GREMLIN Database
Q7LXK0 - Glutamyl-tRNA amidotransferase, subunit A (GatA-1)
UniProt: Q7LXK0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (384)
Sequences: 14649 (10282)
Seq/√Len: 524.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_N69_L4.1621.00
226_Y229_L3.1181.00
126_V184_V3.0981.00
358_I388_A3.0861.00
211_L237_E3.0471.00
61_N66_D3.0121.00
103_D106_R2.9611.00
174_V181_L2.9451.00
377_E380_K2.8841.00
380_K383_D2.8261.00
90_N113_G2.8161.00
316_F387_V2.7921.00
115_S127_G2.7671.00
66_D70_R2.6421.00
350_F375_S2.5281.00
145_V173_I2.4651.00
236_V314_I2.3481.00
376_G380_K2.3471.00
136_V147_G2.3141.00
33_F126_V2.2651.00
389_E393_N2.2111.00
179_R389_E2.2021.00
218_S222_L2.1981.00
35_I65_V2.1901.00
68_I73_G2.1861.00
182_R389_E2.1801.00
206_R234_D2.1761.00
146_I181_L2.1601.00
15_T45_R2.1501.00
17_H44_V2.1231.00
34_G79_T2.1011.00
376_G384_L2.0961.00
26_G29_K2.0551.00
374_I384_L2.0501.00
208_G314_I2.0341.00
289_S292_D2.0141.00
13_F34_G1.9991.00
106_R368_L1.9281.00
101_P143_C1.9111.00
27_K71_E1.8881.00
18_T29_K1.8871.00
90_N98_A1.8811.00
357_S375_S1.8601.00
207_L316_F1.8591.00
148_F381_D1.8271.00
45_R55_N1.8261.00
106_R328_R1.8081.00
146_I178_I1.7861.00
67_A190_P1.7551.00
209_L225_I1.7471.00
119_V173_I1.7051.00
25_K29_K1.6821.00
227_A230_S1.6781.00
321_T359_S1.6771.00
34_G124_V1.6611.00
328_R331_D1.6551.00
48_A161_I1.6471.00
146_I392_L1.6431.00
33_F75_I1.6401.00
105_E328_R1.6311.00
146_I358_I1.6301.00
40_L46_T1.6231.00
39_I170_V1.6181.00
148_F385_L1.6001.00
71_E187_V1.5971.00
18_T25_K1.5961.00
37_D78_K1.5861.00
32_T125_D1.5831.00
46_T78_K1.5771.00
38_V81_T1.5721.00
225_I235_I1.5571.00
63_Y66_D1.5481.00
318_L374_I1.5421.00
154_L185_F1.5421.00
212_F239_D1.5361.00
216_E365_L1.5231.00
10_Y121_L1.5211.00
34_G118_A1.5001.00
220_I370_A1.4951.00
155_I188_V1.4931.00
160_V170_V1.4891.00
325_V364_T1.4771.00
99_R329_I1.4641.00
129_G173_I1.4571.00
38_V85_A1.4551.00
116_A143_C1.4541.00
10_Y117_V1.4511.00
69_L75_I1.4511.00
211_L222_L1.4511.00
222_L226_Y1.4491.00
39_I128_I1.4451.00
142_L322_T1.4391.00
11_N96_G1.4321.00
112_S115_S1.4311.00
308_V378_L1.4201.00
226_Y230_S1.4171.00
270_Y273_K1.4051.00
51_R54_E1.4051.00
149_K351_N1.4041.00
15_T44_V1.3921.00
19_I22_G1.3901.00
109_G138_I1.3861.00
236_V313_N1.3861.00
319_S375_S1.3831.00
231_S394_I1.3601.00
181_L385_L1.3521.00
63_Y67_A1.3471.00
99_R104_P1.3441.00
40_L58_P1.3431.00
355_A375_S1.3321.00
219_R223_K1.3231.00
