Q7LXF7 - SULSO - GREMLIN Contacts

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Q7LXF7 - Uncharacterized protein

UniProt:	Q7LXF7	Sequences: MLRSTVIVTAHRRKAFIKDAIESVMENSLKPTEIIVVKNFKDYQIDSFLETYHVKNIYTDDETLGGKISLGIYQSSGDILFFLDDDDLFSKDKIREVIYKFSKYDIGFYHNAQEVIHNKLTGSNLSTDNQRFMYYTSIDTRRLKELLYKFKAGFNGSSIVISRDLAMRCVDLLKNVNISVDTFLLFCAVENNLPIMIDFRKLTYYRIIMSQNSNTEVNDKLFKMLYEDALYFKQIFSSKALRDFIEMSIIQHDFLYKIISKKEISKRDALISMVKMLRYSLKYPNKWNFFLQGLSLLSVFSAEKSRSLYLKKVRSNSMLSI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	321 (264)
Sequences:	14842 (13368)
Seq/√Len:	822.8

ECOLI - YIBD WCAA WCAE WBBL GTRB ARNC PGAC YAIP
BACSU - GGAA EPSJ CGED EPSH GGAB YFNE EPSE SPSA TUAG YWDF YKCC TAGF YKOT CSBB YDAM
HALSA - Q9HQP4 Q9HQP8 Q9HSC8 Q9HNK3 Q9HQP3 Q9HQQ6 Q9HR08 Q9HSB1
SULSO - Q7LXF7 Q97TZ0 Q7LXG6 Q97TY0 Q97X05 Q97YG5 Q97YN4 Q7LXY2 Q97WK7 Q97YM4 Q97UK7 Q97W52

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
13_R	85_D	3.571	1.00
163_R	167_M	3.540	1.00
14_K	44_Q	2.903	1.00
38_K	58_Y	2.802	1.00
10_A	45_I	2.767	1.00
70_L	74_Q	2.648	1.00
96_E	200_R	2.640	1.00
183_F	187_C	2.566	1.00
19_D	206_R	2.488	1.00
62_E	66_G	2.428	1.00
46_D	58_Y	2.377	1.00
46_D	50_E	2.324	1.00
5_T	77_G	2.281	1.00
106_I	196_M	2.279	1.00
28_S	95_R	2.242	1.00
90_S	204_Y	2.123	1.00
18_K	22_E	2.100	1.00
4_S	98_I	2.081	1.00
50_E	58_Y	2.076	1.00
33_E	55_K	2.067	1.00
81_F	94_I	2.043	1.00
7_I	71_G	2.024	1.00
57_I	74_Q	2.016	1.00
79_I	101_F	1.988	1.00
44_Q	47_S	1.982	1.00
19_D	88_L	1.968	1.00
12_R	42_D	1.919	1.00
114_E	204_Y	1.905	1.00
100_K	196_M	1.901	1.00
8_V	34_I	1.896	1.00
89_F	93_K	1.884	1.00
36_V	49_L	1.879	1.00
37_V	71_G	1.866	1.00
107_G	162_S	1.851	1.00
18_K	52_Y	1.830	1.00
46_D	56_N	1.818	1.00
100_K	198_D	1.816	1.00
88_L	204_Y	1.774	1.00
10_A	36_V	1.762	1.00
81_F	93_K	1.755	1.00
18_K	51_T	1.720	1.00
8_V	20_A	1.720	1.00
81_F	160_V	1.707	1.00
22_E	52_Y	1.706	1.00
97_V	160_V	1.699	1.00
107_G	193_L	1.693	1.00
57_I	70_L	1.691	1.00
59_T	62_E	1.689	1.00
5_T	33_E	1.645	1.00
33_E	77_G	1.639	1.00
29_L	98_I	1.637	1.00
83_L	89_F	1.632	1.00
70_L	73_Y	1.610	1.00
68_I	84_D	1.604	1.00
4_S	94_I	1.568	1.00
97_V	111_N	1.544	1.00
92_D	96_E	1.537	1.00
14_K	48_F	1.528	1.00
3_R	78_D	1.520	1.00
73_Y	171_D	1.515	1.00
