GREMLIN Database
Q7LXG3 - UTP-glucose-1-phosphate uridylyltransferase
UniProt: Q7LXG3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 246 (213)
Sequences: 17810 (10618)
Seq/√Len: 727.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_E194_R3.3221.00
26_K34_E2.9401.00
43_D92_R2.8641.00
102_K106_D2.7241.00
145_T176_N2.6431.00
192_E214_R2.4641.00
192_E210_G2.3431.00
158_D162_C2.3421.00
30_Q58_H2.1781.00
156_L165_D2.1271.00
140_S218_F2.1081.00
162_C218_F2.0201.00
210_G214_R2.0161.00
158_D164_I2.0051.00
30_Q34_E1.9541.00
96_V110_R1.9251.00
210_G213_K1.9111.00
109_L112_E1.8851.00
165_D209_K1.8851.00
169_K173_P1.8781.00
177_L221_I1.8731.00
136_M220_A1.8481.00
145_T221_I1.8201.00
156_L164_I1.8141.00
12_I18_P1.7991.00
6_L10_K1.7971.00
148_D151_P1.7831.00
33_F44_F1.7811.00
209_K213_K1.7721.00
157_V177_L1.7461.00
53_R57_D1.7071.00
45_V114_F1.6971.00
36_L122_V1.6681.00
56_E97_N1.6571.00
48_V52_K1.6541.00
136_M140_S1.6501.00
163_V219_K1.6441.00
37_Y91_S1.6401.00
44_F91_S1.6381.00
143_V219_K1.6351.00
43_D94_A1.6161.00
131_I135_S1.6051.00
108_V121_V1.5651.00
106_D110_R1.5401.00
45_V96_V1.5181.00
52_K97_N1.5151.00
192_E207_G1.4851.00
16_M54_V1.4631.00
235_Y239_L1.4631.00
206_D209_K1.4471.00
45_V111_A1.4461.00
54_V57_D1.4301.00
167_E174_K1.4291.00
142_L145_T1.4271.00
195_Q210_G1.4241.00
48_V95_F1.3961.00
109_L194_R1.3791.00
143_V146_V1.3661.00
119_F187_E1.3601.00
225_K241_R1.3451.00
12_I54_V1.3401.00
132_P135_S1.3171.00
231_T234_N1.3141.00
135_S139_N1.3131.00
155_V163_V1.3131.00
133_I184_M1.3101.00
16_M58_H1.3011.00
106_D109_L1.2951.00
41_I120_L1.2951.00
185_F208_I1.2941.00
29_I59_F1.2921.00
123_A181_P1.2921.00
156_L167_E1.2891.00
48_V56_E1.2891.00
51_G54_V1.2871.00
94_A114_F1.2581.00
29_I46_I1.2581.00
156_L175_S1.2541.00
52_K56_E1.2441.00
227_Y241_R1.2271.00
48_V97_N1.2201.00
188_E216_R1.2191.00
150_R169_K1.2111.00
188_E191_D1.2091.00
227_Y237_E1.2061.00
205_T209_K1.2021.00
236_I240_R1.1951.00
132_P136_M1.1771.00
137_V141_F1.1731.00
234_N237_E1.1661.00
27_P30_Q1.1641.00
20_P25_F1.1591.00
28_I229_L1.1561.00
236_I239_L1.1561.00
29_I55_I1.1431.00
118_E186_D1.1411.00
195_Q214_R1.1271.00
41_I134_S1.1261.00
179_V183_Y1.1221.00
5_L17_F1.0971.00
208_I217_R1.0841.00
153_G168_E1.0821.00
157_V219_K1.0731.00
136_M218_F1.0641.00
115_I119_F1.0581.00
60_T95_F1.0541.00
229_L238_S1.0451.00
121_V185_F1.0431.00
137_V186_D1.0421.00
142_L146_V1.0361.00
112_E190_F1.0361.00
5_L9_S1.0101.00
163_V217_R1.0091.00
39_I131_I1.0091.00
120_L134_S0.9971.00
135_S138_V0.9911.00
120_L184_M0.9871.00
161_G221_I0.9861.00
118_E187_E0.9841.00
117_G187_E0.9821.00
237_E240_R0.9791.00
20_P239_L0.9691.00
49_G52_K0.9691.00
165_D172_Q0.9651.00
30_Q62_D0.9591.00
188_E192_E0.9591.00
191_D195_Q0.9591.00
137_V184_M0.9591.00
53_R56_E0.9511.00
211_L216_R0.9481.00
26_K30_Q0.9451.00
191_D194_R0.9401.00
45_V94_A0.9341.00
109_L193_L0.9291.00
26_K31_I0.9231.00
143_V155_V0.9211.00
192_E195_Q0.9131.00
151_P169_K0.9101.00
36_L41_I0.9081.00
116_Q187_E0.9071.00
137_V140_S0.9041.00
136_M139_N0.8951.00
64_D89_E0.8931.00
42_R92_R0.8911.00
154_V178_V0.8901.00
33_F93_I0.8791.00
15_E124_A0.8781.00
150_R171_K0.8781.00
9_S17_F0.8771.00
233_E237_E0.8681.00
59_F93_I0.8651.00
151_P234_N0.8641.00
188_E214_R0.8611.00
122_V130_M0.8601.00
48_V53_R0.8571.00
126_T226_V0.8521.00
108_V189_I0.8511.00
227_Y238_S0.8491.00
19_I239_L0.8481.00
60_T64_D0.8431.00
8_A12_I0.8411.00
156_L174_K0.8401.00
237_E241_R0.8391.00
27_P31_I0.8371.00
28_I32_I0.8321.00
109_L202_L0.8311.00
