GREMLIN Database
Q7LXJ2 - Uncharacterized protein
UniProt: Q7LXJ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 360 (327)
Sequences: 851 (679)
Seq/√Len: 37.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_L94_T5.6791.00
177_I201_P5.2381.00
270_N275_A4.3091.00
63_N66_W3.9041.00
98_T107_I3.6901.00
94_T176_V3.6541.00
113_G181_G3.3641.00
114_Q181_G3.1431.00
303_L315_A3.0881.00
113_G242_R3.0711.00
91_T178_D3.0191.00
249_Y330_R3.0111.00
55_C205_I2.9891.00
181_G187_N2.9221.00
45_Y48_N2.8751.00
177_I199_I2.8151.00
112_V180_D2.8021.00
67_D70_V2.7901.00
133_L136_E2.7151.00
169_T175_T2.5571.00
113_G182_W2.4741.00
182_W185_G2.3361.00
113_G187_N2.3091.00
181_G242_R2.2931.00
275_A278_E2.2460.99
108_I175_T2.2230.99
273_Y278_E2.1720.99
66_W70_V2.1460.99
158_H180_D2.1420.99
114_Q242_R2.0740.99
145_F340_G2.0330.99
108_I125_E2.0260.99
90_K181_G1.9770.99
122_F314_A1.9490.98
303_L317_L1.9400.98
56_K63_N1.9340.98
14_K52_E1.9070.98
178_D187_N1.8950.98
305_I334_F1.8900.98
125_E169_T1.8250.97
111_D114_Q1.8170.97
81_L196_I1.7960.97
95_N116_T1.7570.97
94_T107_I1.7340.97
91_T181_G1.7290.96
42_T46_D1.7230.96
81_L192_K1.7220.96
315_A327_I1.7170.96
106_K127_K1.6900.96
271_I325_I1.6850.96
56_K59_L1.6830.96
178_D181_G1.6810.96
109_D245_K1.6770.96
45_Y49_T1.6480.95
88_S180_D1.6470.95
13_I43_L1.6290.95
123_I165_L1.6270.95
86_V238_R1.6170.95
101_A105_L1.6140.95
28_Q33_L1.5990.95
90_K242_R1.5990.95
178_D182_W1.5950.94
114_Q187_N1.5740.94
312_I331_V1.5410.93
114_Q182_W1.5360.93
182_W187_N1.5110.93
158_H337_L1.4900.92
125_E175_T1.4830.92
298_L319_D1.4680.92
86_V113_G1.4510.91
32_L177_I1.4340.91
60_D63_N1.4250.90
80_V205_I1.4150.90
113_G185_G1.4140.90
299_K318_D1.4070.90
113_G178_D1.3940.89
208_D228_S1.3940.89
87_D238_R1.3820.89
269_S275_A1.3780.89
108_I177_I1.3730.89
111_D182_W1.3700.88
66_W73_I1.3580.88
150_T182_W1.3360.87
154_N157_L1.3320.87
54_D63_N1.3180.86
270_N278_E1.3150.86
101_A174_L1.3140.86
35_I46_D1.3100.86
114_Q178_D1.2990.86
35_I41_Y1.2960.85
144_E164_R1.2850.85
204_I219_Y1.2840.85
63_N67_D1.2820.85
20_A27_I1.2740.84
109_D123_I1.2730.84
123_I146_F1.2730.84
258_T262_N1.2720.84
84_G111_D1.2640.84
146_F161_K1.2620.84
59_L63_N1.2560.84
318_D326_T1.2540.83
63_N70_V1.2510.83
150_T155_P1.2400.83
106_K169_T1.2310.82
68_E72_E1.2250.82
273_Y276_W1.2220.82
109_D117_L1.2210.82
55_C58_L1.1960.80
36_P46_D1.1880.80
269_S273_Y1.1780.79
123_I329_S1.1750.79
177_I200_D1.1720.79
19_E47_E1.1680.79
35_I43_L1.1670.79
81_L201_P1.1650.79
145_F304_G1.1640.79
109_D178_D1.1570.78
270_N276_W1.1570.78
83_L189_M1.1540.78
190_L226_L1.1500.78
110_A195_L1.1480.78
