Q7LXG5 - SULSO - GREMLIN Contacts

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Q7LXG5 - UDP-glucose 4-epimerase (GalE-2)

UniProt:	Q7LXG5	Sequences: MLMKILISGGAGFLGSHLTEALLEKGEEITIVDDLSTAKYFNIRKDVEFIKKKVEEFETEKKYDVVIHLAARPSPEDYIEHPVDTALSNSLGTYKMLEIARKSNARFIYTSSSEVYGSASIIPTPETYWGYVNPIGIRSCYDESKRFSEALIMAYHRQYKLDTRIQRPFNVYGPGLREDGTYGRVVSRFIYQALKGEDVTVFGDGNQTRAFLYISDWVDATIKLIYKDGLEGEVFNIGSDKEIKIIELANMIIKLTGSKSRIKYLPPRPDDPPRRAADITKAKEKLGWYPKISLEEGLKLTINWFKGVLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	310 (284)
Sequences:	58237 (40475)
Seq/√Len:	2401.7

ECOLI - GALE GM4D RMLB1 HLDD YBJS RMLB2 FCL YFCH RMLD YEEZ QOR2 ARNA YBJT YRAR
BACSU - RMLB YTCB GALE YFNG YFHF SPSK YTBQ YWNB YESF YHFK YHEG
HALSA - Q9HSV1 Q9HSU9 Q9HRD1 Q9HSE7 Q9HS50 Q9HML4 Q9HSQ3 Q9HPF1 Q9HNV3 Q9HR86
SULSO - Q7LXG5 Q97VN5 Q980W1 Q7LXE8 Q97XJ9 Q97XG1 Q97UM3 Q7LX44 Q7LXE6 Q97XF9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
10_G	31_I	3.343	1.00
4_K	28_E	3.059	1.00
220_A	237_I	2.905	1.00
21_A	219_D	2.790	1.00
251_M	295_E	2.752	1.00
233_E	281_K	2.728	1.00
235_F	285_K	2.680	1.00
293_S	296_E	2.612	1.00
87_L	91_L	2.453	1.00
254_K	295_E	2.384	1.00
65_V	225_I	2.326	1.00
110_T	221_T	2.306	1.00
8_S	68_H	2.258	1.00
81_H	84_D	2.254	1.00
283_K	289_Y	2.253	1.00
106_R	162_D	2.253	1.00
68_H	109_Y	2.203	1.00
32_V	52_K	2.155	1.00
21_A	25_K	2.134	1.00
172_Y	297_G	2.117	1.00
67_I	225_I	2.116	1.00
219_D	291_K	2.091	1.00
25_K	226_Y	2.042	1.00
7_I	19_T	2.004	1.00
21_A	222_I	1.981	1.00
6_L	63_Y	1.967	1.00
4_K	30_T	1.933	1.00
246_I	250_N	1.902	1.00
219_D	223_K	1.890	1.00
168_P	221_T	1.869	1.00
30_T	48_E	1.849	1.00
255_L	299_K	1.838	1.00
215_S	300_L	1.835	1.00
251_M	254_K	1.806	1.00
152_I	163_T	1.795	1.00
28_E	48_E	1.792	1.00
30_T	63_Y	1.780	1.00
166_Q	224_L	1.734	1.00
244_K	247_E	1.721	1.00
18_L	218_V	1.682	1.00
240_D	283_K	1.680	1.00
191_Y	195_K	1.677	1.00
55_E	87_L	1.672	1.00
213_Y	300_L	1.656	1.00
18_L	67_I	1.635	1.00
30_T	50_I	1.631	1.00
60_E	63_Y	1.619	1.00
111_S	115_V	1.612	1.00
35_L	49_F	1.590	1.00
116_Y	236_N	1.568	1.00
14_L	171_V	1.563	1.00
94_Y	98_E	1.553	1.00
94_Y	151_L	1.539	1.00
282_A	286_L	1.539	1.00
21_A	24_E	1.531	1.00
247_E	250_N	1.510	1.00
86_A	147_F	1.496	1.00