132_P220_A0.8281.00
34_E89_E0.8171.00
134_S138_V0.8161.00
151_P231_T0.8111.00
189_I211_L0.8071.00
232_V236_I0.8071.00
196_I210_G0.8071.00
47_V107_A0.8061.00
47_V96_V0.7991.00
33_F59_F0.7981.00
199_E203_Q0.7961.00
115_I190_F0.7951.00
133_I142_L0.7901.00
13_P54_V0.7891.00
138_V141_F0.7801.00
37_Y62_D0.7791.00
18_P27_P0.7791.00
117_G188_E0.7781.00
33_F91_S0.7731.00
143_V177_L0.7721.00
30_Q59_F0.7691.00
103_G201_E0.7691.00
37_Y44_F0.7611.00
35_Q39_I0.7601.00
96_V111_A0.7551.00
48_V55_I0.7551.00
133_I220_A0.7481.00
166_I179_V0.7471.00
62_D89_E0.7461.00
37_Y42_R0.7451.00
141_F186_D0.7441.00
56_E95_F0.7371.00
8_A11_E0.7371.00
91_S95_F0.7341.00
188_E215_G0.7341.00
192_E211_L0.7301.00
35_Q38_D0.7211.00
101_P106_D0.7211.00
133_I137_V0.7201.00
187_E190_F0.7201.00
149_P152_Y0.7181.00
212_I217_R0.7171.00
46_I59_F0.7151.00
20_P31_I0.7131.00
134_S184_M0.7121.00
201_E204_L0.7101.00
207_G210_G0.7101.00
34_E37_Y0.7081.00
90_N93_I0.7071.00
49_G101_P0.7061.00
18_P25_F0.7001.00
218_F221_I0.6981.00
191_D214_R0.6961.00
8_A17_F0.6951.00
196_I202_L0.6951.00
8_A232_V0.6951.00
127_I238_S0.6951.00
46_I93_I0.6941.00
31_I242_L0.6931.00
19_I127_I0.6921.00
37_Y90_N0.6901.00
149_P154_V0.6871.00
20_P242_L0.6861.00
34_E38_D0.6801.00
112_E191_D0.6791.00
42_R90_N0.6751.00
13_P51_G0.6731.00
17_F235_Y0.6661.00
131_I134_S0.6611.00
27_P58_H0.6611.00
100_E106_D0.6541.00
35_Q182_Y0.6531.00
33_F46_I0.6531.00
196_I207_G0.6521.00
198_Y202_L0.6521.00
47_V111_A0.6521.00
147_Q176_N0.6511.00
36_L120_L0.6501.00
200_E203_Q0.6471.00
137_V220_A0.6441.00
196_I206_D0.6421.00
144_T180_V0.6361.00
57_D60_T0.6271.00
145_T177_L0.6271.00
104_F123_A0.6261.00
113_P116_Q0.6201.00
134_S137_V0.6181.00
130_M136_M0.6171.00
155_V219_K0.6161.00
31_I35_Q0.6141.00
167_E170_P0.6111.00
165_D213_K0.6101.00
11_E54_V0.6091.00
62_D95_F0.6071.00
111_A114_F0.6071.00
32_I122_V0.6061.00
123_A183_Y0.6021.00
44_F93_I0.6011.00
17_F239_L0.6011.00
228_D234_N0.6001.00
4_R14_K0.5971.00
35_Q130_M0.5931.00
52_K55_I0.5901.00
211_L215_G0.5881.00
123_A126_T0.5851.00
120_L130_M0.5851.00
162_C212_I0.5821.00
172_Q175_S0.5811.00
185_F207_G0.5781.00
32_I124_A0.5741.00
105_G193_L0.5731.00
99_P106_D0.5721.00
119_F190_F0.5701.00
122_V182_Y0.5691.00
3_T6_L0.5671.00
99_P110_R0.5641.00
112_E116_Q0.5641.00
106_D202_L0.5641.00
161_G164_I0.5581.00
12_I17_F0.5551.00
201_E205_T0.5541.00
104_F179_V0.5461.00
16_M27_P0.5461.00
99_P102_K0.5451.00
180_V226_V0.5441.00
128_L180_V0.5441.00
14_K125_D0.5381.00
209_K212_I0.5361.00
105_G202_L0.5301.00
206_D210_G0.5281.00
152_Y228_D0.5231.00
102_K198_Y0.5231.00
180_V222_M0.5221.00
141_F218_F0.5211.00
227_Y234_N0.5211.00
102_K202_L0.5191.00
19_I238_S0.5191.00
193_L200_E0.5181.00
31_I34_E0.5171.00
19_I235_Y0.5161.00
125_D230_G0.5141.00
56_E60_T0.5141.00
164_I167_E0.5131.00
7_P10_K0.5131.00
94_A97_N0.5101.00
15_E55_I0.5101.00
167_E172_Q0.5101.00
201_E206_D0.5071.00
32_I35_Q0.5040.99
163_V166_I0.5030.99
193_L202_L0.5020.99
64_D93_I0.5010.99
128_L222_M0.5000.99
98_Q106_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e3dA 3 0.9675 100 0.351 Contact Map
3jukA 3 0.939 100 0.352 Contact Map
2ux8A 4 0.9675 100 0.367 Contact Map
2pa4A 3 0.9715 100 0.387 Contact Map
1iimA 3 0.8862 100 0.389 Contact Map
1lvwA 3 0.8862 100 0.393 Contact Map
1mc3A 3 0.8862 100 0.394 Contact Map
4ho4A 3 0.8862 100 0.399 Contact Map
1tzfA 4 0.9024 100 0.415 Contact Map
2ggoA 3 0.8537 100 0.415 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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