Q7LXH9 - SULSO - GREMLIN Contacts

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Q7LXH9 - Transposase ISC1476

UniProt:	Q7LXH9	Sequences: MAPSSGQLLGDEEREPTPTPAMPEEGVYEVKYSNRRTNVVRLLPNGFQERKLRRLANLSAKLFNEVNFERRQQFFHEGKVDFKGTWNKYYEKYKAILGVNAQAVLQKNNEAWSSFFSLLKLKKERKLPPHMNHVSPPRYWKDREAGKRKLILVVRQDRYKVDAGNHKLILKDFDMEIDFVGRLKWYGKQGRLEIIFDETKNAWYAHIPIEVGVEETGKKSKHVVKGERKSIQISKPKGNKVTSIDLGINVIASVVVNDGTWLLYKGVRTKEDYFYFQRRISEVQSLADRTRNIGEYDAYLELLREKRRFFKKLTRRLLHLYRNLASHLIETLHELGVSTIYLGYPFNIVQEKGNKFTVNMWSYRKLMVSLD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	371 (283)
Sequences:	3454 (2139)
Seq/√Len:	127.1

ECOLI - INSQ
HALSA - Q9HHJ9 Q9HM87 Q9HSW9 Q9HSW7 Q9HHG8
SULSO - Q7LXH9 Q7LXH2 Q7LXD9 Q7LX75 Q97Y67 Q97XP1 Q97Y44 Q97V47 Q97XQ8 Q97V25 Q97YI5 Q97WY6 Q97X39 Q97YW4 Q97YI2 Q97UQ8 Q97XB6 Q97U68 Q97Y48 Q97Z61 Q97YU1 Q97XA4 Q97V53 Q97WZ3 Q97U51 Q97XQ0 Q97YW9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
319_H	323_N	5.488	1.00
346_F	350_Q	5.360	1.00
251_I	366_L	3.546	1.00
365_K	369_S	2.977	1.00
277_Q	355_K	2.972	1.00
365_K	368_V	2.819	1.00
326_S	330_E	2.739	1.00
192_L	205_A	2.707	1.00
283_V	302_L	2.509	1.00
190_G	210_E	2.402	1.00
141_K	145_A	2.380	1.00
82_F	86_W	2.364	1.00
251_I	320_L	2.358	1.00
68_F	72_Q	2.331	1.00
302_L	306_K	2.287	1.00
83_K	86_W	2.263	1.00
297_D	300_L	2.220	1.00
366_L	370_L	2.188	1.00
67_N	108_N	2.156	1.00
54_R	95_A	2.130	1.00
342_L	370_L	2.106	1.00
66_V	105_L	2.084	1.00
276_F	316_R	2.051	1.00
83_K	87_N	2.044	1.00
322_R	369_S	2.043	1.00
45_N	48_Q	2.031	1.00
325_A	369_S	2.025	1.00
300_L	303_L	2.013	1.00
322_R	325_A	1.996	1.00
61_K	92_K	1.990	1.00
53_R	196_F	1.960	1.00
244_I	252_A	1.911	1.00
52_L	203_W	1.837	1.00
332_L	338_S	1.814	1.00
321_Y	365_K	1.792	1.00
286_L	290_T	1.784	1.00
202_A	311_K	1.750	1.00
250_V	253_S	1.750	1.00
53_R	203_W	1.736	1.00
318_L	365_K	1.720	1.00
254_V	258_D	1.707	1.00
280_I	306_K	1.706	1.00
287_A	303_L	1.697	1.00
37_T	206_H	1.670	1.00
99_V	155_R	1.644	1.00
290_T	302_L	1.633	1.00
163_A	166_H	1.628	1.00
56_A	203_W	1.625	1.00
342_L	367_M	1.624	1.00
41_R	202_A	1.609	1.00
107_K	153_V	1.594	1.00
280_I	310_F	1.592	1.00
109_N	113_S	1.592	1.00
197_D	311_K	1.576	1.00
66_V	108_N	1.553	1.00
294_G	299_Y	1.553	1.00
