GREMLIN Database
Q7LXI3 - Acetylornithine deacetylase (ArgE-1)
UniProt: Q7LXI3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 184 (169)
Sequences: 13115 (8415)
Seq/√Len: 647.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_V144_V3.4521.00
84_R142_E3.1851.00
84_R144_V3.1301.00
131_N144_V3.0031.00
99_E104_N2.7751.00
105_G143_F2.6781.00
161_H165_K2.6541.00
103_I113_Q2.5311.00
82_V146_S2.5231.00
105_G145_F2.4711.00
86_I142_E2.4351.00
165_K169_L2.4251.00
162_G166_I2.3691.00
90_A98_G2.3441.00
49_Y53_V2.1671.00
85_L108_L2.1611.00
129_T146_S2.1231.00
89_Q141_G2.0161.00
85_L105_G2.0141.00
156_E159_A1.9291.00
106_A109_A1.9191.00
49_Y52_E1.9011.00
111_E170_S1.8681.00
107_K110_L1.8081.00
158_L162_G1.7801.00
111_E167_T1.7571.00
159_A163_R1.7561.00
81_G147_F1.6981.00
102_F130_I1.6561.00
83_I145_F1.6281.00
106_A110_L1.6141.00
80_R148_Y1.6041.00
18_V36_L1.5991.00
88_K99_E1.5471.00
81_G161_H1.5231.00
21_M64_G1.5171.00
48_K52_E1.4941.00
107_K113_Q1.4841.00
21_M34_I1.4821.00
14_M17_G1.4771.00
163_R166_I1.4761.00
109_A145_F1.4741.00
102_F132_S1.4651.00
166_I170_S1.4241.00
162_G165_K1.4181.00
108_L168_S1.3921.00
130_I143_F1.3901.00
6_A11_V1.3891.00
115_I163_R1.3801.00
110_L114_K1.3581.00
109_A127_G1.3161.00
111_E114_K1.2861.00
136_D146_S1.2841.00
8_G11_V1.2421.00
23_L26_S1.2251.00
83_I147_F1.2241.00
100_N140_P1.2201.00
25_L34_I1.2031.00
163_R167_T1.1821.00
135_N138_V1.1721.00
65_D68_F1.1641.00
149_R155_N1.1631.00
111_E171_V1.1621.00
167_T170_S1.1611.00
87_E101_A1.1401.00
110_L113_Q1.1381.00
125_L149_R1.1191.00
102_F143_F1.1171.00
159_A162_G1.1171.00
35_S50_L1.1161.00
137_G150_S1.1141.00
30_R59_K1.0911.00
83_I108_L1.0901.00
166_I169_L1.0831.00
101_A143_F1.0741.00
63_I66_P1.0711.00
47_T51_T1.0701.00
23_L27_E1.0451.00
149_R160_I1.0441.00
132_S143_F1.0401.00
107_K114_K1.0381.00
37_V47_T1.0281.00
17_G64_G1.0281.00
50_L54_R1.0261.00
155_N159_A1.0221.00
98_G101_A1.0171.00
158_L161_H1.0101.00
85_L104_N1.0101.00
20_S24_A1.0041.00
131_N146_S0.9981.00
105_G109_A0.9851.00
42_S45_I0.9801.00
155_N160_I0.9791.00
76_L124_N0.9781.00
78_I148_Y0.9751.00
100_N126_G0.9661.00
127_G147_F0.9531.00
167_T171_V0.9521.00
157_S161_H0.9501.00
107_K111_E0.9351.00
105_G130_I0.9211.00
149_R164_L0.9121.00
25_L36_L0.9051.00
151_T157_S0.8981.00
24_A28_T0.8951.00
80_R136_D0.8941.00
33_E58_A0.8931.00
104_N107_K0.8921.00
81_G164_L0.8871.00
116_Y119_K0.8841.00
85_L145_F0.8601.00
123_L152_L0.8551.00
134_D138_V0.8491.00
90_A139_V0.8461.00
39_D46_G0.8431.00
14_M18_V0.8331.00
127_G145_F0.8251.00
19_V23_L0.8211.00
79_I157_S0.8141.00
72_Y75_H0.8131.00
65_D69_P0.8101.00
112_I164_L0.8021.00
90_A95_T0.7961.00
31_P59_K0.7941.00
109_A130_I0.7841.00
94_K97_E0.7841.00
22_Y34_I0.7841.00
45_I49_Y0.7811.00
134_D141_G0.7801.00
21_M36_L0.7751.00
64_G68_F0.7721.00
152_L155_N0.7671.00
17_G21_M0.7651.00
