GREMLIN Database
Q7LXG6 - Uncharacterized protein
UniProt: Q7LXG6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 263 (213)
Sequences: 27114 (23822)
Seq/√Len: 1632.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_R147_T3.5111.00
11_G40_V2.9091.00
91_I188_D2.7501.00
65_L69_E2.6181.00
8_A41_I2.4961.00
171_L175_E2.4941.00
68_K152_K2.4591.00
85_R192_Y2.3841.00
25_T90_E2.3761.00
16_E194_Y2.2791.00
57_V61_E2.2701.00
42_S46_H2.2171.00
49_G52_E2.2001.00
15_R19_E2.1431.00
34_V66_A2.1271.00
3_S72_G2.1011.00
6_I31_V2.0981.00
61_E155_E2.0101.00
5_Q66_A2.0041.00
95_N186_I1.9541.00
16_E83_P1.9431.00
40_V43_D1.9131.00
11_G44_I1.9111.00
84_L88_A1.8921.00
76_F140_L1.8821.00
92_L140_L1.8721.00
2_F93_S1.8571.00
63_R79_D1.8281.00
97_H184_F1.8171.00
15_R48_Y1.8091.00
95_N184_F1.8051.00
6_I17_V1.7741.00
87_D91_I1.7311.00
33_V45_V1.7191.00
88_A92_L1.7161.00
26_F93_S1.7071.00
10_H38_G1.6851.00
54_R65_L1.6681.00
145_L181_N1.6511.00
76_F89_L1.6261.00
60_L168_D1.6111.00
105_R192_Y1.6101.00
65_L68_K1.5981.00
76_F88_A1.5901.00
83_P192_Y1.5871.00
19_E23_E1.5831.00
15_R47_E1.5821.00
59_L63_R1.5771.00
74_Y140_L1.5741.00
2_F89_L1.5261.00
30_E72_G1.5131.00
78_L84_L1.5061.00
8_A80_E1.4981.00
8_A33_V1.4951.00
15_R44_I1.4691.00
154_R171_L1.4651.00
19_E48_Y1.4361.00
26_F29_Y1.4321.00
9_L56_D1.4011.00
148_A179_F1.3941.00
91_I94_K1.3931.00
90_E94_K1.3921.00
67_N146_L1.3741.00
53_V69_E1.3731.00
20_S84_L1.3651.00
75_A143_R1.3551.00
144_E148_A1.3521.00
54_R57_V1.3471.00
145_L176_A1.3471.00
70_S143_R1.3361.00
44_I48_Y1.3341.00
18_L31_V1.3271.00
59_L168_D1.3191.00
83_P194_Y1.3111.00
98_D182_D1.3081.00
36_S56_D1.3011.00
73_D142_K1.2981.00
17_V78_L1.2921.00
53_V65_L1.2901.00
3_S30_E1.2801.00
98_D142_K1.2801.00
63_R77_L1.2741.00
2_F140_L1.2421.00
139_R173_Y1.2391.00
67_N77_L1.2301.00
30_E51_K1.2151.00
34_V62_A1.1921.00
76_F84_L1.1801.00
195_G198_T1.1711.00
30_E71_R1.1691.00
87_D90_E1.1571.00
23_E86_K1.1531.00
92_L102_I1.1441.00
54_R61_E1.1441.00
144_E147_T1.1411.00
35_N42_S1.0791.00
43_D46_H1.0731.00
196_D199_L1.0721.00
142_K145_L1.0631.00
10_H37_G1.0581.00
148_A181_N1.0471.00
91_I186_I1.0461.00
146_L172_I1.0331.00
67_N75_A1.0301.00
25_T87_D1.0301.00
7_P62_A1.0201.00
105_R189_E1.0201.00
19_E22_R1.0201.00
21_I78_L1.0181.00
36_S62_A1.0161.00
13_Y194_Y1.0161.00
18_L48_Y1.0151.00
61_E65_L1.0141.00
107_L192_Y0.9951.00
3_S70_S0.9931.00
57_V62_A0.9861.00
29_Y89_L0.9841.00
74_Y93_S0.9641.00
195_G199_L0.9591.00
63_R168_D0.9531.00
145_L180_S0.9471.00
91_I95_N0.9371.00
88_A190_L0.9301.00
20_S83_P0.9261.00
8_A45_V0.9251.00
42_S52_E0.9121.00
59_L136_A0.9091.00
3_S32_V0.9051.00
149_S179_F0.9031.00
51_K69_E0.8991.00
40_V44_I0.8981.00
6_I21_I0.8941.00
8_A14_L0.8861.00
149_S152_K0.8841.00
88_A102_I0.8831.00
59_L199_L0.8821.00
60_L64_Y0.8741.00
22_R48_Y0.8721.00
18_L33_V0.8711.00
137_L191_V0.8641.00
136_A153_L0.8611.00
97_H100_V0.8501.00
36_S57_V0.8461.00
44_I47_E0.8441.00
17_V20_S0.8431.00
36_S58_K0.8411.00
7_P80_E0.8381.00
67_N70_S0.8371.00
141_F173_Y0.8321.00
25_T86_K0.8301.00
21_I84_L0.8251.00
83_P107_L0.8211.00
11_G15_R0.8191.00
59_L79_D0.8191.00
208_R212_S0.8181.00
149_S176_A0.8171.00
96_L182_D0.8171.00
21_I31_V0.8161.00
59_L62_A0.8121.00
99_M183_I0.8111.00
4_I89_L0.8081.00
77_L153_L0.8081.00
10_H35_N0.8081.00
104_E137_L0.8071.00
103_G185_V0.8051.00
34_V65_L0.8051.00
26_F89_L0.8021.00
4_I21_I0.8011.00
22_R49_G0.7941.00
85_R190_L0.7921.00
