GREMLIN Database
Q7LXJ9 - Uncharacterized protein
UniProt: Q7LXJ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 157 (145)
Sequences: 2607 (1840)
Seq/√Len: 152.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_D143_H4.7201.00
41_L48_Y3.9801.00
28_C104_C3.5641.00
95_F101_N2.7711.00
52_V116_F2.6451.00
50_I118_V2.5541.00
25_K77_E2.5131.00
9_M148_G2.4331.00
21_F153_K2.3141.00
14_S36_E2.2321.00
46_K124_I2.0941.00
69_N126_L2.0771.00
15_A77_E2.0671.00
15_A36_E2.0011.00
115_Y151_M1.8981.00
17_K20_D1.8781.00
117_Y149_F1.8471.00
49_A136_L1.7631.00
16_F152_G1.7601.00
41_L73_N1.7301.00
69_N125_L1.6741.00
32_D102_G1.6391.00
48_Y72_T1.6201.00
11_V118_V1.6191.00
121_I140_M1.6121.00
25_K31_Q1.5881.00
68_Y91_G1.5631.00
34_S75_L1.5321.00
91_G136_L1.4881.00
22_I103_P1.4581.00
110_P155_K1.4511.00
36_E74_R1.4461.00
111_P155_K1.4111.00
38_E74_R1.3881.00
67_I88_G1.3691.00
49_A140_M1.3621.00
117_Y147_R1.3331.00
42_V45_A1.3331.00
56_D113_R1.3301.00
13_S150_V1.3201.00
11_V148_G1.2811.00
85_S88_G1.2751.00
47_S69_N1.2741.00
136_L140_M1.2661.00
16_F23_P1.2591.00
78_G81_R1.2361.00
66_V91_G1.2271.00
47_S123_T1.2131.00
68_Y136_L1.2101.00
39_W75_L1.2051.00
22_I152_G1.1991.00
21_F155_K1.1931.00
54_D64_H1.1881.00
63_I133_A1.1851.00
139_L142_G1.1621.00
123_T143_H1.1551.00
132_N135_K1.1501.00
13_S37_L1.1471.00
76_P79_V1.1371.00
140_M144_G1.1321.00
42_V120_A1.1321.00
11_V37_L1.1040.99
10_R40_D1.0940.99
119_Y140_M1.0900.99
68_Y131_I1.0840.99
25_K33_L1.0690.99
80_P90_Q1.0690.99
115_Y149_F1.0580.99
66_V136_L1.0480.99
100_Y103_P1.0420.99
90_Q99_G1.0420.99
14_S38_E1.0390.99
48_Y73_N1.0130.99
62_F95_F0.9990.99
9_M146_E0.9960.99
49_A121_I0.9900.99
42_V48_Y0.9830.99
64_H112_H0.9640.99
53_E63_I0.9590.98
18_N151_M0.9450.98
69_N89_V0.9440.98
64_H105_P0.9400.98
48_Y118_V0.9390.98
26_Y77_E0.9320.98
53_E61_T0.9320.98
45_A48_Y0.9260.98
44_N145_I0.9180.98
33_L77_E0.9140.98
34_S65_W0.9130.98
47_S124_I0.9090.98
61_T134_D0.9080.98
119_Y144_G0.9050.98
53_E117_Y0.9020.98
26_Y36_E0.9020.98
41_L44_N0.8960.98
118_V148_G0.8920.98
105_P112_H0.8870.97
45_A145_I0.8860.97
35_P116_F0.8820.97
22_I26_Y0.8770.97
47_S125_L0.8760.97
9_M41_L0.8750.97
54_D112_H0.8680.97
60_G137_K0.8580.97
24_I29_D0.8500.97
113_R151_M0.8480.97
131_I136_L0.8460.97
68_Y89_V0.8450.97
45_A120_A0.8450.97
11_V150_V0.8450.97
52_V100_Y0.8310.96
27_T154_Y0.8270.96
19_E151_M0.8200.96
55_P115_Y0.8120.96
21_F24_I0.8120.96
40_D73_N0.7900.95
12_V38_E0.7870.95
