Q7LXG2 - SULSO - GREMLIN Contacts

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Q7LXG2 - Uncharacterized protein

UniProt:	Q7LXG2	Sequences: MMVDLRPFTGIPAKAILSRRSDFAAFYQVIIENIYSHLLSSIREGDVVIDAGANIGLFSILASFKVKEKGRVIAIEPEPNNLKILKQNVELNGLNNVIIIPKALYDKPGKRVNMRGEGVGAFVSEDGEGTVETTTLDVIAEENRLRPRILKMDIEGAEGKALLGSINTVKYLELIEMEVHDEENMKQVEEILFRFKFKKKEVAIEDLRNVYRQFIRHPINILRIEAANRFSTTKRVLLSRINGGKVSLFPKQIVYYRG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	258 (197)
Sequences:	383 (360)
Seq/√Len:	25.6

HALSA - Q9HQP5 Q9HSW3
SULSO - Q7LXG2 Q7LXE1 Q97XT4 Q7LXF6 Q97X54 Q7LXE9 Q97XU3 Q97XG4 Q7LXF9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
103_A	133_T	4.466	1.00
82_L	99_I	4.439	1.00
53_A	85_L	3.396	1.00
106_D	160_K	3.376	1.00
105_Y	133_T	3.358	1.00
51_A	104_L	3.221	1.00
154_I	161_A	3.210	1.00
82_L	85_L	3.206	1.00
135_T	138_V	3.164	1.00
75_I	139_I	3.119	1.00
73_I	100_I	3.081	1.00
51_A	152_M	3.055	1.00
53_A	74_A	2.836	1.00
50_D	151_K	2.790	1.00
137_D	164_G	2.728	0.99
147_P	150_L	2.592	0.99
103_A	131_V	2.570	0.99
137_D	165_S	2.366	0.98
75_I	104_L	2.346	0.98
46_D	148_R	2.271	0.98
82_L	101_P	2.241	0.98
108_P	138_V	2.233	0.98
137_D	168_T	2.179	0.97
105_Y	157_A	2.175	0.97
108_P	134_T	2.143	0.97
152_M	161_A	2.108	0.96
100_I	139_I	2.080	0.96
60_I	88_N	2.060	0.96
134_T	138_V	2.008	0.95
78_E	81_N	1.982	0.95
159_G	191_I	1.911	0.94
110_K	132_E	1.857	0.93
54_N	57_L	1.837	0.93
102_K	132_E	1.805	0.92
59_S	72_V	1.794	0.92
172_L	197_F	1.790	0.92
158_E	177_M	1.780	0.91
175_I	192_L	1.754	0.91
178_E	201_E	1.708	0.89
54_N	178_E	1.689	0.89
16_I	20_R	1.562	0.85
136_L	168_T	1.512	0.83
102_K	134_T	1.468	0.81
155_E	180_H	1.458	0.80
137_D	169_V	1.433	0.79
165_S	169_V	1.433	0.79
153_D	156_G	1.415	0.78
46_D	174_L	1.414	0.78
82_L	86_K	1.400	0.78
140_A	144_R	1.331	0.74
169_V	197_F	1.300	0.72
75_I	136_L	1.284	0.71
150_L	165_S	1.284	0.71
85_L	99_I	1.280	0.71
71_R	98_I	1.275	0.70
124_S	127_G	1.254	0.69
75_I	100_I	1.242	0.68
46_D	70_G	1.211	0.66
58_F	62_A	1.192	0.65
51_A	161_A	1.181	0.64
47_V	73_I	1.163	0.63
55_I	175_I	1.163	0.63
71_R	188_V	1.149	0.62
104_L	134_T	1.148	0.62
44_E	131_V	1.140	0.62
154_I	158_E	1.117	0.60
168_T	171_Y	1.112	0.60
104_L	152_M	1.112	0.60
179_V	184_N	1.103	0.59
45_G	70_G	1.093	0.58
187_Q	193_F	1.090	0.58
49_I	136_L	1.089	0.58
25_A	130_T	1.076	0.57
54_N	119_V	1.069	0.57
55_I	89_V	1.042	0.55
179_V	188_V	1.030	0.54
175_I	179_V	1.026	0.53
159_G	163_L	1.016	0.53
73_I	140_A	1.008	0.52
48_V	72_V	1.005	0.52
19_R	178_E	0.978	0.50
58_F	180_H	0.972	0.50
75_I	164_G	0.969	0.49
79_P	101_P	0.962	0.49
144_R	148_R	0.956	0.48
48_V	204_I	0.954	0.48