25_K	222_I	1.493	1.00
251_M	255_L	1.489	1.00
18_L	69_L	1.489	1.00
166_Q	221_T	1.478	1.00
91_L	94_Y	1.472	1.00
213_Y	297_G	1.467	1.00
68_H	93_T	1.462	1.00
141_Y	145_K	1.438	1.00
222_I	226_Y	1.437	1.00
21_A	218_V	1.428	1.00
58_E	63_Y	1.428	1.00
83_V	87_L	1.421	1.00
279_I	283_K	1.418	1.00
19_T	31_I	1.418	1.00
146_R	150_A	1.412	1.00
67_I	221_T	1.409	1.00
3_M	27_E	1.405	1.00
214_I	218_V	1.397	1.00
168_P	217_W	1.392	1.00
20_E	175_G	1.388	1.00
30_T	61_K	1.387	1.00
69_L	110_T	1.385	1.00
106_R	164_R	1.385	1.00
96_M	107_F	1.378	1.00
126_E	281_K	1.370	1.00
110_T	168_P	1.370	1.00
210_A	240_D	1.368	1.00
93_T	148_S	1.364	1.00
135_I	146_R	1.362	1.00
223_K	227_K	1.358	1.00
101_R	159_Y	1.356	1.00
296_E	299_K	1.345	1.00
89_N	144_S	1.342	1.00
198_D	263_K	1.338	1.00
169_F	277_A	1.338	1.00
192_Q	197_E	1.329	1.00
66_V	100_A	1.316	1.00
97_L	155_Y	1.314	1.00
212_L	217_W	1.306	1.00
150_A	153_M	1.283	1.00
296_E	300_L	1.266	1.00
5_I	27_E	1.261	1.00
27_E	226_Y	1.256	1.00
98_E	101_R	1.234	1.00
11_A	33_D	1.232	1.00
58_E	61_K	1.226	1.00
279_I	290_P	1.219	1.00
100_A	105_A	1.219	1.00
125_P	133_N	1.212	1.00
233_E	285_K	1.203	1.00
10_G	19_T	1.201	1.00
246_I	264_Y	1.201	1.00
22_L	222_I	1.198	1.00
167_R	234_V	1.184	1.00
200_T	263_K	1.165	1.00
153_M	234_V	1.156	1.00
125_P	278_D	1.156	1.00
208_T	242_E	1.151	1.00
109_Y	148_S	1.147	1.00
17_H	215_S	1.139	1.00
3_M	64_D	1.135	1.00
127_T	281_K	1.126	1.00
5_I	22_L	1.122	1.00
100_A	107_F	1.116	1.00
143_E	147_F	1.106	1.00
16_S	175_G	1.097	1.00
167_R	236_N	1.096	1.00
156_H	163_T	1.096	1.00
153_M	165_I	1.092	1.00
69_L	221_T	1.092	1.00
243_I	294_L	1.089	1.00
149_E	167_R	1.088	1.00
20_E	24_E	1.087	1.00
219_D	288_W	1.086	1.00
216_D	239_S	1.086	1.00
4_K	63_Y	1.086	1.00
6_L	32_V	1.079	1.00
13_F	173_G	1.078	1.00
23_L	47_V	1.077	1.00
220_A	282_A	1.076	1.00
98_E	102_K	1.075	1.00
172_Y	213_Y	1.073	1.00
206_N	246_I	1.067	1.00
213_Y	216_D	1.063	1.00
54_V	70_A	1.052	1.00
253_I	259_K	1.048	1.00
108_I	166_Q	1.047	1.00
109_Y	152_I	1.047	1.00
97_L	107_F	1.040	1.00
31_I	47_V	1.039	1.00
54_V	92_G	1.037	1.00
99_I	103_S	1.036	1.00
153_M	163_T	1.035	1.00
21_A	215_S	1.034	1.00
151_L	154_A	1.031	1.00
4_K	64_D	1.027	1.00
281_K	285_K	1.026	1.00
88_S	92_G	1.025	1.00
