GREMLIN Database
Q7LXG9 - Uncharacterized protein
UniProt: Q7LXG9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (145)
Sequences: 163 (124)
Seq/√Len: 10.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_Y135_D4.7841.00
54_I87_L4.4240.99
50_W105_T3.8720.99
82_A90_I3.6780.98
47_F84_T3.4900.97
119_L132_A3.2790.96
114_Y132_A3.1370.95
32_K36_E2.8640.92
113_R125_D2.5120.85
114_Y119_L2.4670.84
79_G87_L2.3830.82
62_L76_Y2.3800.81
106_S110_E2.3580.81
114_Y129_R2.2060.76
58_T90_I2.1510.74
50_W132_A2.1190.73
11_H14_A2.0790.72
58_T82_A2.0750.71
55_S82_A1.9570.67
31_L144_M1.8680.63
19_R43_A1.8470.62
105_T139_L1.8180.61
129_R132_A1.8160.61
44_N115_A1.8050.60
50_W139_L1.6680.54
111_L135_D1.5900.50
88_K135_D1.5590.49
20_I137_I1.5120.47
24_L147_I1.5110.47
89_G128_E1.4850.45
51_K100_K1.4690.45
53_I101_V1.4360.43
39_S114_Y1.4160.42
65_M75_Y1.3970.41
132_A139_L1.3860.41
55_S90_I1.3810.41
60_I75_Y1.3530.39
140_S147_I1.3500.39
26_E34_L1.3120.38
4_K121_K1.3050.37
54_I84_T1.2910.37
88_K126_Y1.2860.36
119_L129_R1.2790.36
14_A17_K1.2460.35
76_Y140_S1.2210.34
42_S48_Q1.2150.33
95_E100_K1.1900.32
105_T132_A1.1890.32
40_R124_S1.1870.32
144_M147_I1.1180.30
33_L77_K1.1100.29
30_G120_Y1.1050.29
50_W119_L1.1030.29
49_S130_E1.0910.29
70_K123_A1.0890.28
119_L133_I1.0790.28
84_T87_L1.0760.28
40_R43_A1.0680.28
8_I55_S1.0580.27
39_S129_R1.0550.27
33_L38_F1.0130.26
27_L136_I1.0120.26
46_V91_S1.0080.25
15_Y56_A1.0040.25
74_W131_E1.0030.25
16_V60_I1.0020.25
61_N64_K1.0010.25
30_G42_S0.9890.25
5_I114_Y0.9770.24
88_K92_Q0.9770.24
73_E98_G0.9630.24
31_L71_E0.9560.24
33_L80_F0.9450.23
88_K110_E0.9360.23
54_I94_L0.9310.23
78_S130_E0.9230.23
133_I137_I0.9220.23
12_R59_V0.9140.22
62_L75_Y0.9050.22
18_I121_K0.9020.22
94_L139_L0.8980.22
19_R65_M0.8950.22
28_A38_F0.8800.21
26_E48_Q0.8750.21
143_I146_V0.8680.21
52_A111_L0.8530.20
50_W114_Y0.8440.20
53_I92_Q0.8260.20
108_A130_E0.8170.19
31_L140_S0.8140.19
41_N51_K0.8040.19
34_L52_A0.8040.19
32_K46_V0.7980.19
59_V62_L0.7960.19
66_P129_R0.7960.19
16_V29_L0.7960.19
14_A66_P0.7940.19
142_E145_K0.7800.18
110_E125_D0.7750.18
71_E136_I0.7710.18
13_D87_L0.7710.18
8_I115_A0.7680.18
103_S107_V0.7640.18
11_H17_K0.7640.18
79_G97_L0.7600.18
119_L127_Y0.7590.18
127_Y145_K0.7520.17
27_L38_F0.7480.17
25_D28_A0.7370.17
5_I8_I0.7340.17
63_E101_V0.7330.17
19_R22_E0.7310.17
69_E144_M0.7280.17
44_N48_Q0.7260.17
142_E146_V0.7260.17
86_G110_E0.7250.17