159_G	187_Q	0.945	0.48
161_A	164_G	0.945	0.48
96_N	146_R	0.942	0.47
43_R	46_D	0.935	0.47
180_H	184_N	0.920	0.46
52_G	76_E	0.916	0.45
147_P	169_V	0.914	0.45
167_N	171_Y	0.913	0.45
58_F	197_F	0.912	0.45
111_R	133_T	0.910	0.45
80_N	190_E	0.899	0.44
28_Q	170_K	0.896	0.44
155_E	197_F	0.896	0.44
34_I	37_H	0.880	0.43
123_V	193_F	0.880	0.43
66_V	70_G	0.878	0.43
74_A	85_L	0.873	0.42
97_V	167_N	0.873	0.42
140_A	165_S	0.868	0.42
33_N	36_S	0.866	0.42
58_F	179_V	0.862	0.42
180_H	185_M	0.862	0.42
22_D	26_F	0.862	0.42
44_E	170_K	0.860	0.41
15_A	18_S	0.853	0.41
173_E	196_K	0.846	0.40
59_S	63_S	0.842	0.40
59_S	89_V	0.839	0.40
48_V	77_P	0.835	0.40
54_N	58_F	0.835	0.40
74_A	139_I	0.831	0.39
137_D	197_F	0.829	0.39
99_I	175_I	0.821	0.39
67_K	70_G	0.821	0.39
78_E	131_V	0.821	0.39
83_K	132_E	0.819	0.38
63_S	88_N	0.815	0.38
14_K	18_S	0.808	0.38
52_G	56_G	0.806	0.38
31_I	110_K	0.805	0.38
161_A	186_K	0.799	0.37
48_V	58_F	0.796	0.37
56_G	76_E	0.788	0.36
14_K	17_L	0.786	0.36
66_V	148_R	0.785	0.36
13_A	17_L	0.782	0.36
48_V	62_A	0.777	0.36
149_I	176_E	0.777	0.36
105_Y	109_G	0.776	0.36
45_G	67_K	0.776	0.36
169_V	172_L	0.775	0.35
180_H	202_V	0.773	0.35
47_V	125_E	0.772	0.35
206_D	210_V	0.763	0.35
180_H	201_E	0.763	0.35
154_I	157_A	0.760	0.34
156_G	169_V	0.756	0.34
86_K	101_P	0.755	0.34
59_S	85_L	0.747	0.34
38_L	41_S	0.747	0.34
163_L	187_Q	0.744	0.33
78_E	116_G	0.742	0.33
79_P	86_K	0.742	0.33
20_R	26_F	0.741	0.33
58_F	196_K	0.735	0.33
17_L	22_D	0.734	0.33
121_A	148_R	0.734	0.33
58_F	202_V	0.729	0.32
105_Y	119_V	0.724	0.32
109_G	135_T	0.713	0.31
175_I	196_K	0.711	0.31
55_I	192_L	0.711	0.31
63_S	70_G	0.709	0.31
40_S	145_L	0.707	0.31
44_E	67_K	0.707	0.31
139_I	183_E	0.707	0.31
79_P	129_G	0.706	0.31
57_L	184_N	0.702	0.31
149_I	162_L	0.702	0.31
79_P	126_D	0.702	0.31
64_F	122_F	0.702	0.31
63_S	96_N	0.701	0.31
97_V	163_L	0.698	0.30
74_A	171_Y	0.694	0.30
65_K	135_T	0.689	0.30
173_E	197_F	0.688	0.30
136_L	140_A	0.687	0.30
144_R	172_L	0.687	0.30
137_D	156_G	0.684	0.30
32_E	160_K	0.679	0.29
179_V	197_F	0.679	0.29
115_R	196_K	0.674	0.29
164_G	169_V	0.672	0.29
105_Y	152_M	0.671	0.29
125_E	130_T	0.667	0.29
81_N	154_I	0.666	0.29
62_A	67_K	0.662	0.28
180_H	189_E	0.662	0.28
169_V	202_V	0.661	0.28
50_D	158_E	0.661	0.28
43_R	109_G	0.657	0.28
163_L	166_I	0.655	0.28
103_A	175_I	0.654	0.28
179_V	185_M	0.653	0.28
60_I	91_L	0.649	0.28
146_R	167_N	0.648	0.27
90_E	99_I	0.648	0.27
18_S	23_F	0.644	0.27
77_P	164_G	0.641	0.27
81_N	160_K	0.635	0.27
206_D	209_N	0.634	0.27
19_R	25_A	0.633	0.27
137_D	150_L	0.633	0.27
44_E	194_R	0.631	0.26
108_P	120_G	0.631	0.26
153_D	158_E	0.631	0.26
28_Q	172_L	0.630	0.26