91_T330_S1.3201.00
220_I362_F1.3191.00
64_V128_I1.3061.00
357_S373_M1.2961.00
117_V121_L1.2941.00
28_L73_G1.2881.00
151_T378_L1.2861.00
206_R236_V1.2831.00
154_L189_L1.2811.00
224_D372_L1.2741.00
210_F213_D1.2691.00
18_T23_N1.2671.00
20_E23_N1.2661.00
80_N92_S1.2651.00
250_T299_H1.2631.00
335_N338_Q1.2621.00
97_P329_I1.2461.00
67_A70_R1.2421.00
13_F77_G1.2381.00
14_I49_G1.2381.00
279_Y283_L1.2371.00
178_I392_L1.2341.00
215_M219_R1.2281.00
122_D175_K1.2271.00
140_S173_I1.2261.00
172_I184_V1.2181.00
358_I384_L1.2081.00
225_I318_L1.2071.00
34_G115_S1.2051.00
40_L56_Y1.2001.00
128_I188_V1.1971.00
129_G136_V1.1921.00
186_D205_P1.1851.00
224_D391_I1.1841.00
220_I363_S1.1751.00
44_V58_P1.1751.00
207_L233_F1.1721.00
41_T46_T1.1701.00
166_S258_E1.1671.00
199_A379_Y1.1631.00
42_K61_N1.1591.00
41_T58_P1.1511.00
148_F185_F1.1511.00
305_E309_K1.1501.00
41_T78_K1.1471.00
359_S371_G1.1471.00
220_I223_K1.1441.00
119_V127_G1.1431.00
309_K312_K1.1411.00
22_G26_G1.1341.00
81_T85_A1.1331.00
41_T44_V1.1321.00
118_A123_M1.1301.00
217_V370_A1.1291.00
350_F357_S1.1291.00
34_G127_G1.1251.00
151_T381_D1.1201.00
136_V172_I1.1151.00
60_R66_D1.1151.00
304_I308_V1.1141.00
79_T115_S1.1131.00
148_F358_I1.1101.00
45_R57_V1.1051.00
223_K226_Y1.1011.00
63_Y158_D1.1001.00
229_L234_D1.0971.00
64_V170_V1.0971.00
221_L225_I1.0941.00
211_L239_D1.0901.00
131_D137_R1.0881.00
142_L326_A1.0871.00
238_V310_V1.0851.00
98_A117_V1.0831.00
225_I229_L1.0821.00
227_A231_S1.0781.00
66_D69_L1.0781.00
124_V127_G1.0761.00
382_G386_E1.0761.00
302_V306_E1.0731.00
140_S147_G1.0701.00
50_S84_F1.0681.00
35_I75_I1.0661.00
223_K227_A1.0651.00
149_K169_T1.0601.00
216_E364_T1.0601.00
148_F181_L1.0591.00
306_E309_K1.0571.00
155_I185_F1.0571.00
293_Y297_L1.0481.00
47_T55_N1.0421.00
178_I388_A1.0241.00
130_T170_V1.0211.00
208_G238_V1.0211.00
242_L306_E1.0211.00
62_A65_V1.0161.00
19_I24_D1.0101.00
360_V374_I1.0101.00
14_I80_N1.0091.00
374_I387_V1.0071.00
98_A108_S1.0071.00
22_G25_K1.0051.00
260_A286_M1.0011.00
33_F73_G0.9931.00
19_I29_K0.9911.00
146_I360_V0.9831.00
99_R105_E0.9741.00
44_V78_K0.9741.00
253_T296_A0.9681.00
63_Y156_P0.9611.00
228_K391_I0.9611.00
24_D29_K0.9601.00
9_K104_P0.9581.00
64_V155_I0.9571.00
362_F370_A0.9541.00
300_R304_I0.9491.00
39_I160_V0.9491.00
299_H302_V0.9491.00
377_E383_D0.9431.00
41_T75_I0.9421.00
19_I25_K0.9411.00
80_N95_G0.9401.00
297_L300_R0.9391.00
39_I62_A0.9381.00
