Q7LXI3 - SULSO - GREMLIN Contacts

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Q7LXI3 - Acetylornithine deacetylase (ArgE-1)

UniProt:	Q7LXI3	Sequences: MVGDKAYGKGVSDMKGGVVSMYLALSETKRPVEISLVPDEESGGIGTKYLTEVRKIRAKYVIIGDPSFPNIYIGHLGIIRGVIRLIEKQAHASKTKEGENAFINGAKLALEIQKIYGVKEVSLNLGGYTINSSDNDGVVPGEFVFSFYRSTLQKNESLAIHGRLKITSLSVSTRWKNSLDQYPI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	184 (169)
Sequences:	13115 (8415)
Seq/√Len:	647.3

ECOLI - ARGE YGEY DAPE PEPT ABGA ABGB PEPD ALLC
BACSU - YODQ FAPD YQJE PEPT AMHX YHAA DAPEL YXEP YTNL YQJN ALLC ROCB PEPVL
HALSA - Q9HS25
SULSO - Q7LXI3 Q97ZB7 Q97Y12 LYSK Q97V97 CBPX1 CBPX2 Q97VB6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
82_V	144_V	3.452	1.00
84_R	142_E	3.185	1.00
84_R	144_V	3.130	1.00
131_N	144_V	3.003	1.00
99_E	104_N	2.775	1.00
105_G	143_F	2.678	1.00
161_H	165_K	2.654	1.00
103_I	113_Q	2.531	1.00
82_V	146_S	2.523	1.00
105_G	145_F	2.471	1.00
86_I	142_E	2.435	1.00
165_K	169_L	2.425	1.00
162_G	166_I	2.369	1.00
90_A	98_G	2.344	1.00
49_Y	53_V	2.167	1.00
85_L	108_L	2.161	1.00
129_T	146_S	2.123	1.00
89_Q	141_G	2.016	1.00
85_L	105_G	2.014	1.00
156_E	159_A	1.929	1.00
106_A	109_A	1.919	1.00
49_Y	52_E	1.901	1.00
111_E	170_S	1.868	1.00
107_K	110_L	1.808	1.00
158_L	162_G	1.780	1.00
111_E	167_T	1.757	1.00
159_A	163_R	1.756	1.00
81_G	147_F	1.698	1.00
102_F	130_I	1.656	1.00
83_I	145_F	1.628	1.00
106_A	110_L	1.614	1.00
80_R	148_Y	1.604	1.00
18_V	36_L	1.599	1.00
88_K	99_E	1.547	1.00
81_G	161_H	1.523	1.00
21_M	64_G	1.517	1.00
48_K	52_E	1.494	1.00
107_K	113_Q	1.484	1.00
21_M	34_I	1.482	1.00
14_M	17_G	1.477	1.00
163_R	166_I	1.476	1.00
109_A	145_F	1.474	1.00
102_F	132_S	1.465	1.00
166_I	170_S	1.424	1.00
162_G	165_K	1.418	1.00
108_L	168_S	1.392	1.00
130_I	143_F	1.390	1.00
6_A	11_V	1.389	1.00
115_I	163_R	1.380	1.00
110_L	114_K	1.358	1.00
109_A	127_G	1.316	1.00
111_E	114_K	1.286	1.00
136_D	146_S	1.284	1.00
8_G	11_V	1.242	1.00
23_L	26_S	1.225	1.00
83_I	147_F	1.224	1.00
100_N	140_P	1.220	1.00
25_L	34_I	1.203	1.00
163_R	167_T	1.182	1.00
135_N	138_V	1.172	1.00
65_D	68_F	1.164	1.00
149_R	155_N	1.163	1.00
111_E	171_V	1.162	1.00
167_T	170_S	1.161	1.00
87_E	101_A	1.140	1.00
110_L	113_Q	1.138	1.00
125_L	149_R	1.119	1.00
102_F	143_F	1.117	1.00
159_A	162_G	1.117	1.00
35_S	50_L	1.116	1.00
