GREMLIN Database
Q7LXG2 - Uncharacterized protein
UniProt: Q7LXG2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 258 (197)
Sequences: 383 (360)
Seq/√Len: 25.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_A133_T4.4661.00
82_L99_I4.4391.00
53_A85_L3.3961.00
106_D160_K3.3761.00
105_Y133_T3.3581.00
51_A104_L3.2211.00
154_I161_A3.2101.00
82_L85_L3.2061.00
135_T138_V3.1641.00
75_I139_I3.1191.00
73_I100_I3.0811.00
51_A152_M3.0551.00
53_A74_A2.8361.00
50_D151_K2.7901.00
137_D164_G2.7280.99
147_P150_L2.5920.99
103_A131_V2.5700.99
137_D165_S2.3660.98
75_I104_L2.3460.98
46_D148_R2.2710.98
82_L101_P2.2410.98
108_P138_V2.2330.98
137_D168_T2.1790.97
105_Y157_A2.1750.97
108_P134_T2.1430.97
152_M161_A2.1080.96
100_I139_I2.0800.96
60_I88_N2.0600.96
134_T138_V2.0080.95
78_E81_N1.9820.95
159_G191_I1.9110.94
110_K132_E1.8570.93
54_N57_L1.8370.93
102_K132_E1.8050.92
59_S72_V1.7940.92
172_L197_F1.7900.92
158_E177_M1.7800.91
175_I192_L1.7540.91
178_E201_E1.7080.89
54_N178_E1.6890.89
16_I20_R1.5620.85
136_L168_T1.5120.83
102_K134_T1.4680.81
155_E180_H1.4580.80
137_D169_V1.4330.79
165_S169_V1.4330.79
153_D156_G1.4150.78
46_D174_L1.4140.78
82_L86_K1.4000.78
140_A144_R1.3310.74
169_V197_F1.3000.72
75_I136_L1.2840.71
150_L165_S1.2840.71
85_L99_I1.2800.71
71_R98_I1.2750.70
124_S127_G1.2540.69
75_I100_I1.2420.68
46_D70_G1.2110.66
58_F62_A1.1920.65
51_A161_A1.1810.64
47_V73_I1.1630.63
55_I175_I1.1630.63
71_R188_V1.1490.62
104_L134_T1.1480.62
44_E131_V1.1400.62
154_I158_E1.1170.60
168_T171_Y1.1120.60
104_L152_M1.1120.60
179_V184_N1.1030.59
45_G70_G1.0930.58
187_Q193_F1.0900.58
49_I136_L1.0890.58
25_A130_T1.0760.57
54_N119_V1.0690.57
55_I89_V1.0420.55
179_V188_V1.0300.54
175_I179_V1.0260.53
159_G163_L1.0160.53
73_I140_A1.0080.52
48_V72_V1.0050.52
19_R178_E0.9780.50
58_F180_H0.9720.50
75_I164_G0.9690.49
79_P101_P0.9620.49
144_R148_R0.9560.48
48_V204_I0.9540.48
159_G187_Q0.9450.48
161_A164_G0.9450.48
96_N146_R0.9420.47
43_R46_D0.9350.47
180_H184_N0.9200.46
52_G76_E0.9160.45
147_P169_V0.9140.45
167_N171_Y0.9130.45
58_F197_F0.9120.45
111_R133_T0.9100.45
80_N190_E0.8990.44
28_Q170_K0.8960.44
155_E197_F0.8960.44
34_I37_H0.8800.43
123_V193_F0.8800.43
66_V70_G0.8780.43
74_A85_L0.8730.42
97_V167_N0.8730.42
140_A165_S0.8680.42
33_N36_S0.8660.42
58_F179_V0.8620.42
180_H185_M0.8620.42
22_D26_F0.8620.42
44_E170_K0.8600.41
15_A18_S0.8530.41
173_E196_K0.8460.40
59_S63_S0.8420.40
59_S89_V0.8390.40
48_V77_P0.8350.40
54_N58_F0.8350.40
74_A139_I0.8310.39
137_D197_F0.8290.39
99_I175_I0.8210.39
67_K70_G0.8210.39
78_E131_V0.8210.39
83_K132_E0.8190.38
63_S88_N0.8150.38
14_K18_S0.8080.38
52_G56_G0.8060.38
31_I110_K0.8050.38
161_A186_K0.7990.37
48_V58_F0.7960.37
56_G76_E0.7880.36
14_K17_L0.7860.36
66_V148_R0.7850.36
13_A17_L0.7820.36
48_V62_A0.7770.36
149_I176_E0.7770.36
105_Y109_G0.7760.36
45_G67_K0.7760.36
169_V172_L0.7750.35
180_H202_V0.7730.35
47_V125_E0.7720.35
206_D210_V0.7630.35
180_H201_E0.7630.35
154_I157_A0.7600.34
156_G169_V0.7560.34
86_K101_P0.7550.34
59_S85_L0.7470.34
38_L41_S0.7470.34
163_L187_Q0.7440.33
78_E116_G0.7420.33
79_P86_K0.7420.33
20_R26_F0.7410.33
58_F196_K0.7350.33
17_L22_D0.7340.33
121_A148_R0.7340.33
58_F202_V0.7290.32
105_Y119_V0.7240.32
109_G135_T0.7130.31
