GREMLIN Database
Q7LXI4 - Uncharacterized protein
UniProt: Q7LXI4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (291)
Sequences: 157 (103)
Seq/√Len: 6.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_L76_A4.4370.97
199_T289_Q4.0080.94
116_I125_V3.8540.92
72_L80_I3.6990.91
2_M254_S3.3140.85
16_K20_N3.0930.80
180_V227_I3.0080.78
165_T195_V2.9900.78
87_L90_L2.9200.76
148_I257_C2.8450.74
181_I192_V2.8290.74
57_L90_L2.7130.70
76_A80_I2.6360.68
198_T209_V2.6330.68
157_A195_V2.5390.65
247_I251_E2.5210.64
162_F188_T2.5060.64
80_I250_L2.4300.61
16_K23_R2.4190.61
209_V279_L2.3760.60
19_L23_R2.3610.59
22_L90_L2.2720.56
175_K178_D2.2210.54
186_R238_P2.1670.52
105_F279_L2.1540.52
183_I238_P2.1350.51
16_K19_L2.1340.51
20_N23_R2.0230.47
41_F128_I2.0200.47
9_A83_L2.0140.47
26_L90_L1.9640.45
155_R178_D1.9570.45
175_K198_T1.8550.41
104_S142_A1.8340.40
5_S87_L1.8000.39
56_I212_I1.8000.39
164_L229_I1.7920.39
183_I187_V1.7770.39
22_L87_L1.7560.38
247_I250_L1.7470.38
59_R137_E1.7440.37
2_M83_L1.7200.37
162_F184_Y1.7090.36
175_K275_E1.6850.35
13_L83_L1.6480.34
100_D265_E1.6390.34
3_L247_I1.6360.34
76_A158_K1.6100.33
91_N95_K1.6010.33
122_N241_V1.5960.33
6_L84_A1.5950.33
81_V250_L1.5850.32
36_I125_V1.5710.32
199_T286_S1.5550.31
43_K271_Y1.5490.31
156_L164_L1.5450.31
2_M6_L1.5430.31
30_E57_L1.5400.31
238_P287_N1.5310.31
159_F193_Y1.5130.30
83_L109_I1.5110.30
194_L241_V1.4990.30
152_K231_T1.4870.29
69_S122_N1.4640.29
6_L250_L1.4600.29
162_F229_I1.4440.28
4_K8_D1.4420.28
245_Q251_E1.4220.27
278_E282_K1.3790.26
238_P285_E1.3750.26
190_H234_K1.3680.26
56_I190_H1.3540.26
11_E250_L1.3490.25
156_L219_W1.3460.25
85_V258_L1.3410.25
93_K98_A1.3280.25
193_Y196_S1.3160.25
23_R26_L1.2950.24
41_F142_A1.2950.24
220_L254_S1.2910.24
240_Y249_M1.2810.24
241_V264_V1.2790.24
184_Y195_V1.2700.23
119_Q210_Y1.2690.23
6_L122_N1.2590.23
122_N182_D1.2550.23
143_G164_L1.2430.23
63_I76_A1.2280.22
24_S266_G1.2240.22
57_L119_Q1.2180.22
234_K258_L1.2150.22
7_I247_I1.2110.22
245_Q250_L1.2060.22
110_S240_Y1.2010.22
145_I224_S1.2000.22
110_S127_L1.1960.21
9_A72_L1.1940.21
142_A200_G1.1920.21
184_Y187_V1.1890.21
133_A194_L1.1850.21
20_N26_L1.1740.21
63_I72_L1.1600.21
34_K37_G1.1560.21
140_P145_I1.1530.20
54_V143_G1.1500.20
117_P238_P1.1480.20
57_L136_E1.1310.20
199_T288_L1.1300.20
19_L26_L1.1290.20
146_L208_N1.1270.20
148_I197_L1.1260.20
62_A110_S1.1180.20
192_V250_L1.1150.20
6_L251_E1.1130.20
156_L210_Y1.1080.19
53_K102_D1.1070.19
134_L244_V1.1060.19
175_K219_W1.1040.19
63_I240_Y1.1040.19
22_L26_L1.0990.19
83_L209_V1.0940.19
15_S95_K1.0920.19
35_K236_M1.0810.19
30_E56_I1.0720.19
33_E116_I1.0600.18
266_G277_K1.0580.18
80_I247_I1.0510.18
117_P289_Q1.0510.18
3_L148_I1.0470.18
5_S195_V1.0430.18
162_F232_V1.0400.18
156_L287_N1.0360.18
6_L68_A1.0330.18
131_D220_L1.0310.18
80_I251_E1.0250.18
208_N271_Y1.0200.18
187_V246_D1.0190.18
151_T212_I1.0170.17
72_L250_L1.0150.17
122_N238_P1.0130.17
25_K87_L1.0100.17
169_K271_Y1.0080.17
236_M280_K1.0010.17
223_D287_N0.9820.17
125_V220_L0.9780.17
31_Y38_E0.9740.17
194_L197_L0.9640.16
