GREMLIN Database
Q7LXF9 - Uncharacterized protein
UniProt: Q7LXF9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 244 (200)
Sequences: 303 (289)
Seq/√Len: 20.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_C195_I5.1561.00
131_V174_L4.1341.00
204_S225_Y4.0221.00
186_I195_I3.2981.00
116_S120_F3.2441.00
162_I194_I3.1791.00
117_P153_V3.1110.99
138_V155_V2.8460.99
109_I160_V2.7090.99
161_G191_C2.6850.98
116_S210_D2.6650.98
111_A141_M2.5530.98
188_C191_C2.4110.97
109_I188_C2.3810.97
138_V157_D2.3680.97
164_D173_K2.3480.96
106_V128_V2.3250.96
96_Y210_D2.2520.95
189_D210_D2.1980.95
143_E146_K2.1600.94
197_P201_E2.1250.94
172_P184_A2.0810.93
138_V142_R2.0380.92
112_G115_D2.0250.92
199_I204_S2.0160.92
112_G208_E1.9680.91
208_E229_V1.9120.89
111_A130_A1.8900.89
193_K225_Y1.8210.87
109_I195_I1.7490.84
171_W198_Y1.7040.83
172_P188_C1.6850.82
118_I144_N1.6660.81
115_D225_Y1.6650.81
170_S173_K1.6280.80
205_L214_K1.5920.78
172_P225_Y1.5570.77
205_L208_E1.5500.76
205_L232_T1.5490.76
103_G126_K1.5440.76
202_I225_Y1.5120.75
196_V200_K1.5000.74
131_V160_V1.4930.74
160_V170_S1.4920.74
104_K126_K1.4890.73
142_R155_V1.4470.71
171_W175_I1.4080.69
208_E214_K1.4080.69
184_A204_S1.3850.68
108_D185_K1.3730.67
144_N208_E1.3620.66
199_I202_I1.3410.65
124_G128_V1.3350.65
172_P204_S1.3240.64
212_N220_L1.2800.61
186_I205_L1.2650.60
104_K182_D1.2600.60
116_S209_W1.2520.60
107_L160_V1.2500.60
107_L210_D1.2500.60
154_I180_P1.2500.60
111_A155_V1.2440.59
172_P199_I1.2220.58
172_P198_Y1.2020.56
135_S157_D1.1950.56
145_L155_V1.1800.55
65_L68_D1.1720.55
144_N148_N1.1670.54
142_R158_K1.1610.54
217_V221_T1.1580.54
113_I130_A1.1510.53
121_S128_V1.1460.53
199_I214_K1.1160.51
112_G137_K1.1100.50
115_D120_F1.1040.50
112_G116_S1.0830.49
134_D169_I1.0750.48
36_R39_C1.0700.48
159_G213_Y1.0590.47
208_E227_V1.0530.47
188_C192_E1.0500.47
127_E180_P1.0410.46
161_G171_W1.0330.45
112_G126_K1.0310.45
208_E217_V1.0280.45
123_A169_I1.0240.45
41_L166_E1.0190.45
188_C210_D1.0130.44
115_D210_D0.9990.43
195_I208_E0.9940.43
133_V188_C0.9910.43
161_G169_I0.9820.42
160_V195_I0.9800.42
64_E67_E0.9780.42
186_I192_E0.9760.42
183_V188_C0.9730.42
119_Y144_N0.9670.41
185_K189_D0.9660.41
38_K41_L0.9640.41
183_V205_L0.9570.41
95_D98_R0.9550.40
207_I216_I0.9480.40
56_L162_I0.9460.40
184_A202_I0.9360.39
103_G182_D0.9360.39
152_N159_G0.9300.39
71_R76_G0.9300.39
145_L150_I0.9250.39
189_D192_E0.9230.38
110_G114_G0.9220.38
67_E107_L0.9220.38
124_G220_L0.9100.38
126_K182_D0.9090.38
138_V206_L0.9040.37
107_L148_N0.8940.37
109_I184_A0.8870.36
35_E39_C0.8820.36
60_L63_V0.8710.35
184_A205_L0.8660.35
133_V159_G0.8650.35
112_G217_V0.8650.35
172_P195_I0.8630.35
145_L149_S0.8610.35
187_D190_G0.8570.34
37_I46_L0.8550.34
133_V169_I0.8430.34
41_L45_Q0.8420.34
72_F163_K0.8400.33
199_I223_N0.8370.33
188_C208_E0.8360.33
112_G117_P0.8280.33
122_I135_S0.8260.33
35_E40_K0.8230.32
38_K46_L0.8200.32
84_W177_N0.8180.32
135_S145_L0.8160.32
182_D230_E0.8130.32
37_I41_L0.8050.31
124_G202_I0.7950.31
107_L209_W0.7930.31
135_S226_K0.7930.31
109_I208_E0.7900.31
144_N207_I0.7890.31
99_I151_N0.7890.31
106_V126_K0.7820.30
106_V202_I0.7810.30
49_L173_K0.7810.30
198_Y218_S0.7770.30
183_V204_S0.7770.30
89_P93_F0.7650.29
59_G63_V0.7650.29
144_N147_A0.7650.29
67_E122_I0.7640.29
113_I144_N0.7640.29
167_N195_I0.7590.29
133_V141_M0.7580.29
118_I122_I0.7560.29
