GREMLIN Database
Q7LXI8 - Uncharacterized protein
UniProt: Q7LXI8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 214 (194)
Sequences: 1791 (1478)
Seq/√Len: 106.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_F203_I3.7981.00
179_I184_I3.7191.00
166_I170_M3.5021.00
145_G148_L3.3501.00
129_I136_F2.9951.00
163_I188_L2.9561.00
194_D198_H2.9511.00
191_S194_D2.8081.00
166_I184_I2.7751.00
170_M187_I2.7561.00
170_M184_I2.6661.00
180_K183_D2.6091.00
179_I183_D2.5991.00
105_I123_A2.5721.00
168_L208_T2.5671.00
98_L105_I2.4911.00
159_K198_H2.3421.00
174_N178_N2.3001.00
181_A195_F2.2401.00
159_K162_L2.2171.00
139_E145_G2.2011.00
131_S136_F2.1521.00
141_I145_G2.0791.00
175_Y196_L2.0141.00
129_I135_R1.9941.00
143_V146_V1.9661.00
131_S135_R1.8601.00
19_R116_V1.8291.00
161_V165_K1.7741.00
181_A196_L1.7501.00
177_R200_R1.7281.00
164_L207_I1.7111.00
159_K163_I1.6261.00
192_K196_L1.6241.00
198_H201_N1.6161.00
50_V86_F1.5671.00
128_V131_S1.5561.00
198_H205_K1.5281.00
184_I195_F1.5251.00
190_I195_F1.4721.00
60_I84_I1.4671.00
39_K42_P1.4571.00
136_F141_I1.4401.00
108_Y122_V1.4391.00
207_I210_I1.4151.00
18_V121_F1.4071.00
197_Y201_N1.4001.00
139_E143_V1.3861.00
74_K84_I1.3801.00
139_E146_V1.3781.00
69_V72_V1.3591.00
52_I59_I1.3440.99
163_I198_H1.3440.99
73_I179_I1.3310.99
153_G210_I1.3270.99
181_A198_H1.3260.99
143_V148_L1.3100.99
30_I66_S1.2980.99
138_I145_G1.2880.99
164_L173_F1.2600.99
171_G178_N1.2140.99
138_I143_V1.2070.99
75_Y83_L1.1960.99
129_I143_V1.1880.99
206_I210_I1.1750.99
129_I133_K1.1650.99
128_V132_L1.1650.99
179_I187_I1.1640.99
183_D186_E1.1600.98
139_E148_L1.1560.98
186_E189_G1.1500.98
163_I184_I1.1370.98
136_F139_E1.1370.98
81_G158_E1.1100.98
74_K82_Y1.1100.98
136_F145_G1.1090.98
173_F199_L1.1040.98
75_Y112_I1.0950.98
172_Y177_R1.0910.98
133_K136_F1.0870.98
37_T52_I1.0860.98
175_Y193_Q1.0760.98
146_V149_D1.0690.97
126_K191_S1.0620.97
194_D199_L1.0560.97
138_I146_V1.0550.97
68_N157_T1.0440.97
175_Y197_Y1.0420.97
170_M179_I1.0420.97
168_L211_D1.0280.97
163_I190_I1.0210.97
136_F143_V1.0100.96
129_I145_G1.0090.96
51_I120_D0.9950.96
16_V19_R0.9850.96
132_L136_F0.9800.96
58_Q61_K0.9790.96
175_Y204_N0.9740.96
191_S200_R0.9730.96
138_I148_L0.9670.95
199_L203_I0.9650.95
194_D197_Y0.9610.95
156_L202_S0.9610.95
52_I82_Y0.9570.95
105_I109_S0.9550.95
163_I202_S0.9480.95
185_A195_F0.9480.95
70_N89_D0.9470.95
181_A192_K0.9370.95
109_S173_F0.9360.94
193_Q197_Y0.9250.94
93_T96_G0.9240.94
128_V145_G0.9120.94
58_Q186_E0.9120.94
172_Y181_A0.9110.94
96_G140_D0.9060.93
182_K192_K0.9020.93
39_K50_V0.8990.93
71_E74_K0.8990.93
111_V118_F0.8980.93
175_Y198_H0.8970.93
192_K201_N0.8950.93
175_Y200_R0.8950.93
53_A81_G0.8880.93
184_I188_L0.8840.93
42_P162_L0.8770.92
168_L173_F0.8700.92
130_N133_K0.8660.92
129_I132_L0.8620.92
174_N204_N0.8580.91
51_I83_L0.8440.91
165_K169_N0.8430.91
39_K44_G0.8400.91
113_N116_V0.8380.90
48_V88_E0.8350.90
129_I146_V0.8340.90
159_K203_I0.8310.90
176_P200_R0.8310.90
132_L139_E0.8290.90
138_I144_K0.8280.90
127_G130_N0.8270.90
26_W30_I0.8180.89
15_S110_N0.8160.89
65_E80_G0.8150.89
105_I108_Y0.8130.89
162_L165_K0.8120.89
166_I187_I0.8080.89
66_S69_V0.8080.89
140_D146_V0.8050.89
17_K118_F0.8020.88
82_Y85_E0.7990.88
16_V126_K0.7860.87
