1.753	1.00
315_K	318_E	1.750	1.00
191_I	226_V	1.748	1.00
167_L	226_V	1.734	1.00
308_V	316_G	1.706	1.00
197_E	201_A	1.701	1.00
227_N	246_W	1.689	1.00
148_T	178_H	1.679	1.00
194_T	200_A	1.678	1.00
132_V	138_D	1.669	1.00
132_V	141_A	1.658	1.00
319_I	324_H	1.653	1.00
200_A	211_I	1.646	1.00
70_G	73_A	1.646	1.00
185_A	299_K	1.637	1.00
250_R	276_A	1.620	1.00
169_T	241_S	1.604	1.00
315_K	319_I	1.601	1.00
245_L	251_L	1.580	1.00
158_A	228_V	1.572	1.00
76_F	131_K	1.551	1.00
4_V	313_I	1.525	1.00
202_F	205_K	1.516	1.00
197_E	213_G	1.515	1.00
219_E	222_K	1.506	1.00
250_R	278_I	1.495	1.00
69_I	78_E	1.491	1.00
245_L	275_I	1.491	1.00
27_E	125_K	1.479	1.00
68_Q	78_E	1.465	1.00
29_V	121_K	1.459	1.00
118_F	317_Y	1.456	1.00
23_P	123_K	1.453	1.00
32_V	62_V	1.449	1.00
245_L	249_G	1.441	1.00
81_K	134_T	1.432	1.00
76_F	80_D	1.423	1.00
305_A	319_I	1.418	1.00
189_K	209_H	1.408	1.00
217_S	222_K	1.407	1.00
23_P	29_V	1.396	1.00
65_T	81_K	1.388	1.00
26_D	125_K	1.379	1.00
27_E	123_K	1.373	1.00
180_I	192_G	1.370	1.00
34_R	139_E	1.361	1.00
229_V	241_S	1.353	1.00
66_I	76_F	1.336	1.00
314_D	318_E	1.331	1.00
218_E	221_K	1.329	1.00
45_L	317_Y	1.319	1.00
229_V	245_L	1.315	1.00
165_T	191_I	1.306	1.00
28_V	76_F	1.299	1.00
216_F	221_K	1.293	1.00
29_V	68_Q	1.283	1.00
65_T	138_D	1.268	1.00
169_T	193_V	1.256	1.00
293_K	296_G	1.247	1.00
218_E	222_K	1.242	1.00
4_V	15_I	1.227	1.00
179_A	230_I	1.222	1.00
195_T	214_S	1.221	1.00
185_A	294_L	1.216	1.00
156_R	290_E	1.206	1.00
144_V	295_T	1.199	1.00
76_F	129_I	1.192	1.00
160_L	188_A	1.185	1.00
33_N	81_K	1.171	1.00
156_R	287_D	1.166	1.00
140_G	301_N	1.151	1.00
216_F	222_K	1.148	1.00
20_D	29_V	1.146	1.00
165_T	227_N	1.142	1.00
216_F	220_A	1.136	1.00
204_R	211_I	1.128	1.00
200_A	213_G	1.127	1.00
219_E	223_I	1.123	1.00
197_E	200_A	1.114	1.00
23_P	27_E	1.104	1.00
26_D	126_V	1.102	1.00
124_V	129_I	1.086	1.00
32_V	122_A	1.086	1.00
8_G	12_G	1.084	1.00
285_K	289_E	1.080	1.00
67_E	78_E	1.077	1.00
164_E	227_N	1.076	1.00
181_Q	301_N	1.070	1.00
158_A	252_V	1.068	1.00
204_R	210_V	1.066	1.00
290_E	293_K	1.061	1.00
213_G	216_F	1.058	1.00
45_L	321_K	1.055	1.00
30_I	64_G	1.054	1.00
243_K	269_Y	1.052	1.00
192_G	208_D	1.052	1.00
37_L	316_G	1.040	1.00
220_A	223_I	1.039	1.00
15_I	311_D	1.038	1.00
4_V	310_L	1.034	1.00
153_R	287_D	1.033	1.00
233_V	237_T	1.026	1.00
34_R	138_D	1.023	1.00
157_R	276_A	1.015	1.00
202_F	326_I	1.012	1.00
294_L	299_K	1.006	1.00