156_V174_L0.7530.29
38_K48_Y0.7430.28
193_K219_N0.7430.28
112_G209_W0.7410.28
134_D137_K0.7400.28
87_S169_I0.7400.28
163_K177_N0.7380.28
110_G132_E0.7350.28
100_D135_S0.7320.27
188_C204_S0.7320.27
82_K120_F0.7220.27
79_I111_A0.7210.27
97_W106_V0.7200.27
209_W221_T0.7190.27
110_G187_D0.7170.27
109_I143_E0.7140.27
71_R75_N0.7120.26
172_P212_N0.7110.26
154_I200_K0.7110.26
104_K230_E0.7100.26
87_S226_K0.7090.26
103_G194_I0.7070.26
129_V164_D0.7040.26
138_V141_M0.7030.26
45_Q51_P0.7010.26
38_K42_R0.7010.26
118_I130_A0.7000.26
169_I228_K0.7000.26
209_W217_V0.6930.25
107_L174_L0.6870.25
49_L53_E0.6870.25
97_W104_K0.6850.25
102_R177_N0.6830.25
129_V174_L0.6810.25
166_E173_K0.6780.25
138_V164_D0.6760.25
187_D192_E0.6750.25
108_D145_L0.6730.24
209_W216_I0.6720.24
39_C107_L0.6710.24
130_A140_L0.6600.24
171_W195_I0.6570.24
35_E130_A0.6530.24
161_G167_N0.6520.23
204_S223_N0.6490.23
108_D114_G0.6480.23
137_K216_I0.6480.23
197_P221_T0.6470.23
88_Y111_A0.6440.23
116_S138_V0.6420.23
145_L153_V0.6410.23
186_I208_E0.6350.23
158_K202_I0.6330.23
37_I177_N0.6280.22
40_K220_L0.6260.22
98_R205_L0.6260.22
135_S165_D0.6210.22
37_I48_Y0.6190.22
143_E224_G0.6180.22
90_G213_Y0.6180.22
120_F152_N0.6160.22
35_E44_G0.6160.22
122_I224_G0.6140.22
184_A195_I0.6110.22
188_C216_I0.6100.22
62_I149_S0.6080.21
118_I148_N0.6080.21
128_V217_V0.6080.21
189_D209_W0.6030.21
228_K231_H0.6020.21
36_R52_N0.5980.21
146_K222_K0.5970.21
131_V223_N0.5970.21
81_L140_L0.5950.21
119_Y234_K0.5950.21
106_V124_G0.5950.21
130_A224_G0.5950.21
39_C42_R0.5940.21
129_V183_V0.5940.21
35_E128_V0.5910.21
106_V232_T0.5910.21
62_I65_L0.5900.21
118_I153_V0.5890.21
162_I220_L0.5880.21
106_V204_S0.5880.21
205_L220_L0.5880.21
101_V151_N0.5880.21
155_V186_I0.5860.20
108_D111_A0.5850.20
193_K212_N0.5850.20
119_Y225_Y0.5850.20
118_I231_H0.5830.20
127_E154_I0.5820.20
109_I186_I0.5810.20
153_V161_G0.5790.20
130_A141_M0.5760.20
136_K225_Y0.5760.20
79_I176_S0.5740.20
175_I198_Y0.5710.20
168_Y226_K0.5700.20
36_R42_R0.5690.20
129_V138_V0.5680.20
206_L210_D0.5650.20
70_V73_Q0.5630.20
195_I217_V0.5630.20
106_V119_Y0.5620.19
103_G106_V0.5590.19
102_R159_G0.5560.19
175_I213_Y0.5540.19
144_N150_I0.5530.19
199_I213_Y0.5520.19
168_Y194_I0.5510.19
131_V215_D0.5480.19
131_V155_V0.5460.19
198_Y204_S0.5450.19
117_P148_N0.5440.19
211_Y217_V0.5440.19
51_P169_I0.5440.19
78_E171_W0.5440.19
132_E190_G0.5430.19
84_W186_I0.5390.19
141_M155_V0.5380.19
170_S207_I0.5360.18
81_L180_P0.5360.18
56_L160_V0.5360.18
56_L109_I0.5320.18
205_L217_V0.5310.18
112_G133_V0.5300.18
109_I210_D0.5290.18
151_N165_D0.5290.18
126_K133_V0.5240.18
103_G125_A0.5170.18
36_R118_I0.5170.18
172_P202_I0.5140.18
153_V191_C0.5120.18
184_A187_D0.5090.17
36_R40_K0.5070.17
198_Y202_I0.5060.17
120_F138_V0.5050.17
59_G129_V0.5050.17
97_W224_G0.5030.17
168_Y200_K0.5020.17
121_S181_F0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2py6A 4 0.9631 100 0.539 Contact Map
3gnlA 1 0.6025 98.2 0.839 Contact Map
3kr9A 1 0.5984 98.2 0.84 Contact Map
3lecA 2 0.6107 98.2 0.84 Contact Map
2yxdA 4 0.6557 98.1 0.846 Contact Map
3opnA 1 0.6393 98 0.848 Contact Map
3k6rA 1 0.9057 98 0.849 Contact Map
3bzbA 1 0.6639 98 0.85 Contact Map
3evzA 1 0.7295 97.9 0.852 Contact Map
1l3iA 5 0.668 97.9 0.853 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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