14_L80_E0.7891.00
211_K215_V0.7871.00
98_D181_N0.7831.00
18_L22_R0.7831.00
43_D47_E0.7831.00
85_R88_A0.7821.00
32_V69_E0.7751.00
42_S45_V0.7751.00
145_L149_S0.7721.00
32_V66_A0.7691.00
4_I76_F0.7641.00
17_V21_I0.7581.00
64_Y152_K0.7571.00
101_I104_E0.7531.00
67_N152_K0.7511.00
100_V103_G0.7471.00
136_A139_R0.7461.00
62_A65_L0.7461.00
154_R175_E0.7451.00
57_V65_L0.7421.00
92_L100_V0.7411.00
118_L123_I0.7341.00
93_S140_L0.7251.00
85_R105_R0.7211.00
76_F138_P0.7211.00
102_I190_L0.7171.00
32_V70_S0.7171.00
172_I176_A0.7141.00
26_F90_E0.7141.00
22_R50_F0.7131.00
16_E19_E0.7081.00
186_I189_E0.7071.00
214_K218_D0.7021.00
38_G41_I0.7001.00
104_E138_P0.6911.00
7_P63_R0.6901.00
82_R193_H0.6891.00
141_F172_I0.6851.00
97_H102_I0.6831.00
11_G41_I0.6821.00
8_A35_N0.6801.00
152_K172_I0.6801.00
24_Q90_E0.6791.00
64_Y153_L0.6781.00
101_I183_I0.6771.00
70_S75_A0.6761.00
73_D144_E0.6691.00
145_L148_A0.6671.00
88_A138_P0.6631.00
31_V50_F0.6621.00
125_E128_S0.6581.00
91_I190_L0.6551.00
146_L152_K0.6541.00
198_T201_E0.6501.00
11_G14_L0.6491.00
17_V81_T0.6471.00
167_P170_E0.6441.00
122_N125_E0.6431.00
84_L89_L0.6431.00
2_F76_F0.6391.00
212_S215_V0.6391.00
130_E182_D0.6351.00
119_D122_N0.6341.00
4_I29_Y0.6291.00
79_D168_D0.6291.00
22_R31_V0.6281.00
64_Y155_E0.6261.00
116_A119_D0.6261.00
177_S183_I0.6251.00
14_L44_I0.6241.00
74_Y142_K0.6241.00
99_M176_A0.6191.00
134_G173_Y0.6171.00
110_S113_S0.6161.00
14_L45_V0.6161.00
210_G213_L0.6131.00
103_G187_K0.6131.00
195_G200_K0.6101.00
211_K214_K0.6061.00
207_Y211_K0.6061.00
9_L36_S0.6031.00
6_I33_V0.6021.00
24_Q89_L0.6001.00
119_D124_M0.5991.00
170_E174_Y0.5991.00
97_H101_I0.5931.00
78_L191_V0.5921.00
123_I126_C0.5921.00
54_R62_A0.5911.00
78_L82_R0.5901.00
116_A120_K0.5861.00
84_L191_V0.5851.00
11_G43_D0.5851.00
7_P36_S0.5841.00
134_G139_R0.5841.00
24_Q84_L0.5801.00
108_G111_F0.5761.00
141_F146_L0.5751.00
176_A181_N0.5741.00
5_Q34_V0.5721.00
147_T152_K0.5681.00
121_E124_M0.5681.00
14_L41_I0.5661.00
213_L217_K0.5661.00
21_I24_Q0.5661.00
164_V167_P0.5631.00
176_A180_S0.5611.00
98_D180_S0.5601.00
6_I18_L0.5591.00
36_S79_D0.5591.00
103_G189_E0.5581.00
59_L77_L0.5511.00
17_V80_E0.5491.00
101_I185_V0.5481.00
51_K71_R0.5471.00
101_I139_R0.5451.00
100_V181_N0.5441.00
5_Q70_S0.5421.00
35_N56_D0.5411.00
204_R208_R0.5401.00
7_P59_L0.5401.00
97_H104_E0.5391.00
137_L193_H0.5391.00
210_G214_K0.5381.00
209_Y213_L0.5371.00
115_A118_L0.5361.00
189_E192_Y0.5341.00
108_G113_S0.5321.00
5_Q63_R0.5311.00
141_F176_A0.5291.00
213_L216_L0.5291.00
82_R191_V0.5281.00
6_I80_E0.5261.00
10_H41_I0.5241.00
29_Y72_G0.5191.00
5_Q77_L0.5171.00
129_P132_V0.5151.00
17_V82_R0.5151.00
13_Y17_V0.5141.00
92_L138_P0.5131.00
62_A79_D0.5121.00
64_Y68_K0.5121.00
56_D62_A0.5111.00
11_G80_E0.5091.00
87_D188_D0.5091.00
17_V84_L0.5071.00
25_T29_Y0.5061.00
208_R211_K0.5041.00
13_Y195_G0.5011.00
117_Q122_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l7iA 4 0 100 0.363 Contact Map
3bcvA 2 0.616 100 0.375 Contact Map
1qg8A 1 0.8023 100 0.385 Contact Map
2z86A 2 0.8897 100 0.399 Contact Map
2d7iA 1 0.9316 100 0.408 Contact Map
1xhbA 1 0.9049 100 0.418 Contact Map
5ajoA 1 0.9278 100 0.435 Contact Map
4fixA 3 0.9696 100 0.462 Contact Map
2bo4A 4 0.962 100 0.467 Contact Map
4p02A 1 0.9544 100 0.468 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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