GREMLIN Database
Q7LXG4 - UDP-glucose 6-dehydrogenase (Ugd)
UniProt: Q7LXG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 409 (387)
Sequences: 8317 (4890)
Seq/√Len: 248.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_R186_E5.0081.00
33_Q37_K4.6741.00
337_Y371_F4.2191.00
289_M363_I3.3921.00
300_T333_N3.3651.00
2_R25_E3.3451.00
311_N369_D3.3251.00
300_T335_I3.1821.00
38_G43_R3.0981.00
290_E330_I3.0641.00
135_V169_I2.7891.00
289_M361_G2.6991.00
183_T223_T2.6861.00
302_C359_S2.6351.00
161_D164_A2.6021.00
127_K134_V2.5951.00
283_R326_L2.5941.00
303_I324_A2.5441.00
100_K129_I2.5001.00
4_G74_V2.4611.00
214_E288_I2.4161.00
184_S187_E2.3981.00
40_Q64_F2.3511.00
323_I365_A2.3141.00
37_K41_C2.3021.00
269_K276_K2.2181.00
107_K110_A2.2141.00
307_A341_A2.1951.00
220_D223_T2.1941.00
148_I152_K2.1331.00
25_E63_L2.1151.00
76_I172_L2.0941.00
8_L28_G2.0531.00
33_Q66_T2.0221.00
25_E61_R2.0221.00
301_I332_A2.0061.00
351_S354_E2.0021.00
335_I359_S1.9941.00
68_Y101_T1.9741.00
364_I389_V1.9231.00
195_A228_I1.9201.00
197_S205_F1.9001.00
100_K132_R1.8861.00
216_I264_L1.8731.00
86_V89_K1.8721.00
44_S55_L1.8611.00
34_N37_K1.8501.00
183_T191_I1.8441.00
262_R272_E1.8331.00
133_E162_S1.7801.00
77_V110_A1.7771.00
190_M213_C1.7631.00
201_T274_A1.7571.00
97_D100_K1.7521.00
112_V130_V1.7471.00
302_C355_C1.7451.00
32_D35_K1.7291.00
267_E272_E1.7061.00
170_E182_R1.6691.00
96_L100_K1.6561.00
111_I168_V1.6541.00
3_I172_L1.6261.00
198_F202_K1.5991.00
2_R73_D1.5981.00
37_K40_Q1.5911.00
284_R288_I1.5701.00
96_L125_K1.5581.00
17_A55_L1.5501.00
17_A62_F1.5461.00
4_G77_V1.5461.00
272_E276_K1.5331.00
258_A272_E1.5261.00
30_D36_V1.5251.00
326_L329_D1.5191.00
306_I336_A1.5021.00
211_N284_R1.5001.00
289_M384_L1.5001.00
167_D171_N1.4971.00
369_D372_R1.4921.00
310_P367_E1.4791.00
38_G45_P1.4791.00
335_I349_V1.4791.00
127_K131_E1.4771.00
39_L64_F1.4741.00
106_L110_A1.4421.00
50_G53_E1.4361.00
53_E57_K1.4311.00
243_L386_G1.4301.00
214_E284_R1.4281.00
326_L330_I1.4261.00
215_V266_E1.4241.00
198_F237_Y1.4211.00
29_V68_Y1.4171.00
19_L172_L1.4111.00
212_L268_L1.4051.00
36_V66_T1.3991.00
327_L332_A1.3961.00
76_I111_I1.3951.00
211_N281_R1.3881.00
17_A54_L1.3801.00
321_L325_K1.3691.00
160_S164_A1.3681.00
167_D181_L1.3631.00
70_A73_D1.3621.00
18_V151_I1.3621.00
201_T205_F1.3611.00
52_D56_L1.3591.00
96_L129_I1.3491.00
67_D70_A1.3471.00
36_V64_F1.3441.00
34_N38_G1.3431.00
63_L70_A1.3361.00
168_V171_N1.3101.00
