Q7LXI5 - SULSO - GREMLIN Contacts

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Q7LXI5 - Uncharacterized protein

UniProt:	Q7LXI5	Sequences: MKLCDEYRIPLVPRGAGTSTIGQVLPIYSSIILDMNDMKEVIEIDDKWVKVTPSVKILRTLDYLRRRGKELRVYPSSFYIATLGGYIAGGDVGIGSFQYGYHFDNNGINSVRVLGVTGKYTLNGKDTLAVAQAAGTTGVITEAELAIIDYEDWKDQLIRLNDLEEVVKILKKLGEFRSKIRRITVEDYEALSLVGKDRLDKVGKWNVIVASTLSFGEEVNLRFLDELAFAAIYVTMSKLTKFKDYFYEVRLLSLDSFLRVVKQVKEALNSNVLIHGDVMTLRGEIIIYTVFISDKSNFEIIDSIMLKEGIPFEIHSIEVNDRVDEEYRLELMKKYKRIMDPHNILNPGKLRL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	352 (340)
Sequences:	18759 (14265)
Seq/√Len:	773.6

ECOLI - GLCD YGCU YDIJ GLCE
BACSU - GLCD YITY YVDP YGAK
HALSA - Q9HMR2
SULSO - Q7LXI5 Q97ZB9 Q7LX43 Q97U60 Q97Y18 Q97U59 Q97Z67

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
112_R	142_E	4.339	1.00
5_D	342_H	4.016	1.00
87_I	143_A	3.727	1.00
109_N	146_A	3.610	1.00
40_E	52_T	3.471	1.00
50_K	144_E	3.288	1.00
39_K	59_R	3.217	1.00
8_R	342_H	3.194	1.00
63_Y	66_R	3.186	1.00
50_K	142_E	3.184	1.00
162_D	165_E	2.926	1.00
69_K	147_I	2.880	1.00
115_G	119_K	2.800	1.00
113_V	130_V	2.756	1.00
110_S	144_E	2.646	1.00
256_S	259_R	2.567	1.00
52_T	142_E	2.397	1.00
55_V	60_T	2.395	1.00
3_L	7_Y	2.324	1.00
116_V	345_L	2.298	1.00
65_R	150_Y	2.260	1.00
46_D	67_R	2.193	1.00
41_V	55_V	2.155	1.00
58_L	62_D	2.112	1.00
56_K	59_R	2.092	1.00
164_E	262_K	2.079	1.00
111_V	130_V	2.035	1.00
120_Y	123_N	2.023	1.00
43_E	50_K	2.005	1.00
49_V	60_T	2.003	1.00
38_M	52_T	2.001	1.00
48_W	144_E	1.967	1.00
113_V	138_G	1.956	1.00
47_K	149_D	1.941	1.00
48_W	109_N	1.938	1.00
35_M	139_V	1.931	1.00
263_Q	306_L	1.908	1.00
112_R	141_T	1.906	1.00
14_R	17_G	1.902	1.00
303_S	306_L	1.898	1.00
47_K	69_K	1.895	1.00
51_V	83_L	1.888	1.00
64_L	147_I	1.821	1.00
13_P	139_V	1.817	1.00
224_L	228_A	1.792	1.00
114_L	141_T	1.784	1.00
33_L	139_V	1.774	1.00
325_E	328_R	1.741	1.00
87_I	108_I	1.736	1.00
216_G	220_N	1.733	1.00
63_Y	67_R	1.727	1.00
2_K	5_D	1.702	1.00
337_R	343_N	1.688	1.00
334_K	338_I	1.663	1.00
88_A	140_I	1.656	1.00
110_S	120_Y	1.648	1.00
291_F	295_K	1.633	1.00
88_A	133_A	1.618	1.00
165_E	168_K	1.614	1.00
330_E	334_K	1.612	1.00
266_E	270_S	1.605	1.00
45_D	48_W	1.596	1.00
86_Y	102_H	1.588	1.00
59_R	62_D	1.585	1.00
44_I	63_Y	1.576	1.00
87_I	145_L	1.566	1.00
172_K	176_F	1.552	1.00
326_E	330_E	1.549	1.00
330_E	333_K	1.547	1.00
41_V	63_Y	1.546	1.00
263_Q	266_E	1.535	1.00
52_T	55_V	1.534	1.00
333_K	337_R	1.530	1.00
263_Q	303_S	1.518	1.00
3_L	9_I	1.518	1.00
130_V	138_G	1.508	1.00
120_Y	124_G	1.507	1.00
49_V	145_L	1.507	1.00
164_E	168_K	1.503	1.00
253_S	256_S	1.489	1.00
