Q7LXH6 - SULSO - GREMLIN Contacts

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Q7LXH6 - Orf in partial transposon ISC1913

UniProt:	Q7LXH6	Sequences: MQVLSMIFTREILEEAINYGLTKNTTSFTRIKAGIYKTEREKHRDLPSHYIYTACEDASERLDSFNKLKKRGRSYTDRPSVRRVTVHLDDHLWKFSLNVISIATKRGRVCISPIFPKIFWRYYNDNWLIASGARFKLLKGNVVEFFIVFKKDVKSYDPRGFIPVDLNEDSVSVLINGKPILLETNTRMITLGYEYKRRSITNGRSTKDREVRRKLRERDKKLDVRRKFAKLIVKEAFGSRSAIVLEDLPRGVPEHMVKGVKDKQLRLRIYRSAFSSMKNAIVEKAREFGVPVILVDPSYTSSICPVHGSKIIYQPDGGSAPRVGVCGKGGERWHRDVVALYNLRKRAGDVSPVPLGSKESHDPPVVQVVEG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	371 (322)
Sequences:	4667 (3038)
Seq/√Len:	169.3

ECOLI - INSQ
HALSA - Q9HSW9 Q9HHJ9 Q9HSZ6 Q9HM87 Q9HSW7 Q9HHG8 Q9HSD4 Q9HHU6 Q9HSY4 Q9HHX8
SULSO - Q7LXH6 Q97WZ3 Q97X39 Q97Y67 Q97Y48 Q97XA4 Q97V47 Q97V53 Q97Z61 Q97XP1 Q97XQ0 Q97XQ8 Q97Y44 Q97YI5 Q97YU1 Q97V25 Q97YW9 Q97U51 Q97UQ8 Q97YI2 Q97U68 Q97YW4 Q97XB6 Q97WY6 Q7LXD9 Q7LXH2 Q97YF7 Q97U09 Q7LX59 Y2105 Q97YK6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
223_D	227_K	5.333	1.00
305_P	338_V	4.360	1.00
249_P	254_E	4.066	1.00
285_A	292_V	3.710	1.00
278_K	294_L	3.020	1.00
171_V	277_M	3.017	1.00
244_V	347_A	3.004	1.00
245_L	281_I	2.986	1.00
230_K	234_K	2.876	1.00
276_S	280_A	2.762	1.00
299_Y	302_S	2.464	1.00
133_A	145_F	2.436	1.00
256_M	270_Y	2.335	1.00
282_V	294_L	2.327	1.00
303_I	310_K	2.316	1.00
190_T	267_L	2.295	1.00
18_N	22_T	2.294	1.00
233_V	285_A	2.274	1.00
276_S	279_N	2.250	1.00
295_V	343_L	2.243	1.00
346_R	349_D	2.229	1.00
226_R	280_A	2.207	1.00
243_I	285_A	2.168	1.00
277_M	281_I	2.148	1.00
226_R	283_E	2.135	1.00
209_R	212_R	2.132	1.00
189_I	220_K	2.125	1.00
300_T	343_L	2.109	1.00
304_C	307_H	2.096	1.00
325_V	332_R	2.093	1.00
130_A	150_K	2.031	1.00
245_L	292_V	1.996	1.00
318_G	321_P	1.967	1.00
302_S	317_G	1.941	1.00
28_F	32_K	1.933	1.00
262_D	266_R	1.923	1.00
222_L	276_S	1.908	1.00
229_A	280_A	1.867	1.00
171_V	224_V	1.842	1.00
307_H	326_C	1.841	1.00
226_R	284_K	1.840	1.00
28_F	56_E	1.839	1.00
263_K	266_R	1.830	1.00
196_K	211_V	1.821	1.00
307_H	329_G	1.815	1.00
302_S	314_Q	1.805	1.00
241_S	290_V	1.774	1.00
39_E	43_H	1.770	1.00
226_R	229_A	1.765	1.00
225_R	280_A	1.754	1.00
29_T	32_K	1.725	1.00
20_G	24_N	1.682	1.00
282_V	286_R	1.676	1.00
306_V	331_E	1.675	1.00
225_R	276_S	1.674	1.00
208_D	211_V	1.650	1.00
245_L	294_L	1.641	1.00
29_T	33_A	1.627	1.00
322_R	335_R	1.625	1.00
211_V	214_K	1.612	1.00
326_C	329_G	1.595	1.00
164_V	172_S	1.590	1.00
324_G	333_W	1.587	1.00
304_C	329_G	1.576	1.00
