GREMLIN Database
Q7LXI7 - Amino acid specific permease
UniProt: Q7LXI7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 466 (417)
Sequences: 24735 (16020)
Seq/√Len: 784.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_T345_G4.4661.00
327_I339_N4.3611.00
389_R393_K3.3891.00
54_Y246_G3.1691.00
330_K339_N3.1291.00
13_G228_K2.9361.00
232_K236_K2.9081.00
227_A233_T2.7251.00
229_V232_K2.7181.00
78_L320_D2.6511.00
178_L255_A2.5861.00
95_G317_M2.5751.00
332_N338_G2.5491.00
318_A329_T2.5441.00
327_I330_K2.5281.00
176_I180_I2.4991.00
139_V349_G2.4971.00
18_A240_L2.4521.00
8_K11_V2.4521.00
14_T240_L2.4351.00
190_P193_A2.3751.00
66_E391_K2.3511.00
286_I290_I2.3191.00
225_E319_R2.2461.00
277_I280_S2.2391.00
14_T233_T2.1461.00
147_L151_L2.1281.00
226_E312_R2.1121.00
381_L410_S2.1121.00
143_L349_G2.1091.00
17_V227_A2.1081.00
315_Y319_R2.1061.00
14_T18_A2.0921.00
82_K91_A2.0881.00
139_V352_S2.0831.00
264_N281_K2.0721.00
146_T341_I2.0691.00
150_W338_G2.0501.00
154_K158_M2.0381.00
400_V403_V2.0381.00
342_L346_I2.0371.00
445_I449_I2.0171.00
397_I400_V2.0111.00
85_L389_R2.0031.00
407_I411_I1.9711.00
236_K240_L1.9611.00
165_L169_V1.9421.00
13_G16_L1.9251.00
82_K87_S1.9101.00
321_G326_K1.9091.00
188_L191_F1.9071.00
416_T419_F1.9061.00
99_I344_T1.8981.00
138_S352_S1.8921.00
328_F343_L1.8861.00
55_L59_T1.8581.00
85_L385_I1.8541.00
63_V384_A1.8001.00
404_L408_V1.7941.00
261_G264_N1.7941.00
143_L345_G1.7921.00
7_L331_I1.7901.00
38_I46_M1.7861.00
439_V443_H1.7861.00
229_V233_T1.7781.00
16_L161_L1.7711.00
239_L243_L1.7581.00
277_I281_K1.7561.00
413_Y416_T1.7521.00
405_V409_S1.7121.00
81_I94_V1.7091.00
395_R399_I1.6841.00
409_S413_Y1.6711.00
389_R392_V1.6591.00
94_V382_F1.6411.00
196_V199_N1.6371.00
149_M304_I1.6291.00
169_V173_I1.6261.00
142_T348_T1.6191.00
18_A244_L1.6131.00
45_S203_I1.5991.00
332_N336_V1.5971.00
150_W342_L1.5871.00
8_K335_G1.5731.00
396_M399_I1.5731.00
49_V206_S1.5661.00
12_L16_L1.5621.00
334_Y338_G1.5521.00
21_G241_E1.5331.00
437_W441_L1.5131.00
326_K329_T1.5081.00
243_L247_V1.5061.00
339_N343_L1.4691.00
184_D187_T1.4641.00
146_T342_L1.4531.00
314_I340_A1.4471.00
310_G344_T1.4431.00
280_S285_T1.4361.00
61_L242_F1.4311.00
271_L277_I1.4291.00
179_I255_A1.4251.00
280_S288_V1.4171.00
81_I382_F1.4041.00
170_Y294_L1.4041.00
289_L293_V1.4021.00
223_V308_T1.4021.00
151_L334_Y1.4021.00
229_V236_K1.3951.00
326_K330_K1.3951.00
418_Y422_Y1.3931.00
385_I389_R1.3901.00
182_A258_V1.3901.00
96_Y443_H1.3841.00
16_L157_G1.3731.00
416_T420_G1.3721.00
315_Y331_I1.3701.00
444_V448_Y1.3591.00
401_K405_V1.3481.00
123_S126_I1.3351.00
139_V143_L1.3351.00
188_L193_A1.3351.00
