GREMLIN Database
Q7LXH2 - Transposase ISC1476
UniProt: Q7LXH2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 455 (345)
Sequences: 3703 (2362)
Seq/√Len: 127.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
315_H319_N5.4321.00
390_A417_N4.0791.00
370_A377_V3.6691.00
337_Y426_A3.4231.00
247_I362_L3.1301.00
398_R401_R3.0351.00
363_M379_E2.9921.00
36_R372_E2.8131.00
338_L366_I2.7781.00
361_K365_S2.7711.00
403_V406_R2.5741.00
273_Q351_K2.5491.00
361_K364_E2.4981.00
322_S326_E2.4961.00
325_I370_A2.4911.00
380_V422_I2.4831.00
425_K428_G2.4791.00
188_L201_A2.4781.00
186_G206_E2.4361.00
399_N402_G2.4281.00
345_V354_V2.3781.00
362_L366_I2.3281.00
385_T422_I2.2031.00
279_V298_L2.1931.00
367_E379_E2.1191.00
336_I370_A2.1191.00
45_N48_Q2.1071.00
384_N387_K2.0971.00
318_R368_L2.0871.00
387_K396_V2.0791.00
298_L302_K2.0601.00
392_H408_L2.0511.00
338_L377_V2.0171.00
163_A166_H2.0161.00
293_D296_L1.9871.00
318_R365_S1.9761.00
334_S375_M1.9741.00
68_F72_Q1.9651.00
321_A365_S1.9381.00
66_V105_L1.9091.00
296_L299_L1.8871.00
389_C408_L1.8851.00
397_K401_R1.8851.00
391_Y410_H1.8761.00
318_R369_K1.8591.00
54_R95_T1.8531.00
247_I316_L1.8371.00
272_F312_R1.8221.00
401_R406_R1.8221.00
99_V155_R1.8121.00
176_V179_L1.7901.00
399_N406_R1.7861.00
398_R414_S1.7841.00
389_C392_H1.7821.00
53_R199_W1.7591.00
318_R321_A1.7371.00
398_R402_G1.7091.00
240_I248_A1.6961.00
397_K402_G1.6751.00
61_K92_K1.6701.00
67_N108_N1.6411.00
314_P361_K1.6331.00
249_S416_L1.6241.00
41_R198_A1.6231.00
367_E371_Q1.6221.00
53_R192_F1.6171.00
37_T202_H1.6071.00
397_K404_V1.5951.00
99_V156_Q1.5911.00
317_Y361_K1.5881.00
347_E350_N1.5831.00
387_K397_K1.5731.00
400_P406_R1.5681.00
86_W89_Y1.5341.00
276_I302_K1.5311.00
246_V249_S1.5081.00
238_T250_V1.4831.00
282_L286_T1.4761.00
250_V254_D1.4721.00
317_Y365_S1.4651.00
321_A368_L1.4621.00
327_T333_V1.4551.00
276_I306_F1.4341.00
107_K153_V1.4261.00
52_L199_W1.4161.00
198_A307_K1.4061.00
401_R404_V1.4061.00
56_A199_W1.4011.00
401_R405_N1.3981.00
283_A299_L1.3841.00
234_G334_S1.3811.00
399_N403_V1.3781.00
109_N113_S1.3741.00
338_L363_M1.3671.00
338_L379_E1.3621.00
405_N411_K1.3541.00
237_V423_L1.3451.00
339_G382_E1.3431.00
420_L424_K1.3301.00
286_T298_L1.3271.00
398_R403_V1.3241.00
321_A369_K1.3151.00
402_G414_S1.3141.00
399_N405_N1.3001.00
49_E53_R1.2901.00
398_R406_R1.2881.00
66_V108_N1.2881.00
50_R54_R1.2861.00
307_K311_R1.2701.00
321_A362_L1.2701.00
321_A366_I1.2691.00
272_F309_L1.2681.00
353_T359_Y1.2651.00
175_F179_L1.2631.00
196_K307_K1.2521.00
398_R405_N1.2461.00
177_G180_K1.2431.00
395_E404_V1.2421.00
389_C406_R1.2391.00
400_P403_V1.2371.00
404_V412_L1.2311.00
367_E377_V1.2291.00
397_K406_R1.2240.99
399_N404_V1.2170.99
392_H406_R1.2160.99
340_Y379_E1.2150.99
402_G406_R1.2000.99