304_C	326_C	1.563	1.00
245_L	278_K	1.553	1.00
21_L	78_R	1.543	1.00
69_K	76_T	1.536	1.00
311_I	317_G	1.511	1.00
17_I	58_A	1.507	1.00
204_R	208_D	1.505	1.00
247_D	294_L	1.501	1.00
10_R	14_E	1.500	1.00
196_K	199_S	1.473	1.00
341_Y	345_K	1.459	1.00
246_E	297_P	1.455	1.00
16_A	55_C	1.433	1.00
309_S	327_G	1.426	1.00
170_S	173_V	1.426	1.00
208_D	212_R	1.421	1.00
173_V	337_V	1.418	1.00
229_A	283_E	1.416	1.00
6_M	143_V	1.398	1.00
20_G	23_K	1.398	1.00
9_T	13_L	1.377	1.00
323_V	332_R	1.374	1.00
174_L	178_K	1.372	1.00
192_G	196_K	1.369	1.00
324_G	331_E	1.358	1.00
68_L	76_T	1.356	1.00
59_S	63_D	1.338	1.00
162_I	174_L	1.325	1.00
311_I	324_G	1.321	1.00
317_G	321_P	1.316	1.00
33_A	36_Y	1.294	1.00
197_R	201_T	1.292	1.00
64_S	76_T	1.286	1.00
229_A	284_K	1.285	1.00
161_F	344_R	1.273	1.00
319_S	322_R	1.253	1.00
62_L	78_R	1.243	1.00
19_Y	23_K	1.241	1.00
269_I	274_F	1.234	1.00
173_V	179_P	1.222	1.00
32_K	56_E	1.211	1.00
175_I	340_L	1.209	1.00
103_A	106_R	1.208	1.00
27_S	30_R	1.208	1.00
166_L	274_F	1.207	1.00
233_V	288_F	1.198	1.00
305_P	341_Y	1.187	1.00
206_T	209_R	1.184	1.00
225_R	277_M	1.177	1.00
229_A	277_M	1.175	1.00
179_P	334_H	1.167	1.00
136_K	146_F	1.165	1.00
311_I	327_G	1.161	1.00
53_T	56_E	1.160	1.00
282_V	292_V	1.155	1.00
158_P	241_S	1.153	1.00
35_I	55_C	1.149	1.00
164_V	174_L	1.147	1.00
60_E	64_S	1.145	1.00
280_A	283_E	1.140	1.00
234_K	288_F	1.138	1.00
161_F	242_A	1.132	1.00
205_S	208_D	1.123	1.00
39_E	42_K	1.116	1.00
32_K	55_C	1.112	1.00
311_I	314_Q	1.107	1.00
163_P	344_R	1.106	1.00
317_G	335_R	1.102	1.00
64_S	68_L	1.101	1.00
337_V	341_Y	1.099	1.00
16_A	58_A	1.096	1.00
10_R	13_L	1.096	1.00
18_N	21_L	1.095	1.00
15_E	19_Y	1.094	1.00
13_L	17_I	1.092	1.00
305_P	333_W	1.082	1.00
230_K	288_F	1.071	1.00
249_P	297_P	1.069	1.00
11_E	15_E	1.067	1.00
28_F	55_C	1.063	1.00
193_Y	215_L	1.058	0.99
36_Y	40_R	1.056	0.99
189_I	217_E	1.056	0.99
63_D	67_K	1.040	0.99
207_K	210_E	1.035	0.99
303_I	346_R	1.034	0.99
64_S	69_K	1.032	0.99
295_V	346_R	1.032	0.99
14_E	17_I	1.028	0.99
138_L	142_V	1.022	0.99
305_P	331_E	1.014	0.99
178_K	231_L	1.011	0.99
47_P	50_Y	1.010	0.99
35_I	52_Y	1.007	0.99
137_L	143_V	1.003	0.99
218_R	222_L	1.002	0.99
168_E	272_S	0.997	0.99
9_T	14_E	0.996	0.99
96_S	99_V	0.987	0.99
233_V	290_V	0.986	0.99
207_K	214_K	0.983	0.99
222_L	280_A	0.982	0.99
49_H	53_T	0.981	0.99
333_W	341_Y	0.979	0.99
185_N	220_K	0.976	0.99
321_P	324_G	0.973	0.99
119_F	123_Y	0.971	0.99
194_E	198_R	0.970	0.99
194_E	197_R	0.966	0.99
7_I	11_E	0.962	0.99
295_V	347_A	0.961	0.99
