GREMLIN Database
Q7LXK1 - Alcohol dehydrogenase (Zn containing) (Adh-2)
UniProt: Q7LXK1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (299)
Sequences: 52804 (36406)
Seq/√Len: 2105.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
312_E315_K2.9461.00
33_N138_D2.8891.00
31_R67_E2.8121.00
33_N65_T2.7351.00
7_P16_E2.6791.00
29_V67_E2.6531.00
28_V129_I2.5881.00
165_T189_K2.5361.00
184_K209_H2.5081.00
137_P140_G2.4931.00
81_K132_V2.4111.00
77_K80_D2.3841.00
80_D131_K2.3771.00
308_V319_I2.3571.00
201_A205_K2.3011.00
62_V117_F2.2901.00
31_R65_T2.2451.00
171_A192_G2.1951.00
20_D121_K2.1831.00
139_E307_T2.1581.00
31_R121_K2.1541.00
189_K210_V2.1461.00
7_P14_R2.0961.00
166_V183_A2.0881.00
200_A204_R2.0821.00
293_K297_E2.0761.00
75_G126_V2.0431.00
309_G312_E2.0291.00
5_V16_E1.9981.00
24_G27_E1.9811.00
25_K71_E1.9801.00
161_Q164_E1.9761.00
26_D72_N1.9631.00
180_I208_D1.9631.00
306_A319_I1.9621.00
135_N296_G1.9481.00
63_V138_D1.9081.00
25_K72_N1.9051.00
62_V84_S1.9021.00
81_K138_D1.8991.00
318_E322_D1.8631.00
22_I68_Q1.8521.00
164_E250_R1.8061.00
29_V123_K1.7741.00
216_F219_E1.7701.00
67_E121_K1.7681.00
167_L193_V1.7681.00
46_Q321_K1.7571.00
201_A204_R1.7531.00
315_K318_E1.7501.00
191_I226_V1.7481.00
167_L226_V1.7341.00
308_V316_G1.7061.00
197_E201_A1.7011.00
227_N246_W1.6891.00
148_T178_H1.6791.00
194_T200_A1.6781.00
132_V138_D1.6691.00
132_V141_A1.6581.00
319_I324_H1.6531.00
200_A211_I1.6461.00
70_G73_A1.6461.00
185_A299_K1.6371.00
250_R276_A1.6201.00
169_T241_S1.6041.00
315_K319_I1.6011.00
245_L251_L1.5801.00
158_A228_V1.5721.00
76_F131_K1.5511.00
4_V313_I1.5251.00
202_F205_K1.5161.00
197_E213_G1.5151.00
219_E222_K1.5061.00
250_R278_I1.4951.00
69_I78_E1.4911.00
245_L275_I1.4911.00
27_E125_K1.4791.00
68_Q78_E1.4651.00
29_V121_K1.4591.00
118_F317_Y1.4561.00
23_P123_K1.4531.00
32_V62_V1.4491.00
245_L249_G1.4411.00
81_K134_T1.4321.00
76_F80_D1.4231.00
305_A319_I1.4181.00
189_K209_H1.4081.00
217_S222_K1.4071.00
23_P29_V1.3961.00
65_T81_K1.3881.00
26_D125_K1.3791.00
27_E123_K1.3731.00
180_I192_G1.3701.00
34_R139_E1.3611.00
229_V241_S1.3531.00
66_I76_F1.3361.00
314_D318_E1.3311.00
218_E221_K1.3291.00
45_L317_Y1.3191.00
229_V245_L1.3151.00
165_T191_I1.3061.00
28_V76_F1.2991.00
216_F221_K1.2931.00
29_V68_Q1.2831.00
65_T138_D1.2681.00
169_T193_V1.2561.00
293_K296_G1.2471.00
218_E222_K1.2421.00
4_V15_I1.2271.00
179_A230_I1.2221.00