279_V305_F1.1950.99
397_K400_P1.1830.99
113_S117_S1.1680.99
279_V302_K1.1570.99
46_G49_E1.1570.99
162_D165_N1.1550.99
400_P405_N1.1530.99
38_N205_I1.1470.99
385_T425_K1.1370.99
63_F104_V1.1300.99
59_S104_V1.1270.99
283_A298_L1.1230.99
118_L121_L1.1130.99
191_I202_H1.1120.99
365_S368_L1.1110.99
242_L359_Y1.1080.99
325_I373_Y1.1040.99
326_E373_Y1.1030.99
160_K167_K1.1000.99
71_R112_W1.0990.99
244_I356_M1.0950.99
258_L413_H1.0950.99
390_A418_G1.0950.99
342_F382_E1.0900.99
317_Y362_L1.0820.99
390_A420_L1.0700.99
279_V282_L1.0660.99
310_T314_P1.0530.98
380_V425_K1.0490.98
103_A106_Q1.0430.98
175_F178_R1.0420.98
251_V419_A1.0420.98
71_R75_F1.0400.98
72_Q76_H1.0350.98
242_L363_M1.0350.98
77_E80_V1.0320.98
276_I309_L1.0280.98
322_S373_Y1.0220.98
67_N112_W1.0180.98
345_V350_N1.0170.98
114_S119_L1.0170.98
400_P404_V1.0170.98
238_T251_V1.0140.98
390_A412_L1.0110.98
249_S259_L1.0020.98
170_N179_L1.0020.98
97_L100_N0.9960.98
398_R404_V0.9920.98
237_V335_T0.9880.98
150_Q153_V0.9860.98
275_R278_E0.9830.98
276_I284_D0.9820.98
283_A302_K0.9790.98
396_V401_R0.9740.97
380_V426_A0.9710.97
280_Q284_D0.9710.97
280_Q302_K0.9690.97
70_R109_N0.9690.97
41_R200_Y0.9680.97
388_Y425_K0.9630.97
295_Y299_L0.9600.97
110_E114_S0.9580.97
34_N209_V0.9500.97
314_P365_S0.9490.97
337_Y422_I0.9480.97
268_D312_R0.9470.97
324_L336_I0.9470.97
237_V337_Y0.9460.97
114_S120_K0.9410.97
114_S117_S0.9380.97
158_R169_F0.9370.97
387_K395_E0.9350.97
237_V427_L0.9350.97
115_F137_P0.9330.97
416_L420_L0.9320.97
254_D323_H0.9290.97
317_Y321_A0.9280.97
248_A320_L0.9180.96
340_Y382_E0.9170.96
402_G405_N0.9160.96
258_L416_L0.9150.96
403_V411_K0.9150.96
305_F309_L0.9150.96
93_Y101_A0.9110.96
412_L416_L0.9020.96
240_I250_V0.9010.96
323_H327_T0.9000.96
412_L420_L0.8970.96
404_V410_H0.8930.96
239_S423_L0.8890.96
105_L109_N0.8890.96
112_W115_F0.8860.96
117_S122_K0.8860.96
103_A153_V0.8830.95
327_T334_S0.8810.95
61_K65_E0.8770.95
370_A375_M0.8750.95
397_K414_S0.8710.95
249_S258_L0.8700.95
176_V180_K0.8680.95
71_R136_P0.8680.95
248_A362_L0.8650.95
241_D415_D0.8610.95
287_R291_E0.8600.95
160_K163_A0.8560.95
40_V201_A0.8530.94
369_K372_E0.8510.94
44_P48_Q0.8490.94
158_R161_V0.8490.94
269_Y272_F0.8430.94
384_N425_K0.8420.94
172_E176_V0.8410.94
340_Y363_M0.8400.94
246_V260_Y0.8380.94
425_K429_V0.8350.94
114_S118_L0.8320.94
74_F78_G0.8320.94
122_K136_P0.8280.94
153_V187_R0.8280.94
102_Q106_Q0.8260.93
390_A410_H0.8200.93
49_E199_W0.8190.93
242_L248_A0.8130.93
175_F180_K0.8130.93
325_I375_M0.8130.93
73_Q77_E0.8120.93
278_E282_L0.8080.93
44_P52_L0.8020.92
261_K356_M0.8020.92
397_K405_N0.8010.92
388_Y421_N0.7980.92
268_D272_F0.7880.92
322_S369_K0.7870.92
325_I336_I0.7860.92
270_F352_F0.7830.92
172_E177_G0.7760.91
42_L201_A0.7760.91
52_L56_A0.7760.91