362_F372_L0.9331.00
41_T61_N0.9291.00
301_R305_E0.9281.00
141_S322_T0.9261.00
158_D194_R0.9261.00
227_A391_I0.9221.00
10_Y104_P0.9161.00
151_T379_Y0.9151.00
13_F16_L0.9131.00
60_R158_D0.9111.00
214_D325_V0.9061.00
31_V125_D0.9021.00
146_I388_A0.8971.00
35_I41_T0.8971.00
22_G29_K0.8951.00
374_I391_I0.8931.00
101_P117_V0.8921.00
119_V145_V0.8911.00
209_L221_L0.8891.00
364_T370_A0.8891.00
383_D386_E0.8871.00
184_V188_V0.8861.00
304_I378_L0.8831.00
227_A394_I0.8821.00
165_W262_Y0.8811.00
38_V130_T0.8811.00
79_T118_A0.8791.00
107_I142_L0.8771.00
50_S83_E0.8661.00
108_S117_V0.8651.00
182_R186_D0.8631.00
88_A138_I0.8621.00
221_L362_F0.8591.00
39_I130_T0.8591.00
108_S143_C0.8591.00
132_T168_D0.8561.00
179_R392_L0.8551.00
316_F383_D0.8541.00
136_V171_G0.8531.00
125_D180_L0.8521.00
133_G251_R0.8511.00
128_I170_V0.8511.00
66_D194_R0.8491.00
33_F184_V0.8481.00
142_L343_L0.8471.00
215_M218_S0.8451.00
34_G77_G0.8351.00
106_R326_A0.8341.00
283_L286_M0.8341.00
207_L228_K0.8321.00
191_N198_I0.8291.00
180_L183_R0.8271.00
23_N29_K0.8271.00
13_F79_T0.8251.00
39_I64_V0.8251.00
116_A173_I0.8241.00
141_S371_G0.8241.00
185_F381_D0.8241.00
206_R314_I0.8241.00
35_I128_I0.8221.00
18_T22_G0.8111.00
10_Y123_M0.8071.00
222_L229_L0.7991.00
40_L60_R0.7971.00
233_F390_Y0.7961.00
305_E308_V0.7911.00
65_V75_I0.7861.00
18_T21_E0.7841.00
195_K198_I0.7831.00
294_I298_R0.7821.00
355_A378_L0.7821.00
208_G310_V0.7791.00
307_Y353_V0.7781.00
216_E366_N0.7781.00
358_I385_L0.7781.00
19_I23_N0.7771.00
389_E392_L0.7751.00
148_F384_L0.7741.00
154_L382_G0.7731.00
154_L381_D0.7711.00
67_A156_P0.7711.00
42_K60_R0.7671.00
179_R183_R0.7661.00
62_A159_G0.7661.00
36_K135_S0.7661.00
326_A368_L0.7641.00
80_N96_G0.7621.00
45_R54_E0.7621.00
120_K145_V0.7621.00
308_V377_E0.7621.00
44_V75_I0.7591.00
79_T127_G0.7581.00
229_L235_I0.7571.00
29_K72_G0.7571.00
27_K187_V0.7571.00
54_E94_I0.7541.00
76_I124_V0.7531.00
275_F278_T0.7531.00
13_F123_M0.7511.00
228_K233_F0.7491.00
207_L318_L0.7471.00
177_N180_L0.7471.00
138_I322_T0.7461.00
214_D217_V0.7441.00
158_D192_E0.7421.00
182_R386_E0.7411.00
31_V180_L0.7371.00
13_F124_V0.7351.00
102_V369_P0.7351.00
214_D324_I0.7311.00
12_A123_M0.7301.00
301_R304_I0.7301.00
107_I329_I0.7291.00
222_L237_E0.7291.00
118_A124_V0.7291.00
240_L243_L0.7291.00
376_G383_D0.7281.00
350_F355_A0.7271.00
82_H87_G0.7251.00
316_F374_I0.7231.00
257_A290_A0.7211.00
283_L287_K0.7211.00
381_D384_L0.7211.00
