GREMLIN Database
Q7LXH9 - Transposase ISC1476
UniProt: Q7LXH9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (283)
Sequences: 3454 (2139)
Seq/√Len: 127.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
319_H323_N5.4881.00
346_F350_Q5.3601.00
251_I366_L3.5461.00
365_K369_S2.9771.00
277_Q355_K2.9721.00
365_K368_V2.8191.00
326_S330_E2.7391.00
192_L205_A2.7071.00
283_V302_L2.5091.00
190_G210_E2.4021.00
141_K145_A2.3801.00
82_F86_W2.3641.00
251_I320_L2.3581.00
68_F72_Q2.3311.00
302_L306_K2.2871.00
83_K86_W2.2631.00
297_D300_L2.2201.00
366_L370_L2.1881.00
67_N108_N2.1561.00
54_R95_A2.1301.00
342_L370_L2.1061.00
66_V105_L2.0841.00
276_F316_R2.0511.00
83_K87_N2.0441.00
322_R369_S2.0431.00
45_N48_Q2.0311.00
325_A369_S2.0251.00
300_L303_L2.0131.00
322_R325_A1.9961.00
61_K92_K1.9901.00
53_R196_F1.9601.00
244_I252_A1.9111.00
52_L203_W1.8371.00
332_L338_S1.8141.00
321_Y365_K1.7921.00
286_L290_T1.7841.00
202_A311_K1.7501.00
250_V253_S1.7501.00
53_R203_W1.7361.00
318_L365_K1.7201.00
254_V258_D1.7071.00
280_I306_K1.7061.00
287_A303_L1.6971.00
37_T206_H1.6701.00
99_V155_R1.6441.00
290_T302_L1.6331.00
163_A166_H1.6281.00
56_A203_W1.6251.00
342_L367_M1.6241.00
41_R202_A1.6091.00
107_K153_V1.5941.00
280_I310_F1.5921.00
109_N113_S1.5921.00
197_D311_K1.5761.00
66_V108_N1.5531.00
294_G299_Y1.5531.00
99_V157_D1.5441.00
283_V309_F1.5431.00
357_T363_Y1.5241.00
168_L205_A1.5091.00
238_G338_S1.4981.00
242_T254_V1.4941.00
81_D84_G1.4661.00
82_F85_T1.4601.00
166_H169_I1.4501.00
71_R75_F1.4461.00
59_S104_V1.4221.00
344_Y367_M1.4171.00
321_Y369_S1.4131.00
279_R282_E1.4081.00
200_K311_K1.3931.00
325_A366_L1.3821.00
246_L367_M1.3651.00
287_A302_L1.3591.00
50_R54_R1.3531.00
49_E53_R1.3471.00
179_F182_R1.3371.00
114_S119_L1.3301.00
283_V306_K1.3221.00
110_E114_S1.3181.00
118_L121_L1.3081.00
244_I254_V1.3041.00
246_L363_Y1.2981.00
253_S263_L1.2871.00
287_A306_K1.2651.00
311_K315_R1.2641.00
113_S117_S1.2571.00
276_F313_L1.2521.00
242_T255_V1.2521.00
253_S262_L1.2491.00
250_V262_L1.2391.00
314_T318_L1.2331.00
46_G49_E1.2260.99
321_Y325_A1.2070.99
63_F104_V1.1980.99
71_R136_P1.1820.99
327_H331_T1.1770.99
241_V339_T1.1760.99
39_V197_D1.1760.99
248_I361_W1.1690.99
97_L100_N1.1650.99
284_Q306_K1.1600.99
82_F106_Q1.1570.99
242_T332_L1.1550.99
77_E80_V1.1550.99
353_G357_T1.1370.99
70_R109_N1.1330.99
241_V341_Y1.1330.99
88_K91_E1.1320.99
184_K187_G1.1190.99
283_V286_L1.1190.99
74_F78_G1.1100.99
280_I313_L1.1080.99
68_F139_Y1.1070.99
354_N358_V1.0950.99
348_I364_R1.0870.99
38_N209_I1.0840.99
103_A106_Q1.0820.99
82_F105_L1.0770.99
318_L369_S1.0730.99
44_P52_L1.0680.99
114_S118_L1.0650.99
160_K163_A1.0560.98
331_T338_S1.0520.98
73_Q77_E1.0520.98
71_R112_W1.0490.98
291_R294_G1.0470.98
82_F87_N1.0460.98
290_T298_A1.0380.98
61_K65_E1.0370.98
195_I206_H1.0360.98
197_D202_A1.0340.98
177_I180_V1.0300.98
103_A155_R1.0190.98
250_V264_Y1.0140.98
67_N112_W1.0050.98
166_H170_L1.0040.98
329_I340_I0.9990.98
299_Y303_L0.9990.98
197_D200_K0.9990.98
99_V156_Q0.9990.98
117_S122_K0.9970.98
237_K240_K0.9920.98