333_W	337_V	0.960	0.99
57_D	134_R	0.959	0.99
244_V	343_L	0.955	0.99
166_L	278_K	0.954	0.99
300_T	346_R	0.944	0.99
68_L	77_D	0.944	0.99
225_R	229_A	0.942	0.99
193_Y	217_E	0.941	0.99
100_I	103_A	0.924	0.99
13_L	54_A	0.923	0.99
200_I	211_V	0.922	0.99
106_R	112_S	0.922	0.99
322_R	334_H	0.920	0.99
91_H	94_K	0.919	0.99
311_I	316_D	0.919	0.99
284_K	287_E	0.919	0.99
242_A	291_P	0.917	0.99
229_A	281_I	0.915	0.99
161_F	348_G	0.913	0.98
208_D	214_K	0.911	0.98
262_D	265_L	0.911	0.98
162_I	175_I	0.908	0.98
314_Q	317_G	0.903	0.98
166_L	172_S	0.903	0.98
65_F	78_R	0.902	0.98
247_D	297_P	0.899	0.98
9_T	12_I	0.896	0.98
19_Y	22_T	0.894	0.98
161_F	244_V	0.890	0.98
14_E	18_N	0.889	0.98
279_N	282_V	0.886	0.98
305_P	345_K	0.886	0.98
106_R	109_V	0.882	0.98
309_S	328_K	0.880	0.98
302_S	310_K	0.880	0.98
19_Y	34_G	0.879	0.98
210_E	213_R	0.876	0.98
17_I	21_L	0.872	0.98
216_R	220_K	0.867	0.98
170_S	179_P	0.863	0.98
65_F	79_P	0.862	0.98
311_I	318_G	0.861	0.98
323_V	333_W	0.860	0.98
233_V	243_I	0.860	0.98
64_S	67_K	0.858	0.98
21_L	24_N	0.855	0.98
257_V	262_D	0.853	0.98
321_P	335_R	0.852	0.98
207_K	211_V	0.851	0.98
297_P	300_T	0.845	0.97
197_R	215_L	0.844	0.97
185_N	189_I	0.842	0.97
120_W	123_Y	0.840	0.97
170_S	181_L	0.837	0.97
193_Y	197_R	0.837	0.97
309_S	314_Q	0.829	0.97
134_R	146_F	0.828	0.97
53_T	57_D	0.826	0.97
162_I	243_I	0.825	0.97
252_V	275_S	0.824	0.97
8_F	46_L	0.817	0.97
88_L	91_H	0.817	0.97
189_I	193_Y	0.815	0.97
338_V	342_N	0.804	0.97
20_G	31_I	0.801	0.97
256_M	266_R	0.800	0.97
52_Y	56_E	0.799	0.96
9_T	54_A	0.799	0.96
86_V	90_D	0.797	0.96
310_K	316_D	0.796	0.96
301_S	317_G	0.795	0.96
5_S	9_T	0.794	0.96
90_D	93_W	0.793	0.96
85_T	90_D	0.793	0.96
46_L	49_H	0.792	0.96
285_A	290_V	0.792	0.96
199_S	202_N	0.789	0.96
256_M	262_D	0.789	0.96
10_R	17_I	0.788	0.96
265_L	269_I	0.784	0.96
7_I	10_R	0.783	0.96
337_V	340_L	0.783	0.96
96_S	101_S	0.781	0.96
49_H	52_Y	0.777	0.96
124_N	127_W	0.774	0.96
36_Y	39_E	0.766	0.96
165_D	336_D	0.763	0.95
263_K	270_Y	0.761	0.95
40_R	51_I	0.758	0.95
252_V	274_F	0.756	0.95
225_R	273_A	0.756	0.95
232_I	243_I	0.755	0.95
242_A	293_I	0.753	0.95
275_S	279_N	0.753	0.95
175_I	337_V	0.752	0.95
13_L	20_G	0.750	0.95
230_K	284_K	0.750	0.95
160_G	176_N	0.748	0.95
101_S	108_R	0.747	0.95
293_I	347_A	0.743	0.95
160_G	241_S	0.742	0.95
55_C	59_S	0.742	0.95
182_L	185_N	0.740	0.95
303_I	342_N	0.740	0.95
305_P	339_A	0.739	0.95
5_S	47_P	0.738	0.95
28_F	31_I	0.738	0.95
54_A	58_A	0.738	0.95
346_R	350_V	0.737	0.95
224_V	228_F	0.736	0.94