61_L238_L1.3321.00
414_I418_Y1.3311.00
142_T345_G1.3271.00
45_S196_V1.3261.00
400_V406_P1.3251.00
71_I83_K1.3201.00
397_I401_K1.3191.00
53_S210_G1.3191.00
7_L315_Y1.3141.00
230_P235_P1.3131.00
60_T384_A1.3121.00
55_L408_V1.3091.00
448_Y452_S1.3091.00
330_K338_G1.3081.00
110_F113_L1.2961.00
247_V251_L1.2931.00
14_T236_K1.2901.00
168_I172_I1.2881.00
311_S341_I1.2781.00
106_G348_T1.2711.00
12_L157_G1.2691.00
74_S225_E1.2641.00
99_I314_I1.2601.00
25_N245_L1.2591.00
47_P254_Y1.2551.00
178_L259_V1.2471.00
79_A83_K1.2401.00
59_T408_V1.2381.00
438_A442_I1.2381.00
111_G303_T1.2361.00
145_T303_T1.2291.00
88_S450_L1.2271.00
124_P127_A1.2261.00
233_T236_K1.2241.00
62_L239_L1.2221.00
84_G386_A1.2191.00
135_A139_V1.2171.00
283_F287_T1.2151.00
12_L17_V1.2121.00
175_S251_L1.2111.00
262_V265_M1.2071.00
395_R398_N1.2001.00
409_S412_A1.1901.00
415_L419_F1.1881.00
183_G186_N1.1861.00
15_W19_S1.1761.00
17_V237_A1.1731.00
404_L407_I1.1701.00
434_Y438_A1.1691.00
339_N342_L1.1681.00
271_L274_P1.1681.00
22_I244_L1.1661.00
446_L449_I1.1651.00
189_A192_T1.1521.00
411_I415_L1.1501.00
409_S416_T1.1481.00
148_I159_L1.1411.00
443_H446_L1.1381.00
73_A79_A1.1381.00
228_K233_T1.1341.00
189_A193_A1.1311.00
399_I402_H1.1301.00
319_R329_T1.1221.00
21_G220_P1.1181.00
174_T178_L1.1171.00
183_G187_T1.1111.00
20_Y223_V1.1101.00
449_I452_S1.1051.00
430_N433_V1.1041.00
159_L163_V1.1021.00
314_I323_L1.0991.00
64_V77_Y1.0981.00
68_S80_M1.0921.00
173_I177_A1.0881.00
410_S414_I1.0881.00
114_G296_A1.0841.00
83_K394_V1.0791.00
66_E69_K1.0761.00
11_V228_K1.0711.00
158_M162_I1.0581.00
146_T150_W1.0571.00
409_S419_F1.0501.00
346_I350_A1.0491.00
73_A83_K1.0451.00
402_H405_V1.0421.00
438_A441_L1.0411.00
136_V140_I1.0411.00
385_I410_S1.0401.00
331_I335_G1.0391.00
421_T424_A1.0381.00
417_I420_G1.0341.00
401_K404_L1.0311.00
92_F96_Y1.0281.00
140_I144_E1.0251.00
153_V308_T1.0201.00
397_I402_H1.0191.00
384_A409_S1.0181.00
430_N434_Y1.0091.00
172_I176_I1.0061.00
195_P198_G1.0051.00
446_L450_L0.9991.00
143_L147_L0.9951.00
51_V250_I0.9951.00
441_L445_I0.9871.00
119_L137_I0.9841.00
78_L316_G0.9811.00
406_P410_S0.9801.00
412_A416_T0.9771.00
409_S422_Y0.9751.00
160_N304_I0.9731.00
259_V278_I0.9731.00
261_G281_K0.9731.00
163_V301_S0.9621.00
406_P420_G0.9611.00
401_K406_P0.9581.00
407_I410_S0.9571.00
409_S420_G0.9541.00
418_Y421_T0.9511.00
19_S161_L0.9511.00
215_G376_V0.9501.00
63_V406_P0.9491.00
400_V405_V0.9471.00
224_A234_L0.9471.00
119_L123_S0.9431.00
413_Y417_I0.9401.00
403_V407_I0.9371.00
70_D398_N0.9351.00
22_I245_L0.9341.00
420_G423_P0.9341.00
402_H409_S0.9311.00
144_E300_N0.9281.00
381_L414_I0.9261.00
38_I42_A0.9251.00