38_C	61_E	0.997	1.00
30_I	82_V	0.996	1.00
151_V	182_V	0.992	1.00
289_E	293_K	0.989	1.00
195_T	200_A	0.985	1.00
38_C	60_H	0.984	1.00
33_N	63_V	0.983	1.00
151_V	179_A	0.973	1.00
5_V	18_V	0.971	1.00
9_K	54_Y	0.966	1.00
160_L	164_E	0.965	1.00
313_I	331_V	0.964	1.00
35_A	117_F	0.963	1.00
136_V	141_A	0.961	1.00
35_A	118_F	0.961	1.00
191_I	210_V	0.961	1.00
197_E	216_F	0.958	1.00
154_S	254_I	0.957	1.00
231_D	234_G	0.956	1.00
8_G	11_K	0.955	1.00
171_A	194_T	0.945	1.00
183_A	188_A	0.941	1.00
195_T	215_K	0.940	1.00
118_F	313_I	0.929	1.00
69_I	73_A	0.927	1.00
20_D	68_Q	0.918	1.00
180_I	190_V	0.916	1.00
5_V	57_I	0.914	1.00
318_E	321_K	0.913	1.00
319_I	329_V	0.906	1.00
239_D	243_K	0.897	1.00
168_V	179_A	0.897	1.00
171_A	203_I	0.888	1.00
42_L	320_L	0.888	1.00
191_I	212_V	0.886	1.00
168_V	183_A	0.886	1.00
196_S	213_G	0.882	1.00
73_A	126_V	0.880	1.00
182_V	291_T	0.880	1.00
169_T	229_V	0.879	1.00
31_R	120_E	0.878	1.00
26_D	70_G	0.875	1.00
152_Y	290_E	0.874	1.00
56_V	115_D	0.874	1.00
77_K	131_K	0.873	1.00
196_S	199_K	0.873	1.00
177_I	202_F	0.872	1.00
22_I	29_V	0.871	1.00
240_E	243_K	0.867	1.00
18_V	115_D	0.865	1.00
74_K	126_V	0.856	1.00
154_S	230_I	0.855	1.00
198_E	201_A	0.855	1.00
36_A	61_E	0.855	1.00
193_V	214_S	0.854	1.00
194_T	211_I	0.853	1.00
167_L	244_S	0.852	1.00
165_T	226_V	0.848	1.00
20_D	67_E	0.846	1.00
62_V	122_A	0.842	1.00
269_Y	273_K	0.841	1.00
171_A	180_I	0.839	1.00
83_I	292_L	0.839	1.00
192_G	203_I	0.837	1.00
4_V	13_Y	0.833	1.00
164_E	228_V	0.829	1.00
7_P	12_G	0.829	1.00
157_R	278_I	0.827	1.00
248_G	274_D	0.827	1.00
118_F	331_V	0.825	1.00
290_E	294_L	0.824	1.00
199_K	326_I	0.824	1.00
286_R	290_E	0.815	1.00
320_L	329_V	0.813	1.00
270_V	277_I	0.809	1.00
37_L	320_L	0.804	1.00
38_C	41_D	0.797	1.00
308_V	312_E	0.792	1.00
34_R	330_L	0.791	1.00
4_V	314_D	0.789	1.00
149_G	287_D	0.787	1.00
26_D	71_E	0.785	1.00
151_V	178_H	0.778	1.00
203_I	208_D	0.776	1.00
182_V	294_L	0.769	1.00
306_A	315_K	0.768	1.00
151_V	175_V	0.764	1.00
134_T	296_G	0.763	1.00
24_G	123_K	0.762	1.00
241_S	251_L	0.761	1.00
183_A	190_V	0.761	1.00
266_R	269_Y	0.761	1.00
294_L	298_G	0.758	1.00
82_V	129_I	0.754	1.00
308_V	331_V	0.753	1.00
286_R	289_E	0.751	1.00
229_V	251_L	0.748	1.00
169_T	237_T	0.748	1.00
294_L	297_E	0.746	1.00
40_R	60_H	0.745	1.00
155_L	183_A	0.744	1.00
224_G	246_W	0.742	1.00
63_V	142_V	0.742	1.00
154_S	179_A	0.741	1.00
166_V	188_A	0.741	1.00
