GREMLIN Database
Q7LXI5 - Uncharacterized protein
UniProt: Q7LXI5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 352 (340)
Sequences: 18759 (14265)
Seq/√Len: 773.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_R142_E4.3391.00
5_D342_H4.0161.00
87_I143_A3.7271.00
109_N146_A3.6101.00
40_E52_T3.4711.00
50_K144_E3.2881.00
39_K59_R3.2171.00
8_R342_H3.1941.00
63_Y66_R3.1861.00
50_K142_E3.1841.00
162_D165_E2.9261.00
69_K147_I2.8801.00
115_G119_K2.8001.00
113_V130_V2.7561.00
110_S144_E2.6461.00
256_S259_R2.5671.00
52_T142_E2.3971.00
55_V60_T2.3951.00
3_L7_Y2.3241.00
116_V345_L2.2981.00
65_R150_Y2.2601.00
46_D67_R2.1931.00
41_V55_V2.1551.00
58_L62_D2.1121.00
56_K59_R2.0921.00
164_E262_K2.0791.00
111_V130_V2.0351.00
120_Y123_N2.0231.00
43_E50_K2.0051.00
49_V60_T2.0031.00
38_M52_T2.0011.00
48_W144_E1.9671.00
113_V138_G1.9561.00
47_K149_D1.9411.00
48_W109_N1.9381.00
35_M139_V1.9311.00
263_Q306_L1.9081.00
112_R141_T1.9061.00
14_R17_G1.9021.00
303_S306_L1.8981.00
47_K69_K1.8951.00
51_V83_L1.8881.00
64_L147_I1.8211.00
13_P139_V1.8171.00
224_L228_A1.7921.00
114_L141_T1.7841.00
33_L139_V1.7741.00
325_E328_R1.7411.00
87_I108_I1.7361.00
216_G220_N1.7331.00
63_Y67_R1.7271.00
2_K5_D1.7021.00
337_R343_N1.6881.00
334_K338_I1.6631.00
88_A140_I1.6561.00
110_S120_Y1.6481.00
291_F295_K1.6331.00
88_A133_A1.6181.00
165_E168_K1.6141.00
330_E334_K1.6121.00
266_E270_S1.6051.00
45_D48_W1.5961.00
86_Y102_H1.5881.00
59_R62_D1.5851.00
44_I63_Y1.5761.00
87_I145_L1.5661.00
172_K176_F1.5521.00
326_E330_E1.5491.00
330_E333_K1.5471.00
41_V63_Y1.5461.00
263_Q266_E1.5351.00
52_T55_V1.5341.00
333_K337_R1.5301.00
263_Q303_S1.5181.00
3_L9_I1.5181.00
130_V138_G1.5081.00
120_Y124_G1.5071.00
49_V145_L1.5071.00
164_E168_K1.5031.00
253_S256_S1.4891.00
270_S299_E1.4881.00
295_K299_E1.4871.00
312_F315_H1.4791.00
105_N148_I1.4781.00
302_D306_L1.4701.00
27_I30_S1.4691.00
4_C31_I1.4691.00
35_M38_M1.4631.00
51_V145_L1.4421.00
156_Q160_L1.3951.00
331_L334_K1.3841.00
108_I111_V1.3761.00
4_C11_L1.3731.00
336_K343_N1.3631.00
116_V339_M1.3561.00
328_R331_L1.3481.00
229_F232_I1.3341.00
294_D298_F1.3331.00
274_I278_V1.3271.00
120_Y125_K1.3251.00
298_F302_D1.2911.00
51_V60_T1.2891.00
39_K52_T1.2871.00
81_A86_Y1.2781.00
276_G279_M1.2711.00
184_T187_D1.2661.00
121_T125_K1.2661.00
265_K269_N1.2601.00
72_R105_N1.2421.00
329_L333_K1.2361.00
168_K172_K1.2261.00
62_D66_R1.2171.00
275_H278_V1.2121.00
271_N299_E1.2081.00
40_E55_V1.2001.00
334_K337_R1.1931.00
313_E316_S1.1911.00
14_R32_I1.1791.00
87_I102_H1.1761.00
44_I69_K1.1761.00
129_A331_L1.1481.00
49_V147_I1.1391.00
169_I172_K1.1361.00
84_G143_A1.1351.00
259_R263_Q1.1281.00
273_L278_V1.1241.00
115_G339_M1.1211.00
49_V64_L1.1201.00