195_T214_S1.2211.00
185_A294_L1.2161.00
156_R290_E1.2061.00
144_V295_T1.1991.00
76_F129_I1.1921.00
160_L188_A1.1851.00
33_N81_K1.1711.00
156_R287_D1.1661.00
140_G301_N1.1511.00
216_F222_K1.1481.00
20_D29_V1.1461.00
165_T227_N1.1421.00
216_F220_A1.1361.00
204_R211_I1.1281.00
200_A213_G1.1271.00
219_E223_I1.1231.00
197_E200_A1.1141.00
23_P27_E1.1041.00
26_D126_V1.1021.00
124_V129_I1.0861.00
32_V122_A1.0861.00
8_G12_G1.0841.00
285_K289_E1.0801.00
67_E78_E1.0771.00
164_E227_N1.0761.00
181_Q301_N1.0701.00
158_A252_V1.0681.00
204_R210_V1.0661.00
290_E293_K1.0611.00
213_G216_F1.0581.00
45_L321_K1.0551.00
30_I64_G1.0541.00
243_K269_Y1.0521.00
192_G208_D1.0521.00
37_L316_G1.0401.00
220_A223_I1.0391.00
15_I311_D1.0381.00
4_V310_L1.0341.00
153_R287_D1.0331.00
233_V237_T1.0261.00
34_R138_D1.0231.00
157_R276_A1.0151.00
202_F326_I1.0121.00
294_L299_K1.0061.00
38_C61_E0.9971.00
30_I82_V0.9961.00
151_V182_V0.9921.00
289_E293_K0.9891.00
195_T200_A0.9851.00
38_C60_H0.9841.00
33_N63_V0.9831.00
151_V179_A0.9731.00
5_V18_V0.9711.00
9_K54_Y0.9661.00
160_L164_E0.9651.00
313_I331_V0.9641.00
35_A117_F0.9631.00
136_V141_A0.9611.00
35_A118_F0.9611.00
191_I210_V0.9611.00
197_E216_F0.9581.00
154_S254_I0.9571.00
231_D234_G0.9561.00
8_G11_K0.9551.00
171_A194_T0.9451.00
183_A188_A0.9411.00
195_T215_K0.9401.00
118_F313_I0.9291.00
69_I73_A0.9271.00
20_D68_Q0.9181.00
180_I190_V0.9161.00
5_V57_I0.9141.00
318_E321_K0.9131.00
319_I329_V0.9061.00
239_D243_K0.8971.00
168_V179_A0.8971.00
171_A203_I0.8881.00
42_L320_L0.8881.00
191_I212_V0.8861.00
168_V183_A0.8861.00
196_S213_G0.8821.00
73_A126_V0.8801.00
182_V291_T0.8801.00
169_T229_V0.8791.00
31_R120_E0.8781.00
26_D70_G0.8751.00
152_Y290_E0.8741.00
56_V115_D0.8741.00
77_K131_K0.8731.00
196_S199_K0.8731.00
177_I202_F0.8721.00
22_I29_V0.8711.00
240_E243_K0.8671.00
18_V115_D0.8651.00
74_K126_V0.8561.00
154_S230_I0.8551.00
198_E201_A0.8551.00
36_A61_E0.8551.00
193_V214_S0.8541.00
194_T211_I0.8531.00
167_L244_S0.8521.00
165_T226_V0.8481.00
20_D67_E0.8461.00
62_V122_A0.8421.00
269_Y273_K0.8411.00
171_A180_I0.8391.00
83_I292_L0.8391.00
192_G203_I0.8371.00
4_V13_Y0.8331.00
164_E228_V0.8291.00
7_P12_G0.8291.00
157_R278_I0.8271.00
248_G274_D0.8271.00
118_F331_V0.8251.00
290_E294_L0.8241.00
199_K326_I0.8241.00
286_R290_E0.8151.00
320_L329_V0.8131.00
270_V277_I0.8091.00
37_L320_L0.8041.00
38_C41_D0.7971.00