82_L	93_G	0.628	0.26
124_S	177_M	0.626	0.26
88_N	92_N	0.621	0.26
48_V	66_V	0.617	0.26
104_L	117_E	0.615	0.26
74_A	93_G	0.614	0.26
46_D	210_V	0.613	0.25
59_S	87_Q	0.613	0.25
46_D	66_V	0.612	0.25
73_I	144_R	0.607	0.25
116_G	139_I	0.606	0.25
75_I	137_D	0.606	0.25
133_T	164_G	0.602	0.25
119_V	210_V	0.602	0.25
73_I	139_I	0.602	0.25
71_R	194_R	0.601	0.25
108_P	135_T	0.600	0.25
34_I	38_L	0.599	0.25
114_M	207_L	0.595	0.24
154_I	178_E	0.592	0.24
18_S	54_N	0.587	0.24
58_F	72_V	0.587	0.24
107_K	123_V	0.585	0.24
169_V	184_N	0.584	0.24
16_I	25_A	0.582	0.24
60_I	92_N	0.581	0.24
161_A	175_I	0.581	0.24
50_D	53_A	0.579	0.24
36_S	82_L	0.578	0.24
160_K	167_N	0.578	0.24
105_Y	160_K	0.577	0.24
105_Y	145_L	0.575	0.23
188_V	210_V	0.573	0.23
42_I	171_Y	0.569	0.23
152_M	177_M	0.568	0.23
157_A	209_N	0.567	0.23
97_V	125_E	0.565	0.23
36_S	71_R	0.563	0.23
103_A	124_S	0.563	0.23
111_R	136_L	0.563	0.23
98_I	145_L	0.562	0.23
104_L	165_S	0.561	0.23
57_L	155_E	0.560	0.23
95_N	128_E	0.559	0.23
44_E	70_G	0.558	0.23
153_D	178_E	0.554	0.22
77_P	103_A	0.553	0.22
52_G	153_D	0.552	0.22
41_S	97_V	0.552	0.22
208_R	211_Y	0.551	0.22
79_P	131_V	0.551	0.22
81_N	190_E	0.550	0.22
81_N	155_E	0.549	0.22
107_K	167_N	0.547	0.22
187_Q	191_I	0.544	0.22
55_I	111_R	0.542	0.22
62_A	66_V	0.541	0.22
137_D	166_I	0.539	0.22
42_I	132_E	0.537	0.21
47_V	128_E	0.536	0.21
81_N	85_L	0.535	0.21
197_F	200_K	0.534	0.21
76_E	153_D	0.532	0.21
134_T	139_I	0.529	0.21
120_G	188_V	0.527	0.21
181_D	184_N	0.527	0.21
173_E	198_K	0.525	0.21
118_G	185_M	0.525	0.21
60_I	63_S	0.524	0.21
74_A	194_R	0.524	0.21
54_N	186_K	0.523	0.21
116_G	188_V	0.522	0.21
54_N	59_S	0.521	0.21
13_A	29_V	0.520	0.21
87_Q	194_R	0.520	0.21
49_I	116_G	0.518	0.21
35_Y	58_F	0.517	0.21
29_V	35_Y	0.516	0.20
64_F	86_K	0.514	0.20
180_H	209_N	0.514	0.20
84_I	189_E	0.513	0.20
33_N	109_G	0.512	0.20
164_G	168_T	0.510	0.20
186_K	189_E	0.509	0.20
126_D	145_L	0.509	0.20
66_V	72_V	0.507	0.20
100_I	172_L	0.506	0.20
26_F	84_I	0.506	0.20
113_N	199_K	0.505	0.20
16_I	156_G	0.504	0.20
90_E	110_K	0.504	0.20
127_G	134_T	0.501	0.20
196_K	203_A	0.500	0.20

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2py6A	4	0.7674	100	0.4	Contact Map
3a27A	1	0.7287	98.3	0.845	Contact Map
2jjqA	1	0.686	98.1	0.852	Contact Map
3k6rA	1	0.7248	98	0.854	Contact Map
1wy7A	1	0.7597	98	0.854	Contact Map
1yzhA	1	0.7791	98	0.855	Contact Map
3e05A	4	0.7481	98	0.855	Contact Map
1o54A	4	0.7984	98	0.856	Contact Map
2fcaA	2	0.7829	98	0.857	Contact Map
3bt7A	1	0.7752	97.9	0.858	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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