40_R44_N0.7250.17
25_D121_K0.7230.17
12_R47_F0.7230.17
85_T140_S0.7160.17
86_G127_Y0.7140.16
41_N45_K0.7140.16
48_Q115_A0.7080.16
54_I57_L0.7050.16
56_A84_T0.6990.16
99_Y131_E0.6990.16
28_A77_K0.6920.16
23_S55_S0.6920.16
40_R48_Q0.6870.16
18_I78_S0.6860.16
17_K99_Y0.6840.16
15_Y98_G0.6810.16
45_K150_F0.6800.16
90_I147_I0.6800.16
101_V144_M0.6770.16
48_Q124_S0.6740.15
49_S115_A0.6680.15
41_N135_D0.6670.15
29_L125_D0.6660.15
77_K113_R0.6650.15
34_L85_T0.6650.15
52_A63_E0.6580.15
86_G139_L0.6450.15
73_E77_K0.6390.15
44_N65_M0.6380.15
99_Y106_S0.6350.15
75_Y113_R0.6340.15
30_G143_I0.6330.15
48_Q58_T0.6270.14
13_D20_I0.6260.14
35_K76_Y0.6230.14
90_I125_D0.6230.14
88_K107_V0.6200.14
75_Y80_F0.6190.14
11_H80_F0.6190.14
18_I119_L0.6180.14
122_G127_Y0.6180.14
95_E102_N0.6110.14
62_L79_G0.6070.14
14_A101_V0.6050.14
51_K113_R0.5970.14
23_S150_F0.5950.14
87_L101_V0.5920.14
31_L47_F0.5910.14
13_D97_L0.5880.14
6_P50_W0.5870.13
39_S97_L0.5870.13
41_N49_S0.5860.13
84_T121_K0.5850.13
44_N124_S0.5850.13
22_E40_R0.5830.13
28_A90_I0.5820.13
105_T138_Y0.5710.13
23_S76_Y0.5710.13
17_K91_S0.5650.13
84_T94_L0.5630.13
26_E42_S0.5630.13
17_K78_S0.5610.13
89_G127_Y0.5600.13
50_W102_N0.5590.13
51_K130_E0.5590.13
79_G89_G0.5570.13
100_K150_F0.5570.13
52_A98_G0.5550.13
7_A49_S0.5520.13
96_E130_E0.5500.13
72_K77_K0.5500.13
103_S106_S0.5470.13
8_I48_Q0.5410.13
73_E139_L0.5410.13
63_E73_E0.5400.12
16_V72_K0.5380.12
14_A21_I0.5380.12
53_I135_D0.5350.12
24_L140_S0.5350.12
24_L148_K0.5330.12
88_K106_S0.5280.12
68_N147_I0.5250.12
35_K67_R0.5230.12
113_R137_I0.5220.12
105_T114_Y0.5180.12
18_I143_I0.5180.12
114_Y133_I0.5180.12
111_L125_D0.5160.12
4_K72_K0.5140.12
68_N141_K0.5110.12
43_A54_I0.5090.12
23_S30_G0.5090.12
16_V25_D0.5080.12
43_A65_M0.5080.12
22_E43_A0.5070.12
26_E132_A0.5070.12
13_D16_V0.5060.12
52_A95_E0.5060.12
4_K25_D0.5050.12
86_G89_G0.5050.12
51_K112_H0.5020.12
21_I61_N0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o10A 2 0.75 90 0.926 Contact Map
2hsbA 2 0.7035 86 0.931 Contact Map
4j4rA 3 0.5174 83.5 0.933 Contact Map
2jpuA 1 0.7326 74.2 0.939 Contact Map
4j4wA 3 0.4884 66.2 0.942 Contact Map
1wolA 1 0.6919 65 0.943 Contact Map
3ov9A 3 0.4709 61.4 0.944 Contact Map
4j4yA 4 0.4942 58.7 0.945 Contact Map
4nqfA 2 0.7791 55 0.946 Contact Map
1ufbA 3 0.6977 52.7 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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