Q7LXJ2 - SULSO - GREMLIN Contacts

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Q7LXJ2 - Uncharacterized protein

UniProt:	Q7LXJ2	Sequences: MKKEQIIQGPCTIKVLEGEARILGIEIQKNDLLTIPSDKTYTLVYDENTRLETDCKKLLDNLNLRWDEIVEEIINTVGVVLLLGNVDSGKTYLTNLFTNLATSYLKIIDADVGQSTLFLPTFIAELKPMRKTLNLEELGYDTLEFFGDITPSTNPRLHVQKILRLYETTPKERLTVIDTDGWTVGLNSMLHKFELIYTIDPDYIIVFDQKIKDSLPENYRNKAILLKSVNLHKSRSERKANRIAKYERYFKEAKNIKTLSENLLGKQISNILYCAWGEYIQLSDEEPCTDYYIPLNLLKGALLGIIENKKVIGAALLDDLKENEITILSRVNKFTGLVLGYISLNDKFEERRIRFRKCKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	360 (327)
Sequences:	851 (679)
Seq/√Len:	37.6

SULSO - Q7LXJ2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
82_L	94_T	5.679	1.00
177_I	201_P	5.238	1.00
270_N	275_A	4.309	1.00
63_N	66_W	3.904	1.00
98_T	107_I	3.690	1.00
94_T	176_V	3.654	1.00
113_G	181_G	3.364	1.00
114_Q	181_G	3.143	1.00
303_L	315_A	3.088	1.00
113_G	242_R	3.071	1.00
91_T	178_D	3.019	1.00
249_Y	330_R	3.011	1.00
55_C	205_I	2.989	1.00
181_G	187_N	2.922	1.00
45_Y	48_N	2.875	1.00
177_I	199_I	2.815	1.00
112_V	180_D	2.802	1.00
67_D	70_V	2.790	1.00
133_L	136_E	2.715	1.00
169_T	175_T	2.557	1.00
113_G	182_W	2.474	1.00
182_W	185_G	2.336	1.00
113_G	187_N	2.309	1.00
181_G	242_R	2.293	1.00
275_A	278_E	2.246	0.99
108_I	175_T	2.223	0.99
273_Y	278_E	2.172	0.99
66_W	70_V	2.146	0.99
158_H	180_D	2.142	0.99
114_Q	242_R	2.074	0.99
145_F	340_G	2.033	0.99
108_I	125_E	2.026	0.99
90_K	181_G	1.977	0.99
122_F	314_A	1.949	0.98
303_L	317_L	1.940	0.98
56_K	63_N	1.934	0.98
14_K	52_E	1.907	0.98
178_D	187_N	1.895	0.98
305_I	334_F	1.890	0.98
125_E	169_T	1.825	0.97
111_D	114_Q	1.817	0.97
81_L	196_I	1.796	0.97
95_N	116_T	1.757	0.97
94_T	107_I	1.734	0.97
91_T	181_G	1.729	0.96
42_T	46_D	1.723	0.96
81_L	192_K	1.722	0.96
315_A	327_I	1.717	0.96
106_K	127_K	1.690	0.96
271_I	325_I	1.685	0.96
56_K	59_L	1.683	0.96
178_D	181_G	1.681	0.96
109_D	245_K	1.677	0.96
45_Y	49_T	1.648	0.95
88_S	180_D	1.647	0.95
13_I	43_L	1.629	0.95
123_I	165_L	1.627	0.95
86_V	238_R	1.617	0.95
101_A	105_L	1.614	0.95
28_Q	33_L	1.599	0.95
90_K	242_R	1.599	0.95
178_D	182_W	1.595	0.94
114_Q	187_N	1.574	0.94
312_I	331_V	1.541	0.93
114_Q	182_W	1.536	0.93
182_W	187_N	1.511	0.93
158_H	337_L	1.490	0.92
125_E	175_T	1.483	0.92
298_L	319_D	1.468	0.92
86_V	113_G	1.451	0.91
32_L	177_I	1.434	0.91
60_D	63_N	1.425	0.90
80_V	205_I	1.415	0.90
113_G	185_G	1.414	0.90
299_K	318_D	1.407	0.90
113_G	178_D	1.394	0.89
208_D	228_S	1.394	0.89
87_D	238_R	1.382	0.89