2_K6_E1.1191.00
267_A299_E1.1161.00
218_E221_L1.1151.00
282_R285_I1.1101.00
267_A303_S1.1081.00
100_G104_D1.0991.00
295_K298_F1.0981.00
220_N224_L1.0841.00
266_E269_N1.0641.00
263_Q307_K1.0581.00
44_I49_V1.0561.00
248_E251_L1.0511.00
8_R344_I1.0471.00
210_A213_L1.0431.00
10_P30_S1.0411.00
11_L33_L1.0411.00
222_R225_D1.0391.00
5_D344_I1.0391.00
292_I295_K1.0361.00
299_E302_D1.0331.00
303_S307_K1.0311.00
206_N213_L1.0301.00
207_V212_T1.0241.00
209_V212_T1.0241.00
171_K175_E1.0191.00
35_M53_P1.0191.00
274_I277_D1.0181.00
218_E222_R1.0171.00
279_M282_R1.0151.00
259_R262_K1.0111.00
233_Y236_M1.0081.00
108_I131_A1.0071.00
15_G82_T1.0071.00
161_N165_E1.0061.00
215_F218_E1.0021.00
130_V140_I0.9991.00
206_N212_T0.9961.00
281_L285_I0.9951.00
233_Y237_S0.9951.00
59_R63_Y0.9931.00
274_I279_M0.9901.00
260_V264_V0.9891.00
177_R180_I0.9851.00
210_A214_S0.9821.00
211_S214_S0.9821.00
315_H318_E0.9821.00
14_R34_D0.9791.00
316_S319_V0.9781.00
206_N210_A0.9771.00
192_S195_G0.9741.00
258_L262_K0.9741.00
273_L276_G0.9731.00
275_H279_M0.9731.00
224_L227_L0.9691.00
263_Q267_A0.9641.00
58_L79_Y0.9631.00
313_E319_V0.9621.00
111_V128_L0.9591.00
262_K266_E0.9581.00
267_A270_S0.9571.00
312_F317_I0.9571.00
208_I213_L0.9541.00
126_D129_A0.9501.00
279_M284_E0.9471.00
122_L125_K0.9451.00
208_I211_S0.9451.00
19_S23_Q0.9441.00
276_G282_R0.9431.00
83_L145_L0.9381.00
208_I212_T0.9361.00
16_A82_T0.9351.00
278_V281_L0.9321.00
15_G35_M0.9311.00
172_K175_E0.9291.00
207_V210_A0.9241.00
268_L271_N0.9191.00
225_D228_A0.9191.00
209_V213_L0.9171.00
58_L80_I0.9171.00
156_Q159_R0.9091.00
48_W146_A0.8941.00
9_I31_I0.8931.00
11_L344_I0.8881.00
311_P314_I0.8831.00
69_K149_D0.8801.00
247_Y250_R0.8751.00
190_A193_L0.8711.00
209_V214_S0.8701.00
319_V322_R0.8691.00
318_E323_V0.8661.00
111_V143_A0.8621.00
194_V197_D0.8591.00
133_A137_T0.8591.00
39_K55_V0.8421.00
315_H319_V0.8411.00
188_Y192_S0.8391.00
168_K171_K0.8391.00
108_I143_A0.8391.00
319_V323_V0.8381.00
316_S321_D0.8381.00
140_I143_A0.8361.00
164_E258_L0.8361.00
234_V240_T0.8351.00
273_L277_D0.8351.00
277_D282_R0.8341.00
281_L284_E0.8311.00
277_D281_L0.8281.00
203_G210_A0.8281.00
109_N144_E0.8241.00
84_G88_A0.8231.00
189_E192_S0.8221.00
276_G280_T0.8181.00
38_M141_T0.8181.00
221_L225_D0.8181.00
203_G206_N0.8171.00
278_V282_R0.8161.00
324_D328_R0.8141.00
61_L75_P0.8131.00
283_G289_T0.8121.00
57_I60_T0.8121.00
55_V59_R0.8101.00
279_M283_G0.8081.00
221_L224_L0.8071.00
284_E287_I0.8071.00
170_L174_G0.8061.00
105_N146_A0.8011.00
234_V238_K0.7981.00
205_W212_T0.7941.00
262_K265_K0.7941.00
237_S240_T0.7901.00
280_T287_I0.7891.00
286_I289_T0.7871.00
257_F261_V0.7861.00
189_E193_L0.7851.00
281_L287_I0.7811.00
274_I282_R0.7791.00