15_I	310_L	0.741	1.00
216_F	223_I	0.739	1.00
23_P	68_Q	0.734	1.00
165_T	224_G	0.728	1.00
159_K	250_R	0.727	1.00
304_I	307_T	0.727	1.00
136_V	295_T	0.726	1.00
69_I	77_K	0.723	1.00
153_R	274_D	0.723	1.00
186_L	290_E	0.722	1.00
160_L	228_V	0.720	1.00
37_L	118_F	0.714	1.00
168_V	192_G	0.712	1.00
190_V	209_H	0.711	1.00
6_V	12_G	0.707	1.00
232_T	254_I	0.706	1.00
18_V	57_I	0.706	1.00
38_C	146_C	0.705	1.00
34_R	307_T	0.703	1.00
319_I	322_D	0.703	1.00
145_P	148_T	0.703	1.00
226_V	229_V	0.703	1.00
151_V	155_L	0.701	1.00
130_V	289_E	0.701	1.00
270_V	275_I	0.697	1.00
247_M	273_K	0.697	1.00
28_V	126_V	0.696	1.00
194_T	203_I	0.692	1.00
23_P	70_G	0.689	1.00
133_G	296_G	0.688	1.00
270_V	279_G	0.688	1.00
228_V	252_V	0.684	1.00
238_I	251_L	0.684	1.00
159_K	278_I	0.684	1.00
11_K	318_E	0.681	1.00
60_H	146_C	0.676	1.00
253_Q	277_I	0.672	1.00
81_K	135_N	0.671	1.00
200_A	203_I	0.671	1.00
182_V	186_L	0.671	1.00
148_T	291_T	0.669	1.00
152_Y	291_T	0.661	1.00
226_V	244_S	0.661	1.00
130_V	288_A	0.659	1.00
239_D	269_Y	0.656	1.00
223_I	226_V	0.656	1.00
83_I	132_V	0.656	1.00
117_F	122_A	0.654	1.00
188_A	228_V	0.653	1.00
75_G	285_K	0.648	1.00
28_V	66_I	0.647	1.00
21_P	123_K	0.647	1.00
306_A	329_V	0.647	1.00
152_Y	294_L	0.646	1.00
239_D	262_I	0.646	1.00
325_K	329_V	0.644	1.00
130_V	292_L	0.643	1.00
292_L	296_G	0.642	1.00
80_D	134_T	0.642	1.00
63_V	132_V	0.641	1.00
202_F	303_V	0.640	1.00
75_G	131_K	0.640	1.00
34_R	63_V	0.640	1.00
26_D	127_T	0.638	1.00
8_G	14_R	0.638	1.00
177_I	303_V	0.637	1.00
146_C	150_M	0.636	1.00
156_R	186_L	0.635	1.00
180_I	206_F	0.634	1.00
205_K	301_N	0.634	1.00
39_Y	43_L	0.632	1.00
84_S	124_V	0.632	1.00
317_Y	321_K	0.631	1.00
63_V	81_K	0.630	1.00
144_V	291_T	0.627	1.00
159_K	276_A	0.627	1.00
202_F	206_F	0.625	1.00
75_G	78_E	0.624	1.00
158_A	250_R	0.622	1.00
184_K	190_V	0.622	1.00
32_V	35_A	0.617	1.00
210_V	213_G	0.616	1.00
231_D	251_L	0.614	1.00
236_P	239_D	0.613	1.00
193_V	212_V	0.612	1.00
152_Y	287_D	0.609	1.00
191_I	223_I	0.606	1.00
40_R	44_Q	0.606	1.00
237_T	241_S	0.605	1.00
38_C	147_V	0.604	1.00
179_A	254_I	0.602	1.00
181_Q	206_F	0.602	1.00
308_V	329_V	0.601	1.00
229_V	244_S	0.597	1.00
43_L	48_F	0.596	1.00
166_V	228_V	0.594	1.00
21_P	121_K	0.593	1.00
165_T	225_D	0.587	1.00
52_M	56_V	0.586	1.00
231_D	255_G	0.584	1.00
9_K	47_G	0.581	1.00
228_V	250_R	0.579	1.00
59_G	118_F	0.577	1.00
217_S	220_A	0.575	1.00
200_A	214_S	0.575	1.00
42_L	321_K	0.574	1.00