269_S	275_A	1.378	0.89
108_I	177_I	1.373	0.89
111_D	182_W	1.370	0.88
66_W	73_I	1.358	0.88
150_T	182_W	1.336	0.87
154_N	157_L	1.332	0.87
54_D	63_N	1.318	0.86
270_N	278_E	1.315	0.86
101_A	174_L	1.314	0.86
35_I	46_D	1.310	0.86
114_Q	178_D	1.299	0.86
35_I	41_Y	1.296	0.85
144_E	164_R	1.285	0.85
204_I	219_Y	1.284	0.85
63_N	67_D	1.282	0.85
20_A	27_I	1.274	0.84
109_D	123_I	1.273	0.84
123_I	146_F	1.273	0.84
258_T	262_N	1.272	0.84
84_G	111_D	1.264	0.84
146_F	161_K	1.262	0.84
59_L	63_N	1.256	0.84
318_D	326_T	1.254	0.83
63_N	70_V	1.251	0.83
150_T	155_P	1.240	0.83
106_K	169_T	1.231	0.82
68_E	72_E	1.225	0.82
273_Y	276_W	1.222	0.82
109_D	117_L	1.221	0.82
55_C	58_L	1.196	0.80
36_P	46_D	1.188	0.80
269_S	273_Y	1.178	0.79
123_I	329_S	1.175	0.79
177_I	200_D	1.172	0.79
19_E	47_E	1.168	0.79
35_I	43_L	1.167	0.79
81_L	201_P	1.165	0.79
145_F	304_G	1.164	0.79
109_D	178_D	1.157	0.78
270_N	276_W	1.157	0.78
83_L	189_M	1.154	0.78
190_L	226_L	1.150	0.78
110_A	195_L	1.148	0.78
319_D	326_T	1.146	0.77
258_T	261_E	1.142	0.77
55_C	59_L	1.138	0.77
66_W	69_I	1.134	0.77
92_Y	344_L	1.122	0.76
183_T	187_N	1.118	0.76
159_V	317_L	1.118	0.76
268_I	275_A	1.115	0.75
118_F	176_V	1.114	0.75
111_D	181_G	1.113	0.75
99_N	102_T	1.112	0.75
270_N	273_Y	1.112	0.75
112_V	146_F	1.108	0.75
109_D	182_W	1.106	0.75
23_L	42_T	1.105	0.75
165_L	250_F	1.093	0.74
119_L	196_I	1.092	0.74
90_K	113_G	1.080	0.73
99_N	131_K	1.077	0.73
177_I	234_S	1.069	0.72
87_D	233_K	1.067	0.72
82_L	203_Y	1.065	0.72
328_L	339_L	1.063	0.72
91_T	109_D	1.061	0.72
90_K	178_D	1.060	0.72
268_I	273_Y	1.059	0.72
158_H	253_A	1.054	0.71
35_I	42_T	1.048	0.71
175_T	179_T	1.039	0.70
166_Y	199_I	1.033	0.70
88_S	207_F	1.031	0.70
301_A	339_L	1.027	0.69
109_D	236_S	1.023	0.69
118_F	180_D	1.017	0.68
150_T	181_G	1.017	0.68
109_D	114_Q	1.008	0.68
36_P	44_V	0.990	0.66
125_E	165_L	0.984	0.66
19_E	26_E	0.980	0.66
304_G	311_V	0.976	0.65
96_L	100_L	0.972	0.65
68_E	302_L	0.970	0.65
170_P	200_D	0.966	0.64
185_G	242_R	0.966	0.64
268_I	274_C	0.961	0.64
13_I	28_Q	0.958	0.64
70_V	73_I	0.954	0.63
159_V	167_E	0.950	0.63
163_L	198_T	0.939	0.62
267_Q	324_E	0.938	0.62
36_P	49_T	0.938	0.62
86_V	115_S	0.937	0.62
116_T	299_K	0.936	0.62
201_P	280_I	0.931	0.62
84_G	90_K	0.931	0.62
313_G	329_S	0.930	0.61
84_G	147_G	0.927	0.61
34_T	43_L	0.925	0.61
305_I	317_L	0.922	0.61
15_V	49_T	0.918	0.60
249_Y	313_G	0.918	0.60
82_L	96_L	0.916	0.60
93_L	205_I	0.914	0.60
109_D	115_S	0.912	0.60
45_Y	54_D	0.910	0.60
306_I	311_V	0.908	0.60