219_V223_F0.7771.00
13_P35_M0.7771.00
277_D280_T0.7711.00
206_N211_S0.7701.00
205_W209_V0.7701.00
116_V344_I0.7701.00
260_V307_K0.7701.00
101_Y104_D0.7681.00
282_R286_I0.7681.00
192_S196_K0.7661.00
302_D305_M0.7641.00
279_M286_I0.7641.00
223_F227_L0.7621.00
125_K136_T0.7611.00
280_T283_G0.7581.00
315_H321_D0.7581.00
49_V63_Y0.7581.00
83_L143_A0.7541.00
36_N82_T0.7531.00
311_P315_H0.7521.00
314_I319_V0.7521.00
275_H286_I0.7501.00
57_I86_Y0.7491.00
284_E288_Y0.7481.00
166_V170_L0.7471.00
275_H282_R0.7461.00
256_S307_K0.7441.00
2_K119_K0.7421.00
235_T238_K0.7421.00
310_I313_E0.7401.00
198_R201_K0.7401.00
206_N214_S0.7391.00
121_T124_G0.7391.00
70_E150_Y0.7371.00
314_I317_I0.7351.00
315_H322_R0.7331.00
126_D338_I0.7311.00
236_M239_L0.7291.00
244_D247_Y0.7281.00
314_I318_E0.7281.00
320_N323_V0.7281.00
72_R148_I0.7271.00
10_P346_N0.7261.00
276_G286_I0.7251.00
316_S320_N0.7251.00
243_K246_F0.7211.00
275_H280_T0.7161.00
190_A194_V0.7151.00
68_G150_Y0.7131.00
111_V140_I0.7131.00
312_F318_E0.7131.00
278_V284_E0.7121.00
313_E322_R0.7071.00
279_M287_I0.7061.00
272_V275_H0.7041.00
203_G212_T0.7041.00
124_G339_M0.7041.00
316_S322_R0.7031.00
317_I320_N0.7021.00
193_L196_K0.6991.00
336_K346_N0.6971.00
325_E330_E0.6961.00
167_V171_K0.6951.00
181_R184_T0.6931.00
285_I288_Y0.6921.00
280_T284_E0.6921.00
276_G281_L0.6921.00
105_N109_N0.6901.00
128_L131_A0.6901.00
205_W211_S0.6891.00
283_G286_I0.6871.00
283_G287_I0.6851.00
329_L332_M0.6851.00
287_I290_V0.6851.00
267_A271_N0.6811.00
312_F316_S0.6801.00
15_G53_P0.6781.00
284_E289_T0.6781.00
12_V30_S0.6781.00
199_L202_V0.6771.00
313_E323_V0.6761.00
110_S142_E0.6761.00
273_L280_T0.6721.00
60_T83_L0.6721.00
242_F245_Y0.6711.00
335_Y339_M0.6701.00
248_E252_L0.6691.00
249_V252_L0.6681.00
297_N301_I0.6681.00
257_F260_V0.6671.00
171_K174_G0.6641.00
205_W210_A0.6631.00
220_N227_L0.6621.00
312_F319_V0.6611.00
239_L242_F0.6601.00
301_I305_M0.6591.00
182_R185_V0.6591.00
280_T285_I0.6591.00
36_N56_K0.6581.00
244_D249_V0.6571.00
47_K146_A0.6541.00
293_S297_N0.6541.00
309_G312_F0.6531.00
157_L160_L0.6511.00
318_E321_D0.6501.00
160_L169_I0.6491.00
282_R287_I0.6481.00
219_V226_E0.6481.00
276_G287_I0.6471.00
271_N295_K0.6461.00
43_E46_D0.6461.00
62_D65_R0.6451.00
41_V52_T0.6441.00
277_D283_G0.6441.00
280_T289_T0.6421.00
284_E290_V0.6411.00
272_V277_D0.6401.00
234_V237_S0.6361.00
137_T335_Y0.6351.00
275_H284_E0.6311.00
164_E259_R0.6281.00
259_R307_K0.6261.00
233_Y246_F0.6231.00
236_M240_T0.6231.00
313_E317_I0.6221.00
205_W208_I0.6211.00
53_P143_A0.6191.00
314_I320_N0.6191.00
238_K241_K0.6161.00
310_I315_H0.6161.00
126_D335_Y0.6151.00
272_V276_G0.6131.00
120_Y128_L0.6131.00
241_K244_D0.6131.00
276_G285_I0.6111.00