137_G	150_S	1.114	1.00
30_R	59_K	1.091	1.00
83_I	108_L	1.090	1.00
166_I	169_L	1.083	1.00
101_A	143_F	1.074	1.00
63_I	66_P	1.071	1.00
47_T	51_T	1.070	1.00
23_L	27_E	1.045	1.00
149_R	160_I	1.044	1.00
132_S	143_F	1.040	1.00
107_K	114_K	1.038	1.00
37_V	47_T	1.028	1.00
17_G	64_G	1.028	1.00
50_L	54_R	1.026	1.00
155_N	159_A	1.022	1.00
98_G	101_A	1.017	1.00
158_L	161_H	1.010	1.00
85_L	104_N	1.010	1.00
20_S	24_A	1.004	1.00
131_N	146_S	0.998	1.00
105_G	109_A	0.985	1.00
42_S	45_I	0.980	1.00
155_N	160_I	0.979	1.00
76_L	124_N	0.978	1.00
78_I	148_Y	0.975	1.00
100_N	126_G	0.966	1.00
127_G	147_F	0.953	1.00
167_T	171_V	0.952	1.00
157_S	161_H	0.950	1.00
107_K	111_E	0.935	1.00
105_G	130_I	0.921	1.00
149_R	164_L	0.912	1.00
25_L	36_L	0.905	1.00
151_T	157_S	0.898	1.00
24_A	28_T	0.895	1.00
80_R	136_D	0.894	1.00
33_E	58_A	0.893	1.00
104_N	107_K	0.892	1.00
81_G	164_L	0.887	1.00
116_Y	119_K	0.884	1.00
85_L	145_F	0.860	1.00
123_L	152_L	0.855	1.00
134_D	138_V	0.849	1.00
90_A	139_V	0.846	1.00
39_D	46_G	0.843	1.00
14_M	18_V	0.833	1.00
127_G	145_F	0.825	1.00
19_V	23_L	0.821	1.00
79_I	157_S	0.814	1.00
72_Y	75_H	0.813	1.00
65_D	69_P	0.810	1.00
112_I	164_L	0.802	1.00
90_A	95_T	0.796	1.00
31_P	59_K	0.794	1.00
109_A	130_I	0.784	1.00
94_K	97_E	0.784	1.00
22_Y	34_I	0.784	1.00
45_I	49_Y	0.781	1.00
134_D	141_G	0.780	1.00
21_M	36_L	0.775	1.00
64_G	68_F	0.772	1.00
152_L	155_N	0.767	1.00
17_G	21_M	0.765	1.00
87_E	99_E	0.762	1.00
60_Y	65_D	0.761	1.00
106_A	113_Q	0.761	1.00
56_I	59_K	0.759	1.00
39_D	42_S	0.755	1.00
79_I	161_H	0.749	1.00
117_G	120_E	0.745	1.00
103_I	106_A	0.742	1.00
76_L	150_S	0.740	1.00
104_N	108_L	0.739	1.00
129_T	134_D	0.735	1.00
123_L	155_N	0.734	1.00
153_Q	156_E	0.728	1.00
66_P	69_P	0.726	1.00
126_G	139_V	0.725	1.00
77_G	151_T	0.724	1.00
4_D	7_Y	0.723	1.00
92_A	128_Y	0.716	1.00
115_I	118_V	0.713	1.00
30_R	60_Y	0.704	1.00
85_L	101_A	0.703	1.00
80_R	146_S	0.700	1.00
103_I	107_K	0.695	1.00
106_A	127_G	0.691	1.00
151_T	160_I	0.687	1.00
22_Y	36_L	0.687	1.00
133_S	140_P	0.682	1.00
102_F	140_P	0.682	1.00
114_K	118_V	0.679	1.00
61_V	64_G	0.678	1.00
147_F	164_L	0.673	1.00
102_F	106_A	0.673	1.00
92_A	124_N	0.673	1.00
25_L	32_V	0.672	1.00
112_I	125_L	0.668	1.00
62_I	66_P	0.667	1.00
50_L	53_V	0.667	1.00
64_G	67_S	0.662	1.00
100_N	103_I	0.656	1.00
123_L	149_R	0.653	1.00