11_H	61_D	1.512	1.00
59_T	70_L	1.508	1.00
93_K	97_V	1.494	1.00
55_K	74_Q	1.490	1.00
95_R	99_Y	1.470	1.00
88_L	206_R	1.463	1.00
164_D	168_R	1.457	1.00
38_K	41_K	1.451	1.00
4_S	160_V	1.440	1.00
18_K	48_F	1.424	1.00
116_I	204_Y	1.414	1.00
22_E	26_E	1.414	1.00
81_F	89_F	1.404	1.00
75_S	163_R	1.403	1.00
165_L	193_L	1.400	1.00
64_L	180_V	1.398	1.00
64_L	212_N	1.396	1.00
80_L	163_R	1.383	1.00
29_L	32_T	1.367	1.00
8_V	24_V	1.366	1.00
68_I	82_F	1.364	1.00
34_I	54_V	1.361	1.00
79_I	160_V	1.335	1.00
10_A	13_R	1.328	1.00
101_F	109_Y	1.320	1.00
114_E	201_K	1.318	1.00
72_I	82_F	1.302	1.00
40_F	59_T	1.297	1.00
108_F	195_I	1.294	1.00
165_L	188_A	1.288	1.00
101_F	160_V	1.283	1.00
24_V	83_L	1.281	1.00
98_I	102_S	1.278	1.00
78_D	162_S	1.270	1.00
59_T	66_G	1.267	1.00
38_K	46_D	1.259	1.00
13_R	16_F	1.245	1.00
20_A	83_L	1.243	1.00
37_V	67_K	1.243	1.00
159_I	185_L	1.239	1.00
113_Q	157_S	1.226	1.00
93_K	111_N	1.213	1.00
32_T	94_I	1.207	1.00
48_F	52_Y	1.206	1.00
39_N	61_D	1.205	1.00
100_K	104_Y	1.203	1.00
65_G	180_V	1.199	1.00
73_Y	172_L	1.193	1.00
21_I	34_I	1.192	1.00
21_I	52_Y	1.189	1.00
111_N	202_L	1.168	1.00
88_L	116_I	1.168	1.00
33_E	76_S	1.167	1.00
66_G	174_K	1.164	1.00
96_E	99_Y	1.163	1.00
26_E	91_K	1.151	1.00
97_V	109_Y	1.150	1.00
166_A	184_L	1.143	1.00
93_K	202_L	1.138	1.00
21_I	36_V	1.136	1.00
64_L	68_I	1.127	1.00
72_I	80_L	1.121	1.00
208_I	211_Q	1.115	1.00
92_D	95_R	1.115	1.00
49_L	56_N	1.112	1.00
5_T	35_I	1.110	1.00
66_G	70_L	1.109	1.00
39_N	67_K	1.095	1.00
10_A	85_D	1.094	1.00
72_I	166_A	1.087	1.00
12_R	41_K	1.084	1.00
6_V	24_V	1.078	1.00
104_Y	196_M	1.062	1.00
22_E	25_M	1.057	1.00
10_A	49_L	1.054	1.00
100_K	103_K	1.053	1.00
164_D	167_M	1.052	1.00
25_M	54_V	1.048	1.00
47_S	50_E	1.045	1.00
55_K	76_S	1.044	1.00
112_A	197_I	1.041	1.00
25_M	53_H	1.030	1.00
105_D	194_P	1.028	1.00
62_E	67_K	1.024	1.00
10_A	17_I	1.023	1.00
72_I	75_S	1.011	1.00
68_I	180_V	1.007	1.00
100_K	109_Y	1.002	1.00
173_L	183_F	1.001	1.00
99_Y	103_K	1.000	1.00
64_L	156_G	0.998	1.00
5_T	75_S	0.995	1.00
173_L	176_V	0.991	1.00
108_F	188_A	0.990	1.00
4_S	81_F	0.969	1.00
39_N	63_T	0.968	1.00
9_T	67_K	0.967	1.00
32_T	53_H	0.964	1.00
107_G	194_P	0.962	1.00
168_R	191_N	0.956	1.00
3_R	76_S	0.950	1.00
50_E	56_N	0.947	1.00