295_T	302_P	0.573	1.00
194_T	213_G	0.572	1.00
194_T	214_S	0.571	1.00
274_D	284_T	0.570	1.00
147_V	178_H	0.570	1.00
40_R	43_L	0.567	1.00
194_T	199_K	0.564	1.00
23_P	72_N	0.564	1.00
155_L	182_V	0.561	1.00
20_D	23_P	0.560	1.00
61_E	146_C	0.560	1.00
162_K	187_G	0.560	1.00
21_P	29_V	0.560	1.00
39_Y	173_G	0.559	1.00
319_I	325_K	0.556	1.00
69_I	80_D	0.556	1.00
84_S	129_I	0.556	1.00
74_K	77_K	0.555	1.00
30_I	84_S	0.555	1.00
12_G	314_D	0.554	1.00
156_R	159_K	0.554	1.00
20_D	123_K	0.553	1.00
30_I	129_I	0.553	1.00
63_V	141_A	0.553	1.00
211_I	214_S	0.550	1.00
130_V	285_K	0.549	1.00
162_K	186_L	0.549	1.00
154_S	280_H	0.549	1.00
152_Y	186_L	0.546	1.00
143_L	302_P	0.545	1.00
180_I	203_I	0.545	1.00
143_L	330_L	0.545	1.00
55_P	59_G	0.544	1.00
147_V	328_K	0.544	1.00
150_M	175_V	0.544	1.00
203_I	211_I	0.543	1.00
195_T	213_G	0.542	1.00
239_D	264_Q	0.542	1.00
85_L	130_V	0.542	1.00
219_E	240_E	0.541	1.00
225_D	246_W	0.541	1.00
32_V	84_S	0.540	1.00
218_E	240_E	0.539	1.00
246_W	249_G	0.539	1.00
178_H	182_V	0.537	1.00
252_V	280_H	0.536	1.00
217_S	221_K	0.535	1.00
156_R	286_R	0.534	1.00
44_Q	49_Y	0.534	1.00
167_L	229_V	0.534	1.00
76_F	126_V	0.534	1.00
210_V	222_K	0.532	1.00
42_L	46_Q	0.528	1.00
137_P	307_T	0.527	1.00
21_P	27_E	0.527	1.00
184_K	208_D	0.526	1.00
204_R	208_D	0.525	1.00
306_A	312_E	0.525	1.00
19_S	22_I	0.523	1.00
12_G	45_L	0.522	1.00
177_I	206_F	0.521	1.00
262_I	266_R	0.520	1.00
126_V	129_I	0.520	1.00
57_I	116_G	0.519	1.00
159_K	164_E	0.519	1.00
288_A	292_L	0.518	1.00
308_V	315_K	0.517	1.00
165_T	210_V	0.515	1.00
295_T	300_I	0.512	1.00
178_H	181_Q	0.510	1.00
163_G	188_A	0.508	1.00
6_V	9_K	0.508	1.00
15_I	313_I	0.506	1.00
27_E	114_L	0.506	1.00
275_I	279_G	0.506	1.00
71_E	74_K	0.505	1.00
53_K	56_V	0.503	1.00
220_A	244_S	0.502	1.00
32_V	117_F	0.501	1.00
287_D	290_E	0.501	1.00
145_P	150_M	0.500	1.00
147_V	174_G	0.500	1.00
23_P	26_D	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1rjwA	4	0.988	100	0.157	Contact Map
4gi2A	2	0.997	100	0.157	Contact Map
1h2bA	4	0.982	100	0.158	Contact Map
2eihA	4	0.997	100	0.162	Contact Map
4oaqA	2	0.994	100	0.164	Contact Map
4c4oA	4	0.979	100	0.164	Contact Map
3jv7A	4	0.982	100	0.166	Contact Map
4gkvA	4	0.982	100	0.166	Contact Map
1vj0A	4	0.991	100	0.169	Contact Map
1jvbA	4	0.994	100	0.169	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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