72_Q76_H0.9840.98
114_S120_K0.9790.98
170_L173_F0.9790.98
86_W106_Q0.9770.97
162_D169_I0.9740.97
103_A153_V0.9710.97
350_Q357_T0.9710.97
90_Y93_Y0.9660.97
321_Y362_S0.9590.97
286_L289_R0.9580.97
160_K169_I0.9580.97
268_R316_R0.9560.97
37_T195_I0.9540.97
258_D327_H0.9500.97
57_N60_A0.9490.97
321_Y366_L0.9450.97
235_K238_G0.9440.97
42_L205_A0.9410.97
276_F309_F0.9380.97
114_S117_S0.9360.97
63_F111_A0.9350.97
99_V103_A0.9300.97
49_E203_W0.9280.97
252_A263_L0.9230.96
252_A324_L0.9230.96
312_K316_R0.9200.96
102_Q106_Q0.9190.96
179_F183_L0.9180.96
122_K136_P0.9140.96
86_W105_L0.9130.96
103_A107_K0.9060.96
279_R283_V0.9050.96
39_V195_I0.9040.96
294_G300_L0.9040.96
52_L152_L0.9030.96
81_D86_W0.9030.96
96_I101_A0.8970.96
180_V183_L0.8950.96
274_F356_F0.8940.96
40_V181_G0.8840.95
263_L320_L0.8780.95
44_P48_Q0.8760.95
330_E339_T0.8760.95
348_I363_Y0.8740.95
153_V191_R0.8730.95
154_V157_D0.8710.95
252_A366_L0.8670.95
146_G150_L0.8670.95
153_V193_E0.8640.95
69_E73_Q0.8630.95
265_K361_W0.8590.95
62_L104_V0.8580.95
168_L192_L0.8570.95
281_S286_L0.8540.95
159_Y163_A0.8530.94
283_V305_E0.8430.94
170_L194_I0.8390.94
37_T208_P0.8390.94
162_D165_N0.8380.94
240_K338_S0.8350.94
243_S255_V0.8310.94
112_W115_F0.8280.94
324_L327_H0.8280.94
40_V205_A0.8220.93
61_K90_Y0.8200.93
258_D263_L0.8130.93
93_Y101_A0.8120.93
105_L109_N0.8080.93
115_F137_P0.8080.93
181_G184_K0.8040.93
74_F112_W0.8040.93
239_N338_S0.7990.92
100_N152_L0.7970.92
249_N253_S0.7950.92
246_L348_I0.7940.92
58_L96_I0.7930.92
273_Y276_F0.7930.92
58_L92_K0.7930.92
282_E286_L0.7890.92
54_R96_I0.7870.92
90_Y94_K0.7860.92
280_I288_D0.7820.91
55_L152_L0.7820.91
299_Y302_L0.7800.91
54_R58_L0.7750.91
58_L93_Y0.7750.91
63_F108_N0.7740.91
303_L307_R0.7700.91
246_L252_A0.7700.91
288_D306_K0.7690.91
177_I182_R0.7690.91
288_D302_L0.7670.91
112_W136_P0.7640.91
276_F312_K0.7640.91
240_K256_V0.7610.90
65_E92_K0.7610.90
284_Q288_D0.7600.90
265_K268_R0.7590.90
280_I284_Q0.7590.90
176_E179_F0.7540.90
273_Y313_L0.7530.90
273_Y277_Q0.7510.90
69_E85_T0.7460.89
41_R204_Y0.7460.89
175_M179_F0.7440.89
70_R112_W0.7430.89
79_K84_G0.7420.89
328_L340_I0.7410.89
320_L324_L0.7370.89
251_I325_A0.7340.89
263_L324_L0.7340.89
352_K358_V0.7340.89
305_E308_R0.7320.89
244_I328_L0.7290.88
55_L97_L0.7290.88
315_R318_L0.7280.88
256_V332_L0.7260.88
243_S343_G0.7240.88
74_F116_F0.7230.88
254_V257_N0.7220.88
328_L332_L0.7210.88
74_F80_V0.7200.88
251_I361_W0.7190.88
202_A315_R0.7170.88
158_R171_K0.7150.87
145_A150_L0.7150.87
284_Q310_F0.7130.87
310_F317_L0.7080.87
292_N299_Y0.7070.87
169_I172_D0.7070.87
84_G87_N0.7040.87
364_R368_V0.7040.87
248_I358_V0.7020.86
193_E206_H0.7020.86
309_F313_L0.7020.86
248_I267_V0.7000.86
39_V318_L0.6970.86
242_T340_I0.6950.86
51_K55_L0.6910.86
248_I356_F0.6900.85
351_E357_T0.6890.85
196_F203_W0.6860.85
99_V102_Q0.6830.85
60_A92_K0.6830.85
350_Q353_G0.6800.85
291_R299_Y0.6770.84
65_E69_E0.6740.84
98_G157_D0.6710.84
294_G297_D0.6680.84
98_G158_R0.6660.83
99_V105_L0.6640.83
75_F78_G0.6630.83
345_P348_I0.6620.83
