Q7LXH2 - SULSO - GREMLIN Contacts

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Q7LXH2 - Transposase ISC1476

UniProt:	Q7LXH2	Sequences: MAPSSGQLLGDEEREPTPTPAMPEEGVYEVKYSNRRTNVVRLLPNGFQERKLRRLANLSAKLFNEVNFERRQQFFHEGKVDFKGTWNKYYEKYKTILGVNAQAVLQKNNEAWSSFFSLLKLKKERKLPPHMNRVSPPRYWKDREAGKRKQILVVRQDRYKVDAGNHKDFNMEIDFVGRLKWYGKQGRLEIIFDETKNAWYAHIPIEVGVEETGKKSKHVVKGERKSIQISKPKGNKVTSIDLGINVIASVVVNDGTWLLYKGVRTKEDYFYFQRRISEVQSLADRTRNIGEYDAYLELLREKRRFFKKLTRRLPHLYRNLASHLIETLYELGVSTIYLGYPFNIVQEKGNKFTVNMWSYRKLMESIELKAQEYGMKVFEVVEYNTSKYCAYHDVEVKRNPRGVVNRPLGHKLHSDLNGALNILKKALGVIAEAVKKPLSFIVDHNRVAPIKGCNP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	455 (345)
Sequences:	3703 (2362)
Seq/√Len:	127.2

ECOLI - INSQ
HALSA - Q9HHJ9 Q9HSW9 Q9HM87 Q9HSW7 Q9HHG8 Q9HSZ6 Q9HSD4 Q9HHU6 Q9HSY4 Q9HHX8
SULSO - Q7LXH2 Q7LXD9 Q97Y67 Q97YI5 Q97XP1 Q97Z61 Q97U51 Q97V47 Q97V25 Q97Y48 Q97XQ8 Q97Y44 Q97WY6 Q97X39 Q97UQ8 Q97XQ0 Q97YI2 Q97XB6 Q97YU1 Q97WZ3 Q97YW4 Q97U68 Q97YW9 Q97V53 Q97XA4 Q7LXH6 Q7LXH9 Q97YF7 Q97U09

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
315_H	319_N	5.432	1.00
390_A	417_N	4.079	1.00
370_A	377_V	3.669	1.00
337_Y	426_A	3.423	1.00
247_I	362_L	3.130	1.00
398_R	401_R	3.035	1.00
363_M	379_E	2.992	1.00
36_R	372_E	2.813	1.00
338_L	366_I	2.778	1.00
361_K	365_S	2.771	1.00
403_V	406_R	2.574	1.00
273_Q	351_K	2.549	1.00
361_K	364_E	2.498	1.00
322_S	326_E	2.496	1.00
325_I	370_A	2.491	1.00
380_V	422_I	2.483	1.00
425_K	428_G	2.479	1.00
188_L	201_A	2.478	1.00
186_G	206_E	2.436	1.00
399_N	402_G	2.428	1.00
345_V	354_V	2.378	1.00
362_L	366_I	2.328	1.00
385_T	422_I	2.203	1.00
279_V	298_L	2.193	1.00
367_E	379_E	2.119	1.00
336_I	370_A	2.119	1.00
45_N	48_Q	2.107	1.00
384_N	387_K	2.097	1.00
318_R	368_L	2.087	1.00
387_K	396_V	2.079	1.00
298_L	302_K	2.060	1.00
392_H	408_L	2.051	1.00
338_L	377_V	2.017	1.00
163_A	166_H	2.016	1.00
293_D	296_L	1.987	1.00
318_R	365_S	1.976	1.00
334_S	375_M	1.974	1.00
68_F	72_Q	1.965	1.00
321_A	365_S	1.938	1.00
66_V	105_L	1.909	1.00
296_L	299_L	1.887	1.00
389_C	408_L	1.885	1.00
397_K	401_R	1.885	1.00
391_Y	410_H	1.876	1.00
318_R	369_K	1.859	1.00
54_R	95_T	1.853	1.00
247_I	316_L	1.837	1.00
272_F	312_R	1.822	1.00
401_R	406_R	1.822	1.00
99_V	155_R	1.812	1.00
176_V	179_L	1.790	1.00