33_L	41_Y	0.906	0.59
270_N	274_C	0.905	0.59
144_E	250_F	0.904	0.59
101_A	125_E	0.903	0.59
34_T	307_E	0.900	0.59
36_P	39_K	0.897	0.59
87_D	115_S	0.895	0.58
122_F	244_A	0.889	0.58
90_K	176_V	0.886	0.58
122_F	311_V	0.886	0.58
114_Q	131_K	0.884	0.58
220_R	317_L	0.884	0.58
250_F	330_R	0.882	0.57
13_I	80_V	0.880	0.57
291_Y	327_I	0.877	0.57
54_D	60_D	0.876	0.57
77_V	174_L	0.865	0.56
181_G	184_V	0.863	0.56
204_I	337_L	0.858	0.55
95_N	117_L	0.852	0.55
20_A	43_L	0.852	0.55
100_L	103_S	0.847	0.54
15_V	144_E	0.847	0.54
269_S	278_E	0.847	0.54
181_G	185_G	0.847	0.54
98_T	128_P	0.847	0.54
145_F	245_K	0.846	0.54
92_Y	314_A	0.836	0.53
263_L	266_K	0.836	0.53
128_P	310_K	0.836	0.53
10_P	68_E	0.830	0.53
106_K	125_E	0.824	0.52
81_L	162_I	0.822	0.52
43_L	176_V	0.821	0.52
86_V	184_V	0.820	0.52
113_G	183_T	0.818	0.52
166_Y	169_T	0.815	0.51
98_T	118_F	0.814	0.51
289_T	298_L	0.814	0.51
90_K	179_T	0.813	0.51
18_G	24_G	0.812	0.51
192_K	196_I	0.811	0.51
36_P	41_Y	0.811	0.51
16_L	82_L	0.810	0.51
32_L	317_L	0.809	0.51
157_L	161_K	0.809	0.51
21_R	81_L	0.808	0.51
12_T	45_Y	0.804	0.50
123_I	236_S	0.803	0.50
187_N	191_H	0.802	0.50
163_L	194_E	0.797	0.50
21_R	28_Q	0.791	0.49
307_E	310_K	0.790	0.49
82_L	93_L	0.788	0.49
119_L	302_L	0.787	0.49
317_L	321_K	0.787	0.49
21_R	100_L	0.784	0.49
18_G	84_G	0.782	0.48
146_F	298_L	0.777	0.48
49_T	53_T	0.777	0.48
88_S	215_L	0.776	0.48
267_Q	270_N	0.773	0.48
155_P	191_H	0.771	0.48
87_D	236_S	0.768	0.47
105_L	173_R	0.768	0.47
194_E	198_T	0.766	0.47
81_L	177_I	0.765	0.47
55_C	204_I	0.762	0.47
82_L	262_N	0.758	0.46
95_N	260_S	0.757	0.46
15_V	18_G	0.756	0.46
40_T	54_D	0.754	0.46
16_L	20_A	0.754	0.46
86_V	114_Q	0.753	0.46
216_P	219_Y	0.752	0.46
67_D	72_E	0.747	0.45
54_D	58_L	0.746	0.45
205_I	270_N	0.743	0.45
91_T	196_I	0.741	0.45
108_I	169_T	0.741	0.45
18_G	89_G	0.735	0.44
21_R	103_S	0.734	0.44
182_W	242_R	0.730	0.44
117_L	128_P	0.727	0.44
116_T	178_D	0.726	0.44
22_I	175_T	0.725	0.43
249_Y	304_G	0.722	0.43
165_L	199_I	0.722	0.43
17_E	50_R	0.720	0.43
35_I	44_V	0.718	0.43
20_A	23_L	0.718	0.43
99_N	128_P	0.717	0.43
243_I	246_Y	0.713	0.42
271_I	276_W	0.712	0.42
123_I	323_N	0.711	0.42
152_S	219_Y	0.708	0.42
305_I	312_I	0.706	0.42
22_I	99_N	0.706	0.42
114_Q	185_G	0.705	0.42
10_P	82_L	0.702	0.41
269_S	323_N	0.699	0.41
35_I	39_K	0.698	0.41
323_N	337_L	0.696	0.41
15_V	20_A	0.696	0.41
225_L	230_N	0.694	0.41
119_L	189_M	0.692	0.41
312_I	333_K	0.692	0.41
65_R	68_E	0.691	0.41
341_Y	344_L	0.685	0.40
