GREMLIN Database
Q7LXG5 - UDP-glucose 4-epimerase (GalE-2)
UniProt: Q7LXG5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 310 (284)
Sequences: 58237 (40475)
Seq/√Len: 2401.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_G31_I3.3431.00
4_K28_E3.0591.00
220_A237_I2.9051.00
21_A219_D2.7901.00
251_M295_E2.7521.00
233_E281_K2.7281.00
235_F285_K2.6801.00
293_S296_E2.6121.00
87_L91_L2.4531.00
254_K295_E2.3841.00
65_V225_I2.3261.00
110_T221_T2.3061.00
8_S68_H2.2581.00
81_H84_D2.2541.00
283_K289_Y2.2531.00
106_R162_D2.2531.00
68_H109_Y2.2031.00
32_V52_K2.1551.00
21_A25_K2.1341.00
172_Y297_G2.1171.00
67_I225_I2.1161.00
219_D291_K2.0911.00
25_K226_Y2.0421.00
7_I19_T2.0041.00
21_A222_I1.9811.00
6_L63_Y1.9671.00
4_K30_T1.9331.00
246_I250_N1.9021.00
219_D223_K1.8901.00
168_P221_T1.8691.00
30_T48_E1.8491.00
255_L299_K1.8381.00
215_S300_L1.8351.00
251_M254_K1.8061.00
152_I163_T1.7951.00
28_E48_E1.7921.00
30_T63_Y1.7801.00
166_Q224_L1.7341.00
244_K247_E1.7211.00
18_L218_V1.6821.00
240_D283_K1.6801.00
191_Y195_K1.6771.00
55_E87_L1.6721.00
213_Y300_L1.6561.00
18_L67_I1.6351.00
30_T50_I1.6311.00
60_E63_Y1.6191.00
111_S115_V1.6121.00
35_L49_F1.5901.00
116_Y236_N1.5681.00
14_L171_V1.5631.00
94_Y98_E1.5531.00
94_Y151_L1.5391.00
282_A286_L1.5391.00
21_A24_E1.5311.00
247_E250_N1.5101.00
86_A147_F1.4961.00
25_K222_I1.4931.00
251_M255_L1.4891.00
18_L69_L1.4891.00
166_Q221_T1.4781.00
91_L94_Y1.4721.00
213_Y297_G1.4671.00
68_H93_T1.4621.00
141_Y145_K1.4381.00
222_I226_Y1.4371.00
21_A218_V1.4281.00
58_E63_Y1.4281.00
83_V87_L1.4211.00
279_I283_K1.4181.00
19_T31_I1.4181.00
146_R150_A1.4121.00
67_I221_T1.4091.00
3_M27_E1.4051.00
214_I218_V1.3971.00
168_P217_W1.3921.00
20_E175_G1.3881.00
30_T61_K1.3871.00
69_L110_T1.3851.00
106_R164_R1.3851.00
96_M107_F1.3781.00
126_E281_K1.3701.00
110_T168_P1.3701.00
210_A240_D1.3681.00
93_T148_S1.3641.00
135_I146_R1.3621.00
223_K227_K1.3581.00
101_R159_Y1.3561.00
296_E299_K1.3451.00
89_N144_S1.3421.00
198_D263_K1.3381.00
169_F277_A1.3381.00
192_Q197_E1.3291.00
66_V100_A1.3161.00
97_L155_Y1.3141.00
212_L217_W1.3061.00
150_A153_M1.2831.00
296_E300_L1.2661.00
5_I27_E1.2611.00
27_E226_Y1.2561.00
98_E101_R1.2341.00
11_A33_D1.2321.00
58_E61_K1.2261.00
279_I290_P1.2191.00
100_A105_A1.2191.00
125_P133_N1.2121.00
233_E285_K1.2031.00
10_G19_T1.2011.00
246_I264_Y1.2011.00
22_L222_I1.1981.00
167_R234_V1.1841.00
200_T263_K1.1651.00
153_M234_V1.1561.00
125_P278_D1.1561.00
208_T242_E1.1511.00
109_Y148_S1.1471.00
17_H215_S1.1391.00
3_M64_D1.1351.00
127_T281_K1.1261.00
5_I22_L1.1221.00
100_A107_F1.1161.00
143_E147_F1.1061.00
16_S175_G1.0971.00
167_R236_N1.0961.00
156_H163_T1.0961.00
153_M165_I1.0921.00
69_L221_T1.0921.00
243_I294_L1.0891.00
149_E167_R1.0881.00
20_E24_E1.0871.00
219_D288_W1.0861.00
216_D239_S1.0861.00
4_K63_Y1.0861.00
6_L32_V1.0791.00
13_F173_G1.0781.00
23_L47_V1.0771.00
220_A282_A1.0761.00
98_E102_K1.0751.00
172_Y213_Y1.0731.00
206_N246_I1.0671.00
213_Y216_D1.0631.00
54_V70_A1.0521.00
