GREMLIN Database
Q7LXF7 - Uncharacterized protein
UniProt: Q7LXF7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 321 (264)
Sequences: 14842 (13368)
Seq/√Len: 822.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_R85_D3.5711.00
163_R167_M3.5401.00
14_K44_Q2.9031.00
38_K58_Y2.8021.00
10_A45_I2.7671.00
70_L74_Q2.6481.00
96_E200_R2.6401.00
183_F187_C2.5661.00
19_D206_R2.4881.00
62_E66_G2.4281.00
46_D58_Y2.3771.00
46_D50_E2.3241.00
5_T77_G2.2811.00
106_I196_M2.2791.00
28_S95_R2.2421.00
90_S204_Y2.1231.00
18_K22_E2.1001.00
4_S98_I2.0811.00
50_E58_Y2.0761.00
33_E55_K2.0671.00
81_F94_I2.0431.00
7_I71_G2.0241.00
57_I74_Q2.0161.00
79_I101_F1.9881.00
44_Q47_S1.9821.00
19_D88_L1.9681.00
12_R42_D1.9191.00
114_E204_Y1.9051.00
100_K196_M1.9011.00
8_V34_I1.8961.00
89_F93_K1.8841.00
36_V49_L1.8791.00
37_V71_G1.8661.00
107_G162_S1.8511.00
18_K52_Y1.8301.00
46_D56_N1.8181.00
100_K198_D1.8161.00
88_L204_Y1.7741.00
10_A36_V1.7621.00
81_F93_K1.7551.00
18_K51_T1.7201.00
8_V20_A1.7201.00
81_F160_V1.7071.00
22_E52_Y1.7061.00
97_V160_V1.6991.00
107_G193_L1.6931.00
57_I70_L1.6911.00
59_T62_E1.6891.00
5_T33_E1.6451.00
33_E77_G1.6391.00
29_L98_I1.6371.00
83_L89_F1.6321.00
70_L73_Y1.6101.00
68_I84_D1.6041.00
4_S94_I1.5681.00
97_V111_N1.5441.00
92_D96_E1.5371.00
14_K48_F1.5281.00
3_R78_D1.5201.00
73_Y171_D1.5151.00
11_H61_D1.5121.00
59_T70_L1.5081.00
93_K97_V1.4941.00
55_K74_Q1.4901.00
95_R99_Y1.4701.00
88_L206_R1.4631.00
164_D168_R1.4571.00
38_K41_K1.4511.00
4_S160_V1.4401.00
18_K48_F1.4241.00
116_I204_Y1.4141.00
22_E26_E1.4141.00
81_F89_F1.4041.00
75_S163_R1.4031.00
165_L193_L1.4001.00
64_L180_V1.3981.00
64_L212_N1.3961.00
80_L163_R1.3831.00
29_L32_T1.3671.00
8_V24_V1.3661.00
68_I82_F1.3641.00
34_I54_V1.3611.00
79_I160_V1.3351.00
10_A13_R1.3281.00
101_F109_Y1.3201.00
114_E201_K1.3181.00
72_I82_F1.3021.00
40_F59_T1.2971.00
108_F195_I1.2941.00
165_L188_A1.2881.00
101_F160_V1.2831.00
24_V83_L1.2811.00
98_I102_S1.2781.00
78_D162_S1.2701.00
59_T66_G1.2671.00
38_K46_D1.2591.00
13_R16_F1.2451.00
20_A83_L1.2431.00
37_V67_K1.2431.00
159_I185_L1.2391.00
113_Q157_S1.2261.00
93_K111_N1.2131.00
32_T94_I1.2071.00
48_F52_Y1.2061.00
39_N61_D1.2051.00
100_K104_Y1.2031.00
65_G180_V1.1991.00
73_Y172_L1.1931.00
21_I34_I1.1921.00
21_I52_Y1.1891.00
111_N202_L1.1681.00
88_L116_I1.1681.00
33_E76_S1.1671.00
66_G174_K1.1641.00
96_E99_Y1.1631.00
26_E91_K1.1511.00
97_V109_Y1.1501.00
166_A184_L1.1431.00
93_K202_L1.1381.00
21_I36_V1.1361.00
64_L68_I1.1271.00
72_I80_L1.1211.00
208_I211_Q1.1151.00
92_D95_R1.1151.00
49_L56_N1.1121.00
5_T35_I1.1101.00
66_G70_L1.1091.00
39_N67_K1.0951.00
10_A85_D1.0941.00
72_I166_A1.0871.00
12_R41_K1.0841.00
6_V24_V1.0781.00
104_Y196_M1.0621.00
22_E25_M1.0571.00
10_A49_L1.0541.00