308_V312_E0.7921.00
34_R330_L0.7911.00
4_V314_D0.7891.00
149_G287_D0.7871.00
26_D71_E0.7851.00
151_V178_H0.7781.00
203_I208_D0.7761.00
182_V294_L0.7691.00
306_A315_K0.7681.00
151_V175_V0.7641.00
134_T296_G0.7631.00
24_G123_K0.7621.00
241_S251_L0.7611.00
183_A190_V0.7611.00
266_R269_Y0.7611.00
294_L298_G0.7581.00
82_V129_I0.7541.00
308_V331_V0.7531.00
286_R289_E0.7511.00
229_V251_L0.7481.00
169_T237_T0.7481.00
294_L297_E0.7461.00
40_R60_H0.7451.00
155_L183_A0.7441.00
224_G246_W0.7421.00
63_V142_V0.7421.00
154_S179_A0.7411.00
166_V188_A0.7411.00
15_I310_L0.7411.00
216_F223_I0.7391.00
23_P68_Q0.7341.00
165_T224_G0.7281.00
159_K250_R0.7271.00
304_I307_T0.7271.00
136_V295_T0.7261.00
69_I77_K0.7231.00
153_R274_D0.7231.00
186_L290_E0.7221.00
160_L228_V0.7201.00
37_L118_F0.7141.00
168_V192_G0.7121.00
190_V209_H0.7111.00
6_V12_G0.7071.00
232_T254_I0.7061.00
18_V57_I0.7061.00
38_C146_C0.7051.00
34_R307_T0.7031.00
319_I322_D0.7031.00
145_P148_T0.7031.00
226_V229_V0.7031.00
151_V155_L0.7011.00
130_V289_E0.7011.00
270_V275_I0.6971.00
247_M273_K0.6971.00
28_V126_V0.6961.00
194_T203_I0.6921.00
23_P70_G0.6891.00
133_G296_G0.6881.00
270_V279_G0.6881.00
228_V252_V0.6841.00
238_I251_L0.6841.00
159_K278_I0.6841.00
11_K318_E0.6811.00
60_H146_C0.6761.00
253_Q277_I0.6721.00
81_K135_N0.6711.00
200_A203_I0.6711.00
182_V186_L0.6711.00
148_T291_T0.6691.00
152_Y291_T0.6611.00
226_V244_S0.6611.00
130_V288_A0.6591.00
239_D269_Y0.6561.00
223_I226_V0.6561.00
83_I132_V0.6561.00
117_F122_A0.6541.00
188_A228_V0.6531.00
75_G285_K0.6481.00
28_V66_I0.6471.00
21_P123_K0.6471.00
306_A329_V0.6471.00
152_Y294_L0.6461.00
239_D262_I0.6461.00
325_K329_V0.6441.00
130_V292_L0.6431.00
292_L296_G0.6421.00
80_D134_T0.6421.00
63_V132_V0.6411.00
202_F303_V0.6401.00
75_G131_K0.6401.00
34_R63_V0.6401.00
26_D127_T0.6381.00
8_G14_R0.6381.00
177_I303_V0.6371.00
146_C150_M0.6361.00
156_R186_L0.6351.00
180_I206_F0.6341.00
205_K301_N0.6341.00
39_Y43_L0.6321.00
84_S124_V0.6321.00
317_Y321_K0.6311.00
63_V81_K0.6301.00
144_V291_T0.6271.00
159_K276_A0.6271.00
202_F206_F0.6251.00
75_G78_E0.6241.00
158_A250_R0.6221.00
184_K190_V0.6221.00
32_V35_A0.6171.00
210_V213_G0.6161.00
231_D251_L0.6141.00
236_P239_D0.6131.00
193_V212_V0.6121.00
152_Y287_D0.6091.00
191_I223_I0.6061.00
40_R44_Q0.6061.00
237_T241_S0.6051.00
38_C147_V0.6041.00
179_A254_I0.6021.00
181_Q206_F0.6021.00
308_V329_V0.6011.00
