GREMLIN Database
Q7LXH6 - Orf in partial transposon ISC1913
UniProt: Q7LXH6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (322)
Sequences: 4667 (3038)
Seq/√Len: 169.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
223_D227_K5.3331.00
305_P338_V4.3601.00
249_P254_E4.0661.00
285_A292_V3.7101.00
278_K294_L3.0201.00
171_V277_M3.0171.00
244_V347_A3.0041.00
245_L281_I2.9861.00
230_K234_K2.8761.00
276_S280_A2.7621.00
299_Y302_S2.4641.00
133_A145_F2.4361.00
256_M270_Y2.3351.00
282_V294_L2.3271.00
303_I310_K2.3161.00
190_T267_L2.2951.00
18_N22_T2.2941.00
233_V285_A2.2741.00
276_S279_N2.2501.00
295_V343_L2.2431.00
346_R349_D2.2291.00
226_R280_A2.2071.00
243_I285_A2.1681.00
277_M281_I2.1481.00
226_R283_E2.1351.00
209_R212_R2.1321.00
189_I220_K2.1251.00
300_T343_L2.1091.00
304_C307_H2.0961.00
325_V332_R2.0931.00
130_A150_K2.0311.00
245_L292_V1.9961.00
318_G321_P1.9671.00
302_S317_G1.9411.00
28_F32_K1.9331.00
262_D266_R1.9231.00
222_L276_S1.9081.00
229_A280_A1.8671.00
171_V224_V1.8421.00
307_H326_C1.8411.00
226_R284_K1.8401.00
28_F56_E1.8391.00
263_K266_R1.8301.00
196_K211_V1.8211.00
307_H329_G1.8151.00
302_S314_Q1.8051.00
241_S290_V1.7741.00
39_E43_H1.7701.00
226_R229_A1.7651.00
225_R280_A1.7541.00
29_T32_K1.7251.00
20_G24_N1.6821.00
282_V286_R1.6761.00
306_V331_E1.6751.00
225_R276_S1.6741.00
208_D211_V1.6501.00
245_L294_L1.6411.00
29_T33_A1.6271.00
322_R335_R1.6251.00
211_V214_K1.6121.00
326_C329_G1.5951.00
164_V172_S1.5901.00
324_G333_W1.5871.00
304_C329_G1.5761.00
304_C326_C1.5631.00
245_L278_K1.5531.00
21_L78_R1.5431.00
69_K76_T1.5361.00
311_I317_G1.5111.00
17_I58_A1.5071.00
204_R208_D1.5051.00
247_D294_L1.5011.00
10_R14_E1.5001.00
196_K199_S1.4731.00
341_Y345_K1.4591.00
246_E297_P1.4551.00
16_A55_C1.4331.00
309_S327_G1.4261.00
170_S173_V1.4261.00
208_D212_R1.4211.00
173_V337_V1.4181.00
229_A283_E1.4161.00
6_M143_V1.3981.00
20_G23_K1.3981.00
9_T13_L1.3771.00
323_V332_R1.3741.00
174_L178_K1.3721.00
192_G196_K1.3691.00
324_G331_E1.3581.00
68_L76_T1.3561.00
59_S63_D1.3381.00
162_I174_L1.3251.00
311_I324_G1.3211.00
317_G321_P1.3161.00
33_A36_Y1.2941.00
197_R201_T1.2921.00
64_S76_T1.2861.00
229_A284_K1.2851.00
161_F344_R1.2731.00
319_S322_R1.2531.00
62_L78_R1.2431.00
19_Y23_K1.2411.00
269_I274_F1.2341.00
173_V179_P1.2221.00
32_K56_E1.2111.00
175_I340_L1.2091.00
103_A106_R1.2081.00
27_S30_R1.2081.00
166_L274_F1.2071.00
233_V288_F1.1981.00
305_P341_Y1.1871.00
206_T209_R1.1841.00
225_R277_M1.1771.00
229_A277_M1.1751.00
179_P334_H1.1671.00
136_K146_F1.1651.00
311_I327_G1.1611.00