201_N204_N0.7780.87
139_E147_S0.7780.87
58_Q62_D0.7740.87
128_V136_F0.7690.86
39_K122_V0.7660.86
159_K197_Y0.7630.86
204_N208_T0.7610.86
140_D145_G0.7550.85
40_I51_I0.7540.85
48_V51_I0.7540.85
29_K94_I0.7480.85
23_K28_E0.7350.84
22_H25_C0.7340.84
87_S192_K0.7240.83
135_R139_E0.7210.83
155_A209_S0.7200.82
140_D143_V0.7190.82
157_T205_K0.7130.82
181_A194_D0.7030.81
24_G190_I0.7030.81
53_A96_G0.7020.81
38_I41_S0.6980.80
110_N119_W0.6960.80
57_H60_I0.6960.80
18_V119_W0.6920.80
112_I117_E0.6890.80
175_Y182_K0.6840.79
95_A202_S0.6840.79
18_V39_K0.6780.79
122_V173_F0.6740.78
206_I209_S0.6730.78
36_R94_I0.6730.78
73_I85_E0.6640.77
130_N178_N0.6600.77
132_L137_G0.6590.77
173_F181_A0.6590.77
180_K208_T0.6580.76
194_D202_S0.6570.76
125_S208_T0.6520.76
132_L135_R0.6510.76
129_I137_G0.6510.76
140_D148_L0.6510.76
63_L202_S0.6510.76
31_K172_Y0.6500.76
29_K32_Q0.6490.75
162_L166_I0.6480.75
60_I72_V0.6450.75
135_R143_V0.6430.75
60_I63_L0.6390.74
173_F202_S0.6160.72
91_D173_F0.6080.71
25_C28_E0.6030.70
98_L121_F0.6020.70
95_A107_N0.5970.69
18_V21_L0.5950.69
95_A195_F0.5900.68
93_T105_I0.5890.68
68_N203_I0.5850.68
96_G100_E0.5840.68
142_E145_G0.5840.68
182_K200_R0.5830.67
92_N173_F0.5830.67
175_Y194_D0.5820.67
166_I188_L0.5780.67
135_R138_I0.5760.67
194_D210_I0.5750.66
28_E35_I0.5720.66
109_S203_I0.5710.66
108_Y193_Q0.5700.66
144_K148_L0.5690.66
161_V209_S0.5670.65
62_D69_V0.5660.65
171_G174_N0.5660.65
164_L203_I0.5640.65
133_K137_G0.5640.65
107_N163_I0.5640.65
118_F187_I0.5580.64
131_S134_E0.5550.64
81_G89_D0.5540.64
53_A97_M0.5530.63
21_L28_E0.5520.63
39_K181_A0.5520.63
207_I211_D0.5510.63
92_N98_L0.5500.63
94_I104_K0.5500.63
72_V75_Y0.5500.63
140_D169_N0.5480.63
201_N206_I0.5440.62
26_W63_L0.5440.62
29_K68_N0.5430.62
38_I142_E0.5400.62
133_K141_I0.5370.61
152_L206_I0.5360.61
16_V121_F0.5350.61
128_V134_E0.5350.61
181_A202_S0.5340.61
173_F207_I0.5340.61
188_L196_L0.5340.61
161_V210_I0.5340.61
134_E137_G0.5330.61
53_A58_Q0.5320.60
153_G161_V0.5320.60
165_K211_D0.5310.60
25_C117_E0.5300.60
166_I179_I0.5300.60
64_K74_K0.5290.60
79_N168_L0.5280.60
92_N180_K0.5240.59
23_K26_W0.5240.59
55_P170_M0.5230.59
135_R144_K0.5230.59
19_R36_R0.5210.59
40_I43_Y0.5190.59
153_G174_N0.5170.58
25_C119_W0.5170.58
139_E142_E0.5160.58
130_N189_G0.5150.58
65_E100_E0.5140.58
81_G84_I0.5130.58
142_E146_V0.5130.58
52_I107_N0.5130.58
73_I125_S0.5120.58
124_T187_I0.5120.58
55_P80_G0.5110.57
172_Y180_K0.5110.57
35_I57_H0.5100.57
21_L205_K0.5080.57
120_D144_K0.5070.57
182_K186_E0.5060.57
22_H119_W0.5060.57
89_D189_G0.5060.57
104_K109_S0.5050.57
155_A208_T0.5040.56
85_E190_I0.5030.56
33_Y54_S0.5030.56
202_S207_I0.5020.56
135_R146_V0.5000.56
128_V135_R0.5000.56
129_I144_K0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ku3A 1 0.285 97.7 0.841 Contact Map
2o8xA 7 0.285 97.6 0.844 Contact Map
1s7oA 3 0.3271 97.5 0.845 Contact Map
4wszA 2 0.2617 97.5 0.846 Contact Map
1xsvA 2 0.3224 97.4 0.85 Contact Map
3c57A 2 0.2383 97.3 0.852 Contact Map
3t72q 1 0.3505 97.2 0.854 Contact Map
1je8A 2 0.2664 97.2 0.854 Contact Map
1x3uA 1 0.3131 97.2 0.854 Contact Map
1fseA 2 0.271 97.1 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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