399_N	406_R	1.786	1.00
398_R	414_S	1.784	1.00
389_C	392_H	1.782	1.00
53_R	199_W	1.759	1.00
318_R	321_A	1.737	1.00
398_R	402_G	1.709	1.00
240_I	248_A	1.696	1.00
397_K	402_G	1.675	1.00
61_K	92_K	1.670	1.00
67_N	108_N	1.641	1.00
314_P	361_K	1.633	1.00
249_S	416_L	1.624	1.00
41_R	198_A	1.623	1.00
367_E	371_Q	1.622	1.00
53_R	192_F	1.617	1.00
37_T	202_H	1.607	1.00
397_K	404_V	1.595	1.00
99_V	156_Q	1.591	1.00
317_Y	361_K	1.588	1.00
347_E	350_N	1.583	1.00
387_K	397_K	1.573	1.00
400_P	406_R	1.568	1.00
86_W	89_Y	1.534	1.00
276_I	302_K	1.531	1.00
246_V	249_S	1.508	1.00
238_T	250_V	1.483	1.00
282_L	286_T	1.476	1.00
250_V	254_D	1.472	1.00
317_Y	365_S	1.465	1.00
321_A	368_L	1.462	1.00
327_T	333_V	1.455	1.00
276_I	306_F	1.434	1.00
107_K	153_V	1.426	1.00
52_L	199_W	1.416	1.00
198_A	307_K	1.406	1.00
401_R	404_V	1.406	1.00
56_A	199_W	1.401	1.00
401_R	405_N	1.398	1.00
283_A	299_L	1.384	1.00
234_G	334_S	1.381	1.00
399_N	403_V	1.378	1.00
109_N	113_S	1.374	1.00
338_L	363_M	1.367	1.00
338_L	379_E	1.362	1.00
405_N	411_K	1.354	1.00
237_V	423_L	1.345	1.00
339_G	382_E	1.343	1.00
420_L	424_K	1.330	1.00
286_T	298_L	1.327	1.00
398_R	403_V	1.324	1.00
321_A	369_K	1.315	1.00
402_G	414_S	1.314	1.00
399_N	405_N	1.300	1.00
49_E	53_R	1.290	1.00
398_R	406_R	1.288	1.00
66_V	108_N	1.288	1.00
50_R	54_R	1.286	1.00
307_K	311_R	1.270	1.00
321_A	362_L	1.270	1.00
321_A	366_I	1.269	1.00
272_F	309_L	1.268	1.00
353_T	359_Y	1.265	1.00
175_F	179_L	1.263	1.00
196_K	307_K	1.252	1.00
398_R	405_N	1.246	1.00
177_G	180_K	1.243	1.00
395_E	404_V	1.242	1.00
389_C	406_R	1.239	1.00
400_P	403_V	1.237	1.00
404_V	412_L	1.231	1.00
367_E	377_V	1.229	1.00
397_K	406_R	1.224	0.99
399_N	404_V	1.217	0.99
392_H	406_R	1.216	0.99
340_Y	379_E	1.215	0.99
402_G	406_R	1.200	0.99
279_V	305_F	1.195	0.99
397_K	400_P	1.183	0.99
113_S	117_S	1.168	0.99
279_V	302_K	1.157	0.99
46_G	49_E	1.157	0.99
162_D	165_N	1.155	0.99
400_P	405_N	1.153	0.99
38_N	205_I	1.147	0.99
385_T	425_K	1.137	0.99
63_F	104_V	1.130	0.99
59_S	104_V	1.127	0.99
283_A	298_L	1.123	0.99
118_L	121_L	1.113	0.99
191_I	202_H	1.112	0.99
365_S	368_L	1.111	0.99
242_L	359_Y	1.108	0.99
325_I	373_Y	1.104	0.99
326_E	373_Y	1.103	0.99
160_K	167_K	1.100	0.99
71_R	112_W	1.099	0.99
244_I	356_M	1.095	0.99