270_S	299_E	1.488	1.00
295_K	299_E	1.487	1.00
312_F	315_H	1.479	1.00
105_N	148_I	1.478	1.00
302_D	306_L	1.470	1.00
27_I	30_S	1.469	1.00
4_C	31_I	1.469	1.00
35_M	38_M	1.463	1.00
51_V	145_L	1.442	1.00
156_Q	160_L	1.395	1.00
331_L	334_K	1.384	1.00
108_I	111_V	1.376	1.00
4_C	11_L	1.373	1.00
336_K	343_N	1.363	1.00
116_V	339_M	1.356	1.00
328_R	331_L	1.348	1.00
229_F	232_I	1.334	1.00
294_D	298_F	1.333	1.00
274_I	278_V	1.327	1.00
120_Y	125_K	1.325	1.00
298_F	302_D	1.291	1.00
51_V	60_T	1.289	1.00
39_K	52_T	1.287	1.00
81_A	86_Y	1.278	1.00
276_G	279_M	1.271	1.00
184_T	187_D	1.266	1.00
121_T	125_K	1.266	1.00
265_K	269_N	1.260	1.00
72_R	105_N	1.242	1.00
329_L	333_K	1.236	1.00
168_K	172_K	1.226	1.00
62_D	66_R	1.217	1.00
275_H	278_V	1.212	1.00
271_N	299_E	1.208	1.00
40_E	55_V	1.200	1.00
334_K	337_R	1.193	1.00
313_E	316_S	1.191	1.00
14_R	32_I	1.179	1.00
87_I	102_H	1.176	1.00
44_I	69_K	1.176	1.00
129_A	331_L	1.148	1.00
49_V	147_I	1.139	1.00
169_I	172_K	1.136	1.00
84_G	143_A	1.135	1.00
259_R	263_Q	1.128	1.00
273_L	278_V	1.124	1.00
115_G	339_M	1.121	1.00
49_V	64_L	1.120	1.00
2_K	6_E	1.119	1.00
267_A	299_E	1.116	1.00
218_E	221_L	1.115	1.00
282_R	285_I	1.110	1.00
267_A	303_S	1.108	1.00
100_G	104_D	1.099	1.00
295_K	298_F	1.098	1.00
220_N	224_L	1.084	1.00
266_E	269_N	1.064	1.00
263_Q	307_K	1.058	1.00
44_I	49_V	1.056	1.00
248_E	251_L	1.051	1.00
8_R	344_I	1.047	1.00
210_A	213_L	1.043	1.00
10_P	30_S	1.041	1.00
11_L	33_L	1.041	1.00
222_R	225_D	1.039	1.00
5_D	344_I	1.039	1.00
292_I	295_K	1.036	1.00
299_E	302_D	1.033	1.00
303_S	307_K	1.031	1.00
206_N	213_L	1.030	1.00
207_V	212_T	1.024	1.00
209_V	212_T	1.024	1.00
171_K	175_E	1.019	1.00
35_M	53_P	1.019	1.00
274_I	277_D	1.018	1.00
218_E	222_R	1.017	1.00
279_M	282_R	1.015	1.00
259_R	262_K	1.011	1.00
233_Y	236_M	1.008	1.00
108_I	131_A	1.007	1.00
15_G	82_T	1.007	1.00
161_N	165_E	1.006	1.00
215_F	218_E	1.002	1.00
130_V	140_I	0.999	1.00
206_N	212_T	0.996	1.00
281_L	285_I	0.995	1.00
233_Y	237_S	0.995	1.00
59_R	63_Y	0.993	1.00
274_I	279_M	0.990	1.00
260_V	264_V	0.989	1.00
177_R	180_I	0.985	1.00
210_A	214_S	0.982	1.00
211_S	214_S	0.982	1.00
315_H	318_E	0.982	1.00
14_R	34_D	0.979	1.00
316_S	319_V	0.978	1.00
206_N	210_A	0.977	1.00
192_S	195_G	0.974	1.00
258_L	262_K	0.974	1.00
273_L	276_G	0.973	1.00
275_H	279_M	0.973	1.00
224_L	227_L	0.969	1.00
263_Q	267_A	0.964	1.00
58_L	79_Y	0.963	1.00
313_E	319_V	0.962	1.00
111_V	128_L	0.959	1.00
262_K	266_E	0.958	1.00
267_A	270_S	0.957	1.00
312_F	317_I	0.957	1.00
208_I	213_L	0.954	1.00
126_D	129_A	0.950	1.00
279_M	284_E	0.947	1.00
122_L	125_K	0.945	1.00
208_I	211_S	0.945	1.00