175_I196_K0.7110.31
55_I192_L0.7110.31
63_S70_G0.7090.31
40_S145_L0.7070.31
44_E67_K0.7070.31
139_I183_E0.7070.31
79_P129_G0.7060.31
57_L184_N0.7020.31
149_I162_L0.7020.31
79_P126_D0.7020.31
64_F122_F0.7020.31
63_S96_N0.7010.31
97_V163_L0.6980.30
74_A171_Y0.6940.30
65_K135_T0.6890.30
173_E197_F0.6880.30
136_L140_A0.6870.30
144_R172_L0.6870.30
137_D156_G0.6840.30
32_E160_K0.6790.29
179_V197_F0.6790.29
115_R196_K0.6740.29
164_G169_V0.6720.29
105_Y152_M0.6710.29
125_E130_T0.6670.29
81_N154_I0.6660.29
62_A67_K0.6620.28
180_H189_E0.6620.28
169_V202_V0.6610.28
50_D158_E0.6610.28
43_R109_G0.6570.28
163_L166_I0.6550.28
103_A175_I0.6540.28
179_V185_M0.6530.28
60_I91_L0.6490.28
146_R167_N0.6480.27
90_E99_I0.6480.27
18_S23_F0.6440.27
77_P164_G0.6410.27
81_N160_K0.6350.27
206_D209_N0.6340.27
19_R25_A0.6330.27
137_D150_L0.6330.27
44_E194_R0.6310.26
108_P120_G0.6310.26
153_D158_E0.6310.26
28_Q172_L0.6300.26
82_L93_G0.6280.26
124_S177_M0.6260.26
88_N92_N0.6210.26
48_V66_V0.6170.26
104_L117_E0.6150.26
74_A93_G0.6140.26
46_D210_V0.6130.25
59_S87_Q0.6130.25
46_D66_V0.6120.25
73_I144_R0.6070.25
116_G139_I0.6060.25
75_I137_D0.6060.25
133_T164_G0.6020.25
119_V210_V0.6020.25
73_I139_I0.6020.25
71_R194_R0.6010.25
108_P135_T0.6000.25
34_I38_L0.5990.25
114_M207_L0.5950.24
154_I178_E0.5920.24
18_S54_N0.5870.24
58_F72_V0.5870.24
107_K123_V0.5850.24
169_V184_N0.5840.24
16_I25_A0.5820.24
60_I92_N0.5810.24
161_A175_I0.5810.24
50_D53_A0.5790.24
36_S82_L0.5780.24
160_K167_N0.5780.24
105_Y160_K0.5770.24
105_Y145_L0.5750.23
188_V210_V0.5730.23
42_I171_Y0.5690.23
152_M177_M0.5680.23
157_A209_N0.5670.23
97_V125_E0.5650.23
36_S71_R0.5630.23
103_A124_S0.5630.23
111_R136_L0.5630.23
98_I145_L0.5620.23
104_L165_S0.5610.23
57_L155_E0.5600.23
95_N128_E0.5590.23
44_E70_G0.5580.23
153_D178_E0.5540.22
77_P103_A0.5530.22
52_G153_D0.5520.22
41_S97_V0.5520.22
208_R211_Y0.5510.22
79_P131_V0.5510.22
81_N190_E0.5500.22
81_N155_E0.5490.22
107_K167_N0.5470.22
187_Q191_I0.5440.22
55_I111_R0.5420.22
62_A66_V0.5410.22
137_D166_I0.5390.22
42_I132_E0.5370.21
47_V128_E0.5360.21
81_N85_L0.5350.21
197_F200_K0.5340.21
76_E153_D0.5320.21
134_T139_I0.5290.21
120_G188_V0.5270.21
181_D184_N0.5270.21
173_E198_K0.5250.21
118_G185_M0.5250.21
60_I63_S0.5240.21
74_A194_R0.5240.21
54_N186_K0.5230.21
116_G188_V0.5220.21
54_N59_S0.5210.21
13_A29_V0.5200.21
87_Q194_R0.5200.21
49_I116_G0.5180.21
35_Y58_F0.5170.21
29_V35_Y0.5160.20
64_F86_K0.5140.20
180_H209_N0.5140.20
84_I189_E0.5130.20
33_N109_G0.5120.20
164_G168_T0.5100.20
186_K189_E0.5090.20
126_D145_L0.5090.20
66_V72_V0.5070.20
100_I172_L0.5060.20
26_F84_I0.5060.20
113_N199_K0.5050.20
16_I156_G0.5040.20
90_E110_K0.5040.20
127_G134_T0.5010.20
196_K203_A0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2py6A 4 0.7674 100 0.4 Contact Map
3a27A 1 0.7287 98.3 0.845 Contact Map
2jjqA 1 0.686 98.1 0.852 Contact Map
3k6rA 1 0.7248 98 0.854 Contact Map
1wy7A 1 0.7597 98 0.854 Contact Map
1yzhA 1 0.7791 98 0.855 Contact Map
3e05A 4 0.7481 98 0.855 Contact Map
1o54A 4 0.7984 98 0.856 Contact Map
2fcaA 2 0.7829 98 0.857 Contact Map
3bt7A 1 0.7752 97.9 0.858 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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