319_D326_T1.1460.77
258_T261_E1.1420.77
55_C59_L1.1380.77
66_W69_I1.1340.77
92_Y344_L1.1220.76
183_T187_N1.1180.76
159_V317_L1.1180.76
268_I275_A1.1150.75
118_F176_V1.1140.75
111_D181_G1.1130.75
99_N102_T1.1120.75
270_N273_Y1.1120.75
112_V146_F1.1080.75
109_D182_W1.1060.75
23_L42_T1.1050.75
165_L250_F1.0930.74
119_L196_I1.0920.74
90_K113_G1.0800.73
99_N131_K1.0770.73
177_I234_S1.0690.72
87_D233_K1.0670.72
82_L203_Y1.0650.72
328_L339_L1.0630.72
91_T109_D1.0610.72
90_K178_D1.0600.72
268_I273_Y1.0590.72
158_H253_A1.0540.71
35_I42_T1.0480.71
175_T179_T1.0390.70
166_Y199_I1.0330.70
88_S207_F1.0310.70
301_A339_L1.0270.69
109_D236_S1.0230.69
118_F180_D1.0170.68
150_T181_G1.0170.68
109_D114_Q1.0080.68
36_P44_V0.9900.66
125_E165_L0.9840.66
19_E26_E0.9800.66
304_G311_V0.9760.65
96_L100_L0.9720.65
68_E302_L0.9700.65
170_P200_D0.9660.64
185_G242_R0.9660.64
268_I274_C0.9610.64
13_I28_Q0.9580.64
70_V73_I0.9540.63
159_V167_E0.9500.63
163_L198_T0.9390.62
267_Q324_E0.9380.62
36_P49_T0.9380.62
86_V115_S0.9370.62
116_T299_K0.9360.62
201_P280_I0.9310.62
84_G90_K0.9310.62
313_G329_S0.9300.61
84_G147_G0.9270.61
34_T43_L0.9250.61
305_I317_L0.9220.61
15_V49_T0.9180.60
249_Y313_G0.9180.60
82_L96_L0.9160.60
93_L205_I0.9140.60
109_D115_S0.9120.60
45_Y54_D0.9100.60
306_I311_V0.9080.60
33_L41_Y0.9060.59
270_N274_C0.9050.59
144_E250_F0.9040.59
101_A125_E0.9030.59
34_T307_E0.9000.59
36_P39_K0.8970.59
87_D115_S0.8950.58
122_F244_A0.8890.58
90_K176_V0.8860.58
122_F311_V0.8860.58
114_Q131_K0.8840.58
220_R317_L0.8840.58
250_F330_R0.8820.57
13_I80_V0.8800.57
291_Y327_I0.8770.57
54_D60_D0.8760.57
77_V174_L0.8650.56
181_G184_V0.8630.56
204_I337_L0.8580.55
95_N117_L0.8520.55
20_A43_L0.8520.55
100_L103_S0.8470.54
15_V144_E0.8470.54
269_S278_E0.8470.54
181_G185_G0.8470.54
98_T128_P0.8470.54
145_F245_K0.8460.54
92_Y314_A0.8360.53
263_L266_K0.8360.53
128_P310_K0.8360.53
10_P68_E0.8300.53
106_K125_E0.8240.52
81_L162_I0.8220.52
43_L176_V0.8210.52
86_V184_V0.8200.52
113_G183_T0.8180.52
166_Y169_T0.8150.51
98_T118_F0.8140.51
289_T298_L0.8140.51
90_K179_T0.8130.51
18_G24_G0.8120.51
192_K196_I0.8110.51
36_P41_Y0.8110.51
16_L82_L0.8100.51
32_L317_L0.8090.51
157_L161_K0.8090.51
21_R81_L0.8080.51
12_T45_Y0.8040.50
123_I236_S0.8030.50
187_N191_H0.8020.50
163_L194_E0.7970.50
21_R28_Q0.7910.49
307_E310_K0.7900.49
82_L93_L0.7880.49
119_L302_L0.7870.49
317_L321_K0.7870.49
21_R100_L0.7840.49
18_G84_G0.7820.48
146_F298_L0.7770.48
49_T53_T0.7770.48
88_S215_L0.7760.48
267_Q270_N0.7730.48
155_P191_H0.7710.48
87_D236_S0.7680.47
105_L173_R0.7680.47
194_E198_T0.7660.47