87_E99_E0.7621.00
60_Y65_D0.7611.00
106_A113_Q0.7611.00
56_I59_K0.7591.00
39_D42_S0.7551.00
79_I161_H0.7491.00
117_G120_E0.7451.00
103_I106_A0.7421.00
76_L150_S0.7401.00
104_N108_L0.7391.00
129_T134_D0.7351.00
123_L155_N0.7341.00
153_Q156_E0.7281.00
66_P69_P0.7261.00
126_G139_V0.7251.00
77_G151_T0.7241.00
4_D7_Y0.7231.00
92_A128_Y0.7161.00
115_I118_V0.7131.00
30_R60_Y0.7041.00
85_L101_A0.7031.00
80_R146_S0.7001.00
103_I107_K0.6951.00
106_A127_G0.6911.00
151_T160_I0.6871.00
22_Y36_L0.6871.00
133_S140_P0.6821.00
102_F140_P0.6821.00
114_K118_V0.6791.00
61_V64_G0.6781.00
147_F164_L0.6731.00
102_F106_A0.6731.00
92_A124_N0.6731.00
25_L32_V0.6721.00
112_I125_L0.6681.00
62_I66_P0.6671.00
50_L53_V0.6671.00
64_G67_S0.6621.00
100_N103_I0.6561.00
123_L149_R0.6531.00
115_I167_T0.6471.00
129_T136_D0.6451.00
108_L167_T0.6451.00
103_I126_G0.6391.00
86_I141_G0.6381.00
67_S72_Y0.6361.00
102_F133_S0.6321.00
162_G169_L0.6311.00
87_E98_G0.6311.00
111_E115_I0.6261.00
39_D45_I0.6251.00
92_A148_Y0.6211.00
3_G7_Y0.6201.00
33_E57_R0.6181.00
37_V44_G0.6151.00
88_K98_G0.6141.00
118_V163_R0.6111.00
131_N142_E0.6101.00
21_M25_L0.6091.00
80_R92_A0.6031.00
63_I67_S0.6001.00
103_I109_A0.5991.00
57_R60_Y0.5981.00
53_V56_I0.5971.00
13_D41_E0.5921.00
103_I127_G0.5911.00
95_T116_Y0.5901.00
98_G139_V0.5891.00
103_I110_L0.5891.00
135_N150_S0.5891.00
104_N171_V0.5871.00
22_Y26_S0.5861.00
133_S143_F0.5851.00
83_I168_S0.5831.00
128_Y148_Y0.5821.00
63_I68_F0.5811.00
115_I119_K0.5791.00
128_Y137_G0.5771.00
9_K76_L0.5731.00
14_M65_D0.5731.00
85_L168_S0.5721.00
70_N73_I0.5691.00
87_E104_N0.5691.00
37_V50_L0.5681.00
20_S23_L0.5661.00
63_I69_P0.5651.00
105_G108_L0.5621.00
107_K171_V0.5601.00
125_L147_F0.5591.00
131_N134_D0.5581.00
58_A61_V0.5571.00
46_G49_Y0.5511.00
43_G78_I0.5481.00
108_L112_I0.5481.00
33_E59_K0.5441.00
89_Q138_V0.5441.00
95_T124_N0.5441.00
24_A27_E0.5411.00
119_K163_R0.5401.00
14_M64_G0.5371.00
47_T50_L0.5361.00
126_G148_Y0.5350.99
124_N148_Y0.5320.99
72_Y76_L0.5320.99
61_V66_P0.5300.99
62_I65_D0.5240.99
95_T139_V0.5230.99
38_P44_G0.5220.99
102_F109_A0.5210.99
106_A130_I0.5180.99
33_E50_L0.5180.99
25_L28_T0.5150.99
106_A145_F0.5140.99
128_Y132_S0.5100.99
9_K13_D0.5050.99
88_K139_V0.5040.99
64_G69_P0.5040.99
90_A97_E0.5030.99
39_D43_G0.5030.99
42_S137_G0.5020.99
31_P56_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tx8A 2 0.9946 100 0.244 Contact Map
2f7vA 2 0.962 100 0.246 Contact Map
3pfoA 2 0.9946 100 0.248 Contact Map
1cg2A 4 0.9891 100 0.268 Contact Map
2rb7A 2 0.962 100 0.275 Contact Map
3ct9A 2 0.962 100 0.284 Contact Map
4pqaA 2 1 100 0.295 Contact Map
3gb0A 2 0.9837 100 0.296 Contact Map
3iszA 2 0.9728 100 0.297 Contact Map
3rzaA 2 0.9837 100 0.299 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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