179_P	337_V	0.735	0.94
182_L	272_S	0.734	0.94
195_Y	199_S	0.732	0.94
132_G	148_V	0.731	0.94
32_K	36_Y	0.731	0.94
299_Y	346_R	0.730	0.94
341_Y	344_R	0.728	0.94
87_H	91_H	0.728	0.94
36_Y	43_H	0.724	0.94
58_A	62_L	0.722	0.94
200_I	212_R	0.722	0.94
16_A	31_I	0.719	0.94
135_F	145_F	0.719	0.94
8_F	11_E	0.710	0.93
244_V	293_I	0.708	0.93
169_D	173_V	0.706	0.93
62_L	65_F	0.705	0.93
89_D	92_L	0.704	0.93
10_R	20_G	0.702	0.93
339_A	342_N	0.700	0.93
203_G	206_T	0.697	0.93
244_V	344_R	0.697	0.93
103_A	112_S	0.696	0.93
198_R	201_T	0.690	0.92
306_V	341_Y	0.690	0.92
186_T	190_T	0.688	0.92
171_V	272_S	0.688	0.92
194_E	201_T	0.687	0.92
302_S	318_G	0.687	0.92
168_E	256_M	0.685	0.92
36_Y	55_C	0.684	0.92
6_M	9_T	0.683	0.92
168_E	268_R	0.681	0.92
46_L	51_I	0.681	0.92
111_I	114_I	0.681	0.92
19_Y	24_N	0.680	0.92
119_F	122_Y	0.679	0.92
157_D	160_G	0.677	0.92
37_K	41_E	0.674	0.91
172_S	180_I	0.669	0.91
15_E	18_N	0.666	0.91
204_R	207_K	0.665	0.91
88_L	92_L	0.663	0.91
309_S	316_D	0.662	0.91
228_F	231_L	0.662	0.91
248_L	297_P	0.662	0.91
205_S	214_K	0.660	0.91
100_I	108_R	0.660	0.91
5_S	46_L	0.660	0.91
193_Y	201_T	0.656	0.90
247_D	278_K	0.656	0.90
302_S	316_D	0.654	0.90
172_S	228_F	0.651	0.90
36_Y	42_K	0.650	0.90
12_I	15_E	0.649	0.90
26_T	31_I	0.649	0.90
234_K	242_A	0.647	0.90
123_Y	149_F	0.647	0.90
49_H	89_D	0.646	0.90
90_D	94_K	0.643	0.89
17_I	20_G	0.642	0.89
12_I	18_N	0.641	0.89
299_Y	310_K	0.639	0.89
8_F	12_I	0.637	0.89
21_L	62_L	0.637	0.89
9_T	20_G	0.637	0.89
87_H	90_D	0.637	0.89
333_W	338_V	0.636	0.89
40_R	43_H	0.635	0.89
142_V	219_D	0.635	0.89
309_S	324_G	0.634	0.89
281_I	292_V	0.632	0.89
302_S	311_I	0.630	0.88
25_T	30_R	0.628	0.88
243_I	281_I	0.627	0.88
62_L	66_N	0.622	0.88
138_L	144_E	0.620	0.88
167_N	173_V	0.618	0.88
299_Y	303_I	0.617	0.87
186_T	189_I	0.617	0.87
203_G	207_K	0.615	0.87
310_K	314_Q	0.615	0.87
254_E	297_P	0.613	0.87
14_E	20_G	0.613	0.87
280_A	284_K	0.612	0.87
66_N	69_K	0.611	0.87
317_G	322_R	0.611	0.87
16_A	35_I	0.611	0.87
20_G	62_L	0.606	0.87
222_L	226_R	0.604	0.86
95_F	98_N	0.604	0.86
31_I	34_G	0.598	0.86
114_I	117_K	0.597	0.86
159_R	241_S	0.596	0.86
10_R	16_A	0.595	0.86
95_F	103_A	0.595	0.86
30_R	33_A	0.594	0.85
173_V	180_I	0.594	0.85
87_H	92_L	0.594	0.85
163_P	244_V	0.594	0.85
217_E	271_R	0.594	0.85
180_I	224_V	0.592	0.85
186_T	267_L	0.591	0.85
85_T	89_D	0.591	0.85
20_G	59_S	0.590	0.85
67_K	76_T	0.589	0.85
180_I	228_F	0.588	0.85
12_I	24_N	0.586	0.85
171_V	229_A	0.584	0.84
221_K	271_R	0.583	0.84
187_R	190_T	0.581	0.84