81_L177_I0.7650.47
55_C204_I0.7620.47
82_L262_N0.7580.46
95_N260_S0.7570.46
15_V18_G0.7560.46
40_T54_D0.7540.46
16_L20_A0.7540.46
86_V114_Q0.7530.46
216_P219_Y0.7520.46
67_D72_E0.7470.45
54_D58_L0.7460.45
205_I270_N0.7430.45
91_T196_I0.7410.45
108_I169_T0.7410.45
18_G89_G0.7350.44
21_R103_S0.7340.44
182_W242_R0.7300.44
117_L128_P0.7270.44
116_T178_D0.7260.44
22_I175_T0.7250.43
249_Y304_G0.7220.43
165_L199_I0.7220.43
17_E50_R0.7200.43
35_I44_V0.7180.43
20_A23_L0.7180.43
99_N128_P0.7170.43
243_I246_Y0.7130.42
271_I276_W0.7120.42
123_I323_N0.7110.42
152_S219_Y0.7080.42
305_I312_I0.7060.42
22_I99_N0.7060.42
114_Q185_G0.7050.42
10_P82_L0.7020.41
269_S323_N0.6990.41
35_I39_K0.6980.41
323_N337_L0.6960.41
15_V20_A0.6960.41
225_L230_N0.6940.41
119_L189_M0.6920.41
312_I333_K0.6920.41
65_R68_E0.6910.41
341_Y344_L0.6850.40
206_V212_K0.6840.40
74_I224_I0.6810.40
40_T231_L0.6810.40
95_N330_R0.6800.40
20_A128_P0.6790.39
180_D233_K0.6790.39
335_T343_S0.6760.39
143_L328_L0.6750.39
119_L176_V0.6740.39
88_S112_V0.6730.39
113_G238_R0.6720.39
81_L200_D0.6720.39
107_I149_I0.6720.39
56_K60_D0.6700.39
274_C278_E0.6700.39
322_E341_Y0.6690.39
311_V318_D0.6670.38
173_R202_D0.6670.38
91_T116_T0.6650.38
21_R250_F0.6630.38
23_L45_Y0.6610.38
334_F344_L0.6610.38
21_R44_V0.6600.38
327_I331_V0.6580.38
118_F187_N0.6560.38
50_R255_N0.6560.38
204_I292_Y0.6550.37
20_A49_T0.6540.37
128_P177_I0.6520.37
102_T124_A0.6500.37
205_I341_Y0.6490.37
21_R48_N0.6490.37
122_F143_L0.6490.37
90_K151_P0.6480.37
311_V326_T0.6460.37
273_Y279_Y0.6460.37
39_K42_T0.6460.37
98_T110_A0.6420.36
222_K317_L0.6420.36
106_K270_N0.6420.36
272_L275_A0.6380.36
126_L165_L0.6380.36
157_L298_L0.6380.36
300_G323_N0.6370.36
122_F248_R0.6360.36
290_D293_I0.6360.36
239_K244_A0.6350.36
73_I78_G0.6330.36
67_D71_E0.6330.36
257_K260_S0.6330.36
221_N324_E0.6300.35
290_D307_E0.6270.35
158_H187_N0.6270.35
81_L249_Y0.6240.35
78_G81_L0.6220.35
105_L166_Y0.6210.35
284_D323_N0.6200.35
152_S314_A0.6190.35
91_T139_G0.6180.34
42_T48_N0.6180.34
90_K114_Q0.6160.34
203_Y224_I0.6130.34
78_G174_L0.6120.34
227_K335_T0.6110.34
111_D207_F0.6110.34
155_P186_L0.6100.34
226_L304_G0.6100.34
99_N124_A0.6100.34
117_L325_I0.6080.34
151_P182_W0.6070.34
55_C226_L0.6060.33
22_I31_D0.6030.33
167_E327_I0.6030.33
44_V333_K0.6020.33
150_T317_L0.6010.33
163_L177_I0.5990.33
11_C41_Y0.5990.33
68_E71_E0.5990.33
243_I343_S0.5970.33
280_I284_D0.5970.33
46_D49_T0.5960.33
162_I195_L0.5950.33
166_Y177_I0.5950.33
11_C88_S0.5930.32
128_P170_P0.5910.32
237_E341_Y0.5900.32
194_E197_Y0.5900.32
147_G184_V0.5880.32
143_L314_A0.5850.32