19_S	23_Q	0.944	1.00
276_G	282_R	0.943	1.00
83_L	145_L	0.938	1.00
208_I	212_T	0.936	1.00
16_A	82_T	0.935	1.00
278_V	281_L	0.932	1.00
15_G	35_M	0.931	1.00
172_K	175_E	0.929	1.00
207_V	210_A	0.924	1.00
268_L	271_N	0.919	1.00
225_D	228_A	0.919	1.00
209_V	213_L	0.917	1.00
58_L	80_I	0.917	1.00
156_Q	159_R	0.909	1.00
48_W	146_A	0.894	1.00
9_I	31_I	0.893	1.00
11_L	344_I	0.888	1.00
311_P	314_I	0.883	1.00
69_K	149_D	0.880	1.00
247_Y	250_R	0.875	1.00
190_A	193_L	0.871	1.00
209_V	214_S	0.870	1.00
319_V	322_R	0.869	1.00
318_E	323_V	0.866	1.00
111_V	143_A	0.862	1.00
194_V	197_D	0.859	1.00
133_A	137_T	0.859	1.00
39_K	55_V	0.842	1.00
315_H	319_V	0.841	1.00
188_Y	192_S	0.839	1.00
168_K	171_K	0.839	1.00
108_I	143_A	0.839	1.00
319_V	323_V	0.838	1.00
316_S	321_D	0.838	1.00
140_I	143_A	0.836	1.00
164_E	258_L	0.836	1.00
234_V	240_T	0.835	1.00
273_L	277_D	0.835	1.00
277_D	282_R	0.834	1.00
281_L	284_E	0.831	1.00
277_D	281_L	0.828	1.00
203_G	210_A	0.828	1.00
109_N	144_E	0.824	1.00
84_G	88_A	0.823	1.00
189_E	192_S	0.822	1.00
276_G	280_T	0.818	1.00
38_M	141_T	0.818	1.00
221_L	225_D	0.818	1.00
203_G	206_N	0.817	1.00
278_V	282_R	0.816	1.00
324_D	328_R	0.814	1.00
61_L	75_P	0.813	1.00
283_G	289_T	0.812	1.00
57_I	60_T	0.812	1.00
55_V	59_R	0.810	1.00
279_M	283_G	0.808	1.00
221_L	224_L	0.807	1.00
284_E	287_I	0.807	1.00
170_L	174_G	0.806	1.00
105_N	146_A	0.801	1.00
234_V	238_K	0.798	1.00
205_W	212_T	0.794	1.00
262_K	265_K	0.794	1.00
237_S	240_T	0.790	1.00
280_T	287_I	0.789	1.00
286_I	289_T	0.787	1.00
257_F	261_V	0.786	1.00
189_E	193_L	0.785	1.00
281_L	287_I	0.781	1.00
274_I	282_R	0.779	1.00
219_V	223_F	0.777	1.00
13_P	35_M	0.777	1.00
277_D	280_T	0.771	1.00
206_N	211_S	0.770	1.00
205_W	209_V	0.770	1.00
116_V	344_I	0.770	1.00
260_V	307_K	0.770	1.00
101_Y	104_D	0.768	1.00
282_R	286_I	0.768	1.00
192_S	196_K	0.766	1.00
302_D	305_M	0.764	1.00
279_M	286_I	0.764	1.00
223_F	227_L	0.762	1.00
125_K	136_T	0.761	1.00
280_T	283_G	0.758	1.00
315_H	321_D	0.758	1.00
49_V	63_Y	0.758	1.00
83_L	143_A	0.754	1.00
36_N	82_T	0.753	1.00
311_P	315_H	0.752	1.00
314_I	319_V	0.752	1.00
275_H	286_I	0.750	1.00
57_I	86_Y	0.749	1.00
284_E	288_Y	0.748	1.00
166_V	170_L	0.747	1.00
275_H	282_R	0.746	1.00
256_S	307_K	0.744	1.00
2_K	119_K	0.742	1.00
235_T	238_K	0.742	1.00
310_I	313_E	0.740	1.00
198_R	201_K	0.740	1.00
206_N	214_S	0.739	1.00
121_T	124_G	0.739	1.00
70_E	150_Y	0.737	1.00
314_I	317_I	0.735	1.00
315_H	322_R	0.733	1.00
126_D	338_I	0.731	1.00
236_M	239_L	0.729	1.00
244_D	247_Y	0.728	1.00
314_I	318_E	0.728	1.00
320_N	323_V	0.728	1.00
72_R	148_I	0.727	1.00
10_P	346_N	0.726	1.00