431_I434_Y0.9221.00
96_Y323_L0.9221.00
406_P409_S0.9171.00
404_L409_S0.9171.00
246_G250_I0.9161.00
174_T279_Y0.9121.00
199_N202_L0.9121.00
402_H406_P0.9101.00
254_Y258_V0.9081.00
240_L244_L0.9061.00
75_Y79_A0.9021.00
26_A29_A0.9001.00
150_W336_V0.8981.00
168_I248_G0.8971.00
167_S298_M0.8961.00
416_T421_T0.8931.00
150_W332_N0.8931.00
218_T222_G0.8921.00
205_T209_F0.8881.00
44_G257_T0.8871.00
11_V154_K0.8851.00
145_T304_I0.8811.00
323_L328_F0.8801.00
434_Y437_W0.8781.00
110_F302_S0.8771.00
381_L385_I0.8751.00
388_I407_I0.8711.00
47_P257_T0.8711.00
175_S255_A0.8621.00
54_Y214_F0.8601.00
273_D277_I0.8591.00
48_L52_L0.8581.00
16_L158_M0.8571.00
405_V412_A0.8551.00
345_G349_G0.8521.00
307_A345_G0.8461.00
114_G141_V0.8461.00
118_F122_V0.8451.00
400_V404_L0.8441.00
82_K320_D0.8441.00
86_N451_K0.8411.00
328_F339_N0.8391.00
431_I435_A0.8391.00
412_A419_F0.8331.00
432_A436_A0.8321.00
58_A62_L0.8301.00
196_V203_I0.8291.00
75_Y78_L0.8211.00
219_T309_S0.8191.00
436_A440_L0.8171.00
194_Q197_N0.8151.00
81_I386_A0.8141.00
175_S179_I0.8141.00
98_Y102_Y0.8131.00
158_M161_L0.8061.00
15_W161_L0.8001.00
51_V55_L0.7981.00
338_G342_L0.7971.00
433_V436_A0.7961.00
195_P199_N0.7931.00
145_T307_A0.7911.00
137_I140_I0.7901.00
135_A352_S0.7891.00
147_L150_W0.7841.00
182_A255_A0.7831.00
88_S444_V0.7821.00
67_W387_L0.7781.00
188_L192_T0.7771.00
387_L406_P0.7751.00
59_T63_V0.7731.00
14_T237_A0.7711.00
442_I445_I0.7681.00
387_L391_K0.7681.00
430_N443_H0.7671.00
179_I251_L0.7651.00
115_V134_W0.7641.00
18_A237_A0.7601.00
85_L386_A0.7571.00
374_F436_A0.7561.00
399_I405_V0.7561.00
11_V153_V0.7531.00
56_I412_A0.7491.00
386_A390_H0.7481.00
24_A305_A0.7471.00
388_I392_V0.7451.00
442_I446_L0.7431.00
405_V416_T0.7391.00
235_P238_L0.7391.00
107_A110_F0.7381.00
123_S127_A0.7341.00
26_A167_S0.7331.00
7_L226_E0.7331.00
58_A239_L0.7321.00
443_H447_Y0.7301.00
420_G424_A0.7291.00
196_V200_W0.7281.00
11_V15_W0.7281.00
433_V437_W0.7271.00
118_F123_S0.7271.00
39_A46_M0.7271.00
27_P30_V0.7251.00
419_F422_Y0.7241.00
151_L155_P0.7221.00
139_V353_L0.7211.00
175_S252_N0.7211.00
142_T352_S0.7201.00
57_Y217_A0.7201.00
197_N200_W0.7171.00
441_L444_V0.7171.00
114_G118_F0.7161.00
111_G114_G0.7161.00
432_A435_A0.7161.00
48_L203_I0.7131.00
318_A328_F0.7101.00
27_P249_L0.7081.00
332_N335_G0.7071.00
333_K338_G0.7051.00
200_W204_L0.7011.00
346_I349_G0.7001.00
286_I289_L0.7001.00
150_W334_Y0.7001.00
284_S287_T0.6991.00
381_L413_Y0.6971.00
412_A415_L0.6961.00
412_A421_T0.6941.00
25_N241_E0.6941.00
435_A438_A0.6921.00
405_V408_V0.6911.00
157_G161_L0.6911.00
413_Y419_F0.6911.00
113_L117_S0.6891.00
244_L248_G0.6881.00