123_I191_H0.5850.32
87_D242_R0.5830.32
128_P305_I0.5830.32
13_I18_G0.5810.32
128_P155_P0.5810.32
108_I116_T0.5810.32
207_F327_I0.5790.31
306_I335_T0.5790.31
113_G131_K0.5790.31
107_I305_I0.5790.31
176_V254_K0.5780.31
69_I325_I0.5780.31
140_Y315_A0.5770.31
105_L199_I0.5750.31
207_F321_K0.5750.31
86_V182_W0.5740.31
76_T302_L0.5730.31
45_Y224_I0.5720.31
111_D242_R0.5710.31
152_S155_P0.5700.31
26_E48_N0.5690.31
81_L204_I0.5660.30
69_I73_I0.5640.30
23_L78_G0.5620.30
109_D113_G0.5600.30
108_I192_K0.5600.30
36_P42_T0.5570.30
204_I236_S0.5560.30
141_D252_E0.5560.30
43_L183_T0.5560.30
333_K342_I0.5550.30
150_T168_T0.5550.30
59_L120_P0.5530.29
150_T191_H0.5530.29
185_G305_I0.5530.29
25_I306_I0.5520.29
207_F227_K0.5520.29
212_K228_S0.5520.29
116_T136_E0.5510.29
60_D67_D0.5510.29
317_L325_I0.5500.29
40_T204_I0.5500.29
166_Y317_L0.5480.29
202_D322_E0.5470.29
12_T32_L0.5470.29
33_L36_P0.5460.29
131_K187_N0.5460.29
214_S232_H0.5450.29
70_V74_I0.5440.29
126_L158_H0.5430.29
114_Q183_T0.5420.29
43_L46_D0.5410.29
86_V178_D0.5410.29
202_D303_L0.5410.29
29_K88_S0.5400.28
13_I53_T0.5390.28
135_L248_R0.5380.28
75_N274_C0.5380.28
133_L297_L0.5370.28
192_K207_F0.5370.28
256_I259_L0.5370.28
118_F145_F0.5370.28
176_V179_T0.5350.28
58_L156_R0.5330.28
66_W71_E0.5330.28
159_V197_Y0.5320.28
30_N186_L0.5320.28
154_N299_K0.5300.28
144_E340_G0.5290.28
103_S144_E0.5270.28
158_H313_G0.5270.28
314_A325_I0.5260.27
313_G330_R0.5250.27
80_V323_N0.5240.27
133_L137_E0.5240.27
10_P298_L0.5230.27
66_W74_I0.5200.27
92_Y293_I0.5200.27
226_L229_V0.5200.27
223_A262_N0.5190.27
30_N292_Y0.5180.27
89_G114_Q0.5180.27
174_L206_V0.5170.27
246_Y314_A0.5160.27
91_T131_K0.5160.27
83_L180_D0.5150.27
264_L337_L0.5150.27
82_L204_I0.5140.27
230_N310_K0.5140.27
96_L176_V0.5140.27
36_P204_I0.5140.27
306_I318_D0.5140.27
121_T154_N0.5120.26
115_S125_E0.5120.26
89_G178_D0.5120.26
298_L303_L0.5110.26
301_A336_G0.5100.26
117_L136_E0.5100.26
294_P298_L0.5080.26
24_G99_N0.5070.26
109_D237_E0.5040.26
77_V250_F0.5040.26
43_L57_K0.5020.26
159_V205_I0.5010.26
140_Y180_D0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ohxA 1 0.9222 100 0.601 Contact Map
4oi4A 1 0.95 100 0.614 Contact Map
1nksA 5 0.5083 97.3 0.912 Contact Map
2cdnA 1 0.5111 97.3 0.912 Contact Map
1khtA 5 0.5083 97.3 0.912 Contact Map
1akyA 1 0.5306 97.2 0.914 Contact Map
5aunB 2 0.6083 97.1 0.914 Contact Map
4qbgB 1 0.5361 97.1 0.915 Contact Map
2c95A 1 0.5361 97 0.916 Contact Map
1xjcA 2 0.3806 96.9 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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