206_V	212_K	0.684	0.40
74_I	224_I	0.681	0.40
40_T	231_L	0.681	0.40
95_N	330_R	0.680	0.40
20_A	128_P	0.679	0.39
180_D	233_K	0.679	0.39
335_T	343_S	0.676	0.39
143_L	328_L	0.675	0.39
119_L	176_V	0.674	0.39
88_S	112_V	0.673	0.39
113_G	238_R	0.672	0.39
81_L	200_D	0.672	0.39
107_I	149_I	0.672	0.39
56_K	60_D	0.670	0.39
274_C	278_E	0.670	0.39
322_E	341_Y	0.669	0.39
311_V	318_D	0.667	0.38
173_R	202_D	0.667	0.38
91_T	116_T	0.665	0.38
21_R	250_F	0.663	0.38
23_L	45_Y	0.661	0.38
334_F	344_L	0.661	0.38
21_R	44_V	0.660	0.38
327_I	331_V	0.658	0.38
118_F	187_N	0.656	0.38
50_R	255_N	0.656	0.38
204_I	292_Y	0.655	0.37
20_A	49_T	0.654	0.37
128_P	177_I	0.652	0.37
102_T	124_A	0.650	0.37
205_I	341_Y	0.649	0.37
21_R	48_N	0.649	0.37
122_F	143_L	0.649	0.37
90_K	151_P	0.648	0.37
311_V	326_T	0.646	0.37
273_Y	279_Y	0.646	0.37
39_K	42_T	0.646	0.37
98_T	110_A	0.642	0.36
222_K	317_L	0.642	0.36
106_K	270_N	0.642	0.36
272_L	275_A	0.638	0.36
126_L	165_L	0.638	0.36
157_L	298_L	0.638	0.36
300_G	323_N	0.637	0.36
122_F	248_R	0.636	0.36
290_D	293_I	0.636	0.36
239_K	244_A	0.635	0.36
73_I	78_G	0.633	0.36
67_D	71_E	0.633	0.36
257_K	260_S	0.633	0.36
221_N	324_E	0.630	0.35
290_D	307_E	0.627	0.35
158_H	187_N	0.627	0.35
81_L	249_Y	0.624	0.35
78_G	81_L	0.622	0.35
105_L	166_Y	0.621	0.35
284_D	323_N	0.620	0.35
152_S	314_A	0.619	0.35
91_T	139_G	0.618	0.34
42_T	48_N	0.618	0.34
90_K	114_Q	0.616	0.34
203_Y	224_I	0.613	0.34
78_G	174_L	0.612	0.34
227_K	335_T	0.611	0.34
111_D	207_F	0.611	0.34
155_P	186_L	0.610	0.34
226_L	304_G	0.610	0.34
99_N	124_A	0.610	0.34
117_L	325_I	0.608	0.34
151_P	182_W	0.607	0.34
55_C	226_L	0.606	0.33
22_I	31_D	0.603	0.33
167_E	327_I	0.603	0.33
44_V	333_K	0.602	0.33
150_T	317_L	0.601	0.33
163_L	177_I	0.599	0.33
11_C	41_Y	0.599	0.33
68_E	71_E	0.599	0.33
243_I	343_S	0.597	0.33
280_I	284_D	0.597	0.33
46_D	49_T	0.596	0.33
162_I	195_L	0.595	0.33
166_Y	177_I	0.595	0.33
11_C	88_S	0.593	0.32
128_P	170_P	0.591	0.32
237_E	341_Y	0.590	0.32
194_E	197_Y	0.590	0.32
147_G	184_V	0.588	0.32
143_L	314_A	0.585	0.32
123_I	191_H	0.585	0.32
87_D	242_R	0.583	0.32
128_P	305_I	0.583	0.32
13_I	18_G	0.581	0.32
128_P	155_P	0.581	0.32
108_I	116_T	0.581	0.32
207_F	327_I	0.579	0.31
306_I	335_T	0.579	0.31
113_G	131_K	0.579	0.31
107_I	305_I	0.579	0.31
176_V	254_K	0.578	0.31
69_I	325_I	0.578	0.31
140_Y	315_A	0.577	0.31
105_L	199_I	0.575	0.31
207_F	321_K	0.575	0.31
86_V	182_W	0.574	0.31
76_T	302_L	0.573	0.31
45_Y	224_I	0.572	0.31
111_D	242_R	0.571	0.31