276_G	286_I	0.725	1.00
316_S	320_N	0.725	1.00
243_K	246_F	0.721	1.00
275_H	280_T	0.716	1.00
190_A	194_V	0.715	1.00
68_G	150_Y	0.713	1.00
111_V	140_I	0.713	1.00
312_F	318_E	0.713	1.00
278_V	284_E	0.712	1.00
313_E	322_R	0.707	1.00
279_M	287_I	0.706	1.00
272_V	275_H	0.704	1.00
203_G	212_T	0.704	1.00
124_G	339_M	0.704	1.00
316_S	322_R	0.703	1.00
317_I	320_N	0.702	1.00
193_L	196_K	0.699	1.00
336_K	346_N	0.697	1.00
325_E	330_E	0.696	1.00
167_V	171_K	0.695	1.00
181_R	184_T	0.693	1.00
285_I	288_Y	0.692	1.00
280_T	284_E	0.692	1.00
276_G	281_L	0.692	1.00
105_N	109_N	0.690	1.00
128_L	131_A	0.690	1.00
205_W	211_S	0.689	1.00
283_G	286_I	0.687	1.00
283_G	287_I	0.685	1.00
329_L	332_M	0.685	1.00
287_I	290_V	0.685	1.00
267_A	271_N	0.681	1.00
312_F	316_S	0.680	1.00
15_G	53_P	0.678	1.00
284_E	289_T	0.678	1.00
12_V	30_S	0.678	1.00
199_L	202_V	0.677	1.00
313_E	323_V	0.676	1.00
110_S	142_E	0.676	1.00
273_L	280_T	0.672	1.00
60_T	83_L	0.672	1.00
242_F	245_Y	0.671	1.00
335_Y	339_M	0.670	1.00
248_E	252_L	0.669	1.00
249_V	252_L	0.668	1.00
297_N	301_I	0.668	1.00
257_F	260_V	0.667	1.00
171_K	174_G	0.664	1.00
205_W	210_A	0.663	1.00
220_N	227_L	0.662	1.00
312_F	319_V	0.661	1.00
239_L	242_F	0.660	1.00
301_I	305_M	0.659	1.00
182_R	185_V	0.659	1.00
280_T	285_I	0.659	1.00
36_N	56_K	0.658	1.00
244_D	249_V	0.657	1.00
47_K	146_A	0.654	1.00
293_S	297_N	0.654	1.00
309_G	312_F	0.653	1.00
157_L	160_L	0.651	1.00
318_E	321_D	0.650	1.00
160_L	169_I	0.649	1.00
282_R	287_I	0.648	1.00
219_V	226_E	0.648	1.00
276_G	287_I	0.647	1.00
271_N	295_K	0.646	1.00
43_E	46_D	0.646	1.00
62_D	65_R	0.645	1.00
41_V	52_T	0.644	1.00
277_D	283_G	0.644	1.00
280_T	289_T	0.642	1.00
284_E	290_V	0.641	1.00
272_V	277_D	0.640	1.00
234_V	237_S	0.636	1.00
137_T	335_Y	0.635	1.00
275_H	284_E	0.631	1.00
164_E	259_R	0.628	1.00
259_R	307_K	0.626	1.00
233_Y	246_F	0.623	1.00
236_M	240_T	0.623	1.00
313_E	317_I	0.622	1.00
205_W	208_I	0.621	1.00
53_P	143_A	0.619	1.00
314_I	320_N	0.619	1.00
238_K	241_K	0.616	1.00
310_I	315_H	0.616	1.00
126_D	335_Y	0.615	1.00
272_V	276_G	0.613	1.00
120_Y	128_L	0.613	1.00
241_K	244_D	0.613	1.00
276_G	285_I	0.611	1.00
222_R	227_L	0.610	1.00
281_L	286_I	0.610	1.00
19_S	24_V	0.609	1.00
217_E	220_N	0.608	1.00
315_H	320_N	0.606	1.00
313_E	321_D	0.606	1.00
195_G	198_R	0.606	1.00
252_L	260_V	0.604	1.00
249_V	254_L	0.603	1.00
222_R	226_E	0.601	1.00
173_L	176_F	0.599	1.00
57_I	81_A	0.599	1.00
239_L	243_K	0.597	1.00
16_A	56_K	0.594	1.00
64_L	67_R	0.593	1.00
219_V	222_R	0.592	1.00
260_V	263_Q	0.591	1.00
313_E	318_E	0.591	1.00
93_G	96_S	0.591	1.00
276_G	284_E	0.590	1.00