109_D133_E1.3041.00
223_T226_K1.2881.00
286_V323_I1.2731.00
125_K128_Q1.2661.00
383_V390_L1.2521.00
206_I225_A1.2521.00
292_L384_L1.2511.00
340_K370_E1.2471.00
302_C362_V1.2441.00
58_N61_R1.2421.00
211_N215_V1.2281.00
300_T358_R1.2271.00
170_E174_S1.2231.00
145_S148_I1.2211.00
288_I384_L1.2191.00
2_R27_V1.2151.00
93_G97_D1.2151.00
38_G41_C1.2111.00
171_N174_S1.2041.00
226_K236_P1.2031.00
191_I227_A1.1981.00
270_I273_A1.1961.00
286_V326_L1.1951.00
99_A129_I1.1951.00
27_V74_V1.1941.00
356_V362_V1.1921.00
184_S223_T1.1901.00
194_A209_I1.1821.00
54_L147_V1.1801.00
72_K107_K1.1791.00
245_Y275_I1.1741.00
27_V73_D1.1701.00
133_E164_A1.1611.00
213_C221_V1.1581.00
270_I277_V1.1571.00
76_I168_V1.1521.00
369_D373_G1.1471.00
99_A103_K1.1451.00
40_Q63_L1.1411.00
6_V98_A1.1411.00
304_L374_I1.1341.00
39_L62_F1.1311.00
301_I361_G1.1281.00
322_K325_K1.1251.00
302_C335_I1.1231.00
201_T270_I1.1231.00
232_K237_Y1.1171.00
27_V63_L1.1131.00
162_S165_A1.1111.00
163_K167_D1.1051.00
360_D379_K1.1021.00
187_E219_C1.1021.00
137_N173_W1.0891.00
111_I135_V1.0891.00
96_L126_V1.0891.00
222_N226_K1.0851.00
222_N240_N1.0801.00
364_I390_L1.0791.00
324_A328_V1.0731.00
290_E332_A1.0721.00
100_K104_P1.0711.00
114_V123_S1.0691.00
283_R287_K1.0691.00
27_V65_T1.0681.00
333_N347_E1.0671.00
325_K328_V1.0661.00
209_I221_V1.0631.00
133_E161_D1.0631.00
219_C224_I1.0611.00
69_S72_K1.0551.00
35_K45_P1.0531.00
36_V40_Q1.0521.00
54_L57_K1.0481.00
73_D107_K1.0471.00
8_L16_G1.0401.00
149_D152_K1.0381.00
260_F263_E1.0331.00
51_L55_L1.0261.00
68_Y105_Y1.0211.00
174_S179_V1.0201.00
75_D110_A1.0151.00
6_V77_V1.0111.00
322_K326_L1.0101.00
84_P91_Y1.0071.00
97_D101_T1.0051.00
299_K360_D1.0011.00
127_K161_D1.0011.00
16_G28_G1.0001.00
367_E387_R1.0001.00
296_L332_A0.9971.00
187_E224_I0.9961.00
158_I169_I0.9861.00
103_K130_V0.9801.00
364_I383_V0.9801.00
4_G29_V0.9791.00
69_S73_D0.9721.00
289_M386_G0.9721.00
167_D170_E0.9701.00
90_N119_V0.9661.00
357_K377_M0.9651.00
211_N280_E0.9651.00
124_R185_I0.9641.00
123_S185_I0.9641.00
79_I102_M0.9631.00
213_C224_I0.9621.00
287_K291_E0.9611.00
122_T126_V0.9591.00
325_K329_D0.9541.00
236_P240_N0.9521.00
301_I363_I0.9511.00
290_E296_L0.9511.00
292_L382_A0.9501.00
243_L365_A0.9491.00
282_P322_K0.9481.00
306_I315_T0.9481.00
3_I19_L0.9461.00
63_L69_S0.9451.00
16_G62_F0.9421.00
304_L362_V0.9401.00
306_I318_S0.9401.00
300_T359_S0.9361.00
18_V22_Q0.9341.00
8_L62_F0.9341.00
127_K185_I0.9321.00