99_V	157_D	1.544	1.00
283_V	309_F	1.543	1.00
357_T	363_Y	1.524	1.00
168_L	205_A	1.509	1.00
238_G	338_S	1.498	1.00
242_T	254_V	1.494	1.00
81_D	84_G	1.466	1.00
82_F	85_T	1.460	1.00
166_H	169_I	1.450	1.00
71_R	75_F	1.446	1.00
59_S	104_V	1.422	1.00
344_Y	367_M	1.417	1.00
321_Y	369_S	1.413	1.00
279_R	282_E	1.408	1.00
200_K	311_K	1.393	1.00
325_A	366_L	1.382	1.00
246_L	367_M	1.365	1.00
287_A	302_L	1.359	1.00
50_R	54_R	1.353	1.00
49_E	53_R	1.347	1.00
179_F	182_R	1.337	1.00
114_S	119_L	1.330	1.00
283_V	306_K	1.322	1.00
110_E	114_S	1.318	1.00
118_L	121_L	1.308	1.00
244_I	254_V	1.304	1.00
246_L	363_Y	1.298	1.00
253_S	263_L	1.287	1.00
287_A	306_K	1.265	1.00
311_K	315_R	1.264	1.00
113_S	117_S	1.257	1.00
276_F	313_L	1.252	1.00
242_T	255_V	1.252	1.00
253_S	262_L	1.249	1.00
250_V	262_L	1.239	1.00
314_T	318_L	1.233	1.00
46_G	49_E	1.226	0.99
321_Y	325_A	1.207	0.99
63_F	104_V	1.198	0.99
71_R	136_P	1.182	0.99
327_H	331_T	1.177	0.99
241_V	339_T	1.176	0.99
39_V	197_D	1.176	0.99
248_I	361_W	1.169	0.99
97_L	100_N	1.165	0.99
284_Q	306_K	1.160	0.99
82_F	106_Q	1.157	0.99
242_T	332_L	1.155	0.99
77_E	80_V	1.155	0.99
353_G	357_T	1.137	0.99
70_R	109_N	1.133	0.99
241_V	341_Y	1.133	0.99
88_K	91_E	1.132	0.99
184_K	187_G	1.119	0.99
283_V	286_L	1.119	0.99
74_F	78_G	1.110	0.99
280_I	313_L	1.108	0.99
68_F	139_Y	1.107	0.99
354_N	358_V	1.095	0.99
348_I	364_R	1.087	0.99
38_N	209_I	1.084	0.99
103_A	106_Q	1.082	0.99
82_F	105_L	1.077	0.99
318_L	369_S	1.073	0.99
44_P	52_L	1.068	0.99
114_S	118_L	1.065	0.99
160_K	163_A	1.056	0.98
331_T	338_S	1.052	0.98
73_Q	77_E	1.052	0.98
71_R	112_W	1.049	0.98
291_R	294_G	1.047	0.98
82_F	87_N	1.046	0.98
290_T	298_A	1.038	0.98
61_K	65_E	1.037	0.98
195_I	206_H	1.036	0.98
197_D	202_A	1.034	0.98
177_I	180_V	1.030	0.98
103_A	155_R	1.019	0.98
250_V	264_Y	1.014	0.98
67_N	112_W	1.005	0.98
166_H	170_L	1.004	0.98
329_I	340_I	0.999	0.98
299_Y	303_L	0.999	0.98
197_D	200_K	0.999	0.98
99_V	156_Q	0.999	0.98
117_S	122_K	0.997	0.98
237_K	240_K	0.992	0.98
72_Q	76_H	0.984	0.98
114_S	120_K	0.979	0.98
170_L	173_F	0.979	0.98
86_W	106_Q	0.977	0.97
162_D	169_I	0.974	0.97
103_A	153_V	0.971	0.97
350_Q	357_T	0.971	0.97
90_Y	93_Y	0.966	0.97
321_Y	362_S	0.959	0.97
286_L	289_R	0.958	0.97
160_K	169_I	0.958	0.97