53_T56_E1.1601.00
282_V292_V1.1551.00
158_P241_S1.1531.00
35_I55_C1.1491.00
164_V174_L1.1471.00
60_E64_S1.1451.00
280_A283_E1.1401.00
234_K288_F1.1381.00
161_F242_A1.1321.00
205_S208_D1.1231.00
39_E42_K1.1161.00
32_K55_C1.1121.00
311_I314_Q1.1071.00
163_P344_R1.1061.00
317_G335_R1.1021.00
64_S68_L1.1011.00
337_V341_Y1.0991.00
16_A58_A1.0961.00
10_R13_L1.0961.00
18_N21_L1.0951.00
15_E19_Y1.0941.00
13_L17_I1.0921.00
305_P333_W1.0821.00
230_K288_F1.0711.00
249_P297_P1.0691.00
11_E15_E1.0671.00
28_F55_C1.0631.00
193_Y215_L1.0580.99
36_Y40_R1.0560.99
189_I217_E1.0560.99
63_D67_K1.0400.99
207_K210_E1.0350.99
303_I346_R1.0340.99
64_S69_K1.0320.99
295_V346_R1.0320.99
14_E17_I1.0280.99
138_L142_V1.0220.99
305_P331_E1.0140.99
178_K231_L1.0110.99
47_P50_Y1.0100.99
35_I52_Y1.0070.99
137_L143_V1.0030.99
218_R222_L1.0020.99
168_E272_S0.9970.99
9_T14_E0.9960.99
96_S99_V0.9870.99
233_V290_V0.9860.99
207_K214_K0.9830.99
222_L280_A0.9820.99
49_H53_T0.9810.99
333_W341_Y0.9790.99
185_N220_K0.9760.99
321_P324_G0.9730.99
119_F123_Y0.9710.99
194_E198_R0.9700.99
194_E197_R0.9660.99
7_I11_E0.9620.99
295_V347_A0.9610.99
333_W337_V0.9600.99
57_D134_R0.9590.99
244_V343_L0.9550.99
166_L278_K0.9540.99
300_T346_R0.9440.99
68_L77_D0.9440.99
225_R229_A0.9420.99
193_Y217_E0.9410.99
100_I103_A0.9240.99
13_L54_A0.9230.99
200_I211_V0.9220.99
106_R112_S0.9220.99
322_R334_H0.9200.99
91_H94_K0.9190.99
311_I316_D0.9190.99
284_K287_E0.9190.99
242_A291_P0.9170.99
229_A281_I0.9150.99
161_F348_G0.9130.98
208_D214_K0.9110.98
262_D265_L0.9110.98
162_I175_I0.9080.98
314_Q317_G0.9030.98
166_L172_S0.9030.98
65_F78_R0.9020.98
247_D297_P0.8990.98
9_T12_I0.8960.98
19_Y22_T0.8940.98
161_F244_V0.8900.98
14_E18_N0.8890.98
279_N282_V0.8860.98
305_P345_K0.8860.98
106_R109_V0.8820.98
309_S328_K0.8800.98
302_S310_K0.8800.98
19_Y34_G0.8790.98
210_E213_R0.8760.98
17_I21_L0.8720.98
216_R220_K0.8670.98
170_S179_P0.8630.98
65_F79_P0.8620.98
311_I318_G0.8610.98
323_V333_W0.8600.98
233_V243_I0.8600.98
64_S67_K0.8580.98
21_L24_N0.8550.98
257_V262_D0.8530.98
321_P335_R0.8520.98
207_K211_V0.8510.98
297_P300_T0.8450.97
197_R215_L0.8440.97
185_N189_I0.8420.97
120_W123_Y0.8400.97
170_S181_L0.8370.97
193_Y197_R0.8370.97
309_S314_Q0.8290.97
134_R146_F0.8280.97
53_T57_D0.8260.97
162_I243_I0.8250.97
252_V275_S0.8240.97
8_F46_L0.8170.97
88_L91_H0.8170.97
189_I193_Y0.8150.97
338_V342_N0.8040.97
20_G31_I0.8010.97
256_M266_R0.8000.97
52_Y56_E0.7990.96
9_T54_A0.7990.96
86_V90_D0.7970.96
310_K316_D0.7960.96
301_S317_G0.7950.96
5_S9_T0.7940.96