177_A181_I0.6871.00
84_G389_R0.6871.00
432_A443_H0.6851.00
371_F375_Y0.6841.00
15_W158_M0.6841.00
48_L51_V0.6831.00
105_A372_G0.6831.00
285_T289_L0.6821.00
417_I421_T0.6821.00
410_S413_Y0.6811.00
409_S423_P0.6811.00
413_Y421_T0.6781.00
67_W80_M0.6771.00
388_I406_P0.6771.00
101_Q376_V0.6761.00
78_L82_K0.6751.00
321_G325_P0.6751.00
33_L369_I0.6751.00
36_V366_I0.6741.00
115_V118_F0.6721.00
410_S421_T0.6701.00
180_I183_G0.6691.00
229_V235_P0.6681.00
46_M253_A0.6681.00
415_L418_Y0.6661.00
215_G380_H0.6631.00
198_G201_V0.6591.00
252_N275_M0.6581.00
364_A367_F0.6571.00
149_M341_I0.6571.00
26_A31_A0.6561.00
142_T349_G0.6531.00
111_G142_T0.6521.00
78_L95_G0.6521.00
149_M308_T0.6511.00
327_I343_L0.6501.00
111_G115_V0.6501.00
314_I343_L0.6491.00
118_F121_L0.6491.00
64_V383_A0.6481.00
117_S121_L0.6471.00
398_N402_H0.6461.00
406_P413_Y0.6451.00
413_Y420_G0.6441.00
31_A35_F0.6441.00
424_A430_N0.6441.00
47_P51_V0.6441.00
395_R400_V0.6421.00
251_L255_A0.6421.00
412_A420_G0.6421.00
155_P158_M0.6401.00
67_W84_G0.6391.00
328_F340_A0.6381.00
448_Y451_K0.6371.00
406_P423_P0.6361.00
74_S315_Y0.6351.00
384_A412_A0.6351.00
143_L146_T0.6341.00
115_V119_L0.6331.00
61_L217_A0.6331.00
412_A423_P0.6331.00
77_Y218_T0.6321.00
240_L243_L0.6301.00
419_F423_P0.6301.00
68_S221_V0.6271.00
120_Y124_P0.6251.00
7_L312_R0.6241.00
337_P340_A0.6241.00
307_A311_S0.6221.00
18_A21_G0.6221.00
145_T300_N0.6211.00
50_T213_T0.6191.00
311_S340_A0.6181.00
446_L451_K0.6171.00
406_P416_T0.6171.00
110_F114_G0.6171.00
24_A306_F0.6171.00
200_W203_I0.6161.00
225_E315_Y0.6161.00
84_G390_H0.6161.00
88_S93_T0.6151.00
152_G155_P0.6151.00
343_L347_I0.6151.00
65_Y69_K0.6141.00
141_V303_T0.6141.00
402_H419_F0.6131.00
390_H394_V0.6131.00
135_A138_S0.6121.00
59_T405_V0.6081.00
103_L347_I0.6061.00
115_V137_I0.6051.00
312_R315_Y0.6041.00
112_V368_L0.6041.00
252_N256_Q0.6031.00
68_S234_L0.6021.00
23_A164_G0.6011.00
375_Y379_G0.6011.00
399_I403_V0.5991.00
39_A42_A0.5991.00
327_I331_I0.5981.00
122_V125_S0.5971.00
30_V34_Y0.5971.00
416_T423_P0.5961.00
52_L207_M0.5951.00
78_L91_A0.5931.00
29_A35_F0.5931.00
103_L344_T0.5921.00
111_G117_S0.5911.00
202_L205_T0.5901.00
177_A283_F0.5901.00
293_V297_F0.5901.00
215_G218_T0.5891.00
274_P279_Y0.5891.00
17_V223_V0.5881.00
392_V403_V0.5861.00
310_G314_I0.5861.00
150_W341_I0.5841.00
298_M301_S0.5831.00
440_L444_V0.5821.00
227_A234_L0.5821.00
190_P195_P0.5811.00
53_S211_I0.5811.00
116_T134_W0.5801.00
443_H450_L0.5791.00
222_G309_S0.5791.00
161_L165_L0.5791.00
140_I143_L0.5791.00
384_A410_S0.5781.00
111_G116_T0.5771.00
81_I91_A0.5771.00
155_P159_L0.5751.00
405_V413_Y0.5741.00
234_L238_L0.5731.00