268_R	316_R	0.956	0.97
37_T	195_I	0.954	0.97
258_D	327_H	0.950	0.97
57_N	60_A	0.949	0.97
321_Y	366_L	0.945	0.97
235_K	238_G	0.944	0.97
42_L	205_A	0.941	0.97
276_F	309_F	0.938	0.97
114_S	117_S	0.936	0.97
63_F	111_A	0.935	0.97
99_V	103_A	0.930	0.97
49_E	203_W	0.928	0.97
252_A	263_L	0.923	0.96
252_A	324_L	0.923	0.96
312_K	316_R	0.920	0.96
102_Q	106_Q	0.919	0.96
179_F	183_L	0.918	0.96
122_K	136_P	0.914	0.96
86_W	105_L	0.913	0.96
103_A	107_K	0.906	0.96
279_R	283_V	0.905	0.96
39_V	195_I	0.904	0.96
294_G	300_L	0.904	0.96
52_L	152_L	0.903	0.96
81_D	86_W	0.903	0.96
96_I	101_A	0.897	0.96
180_V	183_L	0.895	0.96
274_F	356_F	0.894	0.96
40_V	181_G	0.884	0.95
263_L	320_L	0.878	0.95
44_P	48_Q	0.876	0.95
330_E	339_T	0.876	0.95
348_I	363_Y	0.874	0.95
153_V	191_R	0.873	0.95
154_V	157_D	0.871	0.95
252_A	366_L	0.867	0.95
146_G	150_L	0.867	0.95
153_V	193_E	0.864	0.95
69_E	73_Q	0.863	0.95
265_K	361_W	0.859	0.95
62_L	104_V	0.858	0.95
168_L	192_L	0.857	0.95
281_S	286_L	0.854	0.95
159_Y	163_A	0.853	0.94
283_V	305_E	0.843	0.94
170_L	194_I	0.839	0.94
37_T	208_P	0.839	0.94
162_D	165_N	0.838	0.94
240_K	338_S	0.835	0.94
243_S	255_V	0.831	0.94
112_W	115_F	0.828	0.94
324_L	327_H	0.828	0.94
40_V	205_A	0.822	0.93
61_K	90_Y	0.820	0.93
258_D	263_L	0.813	0.93
93_Y	101_A	0.812	0.93
105_L	109_N	0.808	0.93
115_F	137_P	0.808	0.93
181_G	184_K	0.804	0.93
74_F	112_W	0.804	0.93
239_N	338_S	0.799	0.92
100_N	152_L	0.797	0.92
249_N	253_S	0.795	0.92
246_L	348_I	0.794	0.92
58_L	96_I	0.793	0.92
273_Y	276_F	0.793	0.92
58_L	92_K	0.793	0.92
282_E	286_L	0.789	0.92
54_R	96_I	0.787	0.92
90_Y	94_K	0.786	0.92
280_I	288_D	0.782	0.91
55_L	152_L	0.782	0.91
299_Y	302_L	0.780	0.91
54_R	58_L	0.775	0.91
58_L	93_Y	0.775	0.91
63_F	108_N	0.774	0.91
303_L	307_R	0.770	0.91
246_L	252_A	0.770	0.91
288_D	306_K	0.769	0.91
177_I	182_R	0.769	0.91
288_D	302_L	0.767	0.91
112_W	136_P	0.764	0.91
276_F	312_K	0.764	0.91
240_K	256_V	0.761	0.90
65_E	92_K	0.761	0.90
284_Q	288_D	0.760	0.90
265_K	268_R	0.759	0.90
280_I	284_Q	0.759	0.90
176_E	179_F	0.754	0.90
273_Y	313_L	0.753	0.90
273_Y	277_Q	0.751	0.90
69_E	85_T	0.746	0.89
41_R	204_Y	0.746	0.89
175_M	179_F	0.744	0.89
70_R	112_W	0.743	0.89
79_K	84_G	0.742	0.89
328_L	340_I	0.741	0.89