295_E	299_K	1.009	1.00
171_V	217_W	0.999	1.00
111_S	149_E	0.999	1.00
58_E	62_K	0.996	1.00
109_Y	165_I	0.996	1.00
13_F	214_I	0.987	1.00
101_R	161_L	0.981	1.00
17_H	214_I	0.979	1.00
235_F	281_K	0.975	1.00
162_D	231_E	0.975	1.00
23_L	46_D	0.972	1.00
250_N	253_I	0.970	1.00
255_L	302_I	0.966	1.00
242_E	274_R	0.964	1.00
48_E	61_K	0.958	1.00
107_F	152_I	0.957	1.00
238_G	277_A	0.952	1.00
8_S	70_A	0.951	1.00
121_I	125_P	0.949	1.00
5_I	65_V	0.947	1.00
185_V	189_F	0.941	1.00
72_R	88_S	0.938	1.00
171_V	212_L	0.938	1.00
154_A	158_Q	0.938	1.00
164_R	224_L	0.937	1.00
198_D	261_R	0.935	1.00
208_T	244_K	0.933	1.00
265_L	268_R	0.925	1.00
97_L	151_L	0.914	1.00
256_T	302_I	0.914	1.00
242_E	276_A	0.908	1.00
53_K	56_E	0.906	1.00
95_K	98_E	0.904	1.00
230_L	233_E	0.904	1.00
91_L	95_K	0.900	1.00
223_K	286_L	0.899	1.00
5_I	67_I	0.894	1.00
206_N	244_K	0.892	1.00
18_L	22_L	0.890	1.00
35_L	38_A	0.887	1.00
255_L	298_L	0.886	1.00
85_T	144_S	0.885	1.00
165_I	234_V	0.885	1.00
86_A	90_S	0.885	1.00
220_A	288_W	0.884	1.00
253_I	260_S	0.883	1.00
153_M	157_R	0.883	1.00
41_F	44_R	0.880	1.00
19_T	29_I	0.875	1.00
266_P	269_P	0.873	1.00
3_M	65_V	0.872	1.00
23_L	29_I	0.872	1.00
166_Q	237_I	0.866	1.00
97_L	152_I	0.863	1.00
243_I	247_E	0.859	1.00
237_I	282_A	0.857	1.00
8_S	96_M	0.856	1.00
224_L	286_L	0.852	1.00
224_L	282_A	0.850	1.00
58_E	102_K	0.846	1.00
238_G	279_I	0.841	1.00
255_L	295_E	0.832	1.00
95_K	99_I	0.828	1.00
5_I	225_I	0.823	1.00
34_D	53_K	0.819	1.00
30_T	62_K	0.816	1.00
184_R	187_S	0.815	1.00
92_G	95_K	0.813	1.00
58_E	66_V	0.805	1.00
223_K	226_Y	0.804	1.00
262_I	265_L	0.803	1.00
17_H	20_E	0.802	1.00
250_N	254_K	0.801	1.00
205_G	246_I	0.796	1.00
169_F	238_G	0.796	1.00
86_A	144_S	0.796	1.00
14_L	217_W	0.795	1.00
147_F	150_A	0.795	1.00
196_G	199_V	0.793	1.00
253_I	258_S	0.792	1.00
4_K	61_K	0.792	1.00
137_I	142_D	0.790	1.00
90_S	147_F	0.789	1.00
240_D	279_I	0.789	1.00
86_A	91_L	0.784	1.00
113_S	169_F	0.783	1.00
223_K	287_G	0.782	1.00
115_V	149_E	0.781	1.00
82_P	143_E	0.781	1.00
6_L	52_K	0.780	1.00
243_I	248_L	0.777	1.00
191_Y	194_L	0.777	1.00
17_H	21_A	0.772	1.00
33_D	49_F	0.772	1.00
241_K	293_S	0.771	1.00
17_H	218_V	0.765	1.00
59_T	62_K	0.758	1.00
195_K	198_D	0.756	1.00