152_S	155_P	0.570	0.31
26_E	48_N	0.569	0.31
81_L	204_I	0.566	0.30
69_I	73_I	0.564	0.30
23_L	78_G	0.562	0.30
109_D	113_G	0.560	0.30
108_I	192_K	0.560	0.30
36_P	42_T	0.557	0.30
204_I	236_S	0.556	0.30
141_D	252_E	0.556	0.30
43_L	183_T	0.556	0.30
333_K	342_I	0.555	0.30
150_T	168_T	0.555	0.30
59_L	120_P	0.553	0.29
150_T	191_H	0.553	0.29
185_G	305_I	0.553	0.29
25_I	306_I	0.552	0.29
207_F	227_K	0.552	0.29
212_K	228_S	0.552	0.29
116_T	136_E	0.551	0.29
60_D	67_D	0.551	0.29
317_L	325_I	0.550	0.29
40_T	204_I	0.550	0.29
166_Y	317_L	0.548	0.29
202_D	322_E	0.547	0.29
12_T	32_L	0.547	0.29
33_L	36_P	0.546	0.29
131_K	187_N	0.546	0.29
214_S	232_H	0.545	0.29
70_V	74_I	0.544	0.29
126_L	158_H	0.543	0.29
114_Q	183_T	0.542	0.29
43_L	46_D	0.541	0.29
86_V	178_D	0.541	0.29
202_D	303_L	0.541	0.29
29_K	88_S	0.540	0.28
13_I	53_T	0.539	0.28
135_L	248_R	0.538	0.28
75_N	274_C	0.538	0.28
133_L	297_L	0.537	0.28
192_K	207_F	0.537	0.28
256_I	259_L	0.537	0.28
118_F	145_F	0.537	0.28
176_V	179_T	0.535	0.28
58_L	156_R	0.533	0.28
66_W	71_E	0.533	0.28
159_V	197_Y	0.532	0.28
30_N	186_L	0.532	0.28
154_N	299_K	0.530	0.28
144_E	340_G	0.529	0.28
103_S	144_E	0.527	0.28
158_H	313_G	0.527	0.28
314_A	325_I	0.526	0.27
313_G	330_R	0.525	0.27
80_V	323_N	0.524	0.27
133_L	137_E	0.524	0.27
10_P	298_L	0.523	0.27
66_W	74_I	0.520	0.27
92_Y	293_I	0.520	0.27
226_L	229_V	0.520	0.27
223_A	262_N	0.519	0.27
30_N	292_Y	0.518	0.27
89_G	114_Q	0.518	0.27
174_L	206_V	0.517	0.27
246_Y	314_A	0.516	0.27
91_T	131_K	0.516	0.27
83_L	180_D	0.515	0.27
264_L	337_L	0.515	0.27
82_L	204_I	0.514	0.27
230_N	310_K	0.514	0.27
96_L	176_V	0.514	0.27
36_P	204_I	0.514	0.27
306_I	318_D	0.514	0.27
121_T	154_N	0.512	0.26
115_S	125_E	0.512	0.26
89_G	178_D	0.512	0.26
298_L	303_L	0.511	0.26
301_A	336_G	0.510	0.26
117_L	136_E	0.510	0.26
294_P	298_L	0.508	0.26
24_G	99_N	0.507	0.26
109_D	237_E	0.504	0.26
77_V	250_F	0.504	0.26
43_L	57_K	0.502	0.26
159_V	205_I	0.501	0.26
140_Y	180_D	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ohxA	1	0.9222	100	0.601	Contact Map
4oi4A	1	0.95	100	0.614	Contact Map
1nksA	5	0.5083	97.3	0.912	Contact Map
2cdnA	1	0.5111	97.3	0.912	Contact Map
1khtA	5	0.5083	97.3	0.912	Contact Map
1akyA	1	0.5306	97.2	0.914	Contact Map
5aunB	2	0.6083	97.1	0.914	Contact Map
4qbgB	1	0.5361	97.1	0.915	Contact Map
2c95A	1	0.5361	97	0.916	Contact Map
1xjcA	2	0.3806	96.9	0.917	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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