320_L	324_L	0.737	0.89
251_I	325_A	0.734	0.89
263_L	324_L	0.734	0.89
352_K	358_V	0.734	0.89
305_E	308_R	0.732	0.89
244_I	328_L	0.729	0.88
55_L	97_L	0.729	0.88
315_R	318_L	0.728	0.88
256_V	332_L	0.726	0.88
243_S	343_G	0.724	0.88
74_F	116_F	0.723	0.88
254_V	257_N	0.722	0.88
328_L	332_L	0.721	0.88
74_F	80_V	0.720	0.88
251_I	361_W	0.719	0.88
202_A	315_R	0.717	0.88
158_R	171_K	0.715	0.87
145_A	150_L	0.715	0.87
284_Q	310_F	0.713	0.87
310_F	317_L	0.708	0.87
292_N	299_Y	0.707	0.87
169_I	172_D	0.707	0.87
84_G	87_N	0.704	0.87
364_R	368_V	0.704	0.87
248_I	358_V	0.702	0.86
193_E	206_H	0.702	0.86
309_F	313_L	0.702	0.86
248_I	267_V	0.700	0.86
39_V	318_L	0.697	0.86
242_T	340_I	0.695	0.86
51_K	55_L	0.691	0.86
248_I	356_F	0.690	0.85
351_E	357_T	0.689	0.85
196_F	203_W	0.686	0.85
99_V	102_Q	0.683	0.85
60_A	92_K	0.683	0.85
350_Q	353_G	0.680	0.85
291_R	299_Y	0.677	0.84
65_E	69_E	0.674	0.84
98_G	157_D	0.671	0.84
294_G	297_D	0.668	0.84
98_G	158_R	0.666	0.83
99_V	105_L	0.664	0.83
75_F	78_G	0.663	0.83
345_P	348_I	0.662	0.83
235_K	239_N	0.661	0.83
263_L	327_H	0.660	0.83
62_L	101_A	0.658	0.83
353_G	356_F	0.657	0.83
70_R	85_T	0.657	0.83
273_Y	355_K	0.657	0.83
43_L	178_D	0.656	0.83
73_Q	78_G	0.654	0.82
317_L	360_M	0.652	0.82
107_K	193_E	0.652	0.82
55_L	59_S	0.652	0.82
38_N	181_G	0.650	0.82
246_L	342_L	0.649	0.82
188_K	210_E	0.648	0.82
325_A	370_L	0.648	0.82
300_L	304_R	0.647	0.82
249_N	262_L	0.645	0.81
285_S	288_D	0.645	0.81
281_S	284_Q	0.643	0.81
112_W	116_F	0.643	0.81
47_F	50_R	0.642	0.81
150_L	153_V	0.642	0.81
39_V	206_H	0.641	0.81
118_L	122_K	0.639	0.81
279_R	309_F	0.634	0.80
159_Y	171_K	0.634	0.80
281_S	306_K	0.633	0.80
167_K	170_L	0.629	0.80
46_G	50_R	0.628	0.80
310_F	314_T	0.626	0.80
69_E	72_Q	0.626	0.80
166_H	171_K	0.626	0.80
204_Y	311_K	0.624	0.79
35_R	208_P	0.624	0.79
286_L	302_L	0.623	0.79
57_N	61_K	0.622	0.79
233_I	238_G	0.620	0.79
352_K	356_F	0.620	0.79
295_E	298_A	0.620	0.79
74_F	115_F	0.619	0.79
102_Q	105_L	0.619	0.79
242_T	256_V	0.618	0.79
154_V	170_L	0.617	0.79
274_F	277_Q	0.614	0.78
59_S	96_I	0.614	0.78
158_R	161_V	0.614	0.78
163_A	167_K	0.613	0.78
99_V	158_R	0.611	0.78
171_K	174_D	0.610	0.78
324_L	366_L	0.610	0.78
55_L	96_I	0.609	0.78
197_D	204_Y	0.605	0.77
274_F	355_K	0.603	0.77