45_Y104_S0.9630.16
162_F233_S0.9620.16
60_L79_A0.9580.16
263_Y276_L0.9570.16
62_A111_L0.9540.16
16_K44_V0.9520.16
195_V212_I0.9510.16
6_L187_V0.9490.16
80_I245_Q0.9390.16
33_E234_K0.9330.16
129_G133_A0.9320.16
156_L197_L0.9310.16
57_L143_G0.9270.16
102_D134_L0.9270.16
119_Q267_G0.9260.16
62_A126_P0.9260.16
32_E81_V0.9230.16
168_I216_I0.9230.16
54_V142_A0.9220.16
48_S102_D0.9170.16
68_A122_N0.9140.15
133_A136_E0.9140.15
57_L145_I0.9120.15
162_F257_C0.9110.15
243_G284_G0.9110.15
276_L286_S0.9080.15
7_I84_A0.9080.15
258_L270_V0.9050.15
76_A216_I0.9050.15
109_I146_L0.9050.15
3_L185_N0.9040.15
157_A254_S0.9040.15
22_L25_K0.9030.15
111_L126_P0.8980.15
24_S125_V0.8980.15
220_L264_V0.8950.15
114_K126_P0.8950.15
13_L155_R0.8880.15
46_Y105_F0.8810.15
16_K26_L0.8780.15
56_I85_V0.8770.15
187_V219_W0.8750.15
89_L266_G0.8740.15
165_T186_R0.8670.15
4_K220_L0.8670.15
106_V220_L0.8600.14
192_V245_Q0.8600.14
143_G162_F0.8580.14
248_E263_Y0.8470.14
156_L208_N0.8470.14
98_A277_K0.8440.14
152_K246_D0.8400.14
17_D210_Y0.8390.14
79_A243_G0.8380.14
18_P260_M0.8350.14
86_L276_L0.8340.14
63_I148_I0.8310.14
197_L209_V0.8300.14
80_I238_P0.8290.14
114_K206_D0.8280.14
54_V286_S0.8260.14
175_K197_L0.8240.14
165_T247_I0.8210.14
277_K281_E0.8180.14
49_G53_K0.8140.14
95_K145_I0.8110.14
35_K212_I0.8090.14
155_R182_D0.8070.14
81_V162_F0.8050.14
56_I148_I0.8040.14
240_Y246_D0.8000.13
187_V194_L0.8000.13
5_S190_H0.8000.13
84_A285_E0.7990.13
187_V264_V0.7980.13
42_V82_T0.7960.13
145_I280_K0.7940.13
280_K285_E0.7930.13
23_R27_K0.7920.13
10_I245_Q0.7910.13
22_L27_K0.7910.13
142_A257_C0.7900.13
157_A234_K0.7900.13
76_A250_L0.7890.13
182_D251_E0.7870.13
172_Y195_V0.7870.13
81_V172_Y0.7850.13
116_I155_R0.7790.13
142_A220_L0.7770.13
143_G233_S0.7760.13
9_A250_L0.7720.13
4_K105_F0.7720.13
9_A80_I0.7710.13
68_A264_V0.7710.13
146_L162_F0.7710.13
235_Q276_L0.7700.13
48_S53_K0.7660.13
119_Q175_K0.7610.13
14_E134_L0.7610.13
170_D290_R0.7600.13
49_G102_D0.7570.13
126_P151_T0.7560.13
14_E244_V0.7560.13
156_L176_L0.7520.13
264_V274_N0.7520.13
2_M7_I0.7480.13
6_L195_V0.7470.13
146_L268_G0.7450.13
51_R146_L0.7440.13
160_D249_M0.7370.12
29_V162_F0.7370.12
60_L243_G0.7370.12
69_S183_I0.7300.12
145_I273_E0.7300.12
165_T198_T0.7290.12
18_P164_L0.7270.12
2_M212_I0.7260.12
179_E268_G0.7240.12
34_K62_A0.7230.12
22_L91_N0.7230.12
10_I268_G0.7220.12
130_L254_S0.7200.12
11_E72_L0.7180.12
17_D91_N0.7160.12
85_V132_E0.7160.12
194_L255_R0.7150.12
197_L250_L0.7140.12
192_V206_D0.7110.12
194_L251_E0.7090.12
9_A84_A0.7080.12
69_S238_P0.7080.12
15_S236_M0.7050.12
7_I251_E0.7040.12
113_A284_G0.7010.12
157_A184_Y0.6990.12
2_M80_I0.6980.12
143_G173_I0.6970.12
40_T215_L0.6950.12
160_D252_H0.6950.12
21_L26_L0.6910.12
224_S253_A0.6860.12
156_L216_I0.6860.12
156_L269_K0.6840.12
81_V104_S0.6800.12
16_K235_Q0.6790.12
79_A151_T0.6770.12
43_K142_A0.6770.12
28_G273_E0.6730.11
165_T290_R0.6720.11
7_I254_S0.6720.11
45_Y183_I0.6700.11
175_K277_K0.6700.11
145_I168_I0.6660.11
17_D43_K0.6640.11
90_L248_E0.6620.11
81_V257_C0.6620.11
122_N264_V0.6600.11
8_D95_K0.6600.11