90_D93_W0.7930.96
85_T90_D0.7930.96
46_L49_H0.7920.96
285_A290_V0.7920.96
199_S202_N0.7890.96
256_M262_D0.7890.96
10_R17_I0.7880.96
265_L269_I0.7840.96
7_I10_R0.7830.96
337_V340_L0.7830.96
96_S101_S0.7810.96
49_H52_Y0.7770.96
124_N127_W0.7740.96
36_Y39_E0.7660.96
165_D336_D0.7630.95
263_K270_Y0.7610.95
40_R51_I0.7580.95
252_V274_F0.7560.95
225_R273_A0.7560.95
232_I243_I0.7550.95
242_A293_I0.7530.95
275_S279_N0.7530.95
175_I337_V0.7520.95
13_L20_G0.7500.95
230_K284_K0.7500.95
160_G176_N0.7480.95
101_S108_R0.7470.95
293_I347_A0.7430.95
160_G241_S0.7420.95
55_C59_S0.7420.95
182_L185_N0.7400.95
303_I342_N0.7400.95
305_P339_A0.7390.95
5_S47_P0.7380.95
28_F31_I0.7380.95
54_A58_A0.7380.95
346_R350_V0.7370.95
224_V228_F0.7360.94
179_P337_V0.7350.94
182_L272_S0.7340.94
195_Y199_S0.7320.94
132_G148_V0.7310.94
32_K36_Y0.7310.94
299_Y346_R0.7300.94
341_Y344_R0.7280.94
87_H91_H0.7280.94
36_Y43_H0.7240.94
58_A62_L0.7220.94
200_I212_R0.7220.94
16_A31_I0.7190.94
135_F145_F0.7190.94
8_F11_E0.7100.93
244_V293_I0.7080.93
169_D173_V0.7060.93
62_L65_F0.7050.93
89_D92_L0.7040.93
10_R20_G0.7020.93
339_A342_N0.7000.93
203_G206_T0.6970.93
244_V344_R0.6970.93
103_A112_S0.6960.93
198_R201_T0.6900.92
306_V341_Y0.6900.92
186_T190_T0.6880.92
171_V272_S0.6880.92
194_E201_T0.6870.92
302_S318_G0.6870.92
168_E256_M0.6850.92
36_Y55_C0.6840.92
6_M9_T0.6830.92
168_E268_R0.6810.92
46_L51_I0.6810.92
111_I114_I0.6810.92
19_Y24_N0.6800.92
119_F122_Y0.6790.92
157_D160_G0.6770.92
37_K41_E0.6740.91
172_S180_I0.6690.91
15_E18_N0.6660.91
204_R207_K0.6650.91
88_L92_L0.6630.91
309_S316_D0.6620.91
228_F231_L0.6620.91
248_L297_P0.6620.91
205_S214_K0.6600.91
100_I108_R0.6600.91
5_S46_L0.6600.91
193_Y201_T0.6560.90
247_D278_K0.6560.90
302_S316_D0.6540.90
172_S228_F0.6510.90
36_Y42_K0.6500.90
12_I15_E0.6490.90
26_T31_I0.6490.90
234_K242_A0.6470.90
123_Y149_F0.6470.90
49_H89_D0.6460.90
90_D94_K0.6430.89
17_I20_G0.6420.89
12_I18_N0.6410.89
299_Y310_K0.6390.89
8_F12_I0.6370.89
21_L62_L0.6370.89
9_T20_G0.6370.89
87_H90_D0.6370.89
333_W338_V0.6360.89
40_R43_H0.6350.89
142_V219_D0.6350.89
309_S324_G0.6340.89
281_I292_V0.6320.89
302_S311_I0.6300.88
25_T30_R0.6280.88
243_I281_I0.6270.88
62_L66_N0.6220.88
138_L144_E0.6200.88
167_N173_V0.6180.88
299_Y303_I0.6170.87
186_T189_I0.6170.87
203_G207_K0.6150.87
310_K314_Q0.6150.87
254_E297_P0.6130.87
14_E20_G0.6130.87
280_A284_K0.6120.87
66_N69_K0.6110.87
317_G322_R0.6110.87
16_A35_I0.6110.87
20_G62_L0.6060.87
222_L226_R0.6040.86
95_F98_N0.6040.86
31_I34_G0.5980.86
114_I117_K0.5970.86