284_Q	287_A	0.602	0.77
243_S	341_Y	0.602	0.77
117_S	120_K	0.600	0.77
273_Y	316_R	0.596	0.76
57_N	92_K	0.594	0.76
108_N	112_W	0.590	0.75
55_L	100_N	0.589	0.75
364_R	367_M	0.585	0.75
262_L	324_L	0.583	0.75
98_G	155_R	0.583	0.75
277_Q	360_M	0.582	0.74
318_L	322_R	0.580	0.74
240_K	332_L	0.580	0.74
187_G	209_I	0.579	0.74
248_I	357_T	0.575	0.74
66_V	85_T	0.574	0.73
179_F	184_K	0.574	0.73
287_A	290_T	0.574	0.73
150_L	196_F	0.573	0.73
348_I	357_T	0.573	0.73
154_V	158_R	0.571	0.73
68_F	71_R	0.571	0.73
283_V	287_A	0.569	0.73
251_I	321_Y	0.569	0.73
96_I	99_V	0.566	0.72
71_R	139_Y	0.565	0.72
291_R	300_L	0.565	0.72
252_A	342_L	0.564	0.72
65_E	68_F	0.562	0.72
298_A	301_E	0.561	0.72
119_L	122_K	0.560	0.72
362_S	365_K	0.559	0.71
91_E	94_K	0.559	0.71
97_L	154_V	0.559	0.71
155_R	158_R	0.559	0.71
35_R	210_E	0.558	0.71
332_L	340_I	0.556	0.71
100_N	154_V	0.554	0.71
194_I	205_A	0.553	0.71
86_W	102_Q	0.551	0.70
345_P	351_E	0.550	0.70
285_S	289_R	0.548	0.70
101_A	104_V	0.545	0.70
42_L	175_M	0.543	0.69
66_V	102_Q	0.542	0.69
154_V	159_Y	0.542	0.69
197_D	314_T	0.537	0.68
117_S	121_L	0.536	0.68
155_R	159_Y	0.535	0.68
286_L	305_E	0.535	0.68
323_N	326_S	0.533	0.68
40_V	180_V	0.532	0.68
97_L	171_K	0.528	0.67
40_V	179_F	0.528	0.67
58_L	95_A	0.528	0.67
313_L	360_M	0.528	0.67
149_K	195_I	0.527	0.67
176_E	181_G	0.526	0.67
315_R	319_H	0.523	0.66
279_R	288_D	0.521	0.66
104_V	108_N	0.520	0.66
247_G	348_I	0.519	0.66
209_I	330_E	0.517	0.66
191_R	208_P	0.516	0.65
37_T	207_I	0.513	0.65
39_V	204_Y	0.512	0.65
52_L	56_A	0.512	0.65
56_A	59_S	0.511	0.65
146_G	149_K	0.510	0.64
281_S	355_K	0.509	0.64
159_Y	192_L	0.505	0.64
62_L	93_Y	0.504	0.64
159_Y	165_N	0.503	0.63
175_M	181_G	0.501	0.63
97_L	152_L	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ep4A	2	0.2318	56	0.952	Contact Map
1hjrA	2	0.2372	26.3	0.96	Contact Map
1kcfA	2	0.3666	21.4	0.962	Contact Map
1iv0A	1	0.2183	11.9	0.966	Contact Map
1neiA	2	0.1617	11.5	0.966	Contact Map
1nu0A	1	0.2264	11.1	0.967	Contact Map
1u5tB	1	0.1671	10.8	0.967	Contact Map
3zeyL	1	0.1348	6	0.97	Contact Map
2ge7A	2	0.1617	5.2	0.971	Contact Map
3swyA	3	0.124	4.9	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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