258_L	413_H	1.095	0.99
390_A	418_G	1.095	0.99
342_F	382_E	1.090	0.99
317_Y	362_L	1.082	0.99
390_A	420_L	1.070	0.99
279_V	282_L	1.066	0.99
310_T	314_P	1.053	0.98
380_V	425_K	1.049	0.98
103_A	106_Q	1.043	0.98
175_F	178_R	1.042	0.98
251_V	419_A	1.042	0.98
71_R	75_F	1.040	0.98
72_Q	76_H	1.035	0.98
242_L	363_M	1.035	0.98
77_E	80_V	1.032	0.98
276_I	309_L	1.028	0.98
322_S	373_Y	1.022	0.98
67_N	112_W	1.018	0.98
345_V	350_N	1.017	0.98
114_S	119_L	1.017	0.98
400_P	404_V	1.017	0.98
238_T	251_V	1.014	0.98
390_A	412_L	1.011	0.98
249_S	259_L	1.002	0.98
170_N	179_L	1.002	0.98
97_L	100_N	0.996	0.98
398_R	404_V	0.992	0.98
237_V	335_T	0.988	0.98
150_Q	153_V	0.986	0.98
275_R	278_E	0.983	0.98
276_I	284_D	0.982	0.98
283_A	302_K	0.979	0.98
396_V	401_R	0.974	0.97
380_V	426_A	0.971	0.97
280_Q	284_D	0.971	0.97
280_Q	302_K	0.969	0.97
70_R	109_N	0.969	0.97
41_R	200_Y	0.968	0.97
388_Y	425_K	0.963	0.97
295_Y	299_L	0.960	0.97
110_E	114_S	0.958	0.97
34_N	209_V	0.950	0.97
314_P	365_S	0.949	0.97
337_Y	422_I	0.948	0.97
268_D	312_R	0.947	0.97
324_L	336_I	0.947	0.97
237_V	337_Y	0.946	0.97
114_S	120_K	0.941	0.97
114_S	117_S	0.938	0.97
158_R	169_F	0.937	0.97
387_K	395_E	0.935	0.97
237_V	427_L	0.935	0.97
115_F	137_P	0.933	0.97
416_L	420_L	0.932	0.97
254_D	323_H	0.929	0.97
317_Y	321_A	0.928	0.97
248_A	320_L	0.918	0.96
340_Y	382_E	0.917	0.96
402_G	405_N	0.916	0.96
258_L	416_L	0.915	0.96
403_V	411_K	0.915	0.96
305_F	309_L	0.915	0.96
93_Y	101_A	0.911	0.96
412_L	416_L	0.902	0.96
240_I	250_V	0.901	0.96
323_H	327_T	0.900	0.96
412_L	420_L	0.897	0.96
404_V	410_H	0.893	0.96
239_S	423_L	0.889	0.96
105_L	109_N	0.889	0.96
112_W	115_F	0.886	0.96
117_S	122_K	0.886	0.96
103_A	153_V	0.883	0.95
327_T	334_S	0.881	0.95
61_K	65_E	0.877	0.95
370_A	375_M	0.875	0.95
397_K	414_S	0.871	0.95
249_S	258_L	0.870	0.95
176_V	180_K	0.868	0.95
71_R	136_P	0.868	0.95
248_A	362_L	0.865	0.95
241_D	415_D	0.861	0.95
287_R	291_E	0.860	0.95
160_K	163_A	0.856	0.95
40_V	201_A	0.853	0.94
369_K	372_E	0.851	0.94
44_P	48_Q	0.849	0.94
158_R	161_V	0.849	0.94
269_Y	272_F	0.843	0.94
384_N	425_K	0.842	0.94
172_E	176_V	0.841	0.94
340_Y	363_M	0.840	0.94
246_V	260_Y	0.838	0.94
425_K	429_V	0.835	0.94
114_S	118_L	0.832	0.94
74_F	78_G	0.832	0.94
122_K	136_P	0.828	0.94
153_V	187_R	0.828	0.94