253_I259_K1.0481.00
108_I166_Q1.0471.00
109_Y152_I1.0471.00
97_L107_F1.0401.00
31_I47_V1.0391.00
54_V92_G1.0371.00
99_I103_S1.0361.00
153_M163_T1.0351.00
21_A215_S1.0341.00
151_L154_A1.0311.00
4_K64_D1.0271.00
281_K285_K1.0261.00
88_S92_G1.0251.00
295_E299_K1.0091.00
171_V217_W0.9991.00
111_S149_E0.9991.00
58_E62_K0.9961.00
109_Y165_I0.9961.00
13_F214_I0.9871.00
101_R161_L0.9811.00
17_H214_I0.9791.00
235_F281_K0.9751.00
162_D231_E0.9751.00
23_L46_D0.9721.00
250_N253_I0.9701.00
255_L302_I0.9661.00
242_E274_R0.9641.00
48_E61_K0.9581.00
107_F152_I0.9571.00
238_G277_A0.9521.00
8_S70_A0.9511.00
121_I125_P0.9491.00
5_I65_V0.9471.00
185_V189_F0.9411.00
72_R88_S0.9381.00
171_V212_L0.9381.00
154_A158_Q0.9381.00
164_R224_L0.9371.00
198_D261_R0.9351.00
208_T244_K0.9331.00
265_L268_R0.9251.00
97_L151_L0.9141.00
256_T302_I0.9141.00
242_E276_A0.9081.00
53_K56_E0.9061.00
95_K98_E0.9041.00
230_L233_E0.9041.00
91_L95_K0.9001.00
223_K286_L0.8991.00
5_I67_I0.8941.00
206_N244_K0.8921.00
18_L22_L0.8901.00
35_L38_A0.8871.00
255_L298_L0.8861.00
85_T144_S0.8851.00
165_I234_V0.8851.00
86_A90_S0.8851.00
220_A288_W0.8841.00
253_I260_S0.8831.00
153_M157_R0.8831.00
41_F44_R0.8801.00
19_T29_I0.8751.00
266_P269_P0.8731.00
3_M65_V0.8721.00
23_L29_I0.8721.00
166_Q237_I0.8661.00
97_L152_I0.8631.00
243_I247_E0.8591.00
237_I282_A0.8571.00
8_S96_M0.8561.00
224_L286_L0.8521.00
224_L282_A0.8501.00
58_E102_K0.8461.00
238_G279_I0.8411.00
255_L295_E0.8321.00
95_K99_I0.8281.00
5_I225_I0.8231.00
34_D53_K0.8191.00
30_T62_K0.8161.00
184_R187_S0.8151.00
92_G95_K0.8131.00
58_E66_V0.8051.00
223_K226_Y0.8041.00
262_I265_L0.8031.00
17_H20_E0.8021.00
250_N254_K0.8011.00
205_G246_I0.7961.00
169_F238_G0.7961.00
86_A144_S0.7961.00
14_L217_W0.7951.00
147_F150_A0.7951.00
196_G199_V0.7931.00
253_I258_S0.7921.00
4_K61_K0.7921.00
137_I142_D0.7901.00
90_S147_F0.7891.00
240_D279_I0.7891.00
86_A91_L0.7841.00
113_S169_F0.7831.00
223_K287_G0.7821.00
115_V149_E0.7811.00
82_P143_E0.7811.00
6_L52_K0.7801.00
243_I248_L0.7771.00
191_Y194_L0.7771.00
17_H21_A0.7721.00
33_D49_F0.7721.00
241_K293_S0.7711.00
17_H218_V0.7651.00
59_T62_K0.7581.00
195_K198_D0.7561.00
35_L51_K0.7511.00
18_L221_T0.7481.00
188_R191_Y0.7431.00
6_L66_V0.7391.00
36_S51_K0.7391.00
174_P300_L0.7351.00
84_D87_L0.7331.00
155_Y159_Y0.7321.00
66_V96_M0.7321.00
22_L225_I0.7311.00
99_I102_K0.7281.00
219_D222_I0.7271.00
280_T283_K0.7261.00
93_T152_I0.7261.00
93_T97_L0.7241.00
227_K230_L0.7201.00
79_I140_C0.7191.00
208_T274_R0.7181.00
223_K288_W0.7181.00
65_V106_R0.7171.00
40_Y44_R0.7121.00
58_E103_S0.7121.00
98_E155_Y0.7081.00
150_A154_A0.7071.00
55_E88_S0.7041.00
68_H96_M0.7031.00
101_R160_K0.7021.00
148_S152_I0.7001.00
265_L269_P0.6941.00
230_L285_K0.6921.00
72_R84_D0.6921.00
26_G46_D0.6901.00
4_K62_K0.6871.00
193_A253_I0.6851.00
72_R89_N0.6841.00
188_R192_Q0.6821.00
84_D88_S0.6821.00
248_L294_L0.6801.00
272_P275_R0.6801.00
190_I194_L0.6801.00
174_P213_Y0.6791.00
251_M294_L0.6731.00
72_R85_T0.6681.00
119_A124_T0.6681.00