290_G295_Y0.7740.91
99_V103_A0.7740.91
254_D259_L0.7730.91
77_E81_D0.7710.91
63_F108_N0.7700.91
63_F111_A0.7700.91
85_T89_Y0.7640.91
269_Y273_Q0.7620.90
58_L92_K0.7540.90
370_A373_Y0.7540.90
149_K152_L0.7520.90
396_V406_R0.7520.90
316_L320_L0.7520.90
418_G421_N0.7420.89
57_N60_A0.7370.89
294_A297_E0.7350.89
35_R204_P0.7330.89
382_E385_T0.7310.89
99_V102_Q0.7300.88
344_I353_T0.7300.88
184_K206_E0.7300.88
231_K234_G0.7300.88
286_T291_E0.7290.88
276_I280_Q0.7290.88
317_Y358_S0.7290.88
287_R295_Y0.7270.88
103_A107_K0.7260.88
284_D302_K0.7240.88
364_E367_E0.7210.88
74_F112_W0.7200.88
391_Y420_L0.7200.88
277_S282_L0.7190.88
235_N334_S0.7190.88
296_L300_R0.7190.88
78_G82_F0.7180.88
65_E92_K0.7170.88
189_E202_H0.7170.88
283_A286_T0.7170.88
308_K312_R0.7130.87
277_S280_Q0.7110.87
62_L101_A0.7100.87
99_V157_D0.7100.87
270_F273_Q0.7080.87
335_T376_K0.7080.87
349_G353_T0.7080.87
394_V407_P0.7080.87
247_I321_A0.7040.87
62_L104_V0.7040.87
246_V258_L0.7030.87
390_A424_K0.7030.87
245_N249_S0.7000.86
388_Y395_E0.6990.86
238_T336_I0.6980.86
169_F172_E0.6980.86
37_T191_I0.6980.86
360_R364_E0.6960.86
402_G413_H0.6950.86
279_V301_E0.6950.86
171_M175_F0.6910.86
343_N382_E0.6900.86
295_Y298_L0.6870.85
152_L156_Q0.6860.85
280_Q283_A0.6840.85
420_L423_L0.6830.85
39_V191_I0.6820.85
68_F139_Y0.6810.85
39_V314_P0.6790.85
363_M367_E0.6780.85
69_E72_Q0.6770.84
70_R112_W0.6770.84
350_N354_V0.6760.84
73_Q81_D0.6740.84
416_L419_A0.6740.84
98_G156_Q0.6700.84
62_L93_Y0.6680.84
112_W116_F0.6650.83
239_S337_Y0.6640.83
112_W136_P0.6620.83
79_K82_F0.6620.83
288_N291_E0.6610.83
54_R58_L0.6590.83
74_F115_F0.6580.83
82_F86_W0.6570.83
98_G158_R0.6560.83
238_T333_V0.6550.82
277_S285_R0.6540.82
105_L108_N0.6530.82
58_L93_Y0.6530.82
74_F116_F0.6510.82
170_N175_F0.6510.82
172_E175_F0.6510.82
397_K403_V0.6500.82
99_V158_R0.6500.82
258_L261_K0.6470.82
119_L122_K0.6470.82
118_L122_K0.6470.82
365_S369_K0.6450.81
57_N61_K0.6430.81
233_K236_K0.6430.81
98_G155_R0.6420.81
272_F305_F0.6410.81
58_L96_I0.6400.81
335_T378_F0.6380.81
395_E398_R0.6370.81
107_K189_E0.6360.81
152_L155_R0.6360.81
148_R152_L0.6350.80
55_L152_L0.6340.80
251_V416_L0.6330.80
399_N414_S0.6310.80
320_L323_H0.6290.80
154_V157_D0.6280.80
69_E73_Q0.6270.80
42_L173_I0.6260.80
378_F426_A0.6260.80
241_D386_S0.6250.79
81_D84_G0.6230.79
153_V189_E0.6210.79
192_F199_W0.6200.79
422_I427_L0.6200.79
403_V412_L0.6200.79
239_S251_V0.6190.79
170_N177_G0.6190.79
326_E335_T0.6180.79
172_E178_R0.6180.79
37_T204_P0.6170.79
299_L303_R0.6140.78
404_V414_S0.6140.78
245_N258_L0.6140.78
366_I377_V0.6120.78
173_I176_V0.6110.78
46_G50_R0.6110.78
384_N388_Y0.6100.78
69_E86_W0.6080.78
270_F351_K0.6080.78
96_I99_V0.6070.77
396_V404_V0.6070.77
426_A430_I0.6060.77
155_R158_R0.6050.77