102_Q	106_Q	0.826	0.93
390_A	410_H	0.820	0.93
49_E	199_W	0.819	0.93
242_L	248_A	0.813	0.93
175_F	180_K	0.813	0.93
325_I	375_M	0.813	0.93
73_Q	77_E	0.812	0.93
278_E	282_L	0.808	0.93
44_P	52_L	0.802	0.92
261_K	356_M	0.802	0.92
397_K	405_N	0.801	0.92
388_Y	421_N	0.798	0.92
268_D	272_F	0.788	0.92
322_S	369_K	0.787	0.92
325_I	336_I	0.786	0.92
270_F	352_F	0.783	0.92
172_E	177_G	0.776	0.91
42_L	201_A	0.776	0.91
52_L	56_A	0.776	0.91
290_G	295_Y	0.774	0.91
99_V	103_A	0.774	0.91
254_D	259_L	0.773	0.91
77_E	81_D	0.771	0.91
63_F	108_N	0.770	0.91
63_F	111_A	0.770	0.91
85_T	89_Y	0.764	0.91
269_Y	273_Q	0.762	0.90
58_L	92_K	0.754	0.90
370_A	373_Y	0.754	0.90
149_K	152_L	0.752	0.90
396_V	406_R	0.752	0.90
316_L	320_L	0.752	0.90
418_G	421_N	0.742	0.89
57_N	60_A	0.737	0.89
294_A	297_E	0.735	0.89
35_R	204_P	0.733	0.89
382_E	385_T	0.731	0.89
99_V	102_Q	0.730	0.88
344_I	353_T	0.730	0.88
184_K	206_E	0.730	0.88
231_K	234_G	0.730	0.88
286_T	291_E	0.729	0.88
276_I	280_Q	0.729	0.88
317_Y	358_S	0.729	0.88
287_R	295_Y	0.727	0.88
103_A	107_K	0.726	0.88
284_D	302_K	0.724	0.88
364_E	367_E	0.721	0.88
74_F	112_W	0.720	0.88
391_Y	420_L	0.720	0.88
277_S	282_L	0.719	0.88
235_N	334_S	0.719	0.88
296_L	300_R	0.719	0.88
78_G	82_F	0.718	0.88
65_E	92_K	0.717	0.88
189_E	202_H	0.717	0.88
283_A	286_T	0.717	0.88
308_K	312_R	0.713	0.87
277_S	280_Q	0.711	0.87
62_L	101_A	0.710	0.87
99_V	157_D	0.710	0.87
270_F	273_Q	0.708	0.87
335_T	376_K	0.708	0.87
349_G	353_T	0.708	0.87
394_V	407_P	0.708	0.87
247_I	321_A	0.704	0.87
62_L	104_V	0.704	0.87
246_V	258_L	0.703	0.87
390_A	424_K	0.703	0.87
245_N	249_S	0.700	0.86
388_Y	395_E	0.699	0.86
238_T	336_I	0.698	0.86
169_F	172_E	0.698	0.86
37_T	191_I	0.698	0.86
360_R	364_E	0.696	0.86
402_G	413_H	0.695	0.86
279_V	301_E	0.695	0.86
171_M	175_F	0.691	0.86
343_N	382_E	0.690	0.86
295_Y	298_L	0.687	0.85
152_L	156_Q	0.686	0.85
280_Q	283_A	0.684	0.85
420_L	423_L	0.683	0.85
39_V	191_I	0.682	0.85
68_F	139_Y	0.681	0.85
39_V	314_P	0.679	0.85
363_M	367_E	0.678	0.85
69_E	72_Q	0.677	0.84
70_R	112_W	0.677	0.84
350_N	354_V	0.676	0.84
73_Q	81_D	0.674	0.84
416_L	419_A	0.674	0.84
98_G	156_Q	0.670	0.84
62_L	93_Y	0.668	0.84
112_W	116_F	0.665	0.83
239_S	337_Y	0.664	0.83
112_W	136_P	0.662	0.83
79_K	82_F	0.662	0.83