159_R241_S0.5960.86
10_R16_A0.5950.86
95_F103_A0.5950.86
30_R33_A0.5940.85
173_V180_I0.5940.85
87_H92_L0.5940.85
163_P244_V0.5940.85
217_E271_R0.5940.85
180_I224_V0.5920.85
186_T267_L0.5910.85
85_T89_D0.5910.85
20_G59_S0.5900.85
67_K76_T0.5890.85
180_I228_F0.5880.85
12_I24_N0.5860.85
171_V229_A0.5840.84
221_K271_R0.5830.84
187_R190_T0.5810.84
85_T88_L0.5790.84
103_A109_V0.5780.84
122_Y125_D0.5780.84
204_R212_R0.5750.84
187_R267_L0.5740.83
61_R79_P0.5740.83
36_Y48_S0.5740.83
13_L58_A0.5720.83
307_H311_I0.5690.83
296_D299_Y0.5680.83
219_D223_D0.5670.83
130_A148_V0.5670.83
345_K350_V0.5660.83
9_T46_L0.5660.83
11_E14_E0.5630.82
165_D301_S0.5620.82
127_W149_F0.5610.82
311_I321_P0.5600.82
316_D321_P0.5600.82
244_V346_R0.5590.82
283_E287_E0.5570.82
12_I17_I0.5550.81
205_S212_R0.5540.81
19_Y31_I0.5530.81
188_M191_L0.5500.81
14_E24_N0.5490.81
324_G335_R0.5470.80
8_F14_E0.5470.80
180_I231_L0.5470.80
225_R228_F0.5470.80
51_I54_A0.5460.80
111_I115_F0.5430.80
105_K109_V0.5420.80
65_F68_L0.5410.80
197_R200_I0.5400.80
17_I24_N0.5400.80
197_R202_N0.5400.80
196_K200_I0.5390.79
13_L16_A0.5390.79
5_S8_F0.5390.79
254_E269_I0.5390.79
93_W99_V0.5390.79
171_V225_R0.5390.79
172_S277_M0.5390.79
234_K239_S0.5370.79
319_S335_R0.5360.79
215_L221_K0.5340.79
192_G195_Y0.5330.79
105_K108_R0.5310.78
89_D93_W0.5310.78
55_C58_A0.5290.78
189_I216_R0.5280.78
169_D322_R0.5270.78
174_L232_I0.5260.78
325_V331_E0.5260.78
343_L346_R0.5250.78
187_R268_R0.5230.77
12_I19_Y0.5230.77
137_L144_E0.5220.77
227_K230_K0.5220.77
18_N81_V0.5220.77
95_F100_I0.5210.77
54_A57_D0.5190.77
217_E221_K0.5190.77
100_I145_F0.5170.77
12_I51_I0.5160.76
118_I121_R0.5140.76
97_L101_S0.5130.76
321_P334_H0.5130.76
265_L268_R0.5110.76
111_I117_K0.5110.76
331_E338_V0.5100.76
27_S32_K0.5090.76
204_R211_V0.5090.76
198_R202_N0.5090.76
60_E69_K0.5090.76
23_K26_T0.5080.75
252_V255_H0.5070.75
32_K59_S0.5070.75
128_L150_K0.5060.75
311_I335_R0.5060.75
219_D222_L0.5030.75
26_T32_K0.5020.75
319_S334_H0.5020.75
306_V333_W0.5020.75
144_E219_D0.5000.74
301_S311_I0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3531 94.9 0.925 Contact Map
1vhxA 2 0.372 94.7 0.925 Contact Map
1iv0A 1 0.2642 92.7 0.931 Contact Map
4aybP 1 0.1186 86.9 0.939 Contact Map
1qypA 1 0.1321 85.1 0.941 Contact Map
1vq8Z 1 0.1968 83.5 0.942 Contact Map
3j20Y 1 0.1348 79.5 0.944 Contact Map
4c2mI 1 0.1995 75 0.946 Contact Map
2k4xA 1 0.1429 74.9 0.946 Contact Map
1vd4A 1 0.1536 71.1 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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