222_R227_L0.6101.00
281_L286_I0.6101.00
19_S24_V0.6091.00
217_E220_N0.6081.00
315_H320_N0.6061.00
313_E321_D0.6061.00
195_G198_R0.6061.00
252_L260_V0.6041.00
249_V254_L0.6031.00
222_R226_E0.6011.00
173_L176_F0.5991.00
57_I81_A0.5991.00
239_L243_K0.5971.00
16_A56_K0.5941.00
64_L67_R0.5931.00
219_V222_R0.5921.00
260_V263_Q0.5911.00
313_E318_E0.5911.00
93_G96_S0.5911.00
276_G284_E0.5901.00
180_I184_T0.5891.00
78_F81_A0.5891.00
61_L70_E0.5881.00
277_D284_E0.5881.00
207_V211_S0.5881.00
264_V268_L0.5871.00
249_V253_S0.5871.00
206_N209_V0.5861.00
279_M285_I0.5841.00
180_I187_D0.5811.00
239_L245_Y0.5801.00
251_L310_I0.5791.00
176_F225_D0.5791.00
170_L173_L0.5781.00
193_L197_D0.5771.00
275_H285_I0.5761.00
57_I83_L0.5741.00
314_I321_D0.5731.00
195_G201_K0.5721.00
90_G101_Y0.5681.00
5_D117_T0.5661.00
240_T243_K0.5661.00
236_M241_K0.5661.00
237_S245_Y0.5641.00
273_L286_I0.5641.00
274_I287_I0.5641.00
191_L195_G0.5641.00
235_T241_K0.5631.00
237_S243_K0.5601.00
121_T126_D0.5581.00
281_L289_T0.5571.00
296_S300_I0.5551.00
328_R332_M0.5551.00
111_V131_A0.5511.00
278_V285_I0.5501.00
34_D37_D0.5491.00
188_Y195_G0.5491.00
217_E221_L0.5491.00
96_S101_Y0.5481.00
286_I290_V0.5461.00
313_E320_N0.5461.00
44_I147_I0.5461.00
188_Y204_K0.5461.00
61_L64_L0.5441.00
235_T239_L0.5441.00
317_I322_R0.5431.00
183_I187_D0.5421.00
343_N346_N0.5411.00
314_I322_R0.5411.00
261_V265_K0.5401.00
237_S241_K0.5391.00
236_M243_K0.5351.00
299_E303_S0.5351.00
273_L279_M0.5341.00
238_K242_F0.5341.00
240_T245_Y0.5341.00
184_T188_Y0.5321.00
76_S86_Y0.5281.00
41_V51_V0.5281.00
56_K82_T0.5271.00
278_V283_G0.5261.00
60_T71_L0.5261.00
277_D286_I0.5241.00
327_Y330_E0.5231.00
44_I67_R0.5221.00
291_F294_D0.5221.00
234_V246_F0.5191.00
187_D190_A0.5171.00
245_Y250_R0.5171.00
239_L246_F0.5171.00
279_M288_Y0.5161.00
112_R144_E0.5161.00
241_K245_Y0.5141.00
197_D200_D0.5141.00
87_I140_I0.5141.00
298_F301_I0.5131.00
275_H281_L0.5121.00
238_K243_K0.5091.00
204_K210_A0.5091.00
236_M244_D0.5081.00
204_K209_V0.5071.00
265_K268_L0.5051.00
277_D288_Y0.5051.00
43_E48_W0.5041.00
324_D332_M0.5041.00
336_K340_D0.5031.00
3_L31_I0.5021.00
99_Y148_I0.5021.00
298_F323_V0.5021.00
88_A130_V0.5001.00
179_K184_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pm9A 5 0.9886 100 0.292 Contact Map
1f0xA 1 0.9631 100 0.331 Contact Map
2uuuA 2 0.946 100 0.336 Contact Map
4bbyA 2 0.9886 100 0.351 Contact Map
2exrA 1 0.9489 100 0.378 Contact Map
4mlaA 1 0.9318 100 0.383 Contact Map
1wvfA 2 0.9773 100 0.388 Contact Map
1w1oA 1 0.9574 100 0.388 Contact Map
4p8nA 1 0.9773 100 0.41 Contact Map
4o95A 1 0.9545 100 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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