288_N	291_E	0.661	0.83
54_R	58_L	0.659	0.83
74_F	115_F	0.658	0.83
82_F	86_W	0.657	0.83
98_G	158_R	0.656	0.83
238_T	333_V	0.655	0.82
277_S	285_R	0.654	0.82
105_L	108_N	0.653	0.82
58_L	93_Y	0.653	0.82
74_F	116_F	0.651	0.82
170_N	175_F	0.651	0.82
172_E	175_F	0.651	0.82
397_K	403_V	0.650	0.82
99_V	158_R	0.650	0.82
258_L	261_K	0.647	0.82
119_L	122_K	0.647	0.82
118_L	122_K	0.647	0.82
365_S	369_K	0.645	0.81
57_N	61_K	0.643	0.81
233_K	236_K	0.643	0.81
98_G	155_R	0.642	0.81
272_F	305_F	0.641	0.81
58_L	96_I	0.640	0.81
335_T	378_F	0.638	0.81
395_E	398_R	0.637	0.81
107_K	189_E	0.636	0.81
152_L	155_R	0.636	0.81
148_R	152_L	0.635	0.80
55_L	152_L	0.634	0.80
251_V	416_L	0.633	0.80
399_N	414_S	0.631	0.80
320_L	323_H	0.629	0.80
154_V	157_D	0.628	0.80
69_E	73_Q	0.627	0.80
42_L	173_I	0.626	0.80
378_F	426_A	0.626	0.80
241_D	386_S	0.625	0.79
81_D	84_G	0.623	0.79
153_V	189_E	0.621	0.79
192_F	199_W	0.620	0.79
422_I	427_L	0.620	0.79
403_V	412_L	0.620	0.79
239_S	251_V	0.619	0.79
170_N	177_G	0.619	0.79
326_E	335_T	0.618	0.79
172_E	178_R	0.618	0.79
37_T	204_P	0.617	0.79
299_L	303_R	0.614	0.78
404_V	414_S	0.614	0.78
245_N	258_L	0.614	0.78
366_I	377_V	0.612	0.78
173_I	176_V	0.611	0.78
46_G	50_R	0.611	0.78
384_N	388_Y	0.610	0.78
69_E	86_W	0.608	0.78
270_F	351_K	0.608	0.78
96_I	99_V	0.607	0.77
396_V	404_V	0.607	0.77
426_A	430_I	0.606	0.77
155_R	158_R	0.605	0.77
87_N	101_A	0.605	0.77
336_I	366_I	0.604	0.77
236_K	252_V	0.602	0.77
341_P	344_I	0.599	0.76
168_D	190_I	0.595	0.76
112_W	122_K	0.594	0.76
200_Y	307_K	0.594	0.76
384_N	404_V	0.593	0.76
282_L	285_R	0.593	0.76
231_K	375_M	0.592	0.76
100_N	152_L	0.591	0.76
83_K	105_L	0.590	0.75
39_V	195_T	0.588	0.75
55_L	96_I	0.588	0.75
403_V	413_H	0.587	0.75
102_Q	105_L	0.586	0.75
172_E	179_L	0.585	0.75
65_E	69_E	0.585	0.75
396_V	400_P	0.583	0.75
272_F	308_K	0.583	0.75
166_H	169_F	0.582	0.74
42_L	190_I	0.581	0.74
39_V	200_Y	0.580	0.74
343_N	346_Q	0.580	0.74
190_I	201_A	0.579	0.74
83_K	106_Q	0.578	0.74
244_I	352_F	0.578	0.74
162_D	167_K	0.578	0.74
386_S	397_K	0.575	0.74
413_H	418_G	0.575	0.74
391_Y	412_L	0.572	0.73
343_N	347_E	0.570	0.73
275_R	279_V	0.568	0.73
236_K	334_S	0.567	0.73
74_F	77_E	0.567	0.73
183_G	205_I	0.566	0.72
281_S	285_R	0.564	0.72
73_Q	78_G	0.563	0.72