85_T	88_L	0.579	0.84
103_A	109_V	0.578	0.84
122_Y	125_D	0.578	0.84
204_R	212_R	0.575	0.84
187_R	267_L	0.574	0.83
61_R	79_P	0.574	0.83
36_Y	48_S	0.574	0.83
13_L	58_A	0.572	0.83
307_H	311_I	0.569	0.83
296_D	299_Y	0.568	0.83
219_D	223_D	0.567	0.83
130_A	148_V	0.567	0.83
345_K	350_V	0.566	0.83
9_T	46_L	0.566	0.83
11_E	14_E	0.563	0.82
165_D	301_S	0.562	0.82
127_W	149_F	0.561	0.82
311_I	321_P	0.560	0.82
316_D	321_P	0.560	0.82
244_V	346_R	0.559	0.82
283_E	287_E	0.557	0.82
12_I	17_I	0.555	0.81
205_S	212_R	0.554	0.81
19_Y	31_I	0.553	0.81
188_M	191_L	0.550	0.81
14_E	24_N	0.549	0.81
324_G	335_R	0.547	0.80
8_F	14_E	0.547	0.80
180_I	231_L	0.547	0.80
225_R	228_F	0.547	0.80
51_I	54_A	0.546	0.80
111_I	115_F	0.543	0.80
105_K	109_V	0.542	0.80
65_F	68_L	0.541	0.80
197_R	200_I	0.540	0.80
17_I	24_N	0.540	0.80
197_R	202_N	0.540	0.80
196_K	200_I	0.539	0.79
13_L	16_A	0.539	0.79
5_S	8_F	0.539	0.79
254_E	269_I	0.539	0.79
93_W	99_V	0.539	0.79
171_V	225_R	0.539	0.79
172_S	277_M	0.539	0.79
234_K	239_S	0.537	0.79
319_S	335_R	0.536	0.79
215_L	221_K	0.534	0.79
192_G	195_Y	0.533	0.79
105_K	108_R	0.531	0.78
89_D	93_W	0.531	0.78
55_C	58_A	0.529	0.78
189_I	216_R	0.528	0.78
169_D	322_R	0.527	0.78
174_L	232_I	0.526	0.78
325_V	331_E	0.526	0.78
343_L	346_R	0.525	0.78
187_R	268_R	0.523	0.77
12_I	19_Y	0.523	0.77
137_L	144_E	0.522	0.77
227_K	230_K	0.522	0.77
18_N	81_V	0.522	0.77
95_F	100_I	0.521	0.77
54_A	57_D	0.519	0.77
217_E	221_K	0.519	0.77
100_I	145_F	0.517	0.77
12_I	51_I	0.516	0.76
118_I	121_R	0.514	0.76
97_L	101_S	0.513	0.76
321_P	334_H	0.513	0.76
265_L	268_R	0.511	0.76
111_I	117_K	0.511	0.76
331_E	338_V	0.510	0.76
27_S	32_K	0.509	0.76
204_R	211_V	0.509	0.76
198_R	202_N	0.509	0.76
60_E	69_K	0.509	0.76
23_K	26_T	0.508	0.75
252_V	255_H	0.507	0.75
32_K	59_S	0.507	0.75
128_L	150_K	0.506	0.75
311_I	335_R	0.506	0.75
219_D	222_L	0.503	0.75
26_T	32_K	0.502	0.75
319_S	334_H	0.502	0.75
306_V	333_W	0.502	0.75
144_E	219_D	0.500	0.74
301_S	311_I	0.500	0.74

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nu0A	1	0.3531	94.9	0.925	Contact Map
1vhxA	2	0.372	94.7	0.925	Contact Map
1iv0A	1	0.2642	92.7	0.931	Contact Map
4aybP	1	0.1186	86.9	0.939	Contact Map
1qypA	1	0.1321	85.1	0.941	Contact Map
1vq8Z	1	0.1968	83.5	0.942	Contact Map
3j20Y	1	0.1348	79.5	0.944	Contact Map
4c2mI	1	0.1995	75	0.946	Contact Map
2k4xA	1	0.1429	74.9	0.946	Contact Map
1vd4A	1	0.1536	71.1	0.948	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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