35_L	51_K	0.751	1.00
18_L	221_T	0.748	1.00
188_R	191_Y	0.743	1.00
6_L	66_V	0.739	1.00
36_S	51_K	0.739	1.00
174_P	300_L	0.735	1.00
84_D	87_L	0.733	1.00
155_Y	159_Y	0.732	1.00
66_V	96_M	0.732	1.00
22_L	225_I	0.731	1.00
99_I	102_K	0.728	1.00
219_D	222_I	0.727	1.00
280_T	283_K	0.726	1.00
93_T	152_I	0.726	1.00
93_T	97_L	0.724	1.00
227_K	230_L	0.720	1.00
79_I	140_C	0.719	1.00
208_T	274_R	0.718	1.00
223_K	288_W	0.718	1.00
65_V	106_R	0.717	1.00
40_Y	44_R	0.712	1.00
58_E	103_S	0.712	1.00
98_E	155_Y	0.708	1.00
150_A	154_A	0.707	1.00
55_E	88_S	0.704	1.00
68_H	96_M	0.703	1.00
101_R	160_K	0.702	1.00
148_S	152_I	0.700	1.00
265_L	269_P	0.694	1.00
230_L	285_K	0.692	1.00
72_R	84_D	0.692	1.00
26_G	46_D	0.690	1.00
4_K	62_K	0.687	1.00
193_A	253_I	0.685	1.00
72_R	89_N	0.684	1.00
188_R	192_Q	0.682	1.00
84_D	88_S	0.682	1.00
248_L	294_L	0.680	1.00
272_P	275_R	0.680	1.00
190_I	194_L	0.680	1.00
174_P	213_Y	0.679	1.00
251_M	294_L	0.673	1.00
72_R	85_T	0.668	1.00
119_A	124_T	0.668	1.00
247_E	251_M	0.667	1.00
35_L	40_Y	0.666	1.00
16_S	20_E	0.662	1.00
126_E	282_A	0.661	1.00
71_A	89_N	0.661	1.00
147_F	151_L	0.661	1.00
283_K	290_P	0.660	1.00
241_K	295_E	0.660	1.00
58_E	99_I	0.658	1.00
166_Q	220_A	0.658	1.00
59_T	63_Y	0.656	1.00
282_A	285_K	0.654	1.00
113_S	277_A	0.651	1.00
78_Y	85_T	0.651	1.00
101_R	155_Y	0.650	1.00
33_D	37_T	0.646	1.00
66_V	107_F	0.644	1.00
190_I	302_I	0.641	1.00
216_D	291_K	0.641	1.00
190_I	252_I	0.640	1.00
28_E	46_D	0.639	1.00
170_N	209_R	0.636	1.00
218_V	222_I	0.633	1.00
210_A	239_S	0.631	1.00
139_S	142_D	0.631	1.00
59_T	103_S	0.630	1.00
127_T	133_N	0.627	1.00
163_T	232_G	0.625	1.00
114_E	142_D	0.625	1.00
89_N	141_Y	0.624	1.00
207_Q	245_I	0.622	1.00
193_A	199_V	0.621	1.00
152_I	165_I	0.621	1.00
25_K	219_D	0.619	1.00
200_T	265_L	0.619	1.00
168_P	171_V	0.618	1.00
143_E	150_A	0.615	1.00
82_P	140_C	0.615	1.00
144_S	148_S	0.614	1.00
86_A	143_E	0.612	1.00
151_L	155_Y	0.610	1.00
40_Y	51_K	0.610	1.00
126_E	236_N	0.609	1.00
50_I	61_K	0.601	1.00
108_I	225_I	0.600	1.00
124_T	133_N	0.596	1.00
65_V	108_I	0.596	1.00
25_K	223_K	0.595	1.00
11_A	35_L	0.592	1.00
216_D	219_D	0.591	1.00
22_L	27_E	0.589	1.00
27_E	64_D	0.589	1.00
137_I	146_R	0.588	1.00
93_T	109_Y	0.588	1.00