36_K111_S0.7181.00
163_F255_S0.7151.00
312_K377_E0.7121.00
185_F385_L0.7111.00
280_T283_L0.7101.00
383_D387_V0.7081.00
381_D385_L0.7061.00
41_T69_L0.7061.00
12_A118_A0.7051.00
51_R94_I0.7021.00
38_V48_A0.7011.00
231_S390_Y0.7011.00
28_L183_R0.7001.00
177_N181_L0.6991.00
172_I188_V0.6961.00
152_T169_T0.6961.00
106_R327_P0.6961.00
268_S286_M0.6951.00
26_G71_E0.6931.00
106_R366_N0.6891.00
292_D295_D0.6881.00
308_V355_A0.6861.00
263_H266_W0.6861.00
224_D362_F0.6851.00
152_T354_G0.6851.00
311_F355_A0.6831.00
183_R186_D0.6831.00
23_N26_G0.6791.00
219_R222_L0.6781.00
213_D243_L0.6781.00
298_R302_V0.6781.00
178_I389_E0.6761.00
362_F391_I0.6751.00
115_S118_A0.6751.00
43_D57_V0.6751.00
90_N108_S0.6721.00
157_N170_V0.6701.00
216_E219_R0.6701.00
48_A53_L0.6691.00
216_E325_V0.6691.00
295_D298_R0.6671.00
155_I172_I0.6671.00
53_L56_Y0.6651.00
183_R187_V0.6651.00
89_T107_I0.6641.00
51_R273_K0.6641.00
240_L310_V0.6621.00
91_T97_P0.6621.00
265_D269_E0.6601.00
318_L372_L0.6591.00
102_V120_K0.6561.00
209_L237_E0.6561.00
216_E220_I0.6551.00
307_Y355_A0.6531.00
277_D280_T0.6521.00
229_L237_E0.6501.00
380_K384_L0.6501.00
302_V305_E0.6491.00
99_R103_D0.6491.00
138_I347_T0.6481.00
102_V144_G0.6481.00
80_N98_A0.6471.00
126_V174_V0.6461.00
209_L235_I0.6381.00
42_K59_Q0.6381.00
238_V314_I0.6371.00
228_K387_V0.6331.00
20_E25_K0.6311.00
129_G172_I0.6301.00
32_T74_K0.6301.00
231_S391_I0.6291.00
222_L225_I0.6291.00
27_K186_D0.6281.00
68_I184_V0.6281.00
217_V325_V0.6271.00
334_S338_Q0.6271.00
13_F17_H0.6261.00
116_A120_K0.6261.00
128_I184_V0.6261.00
40_L78_K0.6251.00
325_V366_N0.6241.00
46_T58_P0.6231.00
130_T160_V0.6231.00
311_F377_E0.6221.00
63_Y194_R0.6221.00
100_N108_S0.6211.00
191_N200_K0.6181.00
325_V368_L0.6181.00
360_V372_L0.6171.00
63_Y192_E0.6161.00
264_K268_S0.6151.00
321_T347_T0.6141.00
263_H274_Y0.6141.00
390_Y393_N0.6131.00
20_E29_K0.6131.00
271_S279_Y0.6131.00
77_G118_A0.6091.00
141_S321_T0.6061.00
32_T76_I0.6061.00
82_H113_G0.6031.00
310_V314_I0.6031.00
41_T65_V0.6021.00
185_F189_L0.6011.00
117_V143_C0.6001.00
319_S357_S0.5991.00
172_I181_L0.5991.00
151_T356_P0.5981.00
321_T373_M0.5981.00
142_L327_P0.5971.00
229_L232_H0.5961.00
61_N65_V0.5950.99
154_L203_T0.5940.99
136_V173_I0.5920.99
82_H90_N0.5890.99
208_G237_E0.5880.99
309_K313_N0.5880.99
330_S333_I0.5880.99
86_L259_A0.5870.99
290_A294_I0.5860.99
103_D368_L0.5840.99
21_E25_K0.5820.99
219_R365_L0.5820.99