87_N101_A0.6050.77
336_I366_I0.6040.77
236_K252_V0.6020.77
341_P344_I0.5990.76
168_D190_I0.5950.76
112_W122_K0.5940.76
200_Y307_K0.5940.76
384_N404_V0.5930.76
282_L285_R0.5930.76
231_K375_M0.5920.76
100_N152_L0.5910.76
83_K105_L0.5900.75
39_V195_T0.5880.75
55_L96_I0.5880.75
403_V413_H0.5870.75
102_Q105_L0.5860.75
172_E179_L0.5850.75
65_E69_E0.5850.75
396_V400_P0.5830.75
272_F308_K0.5830.75
166_H169_F0.5820.74
42_L190_I0.5810.74
39_V200_Y0.5800.74
343_N346_Q0.5800.74
190_I201_A0.5790.74
83_K106_Q0.5780.74
244_I352_F0.5780.74
162_D167_K0.5780.74
386_S397_K0.5750.74
413_H418_G0.5750.74
391_Y412_L0.5720.73
343_N347_E0.5700.73
275_R279_V0.5680.73
236_K334_S0.5670.73
74_F77_E0.5670.73
183_G205_I0.5660.72
281_S285_R0.5640.72
73_Q78_G0.5630.72
170_N176_V0.5620.72
396_V399_N0.5620.72
96_I101_A0.5610.72
252_V333_V0.5610.72
261_K268_D0.5600.72
240_I324_L0.5590.71
276_I286_T0.5590.71
301_E304_R0.5590.71
422_I425_K0.5580.71
247_I356_M0.5580.71
156_Q184_K0.5570.71
55_L97_L0.5560.71
275_R305_F0.5550.71
347_E354_V0.5530.71
52_L190_I0.5530.71
287_R290_G0.5520.71
51_K55_L0.5520.71
85_T88_K0.5520.71
381_V384_N0.5510.70
284_D298_L0.5500.70
424_K429_V0.5490.70
174_D179_L0.5490.70
269_Y275_R0.5480.70
333_V375_M0.5470.70
248_A259_L0.5460.70
268_D355_N0.5450.70
286_T294_A0.5450.70
78_G81_D0.5450.70
404_V411_K0.5440.69
54_R96_I0.5430.69
348_K352_F0.5410.69
35_R186_G0.5410.69
277_S302_K0.5400.69
269_Y309_L0.5360.68
341_P382_E0.5360.68
269_Y351_K0.5350.68
396_V403_V0.5340.68
344_I359_Y0.5340.68
79_K83_K0.5330.68
60_A92_K0.5330.68
167_K170_N0.5330.68
386_S398_R0.5320.68
317_Y320_L0.5310.68
388_Y393_D0.5310.68
115_F118_L0.5300.67
101_A104_V0.5300.67
77_E82_F0.5300.67
382_E425_K0.5290.67
243_G249_S0.5290.67
269_Y276_I0.5270.67
306_F313_L0.5270.67
417_N421_N0.5260.67
104_V108_N0.5250.67
108_N112_W0.5230.66
76_H80_V0.5220.66
80_V83_K0.5210.66
309_L355_N0.5180.66
34_N206_E0.5170.66
59_S152_L0.5160.65
56_A152_L0.5150.65
344_I347_E0.5130.65
90_Y93_Y0.5130.65
385_T388_Y0.5130.65
248_A324_L0.5120.65
179_L183_G0.5090.64
55_L100_N0.5080.64
250_V324_L0.5080.64
103_A155_R0.5070.64
294_A301_E0.5070.64
395_E399_N0.5070.64
66_V102_Q0.5070.64
70_R105_L0.5040.64
388_Y404_V0.5030.63
40_V179_L0.5020.63
198_A311_R0.5000.63
395_E401_R0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.2857 95.8 0.932 Contact Map
1vhxA 2 0.3011 95.3 0.934 Contact Map
1iv0A 1 0.2132 93 0.941 Contact Map
1qypA 1 0.0945 82.7 0.951 Contact Map
4ep4A 2 0.3429 69.8 0.956 Contact Map
1ffkW 1 0.1538 50.1 0.961 Contact Map
2k4xA 1 0.1165 47.9 0.962 Contact Map
4aybP 1 0.0879 40.4 0.963 Contact Map
3j20Y 1 0.1055 39.2 0.964 Contact Map
1hjrA 2 0.3363 29.4 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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