143_E	154_A	0.585	1.00
249_A	253_I	0.584	1.00
112_S	145_K	0.582	1.00
172_Y	239_S	0.582	1.00
112_S	115_V	0.582	1.00
140_C	144_S	0.579	1.00
231_E	235_F	0.579	1.00
175_G	178_E	0.577	1.00
291_K	296_E	0.573	1.00
50_I	57_F	0.571	1.00
30_T	59_T	0.568	1.00
251_M	298_L	0.566	1.00
7_I	31_I	0.563	1.00
22_L	67_I	0.562	1.00
123_P	278_D	0.560	1.00
196_G	258_S	0.560	1.00
121_I	133_N	0.559	1.00
34_D	37_T	0.559	1.00
140_C	143_E	0.559	1.00
253_I	256_T	0.558	1.00
222_I	225_I	0.557	1.00
20_E	215_S	0.555	1.00
217_W	237_I	0.554	1.00
174_P	215_S	0.553	1.00
169_F	210_A	0.553	1.00
210_A	242_E	0.552	1.00
69_L	168_P	0.552	1.00
201_V	264_Y	0.552	1.00
110_T	166_Q	0.549	1.00
11_A	31_I	0.548	1.00
108_I	224_L	0.547	1.00
66_V	105_A	0.541	1.00
60_E	66_V	0.540	1.00
154_A	157_R	0.540	1.00
6_L	60_E	0.539	1.00
117_G	136_G	0.537	1.00
97_L	101_R	0.536	1.00
78_Y	140_C	0.535	1.00
4_K	27_E	0.534	1.00
173_G	214_I	0.533	1.00
17_H	175_G	0.533	1.00
108_I	221_T	0.533	1.00
192_Q	200_T	0.532	1.00
262_I	268_R	0.528	1.00
209_R	245_I	0.528	1.00
19_T	23_L	0.527	1.00
123_P	276_A	0.527	1.00
141_Y	144_S	0.526	1.00
193_A	252_I	0.526	1.00
18_L	222_I	0.525	1.00
229_G	232_G	0.525	1.00
164_R	229_G	0.525	1.00
115_V	135_I	0.524	1.00
155_Y	161_L	0.522	1.00
208_T	276_A	0.521	1.00
120_S	133_N	0.521	1.00
31_I	49_F	0.520	1.00
252_I	302_I	0.519	1.00
252_I	298_L	0.517	1.00
235_F	282_A	0.517	1.00
23_L	26_G	0.516	1.00
68_H	107_F	0.515	1.00
184_R	188_R	0.515	1.00
297_G	300_L	0.511	1.00
6_L	59_T	0.511	1.00
50_I	60_E	0.509	1.00
170_N	211_F	0.509	1.00
271_D	275_R	0.509	1.00
67_I	222_I	0.507	1.00
279_I	288_W	0.503	1.00
247_E	295_E	0.503	1.00
213_Y	301_T	0.503	1.00
189_F	193_A	0.503	1.00
13_F	17_H	0.502	1.00
282_A	290_P	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1sb8A	2	0.9839	100	0.193	Contact Map
3rufA	2	0.9774	100	0.198	Contact Map
2b69A	2	0.9806	100	0.206	Contact Map
2c20A	2	0.9774	100	0.217	Contact Map
1oc2A	2	0.9645	100	0.218	Contact Map
4wkgA	5	1	100	0.22	Contact Map
1orrA	3	0.9839	100	0.221	Contact Map
3m2pA	2	0.9258	100	0.223	Contact Map
1rpnA	4	0.971	100	0.223	Contact Map
3slgA	4	0.9871	100	0.225	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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