100_K103_K1.0531.00
164_D167_M1.0521.00
25_M54_V1.0481.00
47_S50_E1.0451.00
55_K76_S1.0441.00
112_A197_I1.0411.00
25_M53_H1.0301.00
105_D194_P1.0281.00
62_E67_K1.0241.00
10_A17_I1.0231.00
72_I75_S1.0111.00
68_I180_V1.0071.00
100_K109_Y1.0021.00
173_L183_F1.0011.00
99_Y103_K1.0001.00
64_L156_G0.9981.00
5_T75_S0.9951.00
173_L176_V0.9911.00
108_F188_A0.9901.00
4_S81_F0.9691.00
39_N63_T0.9681.00
9_T67_K0.9671.00
32_T53_H0.9641.00
107_G194_P0.9621.00
168_R191_N0.9561.00
3_R76_S0.9501.00
50_E56_N0.9471.00
23_S89_F0.9411.00
46_D49_L0.9381.00
21_I25_M0.9381.00
16_F206_R0.9371.00
90_S114_E0.9351.00
139_D142_R0.9331.00
211_Q214_N0.9211.00
96_E202_L0.9181.00
227_E231_Y0.9151.00
96_E100_K0.9111.00
66_G175_N0.9051.00
28_S92_D0.9051.00
224_M228_D0.9031.00
161_I185_L0.9021.00
162_S165_L0.8961.00
64_L67_K0.8871.00
168_R193_L0.8851.00
6_V32_T0.8821.00
47_S51_T0.8741.00
9_T85_D0.8601.00
29_L94_I0.8591.00
65_G69_S0.8581.00
96_E198_D0.8511.00
24_V89_F0.8471.00
67_K70_L0.8471.00
6_V94_I0.8431.00
116_I206_R0.8431.00
140_T144_K0.8401.00
3_R31_P0.8351.00
90_S93_K0.8351.00
13_R208_I0.8341.00
25_M52_Y0.8311.00
62_E70_L0.8301.00
3_R77_G0.8271.00
138_I142_R0.8191.00
75_S80_L0.8181.00
42_D45_I0.8171.00
20_A23_S0.8121.00
64_L84_D0.8091.00
224_M227_E0.8061.00
3_R102_S0.7941.00
122_G125_L0.7831.00
184_L188_A0.7791.00
90_S202_L0.7781.00
79_I98_I0.7771.00
97_V101_F0.7721.00
36_V54_V0.7701.00
161_I166_A0.7691.00
169_C188_A0.7691.00
101_F106_I0.7681.00
28_S91_K0.7661.00
157_S203_T0.7641.00
44_Q48_F0.7641.00
110_H159_I0.7621.00
223_K227_E0.7581.00
115_V207_I0.7561.00
232_F235_I0.7511.00
23_S88_L0.7441.00
143_L147_L0.7421.00
9_T39_N0.7411.00
39_N62_E0.7371.00
83_L203_T0.7371.00
228_D231_Y0.7351.00
141_R144_K0.7341.00
179_S182_T0.7301.00
20_A87_D0.7221.00
156_G159_I0.7171.00
110_H197_I0.7171.00
17_I49_L0.7161.00
109_Y160_V0.7131.00
6_V81_F0.7091.00
35_I74_Q0.7071.00
89_F94_I0.7061.00
9_T68_I0.7041.00
24_V34_I0.7041.00
35_I71_G0.7031.00
226_Y230_L0.7031.00
78_D102_S0.7021.00
20_A24_V0.7001.00
229_A233_K0.6951.00
269_A273_M0.6921.00
37_V70_L0.6911.00
55_K58_Y0.6881.00
231_Y234_Q0.6861.00
78_D164_D0.6841.00
35_I75_S0.6801.00
69_S171_D0.6781.00
72_I171_D0.6761.00
40_F61_D0.6721.00
25_M34_I0.6711.00
266_K269_A0.6701.00
231_Y235_I0.6671.00
98_I101_F0.6661.00
169_C191_N0.6621.00
106_I194_P0.6601.00
207_I214_N0.6581.00
161_I188_A0.6571.00
171_D184_L0.6541.00
242_R246_E0.6531.00
123_S126_S0.6531.00
31_P53_H0.6511.00
105_D162_S0.6481.00
35_I55_K0.6481.00
104_Y194_P0.6431.00
48_F51_T0.6421.00
112_A199_F0.6401.00
79_I162_S0.6401.00
69_S174_K0.6381.00
227_E230_L0.6381.00
81_F111_N0.6361.00
98_I160_V0.6341.00
10_A38_K0.6341.00
8_V85_D0.6321.00
137_S141_R0.6321.00
113_Q158_S0.6311.00
7_I75_S0.6261.00
3_R32_T0.6241.00
228_D232_F0.6241.00