115_I	167_T	0.647	1.00
129_T	136_D	0.645	1.00
108_L	167_T	0.645	1.00
103_I	126_G	0.639	1.00
86_I	141_G	0.638	1.00
67_S	72_Y	0.636	1.00
102_F	133_S	0.632	1.00
162_G	169_L	0.631	1.00
87_E	98_G	0.631	1.00
111_E	115_I	0.626	1.00
39_D	45_I	0.625	1.00
92_A	148_Y	0.621	1.00
3_G	7_Y	0.620	1.00
33_E	57_R	0.618	1.00
37_V	44_G	0.615	1.00
88_K	98_G	0.614	1.00
118_V	163_R	0.611	1.00
131_N	142_E	0.610	1.00
21_M	25_L	0.609	1.00
80_R	92_A	0.603	1.00
63_I	67_S	0.600	1.00
103_I	109_A	0.599	1.00
57_R	60_Y	0.598	1.00
53_V	56_I	0.597	1.00
13_D	41_E	0.592	1.00
103_I	127_G	0.591	1.00
95_T	116_Y	0.590	1.00
98_G	139_V	0.589	1.00
103_I	110_L	0.589	1.00
135_N	150_S	0.589	1.00
104_N	171_V	0.587	1.00
22_Y	26_S	0.586	1.00
133_S	143_F	0.585	1.00
83_I	168_S	0.583	1.00
128_Y	148_Y	0.582	1.00
63_I	68_F	0.581	1.00
115_I	119_K	0.579	1.00
128_Y	137_G	0.577	1.00
9_K	76_L	0.573	1.00
14_M	65_D	0.573	1.00
85_L	168_S	0.572	1.00
70_N	73_I	0.569	1.00
87_E	104_N	0.569	1.00
37_V	50_L	0.568	1.00
20_S	23_L	0.566	1.00
63_I	69_P	0.565	1.00
105_G	108_L	0.562	1.00
107_K	171_V	0.560	1.00
125_L	147_F	0.559	1.00
131_N	134_D	0.558	1.00
58_A	61_V	0.557	1.00
46_G	49_Y	0.551	1.00
43_G	78_I	0.548	1.00
108_L	112_I	0.548	1.00
33_E	59_K	0.544	1.00
89_Q	138_V	0.544	1.00
95_T	124_N	0.544	1.00
24_A	27_E	0.541	1.00
119_K	163_R	0.540	1.00
14_M	64_G	0.537	1.00
47_T	50_L	0.536	1.00
126_G	148_Y	0.535	0.99
124_N	148_Y	0.532	0.99
72_Y	76_L	0.532	0.99
61_V	66_P	0.530	0.99
62_I	65_D	0.524	0.99
95_T	139_V	0.523	0.99
38_P	44_G	0.522	0.99
102_F	109_A	0.521	0.99
106_A	130_I	0.518	0.99
33_E	50_L	0.518	0.99
25_L	28_T	0.515	0.99
106_A	145_F	0.514	0.99
128_Y	132_S	0.510	0.99
9_K	13_D	0.505	0.99
88_K	139_V	0.504	0.99
64_G	69_P	0.504	0.99
90_A	97_E	0.503	0.99
39_D	43_G	0.503	0.99
42_S	137_G	0.502	0.99
31_P	56_I	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tx8A	2	0.9946	100	0.244	Contact Map
2f7vA	2	0.962	100	0.246	Contact Map
3pfoA	2	0.9946	100	0.248	Contact Map
1cg2A	4	0.9891	100	0.268	Contact Map
2rb7A	2	0.962	100	0.275	Contact Map
3ct9A	2	0.962	100	0.284	Contact Map
4pqaA	2	1	100	0.295	Contact Map
3gb0A	2	0.9837	100	0.296	Contact Map
3iszA	2	0.9728	100	0.297	Contact Map
3rzaA	2	0.9837	100	0.299	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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