39_W48_Y0.7820.95
44_N146_E0.7770.95
98_I130_N0.7770.95
34_S79_V0.7680.94
16_F20_D0.7670.94
12_V40_D0.7640.94
21_F111_P0.7620.94
135_K139_L0.7470.93
135_K138_S0.7370.93
15_A26_Y0.7350.93
92_V130_N0.7320.93
65_W80_P0.7310.93
65_W90_Q0.7290.92
41_L45_A0.7250.92
122_D144_G0.7190.92
16_F150_V0.7190.92
32_D101_N0.7180.92
32_D95_F0.7180.92
120_A145_I0.7070.91
54_D105_P0.7000.91
131_I135_K0.6990.91
51_I140_M0.6820.90
107_K111_P0.6800.90
28_C101_N0.6720.89
62_F101_N0.6710.89
13_S16_F0.6680.89
67_I90_Q0.6650.89
92_V96_G0.6570.88
93_N101_N0.6550.88
37_L116_F0.6550.88
144_G147_R0.6510.87
57_A62_F0.6510.87
38_E73_N0.6510.87
37_L50_I0.6480.87
67_I70_I0.6470.87
80_P84_K0.6440.87
62_F106_P0.6340.86
37_L150_V0.6340.86
66_V133_A0.6330.86
19_E153_K0.6320.86
91_G133_A0.6270.85
32_D97_N0.6240.85
20_D153_K0.6230.85
54_D57_A0.6210.85
56_D112_H0.6200.85
16_F22_I0.6200.85
133_A137_K0.6180.85
111_P153_K0.6170.85
141_E147_R0.6170.85
53_E133_A0.6140.84
69_N123_T0.6130.84
62_F138_S0.6070.84
24_I27_T0.6020.83
97_N101_N0.6000.83
14_S74_R0.5990.83
50_I70_I0.5930.82
23_P26_Y0.5900.82
24_I31_Q0.5890.82
53_E137_K0.5870.82
127_E136_L0.5850.81
57_A94_D0.5840.81
140_M143_H0.5840.81
92_V98_I0.5770.80
39_W118_V0.5750.80
23_P27_T0.5750.80
64_H106_P0.5750.80
81_R90_Q0.5730.80
21_F27_T0.5730.80
39_W68_Y0.5700.80
62_F135_K0.5690.80
53_E115_Y0.5680.79
33_L78_G0.5650.79
93_N97_N0.5620.79
28_C32_D0.5600.78
41_L146_E0.5570.78
127_E131_I0.5540.78
128_I131_I0.5520.77
18_N150_V0.5520.77
29_D154_Y0.5510.77
49_A119_Y0.5490.77
106_P112_H0.5490.77
22_I27_T0.5480.77
105_P108_T0.5450.77
62_F94_D0.5350.75
22_I25_K0.5310.75
61_T137_K0.5300.75
51_I133_A0.5260.74
98_I129_K0.5260.74
42_V146_E0.5260.74
122_D145_I0.5240.74
90_Q98_I0.5190.73
117_Y137_K0.5160.73
89_V129_K0.5140.72
94_D101_N0.5130.72
67_I80_P0.5090.72
39_W146_E0.5080.71
56_D64_H0.5070.71
118_V147_R0.5070.71
62_F93_N0.5040.71
11_V50_I0.5020.71
47_S72_T0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n08A 2 0.9236 100 0.188 Contact Map
1fuxA 2 0.9618 100 0.189 Contact Map
1fjjA 2 0.9363 100 0.205 Contact Map
4begA 4 1 100 0.206 Contact Map
2evvA 2 0.9299 100 0.237 Contact Map
1wpxB 1 0.9172 99.9 0.533 Contact Map
2iqyA 1 0.8726 99.9 0.566 Contact Map
2gzqA 1 0.8981 99.9 0.566 Contact Map
3axyA 1 0.8471 99.9 0.569 Contact Map
2jyzA 1 0.879 99.9 0.569 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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