8_V83_L0.6241.00
14_K43_Y0.6221.00
17_I45_I0.6211.00
4_S29_L0.6161.00
170_V173_L0.6151.00
150_F194_P0.6131.00
27_N89_F0.6121.00
13_R64_L0.6071.00
14_K45_I0.6061.00
232_F236_F0.6051.00
109_Y198_D0.6051.00
20_A85_D0.6031.00
14_K17_I0.6021.00
82_F172_L0.6011.00
156_G172_L0.6011.00
3_R29_L0.6001.00
7_I82_F0.5981.00
41_K45_I0.5961.00
110_H154_F0.5961.00
112_A201_K0.5941.00
142_R145_E0.5941.00
138_I141_R0.5931.00
17_I48_F0.5911.00
106_I109_Y0.5871.00
213_S216_E0.5871.00
230_L234_Q0.5861.00
69_S172_L0.5861.00
24_V36_V0.5851.00
27_N95_R0.5841.00
141_R145_E0.5841.00
59_T67_K0.5841.00
4_S101_F0.5831.00
198_D202_L0.5821.00
124_N127_T0.5791.00
234_Q238_S0.5791.00
80_L166_A0.5791.00
89_F203_T0.5781.00
166_A171_D0.5771.00
3_R98_I0.5771.00
40_F60_D0.5761.00
32_T76_S0.5741.00
137_S140_T0.5731.00
139_D144_K0.5721.00
136_T139_D0.5711.00
192_N195_I0.5711.00
17_I85_D0.5701.00
198_D201_K0.5651.00
259_I263_E0.5651.00
165_L169_C0.5641.00
20_A86_D0.5631.00
13_R20_A0.5631.00
21_I54_V0.5621.00
16_F20_A0.5611.00
27_N94_I0.5601.00
81_F158_S0.5571.00
12_R45_I0.5561.00
235_I238_S0.5561.00
16_F208_I0.5561.00
190_E235_I0.5541.00
20_A88_L0.5521.00
39_N84_D0.5521.00
134_Y137_S0.5501.00
14_K18_K0.5471.00
248_S251_Q0.5451.00
30_K53_H0.5441.00
84_D180_V0.5431.00
9_T64_L0.5421.00
7_I80_L0.5411.00
165_L192_N0.5411.00
19_D22_E0.5401.00
100_K106_I0.5391.00
11_H39_N0.5381.00
182_T186_F0.5371.00
142_R146_L0.5371.00
209_M212_N0.5371.00
233_K237_S0.5361.00
221_L224_M0.5341.00
87_D203_T0.5331.00
14_K47_S0.5331.00
244_F248_S0.5331.00
224_M231_Y0.5311.00
21_I49_L0.5311.00
25_M32_T0.5301.00
3_R33_E0.5301.00
165_L191_N0.5291.00
155_N158_S0.5291.00
163_R166_A0.5251.00
101_F162_S0.5211.00
137_S142_R0.5211.00
81_F97_V0.5211.00
265_S269_A0.5201.00
49_L54_V0.5201.00
37_V57_I0.5201.00
234_Q237_S0.5161.00
49_L58_Y0.5161.00
260_S263_E0.5141.00
155_N182_T0.5141.00
269_A272_S0.5141.00
92_D202_L0.5121.00
246_E249_I0.5091.00
108_F159_I0.5091.00
173_L187_C0.5081.00
8_V21_I0.5081.00
265_S268_D0.5071.00
135_Y138_I0.5051.00
12_R43_Y0.5051.00
183_F186_F0.5041.00
208_I214_N0.5041.00
37_V74_Q0.5031.00
102_S162_S0.5031.00
243_D247_M0.5031.00
226_Y231_Y0.5021.00
161_I184_L0.5021.00
154_F182_T0.5011.00
99_Y102_S0.5011.00
208_I212_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bcvA 2 0.5514 100 0.306 Contact Map
3l7iA 4 0.0561 100 0.328 Contact Map
1qg8A 1 0.676 100 0.352 Contact Map
2z86A 2 0.7664 100 0.352 Contact Map
1xhbA 1 0.9564 100 0.367 Contact Map
2d7iA 1 0.9751 100 0.38 Contact Map
5ajoA 1 0.9938 100 0.39 Contact Map
4fixA 3 0.9844 100 0.422 Contact Map
4p02A 1 0.9875 100 0.466 Contact Map
2nxvA 4 0.704 100 0.467 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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