280_E283_R0.9261.00
101_T104_P0.9251.00
200_A275_I0.9241.00
269_K280_E0.9221.00
22_Q151_I0.9221.00
29_V70_A0.9161.00
170_E181_L0.9091.00
18_V150_T0.9081.00
65_T70_A0.9071.00
129_I132_R0.9031.00
304_L371_F0.8991.00
55_L62_F0.8991.00
15_T150_T0.8941.00
288_I291_E0.8891.00
99_A114_V0.8891.00
346_V350_S0.8861.00
4_G27_V0.8811.00
361_G382_A0.8801.00
320_A365_A0.8731.00
342_K348_M0.8720.99
293_L299_K0.8720.99
3_I24_H0.8630.99
79_I95_V0.8610.99
43_R51_L0.8590.99
102_M112_V0.8550.99
255_L275_I0.8530.99
164_A169_I0.8530.99
128_Q131_E0.8520.99
285_A386_G0.8510.99
68_Y104_P0.8480.99
165_A181_L0.8430.99
268_L271_V0.8420.99
170_E179_V0.8400.99
259_S263_E0.8390.99
113_V169_I0.8370.99
124_R128_Q0.8330.99
315_T345_L0.8330.99
261_A268_L0.8320.99
245_Y254_T0.8310.99
109_D164_A0.8300.99
167_D182_R0.8270.99
111_I164_A0.8270.99
202_K239_L0.8260.99
212_L257_F0.8240.99
349_V355_C0.8220.99
335_I358_R0.8190.99
302_C356_V0.8190.99
4_G71_L0.8190.99
349_V354_E0.8190.99
298_G333_N0.8170.99
126_V129_I0.8140.99
79_I112_V0.8140.99
29_V65_T0.8120.99
99_A126_V0.8120.99
352_K370_E0.8120.99
289_M327_L0.8110.99
76_I113_V0.8090.99
315_T341_A0.8040.99
377_M381_K0.8020.99
198_F239_L0.8020.99
31_I101_T0.8020.99
318_S321_L0.8020.99
114_V126_V0.8020.99
354_E357_K0.8010.99
289_M301_I0.7980.99
258_A275_I0.7960.99
279_E322_K0.7950.99
328_V346_V0.7940.99
212_L266_E0.7940.99
259_S262_R0.7920.99
310_P369_D0.7860.99
286_V330_I0.7860.99
113_V172_L0.7810.99
27_V70_A0.7800.99
141_L150_T0.7800.99
315_T321_L0.7710.99
306_I324_A0.7700.99
285_A384_L0.7630.99
258_A271_V0.7630.99
5_V16_G0.7620.99
352_K356_V0.7610.99
304_L356_V0.7610.99
159_G165_A0.7610.99
154_D232_K0.7590.99
222_N388_R0.7530.99
102_M105_Y0.7500.98
76_I169_I0.7470.98
324_A336_A0.7470.98
283_R322_K0.7440.98
160_S182_R0.7440.98
135_V160_S0.7440.98
90_N256_A0.7400.98
181_L230_L0.7400.98
29_V66_T0.7380.98
71_L77_V0.7370.98
280_E287_K0.7360.98
353_E377_M0.7350.98
179_V230_L0.7310.98
328_V334_V0.7280.98
202_K206_I0.7280.98
77_V102_M0.7270.98
294_G299_K0.7260.98
35_K38_G0.7250.98
362_V378_L0.7230.98
95_V122_T0.7230.98
378_L381_K0.7220.98
303_I363_I0.7210.98
335_I347_E0.7200.98
367_E372_R0.7170.98
123_S136_A0.7170.98
187_E223_T0.7170.98
142_K145_S0.7160.98
115_K173_W0.7140.98
15_T19_L0.7120.98
4_G70_A0.7120.98
60_N63_L0.7110.98
47_Y340_K0.7110.98
130_V134_V0.7100.98
229_G236_P0.7080.98
215_V267_E0.7070.98
197_S271_V0.7060.98
362_V371_F0.7010.98
279_E282_P0.7010.98