247_E251_M0.6671.00
35_L40_Y0.6661.00
16_S20_E0.6621.00
126_E282_A0.6611.00
71_A89_N0.6611.00
147_F151_L0.6611.00
283_K290_P0.6601.00
241_K295_E0.6601.00
58_E99_I0.6581.00
166_Q220_A0.6581.00
59_T63_Y0.6561.00
282_A285_K0.6541.00
113_S277_A0.6511.00
78_Y85_T0.6511.00
101_R155_Y0.6501.00
33_D37_T0.6461.00
66_V107_F0.6441.00
190_I302_I0.6411.00
216_D291_K0.6411.00
190_I252_I0.6401.00
28_E46_D0.6391.00
170_N209_R0.6361.00
218_V222_I0.6331.00
210_A239_S0.6311.00
139_S142_D0.6311.00
59_T103_S0.6301.00
127_T133_N0.6271.00
163_T232_G0.6251.00
114_E142_D0.6251.00
89_N141_Y0.6241.00
207_Q245_I0.6221.00
193_A199_V0.6211.00
152_I165_I0.6211.00
25_K219_D0.6191.00
200_T265_L0.6191.00
168_P171_V0.6181.00
143_E150_A0.6151.00
82_P140_C0.6151.00
144_S148_S0.6141.00
86_A143_E0.6121.00
151_L155_Y0.6101.00
40_Y51_K0.6101.00
126_E236_N0.6091.00
50_I61_K0.6011.00
108_I225_I0.6001.00
124_T133_N0.5961.00
65_V108_I0.5961.00
25_K223_K0.5951.00
11_A35_L0.5921.00
216_D219_D0.5911.00
22_L27_E0.5891.00
27_E64_D0.5891.00
137_I146_R0.5881.00
93_T109_Y0.5881.00
143_E154_A0.5851.00
249_A253_I0.5841.00
112_S145_K0.5821.00
172_Y239_S0.5821.00
112_S115_V0.5821.00
140_C144_S0.5791.00
231_E235_F0.5791.00
175_G178_E0.5771.00
291_K296_E0.5731.00
50_I57_F0.5711.00
30_T59_T0.5681.00
251_M298_L0.5661.00
7_I31_I0.5631.00
22_L67_I0.5621.00
123_P278_D0.5601.00
196_G258_S0.5601.00
121_I133_N0.5591.00
34_D37_T0.5591.00
140_C143_E0.5591.00
253_I256_T0.5581.00
222_I225_I0.5571.00
20_E215_S0.5551.00
217_W237_I0.5541.00
174_P215_S0.5531.00
169_F210_A0.5531.00
210_A242_E0.5521.00
69_L168_P0.5521.00
201_V264_Y0.5521.00
110_T166_Q0.5491.00
11_A31_I0.5481.00
108_I224_L0.5471.00
66_V105_A0.5411.00
60_E66_V0.5401.00
154_A157_R0.5401.00
6_L60_E0.5391.00
117_G136_G0.5371.00
97_L101_R0.5361.00
78_Y140_C0.5351.00
4_K27_E0.5341.00
173_G214_I0.5331.00
17_H175_G0.5331.00
108_I221_T0.5331.00
192_Q200_T0.5321.00
262_I268_R0.5281.00
209_R245_I0.5281.00
19_T23_L0.5271.00
123_P276_A0.5271.00
141_Y144_S0.5261.00
193_A252_I0.5261.00
18_L222_I0.5251.00
229_G232_G0.5251.00
164_R229_G0.5251.00
115_V135_I0.5241.00
155_Y161_L0.5221.00
208_T276_A0.5211.00
120_S133_N0.5211.00
31_I49_F0.5201.00
252_I302_I0.5191.00
252_I298_L0.5171.00
235_F282_A0.5171.00
23_L26_G0.5161.00
68_H107_F0.5151.00
184_R188_R0.5151.00
297_G300_L0.5111.00
6_L59_T0.5111.00
50_I60_E0.5091.00
170_N211_F0.5091.00
271_D275_R0.5091.00
67_I222_I0.5071.00
279_I288_W0.5031.00
247_E295_E0.5031.00
213_Y301_T0.5031.00
189_F193_A0.5031.00
13_F17_H0.5021.00
282_A290_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sb8A 2 0.9839 100 0.193 Contact Map
3rufA 2 0.9774 100 0.198 Contact Map
2b69A 2 0.9806 100 0.206 Contact Map
2c20A 2 0.9774 100 0.217 Contact Map
1oc2A 2 0.9645 100 0.218 Contact Map
4wkgA 5 1 100 0.22 Contact Map
1orrA 3 0.9839 100 0.221 Contact Map
3m2pA 2 0.9258 100 0.223 Contact Map
1rpnA 4 0.971 100 0.223 Contact Map
3slgA 4 0.9871 100 0.225 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0105 seconds.