153_V223_V0.5721.00
76_G221_V0.5721.00
157_G304_I0.5711.00
445_I448_Y0.5711.00
97_G379_G0.5711.00
166_I170_Y0.5701.00
401_K420_G0.5701.00
436_A443_H0.5681.00
269_A274_P0.5671.00
30_V35_F0.5661.00
104_V371_F0.5661.00
349_G352_S0.5651.00
94_V379_G0.5641.00
61_L65_Y0.5641.00
338_G341_I0.5631.00
91_A95_G0.5631.00
396_M401_K0.5621.00
221_V238_L0.5621.00
366_I369_I0.5621.00
116_T119_L0.5611.00
439_V446_L0.5601.00
66_E70_D0.5581.00
231_K396_M0.5581.00
122_V126_I0.5581.00
255_A258_V0.5581.00
350_A353_L0.5561.00
406_P421_T0.5561.00
431_I436_A0.5561.00
230_P233_T0.5541.00
146_T307_A0.5541.00
70_D390_H0.5541.00
15_W18_A0.5531.00
53_S214_F0.5511.00
113_L118_F0.5501.00
399_I406_P0.5501.00
26_A248_G0.5491.00
279_Y284_S0.5481.00
22_I26_A0.5471.00
244_L251_L0.5461.00
204_L208_I0.5451.00
415_L421_T0.5451.00
77_Y222_G0.5451.00
325_P328_F0.5431.00
102_Y306_F0.5431.00
408_V411_I0.5431.00
103_L107_A0.5431.00
47_P250_I0.5431.00
180_I184_D0.5431.00
376_V379_G0.5421.00
156_G308_T0.5411.00
226_E337_P0.5411.00
260_Y264_N0.5401.00
31_A167_S0.5401.00
88_S448_Y0.5391.00
44_G47_P0.5391.00
244_L247_V0.5381.00
279_Y287_T0.5381.00
177_A284_S0.5381.00
13_G154_K0.5341.00
215_G372_G0.5341.00
270_N274_P0.5341.00
433_V439_V0.5341.00
93_T97_G0.5341.00
101_Q375_Y0.5331.00
22_I164_G0.5331.00
273_D276_V0.5331.00
24_A219_T0.5311.00
415_L420_G0.5311.00
166_I294_L0.5311.00
26_A30_V0.5301.00
397_I405_V0.5291.00
437_W443_H0.5281.00
114_G300_N0.5281.00
110_F303_T0.5261.00
398_N401_K0.5261.00
220_P234_L0.5261.00
144_E148_I0.5261.00
331_I334_Y0.5251.00
409_S415_L0.5241.00
439_V442_I0.5241.00
97_G378_L0.5221.00
41_L206_S0.5211.00
437_W440_L0.5181.00
269_A272_P0.5171.00
197_N201_V0.5151.00
388_I410_S0.5141.00
107_A351_L0.5131.00
160_N301_S0.5121.00
70_D395_R0.5091.00
32_T36_V0.5091.00
34_Y253_A0.5081.00
118_F296_A0.5081.00
164_G167_S0.5071.00
12_L153_V0.5061.00
433_V440_L0.5041.00
32_T35_F0.5031.00
162_I165_L0.5031.00
24_A27_P0.5031.00
226_E331_I0.5021.00
402_H412_A0.5021.00
406_P412_A0.5011.00
303_T306_F0.5011.00
432_A439_V0.5011.00
400_V409_S0.5011.00
435_A447_Y0.5001.00
97_G101_Q0.5001.00
10_E228_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9077 100 0.281 Contact Map
3giaA 1 0.9292 100 0.333 Contact Map
4djkA 2 0.8991 100 0.361 Contact Map
3dh4A 3 0.912 99.1 0.845 Contact Map
2xq2A 2 0.9099 99 0.848 Contact Map
2jlnA 1 0.8884 98.8 0.861 Contact Map
2a65A 2 0.9313 97.5 0.902 Contact Map
4wgvA 2 0.7833 97.4 0.904 Contact Map
4xp4A 1 0.9399 96.6 0.914 Contact Map
4us3A 1 0.8519 96.3 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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