243_L285_A0.7010.98
221_V225_A0.7000.98
124_R127_K0.7000.98
35_K39_L0.6970.98
6_V68_Y0.6940.97
103_K112_V0.6940.97
258_A262_R0.6880.97
95_V99_A0.6860.97
75_D168_V0.6860.97
8_L30_D0.6850.97
29_V101_T0.6840.97
152_K176_T0.6830.97
341_A345_L0.6820.97
229_G238_F0.6790.97
212_L261_A0.6790.97
15_T155_R0.6780.97
128_Q132_R0.6740.97
25_E73_D0.6730.97
209_I257_F0.6710.97
69_S105_Y0.6690.97
164_A168_V0.6650.97
5_V15_T0.6650.97
78_F172_L0.6650.97
162_S167_D0.6590.97
254_T275_I0.6550.96
79_I114_V0.6520.96
170_E180_V0.6520.96
6_V71_L0.6510.96
302_C351_S0.6510.96
205_F209_I0.6500.96
10_V316_R0.6500.96
208_E277_V0.6490.96
183_T187_E0.6490.96
18_V147_V0.6480.96
157_V191_I0.6470.96
31_I94_Y0.6470.96
347_E358_R0.6470.96
43_R52_D0.6450.96
143_E308_F0.6430.96
269_K273_A0.6400.96
53_E56_L0.6400.96
156_I191_I0.6390.96
101_T105_Y0.6380.96
157_V179_V0.6360.96
225_A229_G0.6360.96
141_L146_A0.6340.96
339_P371_F0.6340.96
117_T249_C0.6330.96
117_T253_D0.6320.96
304_L352_K0.6320.96
161_D185_I0.6310.96
358_R379_K0.6310.96
225_A241_A0.6300.96
255_L279_E0.6290.96
115_K137_N0.6290.96
152_K175_F0.6280.96
77_V105_Y0.6280.96
200_A245_Y0.6270.95
293_L301_I0.6270.95
135_V158_I0.6270.95
226_K229_G0.6260.95
72_K105_Y0.6260.95
85_T255_L0.6250.95
328_V333_N0.6250.95
281_R284_R0.6240.95
54_L58_N0.6240.95
262_R269_K0.6200.95
304_L364_I0.6190.95
231_D234_I0.6190.95
293_L361_G0.6190.95
206_I209_I0.6190.95
49_P54_L0.6180.95
225_A240_N0.6170.95
336_A348_M0.6170.95
113_V135_V0.6160.95
260_F264_L0.6160.95
286_V290_E0.6150.95
127_K130_V0.6130.95
86_V96_L0.6130.95
23_G61_R0.6100.95
287_K330_I0.6090.95
372_R389_V0.6070.95
336_A342_K0.6060.95
8_L39_L0.6050.95
89_K263_E0.6040.94
293_L382_A0.6040.94
289_M296_L0.6030.94
216_I219_C0.6030.94
106_L130_V0.6030.94
125_K260_F0.6000.94
139_E249_C0.6000.94
29_V98_A0.5990.94
196_N253_D0.5980.94
71_L110_A0.5980.94
288_I292_L0.5980.94
95_V114_V0.5980.94
266_E277_V0.5970.94
44_S52_D0.5960.94
273_A276_K0.5960.94
155_R195_A0.5950.94
83_T116_S0.5940.94
282_P323_I0.5930.94
306_I320_A0.5920.94
356_V377_M0.5910.94
30_D66_T0.5900.94
114_V130_V0.5900.94
248_S252_K0.5890.94
74_V77_V0.5880.94
125_K129_I0.5880.94
345_L348_M0.5860.94
286_V296_L0.5860.94
361_G384_L0.5850.93
81_V94_Y0.5850.93
346_V349_V0.5830.93
157_V170_E0.5820.93
341_A348_M0.5810.93
229_G234_I0.5790.93
315_T320_A0.5780.93
293_L380_D0.5780.93
194_A197_S0.5770.93
20_A61_R0.5740.93
258_A268_L0.5740.93
353_E356_V0.5740.93