235_K239_N0.6610.83
263_L327_H0.6600.83
62_L101_A0.6580.83
353_G356_F0.6570.83
70_R85_T0.6570.83
273_Y355_K0.6570.83
43_L178_D0.6560.83
73_Q78_G0.6540.82
317_L360_M0.6520.82
107_K193_E0.6520.82
55_L59_S0.6520.82
38_N181_G0.6500.82
246_L342_L0.6490.82
188_K210_E0.6480.82
325_A370_L0.6480.82
300_L304_R0.6470.82
249_N262_L0.6450.81
285_S288_D0.6450.81
281_S284_Q0.6430.81
112_W116_F0.6430.81
47_F50_R0.6420.81
150_L153_V0.6420.81
39_V206_H0.6410.81
118_L122_K0.6390.81
279_R309_F0.6340.80
159_Y171_K0.6340.80
281_S306_K0.6330.80
167_K170_L0.6290.80
46_G50_R0.6280.80
310_F314_T0.6260.80
69_E72_Q0.6260.80
166_H171_K0.6260.80
204_Y311_K0.6240.79
35_R208_P0.6240.79
286_L302_L0.6230.79
57_N61_K0.6220.79
233_I238_G0.6200.79
352_K356_F0.6200.79
295_E298_A0.6200.79
74_F115_F0.6190.79
102_Q105_L0.6190.79
242_T256_V0.6180.79
154_V170_L0.6170.79
274_F277_Q0.6140.78
59_S96_I0.6140.78
158_R161_V0.6140.78
163_A167_K0.6130.78
99_V158_R0.6110.78
171_K174_D0.6100.78
324_L366_L0.6100.78
55_L96_I0.6090.78
197_D204_Y0.6050.77
274_F355_K0.6030.77
284_Q287_A0.6020.77
243_S341_Y0.6020.77
117_S120_K0.6000.77
273_Y316_R0.5960.76
57_N92_K0.5940.76
108_N112_W0.5900.75
55_L100_N0.5890.75
364_R367_M0.5850.75
262_L324_L0.5830.75
98_G155_R0.5830.75
277_Q360_M0.5820.74
318_L322_R0.5800.74
240_K332_L0.5800.74
187_G209_I0.5790.74
248_I357_T0.5750.74
66_V85_T0.5740.73
179_F184_K0.5740.73
287_A290_T0.5740.73
150_L196_F0.5730.73
348_I357_T0.5730.73
154_V158_R0.5710.73
68_F71_R0.5710.73
283_V287_A0.5690.73
251_I321_Y0.5690.73
96_I99_V0.5660.72
71_R139_Y0.5650.72
291_R300_L0.5650.72
252_A342_L0.5640.72
65_E68_F0.5620.72
298_A301_E0.5610.72
119_L122_K0.5600.72
362_S365_K0.5590.71
91_E94_K0.5590.71
97_L154_V0.5590.71
155_R158_R0.5590.71
35_R210_E0.5580.71
332_L340_I0.5560.71
100_N154_V0.5540.71
194_I205_A0.5530.71
86_W102_Q0.5510.70
345_P351_E0.5500.70
285_S289_R0.5480.70
101_A104_V0.5450.70
42_L175_M0.5430.69
66_V102_Q0.5420.69
154_V159_Y0.5420.69
197_D314_T0.5370.68
117_S121_L0.5360.68
155_R159_Y0.5350.68
286_L305_E0.5350.68
323_N326_S0.5330.68
40_V180_V0.5320.68
97_L171_K0.5280.67
40_V179_F0.5280.67
58_L95_A0.5280.67
313_L360_M0.5280.67
149_K195_I0.5270.67
176_E181_G0.5260.67
315_R319_H0.5230.66
279_R288_D0.5210.66
104_V108_N0.5200.66
247_G348_I0.5190.66
209_I330_E0.5170.66
191_R208_P0.5160.65
37_T207_I0.5130.65
39_V204_Y0.5120.65
52_L56_A0.5120.65
56_A59_S0.5110.65
146_G149_K0.5100.64
281_S355_K0.5090.64
159_Y192_L0.5050.64
62_L93_Y0.5040.64
159_Y165_N0.5030.63
175_M181_G0.5010.63
97_L152_L0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ep4A 2 0.2318 56 0.952 Contact Map
1hjrA 2 0.2372 26.3 0.96 Contact Map
1kcfA 2 0.3666 21.4 0.962 Contact Map
1iv0A 1 0.2183 11.9 0.966 Contact Map
1neiA 2 0.1617 11.5 0.966 Contact Map
1nu0A 1 0.2264 11.1 0.967 Contact Map
1u5tB 1 0.1671 10.8 0.967 Contact Map
3zeyL 1 0.1348 6 0.97 Contact Map
2ge7A 2 0.1617 5.2 0.971 Contact Map
3swyA 3 0.124 4.9 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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