228_K231_S0.5820.99
97_P108_S0.5810.99
82_H89_T0.5810.99
175_K180_L0.5800.99
20_E24_D0.5800.99
253_T288_I0.5800.99
251_R255_S0.5780.99
260_A264_K0.5750.99
264_K295_D0.5700.99
262_Y265_D0.5700.99
221_L372_L0.5690.99
384_L387_V0.5690.99
206_R315_D0.5680.99
284_D287_K0.5680.99
78_K81_T0.5670.99
321_T371_G0.5670.99
192_E195_K0.5670.99
115_S128_I0.5650.99
303_L353_V0.5640.99
338_Q342_Y0.5630.99
207_L235_I0.5630.99
98_A113_G0.5630.99
32_T180_L0.5620.99
14_I47_T0.5620.99
76_I123_M0.5590.99
317_I375_S0.5570.99
58_P78_K0.5560.99
136_V140_S0.5560.99
85_A168_D0.5560.99
250_T303_L0.5550.99
300_R352_V0.5550.99
73_G184_V0.5550.99
73_G126_V0.5530.99
223_K363_S0.5500.99
254_I296_A0.5500.99
250_T352_V0.5490.99
85_A132_T0.5460.99
268_S271_S0.5450.99
9_K13_F0.5450.99
288_I292_D0.5450.99
255_S259_A0.5420.99
35_I68_I0.5420.99
276_K280_T0.5410.99
83_E275_F0.5400.99
89_T332_V0.5390.99
295_D299_H0.5390.99
65_V69_L0.5380.99
210_F317_I0.5370.99
8_S11_N0.5360.99
61_N64_V0.5360.99
92_S97_P0.5350.99
255_S258_E0.5350.99
53_L266_W0.5340.99
290_A293_Y0.5330.99
111_S135_S0.5330.99
178_I358_I0.5330.99
178_I181_L0.5320.99
257_A261_S0.5320.99
211_L218_S0.5310.99
85_A130_T0.5310.99
311_F314_I0.5300.99
228_K318_L0.5300.99
47_T54_E0.5280.99
386_E390_Y0.5280.99
260_A285_G0.5280.99
33_F68_I0.5260.99
225_I237_E0.5260.99
37_D47_T0.5250.99
49_G81_T0.5240.99
141_S359_S0.5240.99
186_D382_G0.5240.99
178_I385_L0.5240.99
140_S145_V0.5230.99
282_L286_M0.5230.99
89_T327_P0.5190.99
182_R385_L0.5190.99
322_T326_A0.5190.99
360_V388_A0.5180.99
38_V160_V0.5180.99
137_R357_S0.5180.99
316_F376_G0.5170.99
115_S173_I0.5150.99
230_S394_I0.5140.99
17_H75_I0.5120.98
13_F118_A0.5110.98
210_F240_L0.5100.98
339_F342_Y0.5080.98
40_L62_A0.5080.98
14_I94_I0.5060.98
272_D279_Y0.5040.98
201_L205_P0.5040.98
363_S370_A0.5040.98
221_L224_D0.5030.98
67_A187_V0.5020.98
34_G123_M0.5020.98
317_I320_P0.5000.98
208_G311_F0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ip4A 1 0.9899 100 0.078 Contact Map
2gi3A 2 0.9749 100 0.08 Contact Map
3a2qA 2 0.9975 100 0.081 Contact Map
4wj3A 1 0.9925 100 0.081 Contact Map
2dc0A 2 0.9799 100 0.082 Contact Map
3h0lA 1 0.9925 100 0.082 Contact Map
3kfuE 1 0.9874 100 0.084 Contact Map
1o9pA 2 0.9548 100 0.098 Contact Map
4gysA 2 0.9899 100 0.1 Contact Map
4issA 2 0.9925 100 0.102 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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