43_R56_L0.5730.93
169_I173_W0.5710.93
198_F206_I0.5700.93
211_N214_E0.5700.93
75_D108_R0.5690.93
160_S185_I0.5690.93
24_H76_I0.5680.92
212_L216_I0.5670.92
293_L296_L0.5670.92
243_L310_P0.5670.92
190_M209_I0.5670.92
63_L73_D0.5650.92
356_V359_S0.5650.92
68_Y71_L0.5650.92
282_P319_V0.5630.92
127_K160_S0.5620.92
243_L323_I0.5610.92
254_T271_V0.5610.92
354_E358_R0.5590.92
249_C252_K0.5580.92
104_P108_R0.5550.92
348_M351_S0.5540.92
182_R227_A0.5540.92
210_A281_R0.5540.92
115_K252_K0.5520.91
92_I96_L0.5520.91
39_L45_P0.5500.91
140_F195_A0.5490.91
353_E375_E0.5490.91
204_S270_I0.5480.91
143_E252_K0.5480.91
347_E350_S0.5470.91
36_V39_L0.5470.91
157_V165_A0.5470.91
105_Y110_A0.5470.91
94_Y98_A0.5470.91
269_K272_E0.5460.91
165_A182_R0.5450.91
352_K355_C0.5440.91
296_L299_K0.5440.91
115_K143_E0.5410.91
209_I213_C0.5410.91
337_Y352_K0.5400.91
362_V377_M0.5380.90
255_L317_E0.5370.90
120_P260_F0.5360.90
169_I174_S0.5360.90
84_P314_D0.5360.90
196_N249_C0.5350.90
377_M380_D0.5350.90
24_H171_N0.5320.90
40_Q43_R0.5310.90
187_E191_I0.5290.90
85_T88_G0.5290.90
126_V134_V0.5290.90
324_A365_A0.5290.90
84_P317_E0.5280.90
350_S354_E0.5280.90
50_G54_L0.5260.89
115_K155_R0.5260.89
47_Y313_D0.5260.89
245_Y274_A0.5250.89
20_A60_N0.5250.89
353_E357_K0.5250.89
37_K66_T0.5230.89
155_R173_W0.5220.89
196_N309_K0.5220.89
327_L334_V0.5210.89
297_K331_G0.5210.89
88_G279_E0.5210.89
271_V274_A0.5200.89
93_G96_L0.5200.89
292_L361_G0.5160.88
306_I321_L0.5160.88
360_D378_L0.5140.88
273_A277_V0.5130.88
268_L272_E0.5130.88
114_V134_V0.5130.88
214_E281_R0.5100.88
100_K130_V0.5090.88
285_A323_I0.5090.88
286_V289_M0.5080.88
150_T175_F0.5080.88
351_S355_C0.5060.87
133_E168_V0.5050.87
222_N241_A0.5040.87
324_A334_V0.5040.87
82_A252_K0.5040.87
190_M219_C0.5030.87
289_M292_L0.5010.87
215_V264_L0.5010.87
211_N266_E0.5010.87
253_D316_R0.5010.87
75_D109_D0.5000.87
139_E316_R0.5000.87
208_E269_K0.5000.87
199_L233_R0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y0cA 4 0.9976 100 0.252 Contact Map
2o3jA 4 0.9976 100 0.26 Contact Map
2q3eA 5 0.9976 100 0.263 Contact Map
3gg2A 3 0.978 100 0.271 Contact Map
3ojoA 2 0.9633 100 0.277 Contact Map
3g79A 2 0.9951 100 0.277 Contact Map
4a7pA 2 0.9878 100 0.287 Contact Map
3vtfA 2 0.9804 100 0.298 Contact Map
4xr9A 2 0.9902 100 0.309 Contact Map
1mv8A 2 0.9731 100 0.311 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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