170_N	176_V	0.562	0.72
396_V	399_N	0.562	0.72
96_I	101_A	0.561	0.72
252_V	333_V	0.561	0.72
261_K	268_D	0.560	0.72
240_I	324_L	0.559	0.71
276_I	286_T	0.559	0.71
301_E	304_R	0.559	0.71
422_I	425_K	0.558	0.71
247_I	356_M	0.558	0.71
156_Q	184_K	0.557	0.71
55_L	97_L	0.556	0.71
275_R	305_F	0.555	0.71
347_E	354_V	0.553	0.71
52_L	190_I	0.553	0.71
287_R	290_G	0.552	0.71
51_K	55_L	0.552	0.71
85_T	88_K	0.552	0.71
381_V	384_N	0.551	0.70
284_D	298_L	0.550	0.70
424_K	429_V	0.549	0.70
174_D	179_L	0.549	0.70
269_Y	275_R	0.548	0.70
333_V	375_M	0.547	0.70
248_A	259_L	0.546	0.70
268_D	355_N	0.545	0.70
286_T	294_A	0.545	0.70
78_G	81_D	0.545	0.70
404_V	411_K	0.544	0.69
54_R	96_I	0.543	0.69
348_K	352_F	0.541	0.69
35_R	186_G	0.541	0.69
277_S	302_K	0.540	0.69
269_Y	309_L	0.536	0.68
341_P	382_E	0.536	0.68
269_Y	351_K	0.535	0.68
396_V	403_V	0.534	0.68
344_I	359_Y	0.534	0.68
79_K	83_K	0.533	0.68
60_A	92_K	0.533	0.68
167_K	170_N	0.533	0.68
386_S	398_R	0.532	0.68
317_Y	320_L	0.531	0.68
388_Y	393_D	0.531	0.68
115_F	118_L	0.530	0.67
101_A	104_V	0.530	0.67
77_E	82_F	0.530	0.67
382_E	425_K	0.529	0.67
243_G	249_S	0.529	0.67
269_Y	276_I	0.527	0.67
306_F	313_L	0.527	0.67
417_N	421_N	0.526	0.67
104_V	108_N	0.525	0.67
108_N	112_W	0.523	0.66
76_H	80_V	0.522	0.66
80_V	83_K	0.521	0.66
309_L	355_N	0.518	0.66
34_N	206_E	0.517	0.66
59_S	152_L	0.516	0.65
56_A	152_L	0.515	0.65
344_I	347_E	0.513	0.65
90_Y	93_Y	0.513	0.65
385_T	388_Y	0.513	0.65
248_A	324_L	0.512	0.65
179_L	183_G	0.509	0.64
55_L	100_N	0.508	0.64
250_V	324_L	0.508	0.64
103_A	155_R	0.507	0.64
294_A	301_E	0.507	0.64
395_E	399_N	0.507	0.64
66_V	102_Q	0.507	0.64
70_R	105_L	0.504	0.64
388_Y	404_V	0.503	0.63
40_V	179_L	0.502	0.63
198_A	311_R	0.500	0.63
395_E	401_R	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nu0A	1	0.2857	95.8	0.932	Contact Map
1vhxA	2	0.3011	95.3	0.934	Contact Map
1iv0A	1	0.2132	93	0.941	Contact Map
1qypA	1	0.0945	82.7	0.951	Contact Map
4ep4A	2	0.3429	69.8	0.956	Contact Map
1ffkW	1	0.1538	50.1	0.961	Contact Map
2k4xA	1	0.1165	47.9	0.962	Contact Map
4aybP	1	0.0879	40.4	0.963	Contact Map
3j20Y	1	0.1055	39.2	0.964	Contact Map
1hjrA	2	0.3363	29.4	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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