110_S126_P0.6590.11
7_I246_D0.6590.11
62_A114_K0.6580.11
145_I209_V0.6570.11
54_V279_L0.6550.11
125_V238_P0.6540.11
52_E166_H0.6540.11
10_I133_A0.6540.11
182_D185_N0.6530.11
168_I197_L0.6510.11
1_M268_G0.6440.11
68_A241_V0.6410.11
32_E250_L0.6380.11
83_L182_D0.6370.11
21_L50_G0.6360.11
118_H242_T0.6340.11
130_L209_V0.6340.11
148_I250_L0.6330.11
185_N234_K0.6330.11
183_I277_K0.6330.11
156_L286_S0.6320.11
54_V98_A0.6300.11
42_V263_Y0.6300.11
132_E194_L0.6280.11
44_V172_Y0.6270.11
60_L118_H0.6270.11
70_K122_N0.6260.11
63_I109_I0.6240.11
41_F257_C0.6230.11
142_A197_L0.6200.11
2_M187_V0.6190.11
45_Y238_P0.6190.11
278_E289_Q0.6190.11
24_S233_S0.6180.11
3_L132_E0.6180.11
37_G62_A0.6130.11
208_N286_S0.6110.11
43_K281_E0.6110.11
82_T251_E0.6110.11
140_P178_D0.6100.11
165_T182_D0.6070.11
175_K273_E0.6060.11
170_D188_T0.6040.11
23_R106_V0.6010.10
176_L198_T0.6010.10
209_V236_M0.6000.10
63_I160_D0.5990.10
54_V57_L0.5970.10
125_V252_H0.5960.10
63_I285_E0.5960.10
181_I237_I0.5940.10
48_S134_L0.5940.10
15_S63_I0.5930.10
72_L245_Q0.5860.10
50_G112_N0.5860.10
11_E95_K0.5850.10
185_N192_V0.5850.10
46_Y219_W0.5840.10
195_V234_K0.5800.10
82_T148_I0.5800.10
132_E136_E0.5780.10
53_K134_L0.5740.10
172_Y199_T0.5740.10
251_E255_R0.5740.10
112_N237_I0.5720.10
57_L142_A0.5720.10
13_L103_V0.5710.10
175_K285_E0.5710.10
192_V251_E0.5710.10
60_L284_G0.5700.10
17_D135_K0.5700.10
90_L106_V0.5690.10
114_K151_T0.5650.10
57_L253_A0.5630.10
111_L114_K0.5610.10
29_V42_V0.5610.10
85_V223_D0.5600.10
186_R250_L0.5600.10
255_R291_V0.5570.10
184_Y212_I0.5480.10
57_L106_V0.5450.10
187_V252_H0.5440.10
54_V133_A0.5440.10
197_L216_I0.5420.10
110_S168_I0.5410.10
128_I187_V0.5410.10
43_K175_K0.5410.10
8_D164_L0.5400.10
93_K145_I0.5400.10
209_V280_K0.5360.10
23_R247_I0.5340.10
278_E286_S0.5340.10
11_E209_V0.5330.10
23_R139_D0.5320.10
43_K159_F0.5300.10
72_L87_L0.5290.10
7_I192_V0.5290.10
9_A22_L0.5280.10
157_A210_Y0.5280.10
63_I265_E0.5270.10
187_V285_E0.5270.10
162_F253_A0.5250.10
6_L90_L0.5250.10
230_A239_G0.5240.10
8_D31_Y0.5240.10
139_D288_L0.5230.09
12_I82_T0.5220.09
100_D185_N0.5220.09
128_I244_V0.5210.09
246_D249_M0.5210.09
84_A232_V0.5190.09
182_D186_R0.5170.09
7_I286_S0.5160.09
213_S217_S0.5150.09
214_T217_S0.5150.09
42_V210_Y0.5150.09
160_D199_T0.5140.09
18_P185_N0.5140.09
195_V257_C0.5140.09
91_N129_G0.5130.09
210_Y242_T0.5130.09
4_K146_L0.5130.09
12_I116_I0.5120.09
2_M241_V0.5080.09
13_L188_T0.5070.09
60_L150_S0.5070.09
273_E279_L0.5060.09
274_N277_K0.5050.09
3_L249_M0.5050.09
41_F133_A0.5050.09
253_A275_E0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rb7A 2 0.8514 30.2 0.98 Contact Map
2w6rA 1 0.4122 25.6 0.98 Contact Map
2cujA 1 0.2399 15.5 0.982 Contact Map
1q7lA 2 0.5203 13.7 0.983 Contact Map
3gwmA 3 0.1858 10.7 0.983 Contact Map
1thfD 2 0.4426 9.4 0.984 Contact Map
4jqpA 2 0.5777 9.1 0.984 Contact Map
1yxoA 2 0.5811 8.8 0.984 Contact Map
1vmiA 2 0.5473 7.4 0.985 Contact Map
3bywA 5 0.25 7.1 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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