229_V244_S0.5971.00
43_L48_F0.5961.00
166_V228_V0.5941.00
21_P121_K0.5931.00
165_T225_D0.5871.00
52_M56_V0.5861.00
231_D255_G0.5841.00
9_K47_G0.5811.00
228_V250_R0.5791.00
59_G118_F0.5771.00
217_S220_A0.5751.00
200_A214_S0.5751.00
42_L321_K0.5741.00
295_T302_P0.5731.00
194_T213_G0.5721.00
194_T214_S0.5711.00
274_D284_T0.5701.00
147_V178_H0.5701.00
40_R43_L0.5671.00
194_T199_K0.5641.00
23_P72_N0.5641.00
155_L182_V0.5611.00
20_D23_P0.5601.00
61_E146_C0.5601.00
162_K187_G0.5601.00
21_P29_V0.5601.00
39_Y173_G0.5591.00
319_I325_K0.5561.00
69_I80_D0.5561.00
84_S129_I0.5561.00
74_K77_K0.5551.00
30_I84_S0.5551.00
12_G314_D0.5541.00
156_R159_K0.5541.00
20_D123_K0.5531.00
30_I129_I0.5531.00
63_V141_A0.5531.00
211_I214_S0.5501.00
130_V285_K0.5491.00
162_K186_L0.5491.00
154_S280_H0.5491.00
152_Y186_L0.5461.00
143_L302_P0.5451.00
180_I203_I0.5451.00
143_L330_L0.5451.00
55_P59_G0.5441.00
147_V328_K0.5441.00
150_M175_V0.5441.00
203_I211_I0.5431.00
195_T213_G0.5421.00
239_D264_Q0.5421.00
85_L130_V0.5421.00
219_E240_E0.5411.00
225_D246_W0.5411.00
32_V84_S0.5401.00
218_E240_E0.5391.00
246_W249_G0.5391.00
178_H182_V0.5371.00
252_V280_H0.5361.00
217_S221_K0.5351.00
156_R286_R0.5341.00
44_Q49_Y0.5341.00
167_L229_V0.5341.00
76_F126_V0.5341.00
210_V222_K0.5321.00
42_L46_Q0.5281.00
137_P307_T0.5271.00
21_P27_E0.5271.00
184_K208_D0.5261.00
204_R208_D0.5251.00
306_A312_E0.5251.00
19_S22_I0.5231.00
12_G45_L0.5221.00
177_I206_F0.5211.00
262_I266_R0.5201.00
126_V129_I0.5201.00
57_I116_G0.5191.00
159_K164_E0.5191.00
288_A292_L0.5181.00
308_V315_K0.5171.00
165_T210_V0.5151.00
295_T300_I0.5121.00
178_H181_Q0.5101.00
163_G188_A0.5081.00
6_V9_K0.5081.00
15_I313_I0.5061.00
27_E114_L0.5061.00
275_I279_G0.5061.00
71_E74_K0.5051.00
53_K56_V0.5031.00
220_A244_S0.5021.00
32_V117_F0.5011.00
287_D290_E0.5011.00
145_P150_M0.5001.00
147_V174_G0.5001.00
23_P26_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rjwA 4 0.988 100 0.157 Contact Map
4gi2A 2 0.997 100 0.157 Contact Map
1h2bA 4 0.982 100 0.158 Contact Map
2eihA 4 0.997 100 0.162 Contact Map
4oaqA 2 0.994 100 0.164 Contact Map
4c4oA 4 0.979 100 0.164 Contact Map
3jv7A 4 0.982 100 0.166 Contact Map
4gkvA 4 0.982 100 0.166 Contact Map
1vj0A 4 0.991 100 0.169 Contact Map
1jvbA 4 0.994 100 0.169 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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