180_I	184_T	0.589	1.00
78_F	81_A	0.589	1.00
61_L	70_E	0.588	1.00
277_D	284_E	0.588	1.00
207_V	211_S	0.588	1.00
264_V	268_L	0.587	1.00
249_V	253_S	0.587	1.00
206_N	209_V	0.586	1.00
279_M	285_I	0.584	1.00
180_I	187_D	0.581	1.00
239_L	245_Y	0.580	1.00
251_L	310_I	0.579	1.00
176_F	225_D	0.579	1.00
170_L	173_L	0.578	1.00
193_L	197_D	0.577	1.00
275_H	285_I	0.576	1.00
57_I	83_L	0.574	1.00
314_I	321_D	0.573	1.00
195_G	201_K	0.572	1.00
90_G	101_Y	0.568	1.00
5_D	117_T	0.566	1.00
240_T	243_K	0.566	1.00
236_M	241_K	0.566	1.00
237_S	245_Y	0.564	1.00
273_L	286_I	0.564	1.00
274_I	287_I	0.564	1.00
191_L	195_G	0.564	1.00
235_T	241_K	0.563	1.00
237_S	243_K	0.560	1.00
121_T	126_D	0.558	1.00
281_L	289_T	0.557	1.00
296_S	300_I	0.555	1.00
328_R	332_M	0.555	1.00
111_V	131_A	0.551	1.00
278_V	285_I	0.550	1.00
34_D	37_D	0.549	1.00
188_Y	195_G	0.549	1.00
217_E	221_L	0.549	1.00
96_S	101_Y	0.548	1.00
286_I	290_V	0.546	1.00
313_E	320_N	0.546	1.00
44_I	147_I	0.546	1.00
188_Y	204_K	0.546	1.00
61_L	64_L	0.544	1.00
235_T	239_L	0.544	1.00
317_I	322_R	0.543	1.00
183_I	187_D	0.542	1.00
343_N	346_N	0.541	1.00
314_I	322_R	0.541	1.00
261_V	265_K	0.540	1.00
237_S	241_K	0.539	1.00
236_M	243_K	0.535	1.00
299_E	303_S	0.535	1.00
273_L	279_M	0.534	1.00
238_K	242_F	0.534	1.00
240_T	245_Y	0.534	1.00
184_T	188_Y	0.532	1.00
76_S	86_Y	0.528	1.00
41_V	51_V	0.528	1.00
56_K	82_T	0.527	1.00
278_V	283_G	0.526	1.00
60_T	71_L	0.526	1.00
277_D	286_I	0.524	1.00
327_Y	330_E	0.523	1.00
44_I	67_R	0.522	1.00
291_F	294_D	0.522	1.00
234_V	246_F	0.519	1.00
187_D	190_A	0.517	1.00
245_Y	250_R	0.517	1.00
239_L	246_F	0.517	1.00
279_M	288_Y	0.516	1.00
112_R	144_E	0.516	1.00
241_K	245_Y	0.514	1.00
197_D	200_D	0.514	1.00
87_I	140_I	0.514	1.00
298_F	301_I	0.513	1.00
275_H	281_L	0.512	1.00
238_K	243_K	0.509	1.00
204_K	210_A	0.509	1.00
236_M	244_D	0.508	1.00
204_K	209_V	0.507	1.00
265_K	268_L	0.505	1.00
277_D	288_Y	0.505	1.00
43_E	48_W	0.504	1.00
324_D	332_M	0.504	1.00
336_K	340_D	0.503	1.00
3_L	31_I	0.502	1.00
99_Y	148_I	0.502	1.00
298_F	323_V	0.502	1.00
88_A	130_V	0.500	1.00
179_K	184_T	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3pm9A	5	0.9886	100	0.292	Contact Map
1f0xA	1	0.9631	100	0.331	Contact Map
2uuuA	2	0.946	100	0.336	Contact Map
4bbyA	2	0.9886	100	0.351	Contact Map
2exrA	1	0.9489	100	0.378	Contact Map
4mlaA	1	0.9318	100	0.383	Contact Map
1wvfA	2	0.9773	100	0.388	Contact Map
1w1oA	1	0.9574	100	0.388	Contact Map
4p8nA	1	0.9773	100	0.41	Contact Map
4o95A	1	0.9545	100	0.41	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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