23_S	89_F	0.941	1.00
46_D	49_L	0.938	1.00
21_I	25_M	0.938	1.00
16_F	206_R	0.937	1.00
90_S	114_E	0.935	1.00
139_D	142_R	0.933	1.00
211_Q	214_N	0.921	1.00
96_E	202_L	0.918	1.00
227_E	231_Y	0.915	1.00
96_E	100_K	0.911	1.00
66_G	175_N	0.905	1.00
28_S	92_D	0.905	1.00
224_M	228_D	0.903	1.00
161_I	185_L	0.902	1.00
162_S	165_L	0.896	1.00
64_L	67_K	0.887	1.00
168_R	193_L	0.885	1.00
6_V	32_T	0.882	1.00
47_S	51_T	0.874	1.00
9_T	85_D	0.860	1.00
29_L	94_I	0.859	1.00
65_G	69_S	0.858	1.00
96_E	198_D	0.851	1.00
24_V	89_F	0.847	1.00
67_K	70_L	0.847	1.00
6_V	94_I	0.843	1.00
116_I	206_R	0.843	1.00
140_T	144_K	0.840	1.00
3_R	31_P	0.835	1.00
90_S	93_K	0.835	1.00
13_R	208_I	0.834	1.00
25_M	52_Y	0.831	1.00
62_E	70_L	0.830	1.00
3_R	77_G	0.827	1.00
138_I	142_R	0.819	1.00
75_S	80_L	0.818	1.00
42_D	45_I	0.817	1.00
20_A	23_S	0.812	1.00
64_L	84_D	0.809	1.00
224_M	227_E	0.806	1.00
3_R	102_S	0.794	1.00
122_G	125_L	0.783	1.00
184_L	188_A	0.779	1.00
90_S	202_L	0.778	1.00
79_I	98_I	0.777	1.00
97_V	101_F	0.772	1.00
36_V	54_V	0.770	1.00
161_I	166_A	0.769	1.00
169_C	188_A	0.769	1.00
101_F	106_I	0.768	1.00
28_S	91_K	0.766	1.00
157_S	203_T	0.764	1.00
44_Q	48_F	0.764	1.00
110_H	159_I	0.762	1.00
223_K	227_E	0.758	1.00
115_V	207_I	0.756	1.00
232_F	235_I	0.751	1.00
23_S	88_L	0.744	1.00
143_L	147_L	0.742	1.00
9_T	39_N	0.741	1.00
39_N	62_E	0.737	1.00
83_L	203_T	0.737	1.00
228_D	231_Y	0.735	1.00
141_R	144_K	0.734	1.00
179_S	182_T	0.730	1.00
20_A	87_D	0.722	1.00
156_G	159_I	0.717	1.00
110_H	197_I	0.717	1.00
17_I	49_L	0.716	1.00
109_Y	160_V	0.713	1.00
6_V	81_F	0.709	1.00
35_I	74_Q	0.707	1.00
89_F	94_I	0.706	1.00
9_T	68_I	0.704	1.00
24_V	34_I	0.704	1.00
35_I	71_G	0.703	1.00
226_Y	230_L	0.703	1.00
78_D	102_S	0.702	1.00
20_A	24_V	0.700	1.00
229_A	233_K	0.695	1.00
269_A	273_M	0.692	1.00
37_V	70_L	0.691	1.00
55_K	58_Y	0.688	1.00
231_Y	234_Q	0.686	1.00
78_D	164_D	0.684	1.00
35_I	75_S	0.680	1.00
69_S	171_D	0.678	1.00
72_I	171_D	0.676	1.00
40_F	61_D	0.672	1.00
25_M	34_I	0.671	1.00
266_K	269_A	0.670	1.00
231_Y	235_I	0.667	1.00
98_I	101_F	0.666	1.00
169_C	191_N	0.662	1.00
106_I	194_P	0.660	1.00
207_I	214_N	0.658	1.00
161_I	188_A	0.657	1.00
171_D	184_L	0.654	1.00
242_R	246_E	0.653	1.00
123_S	126_S	0.653	1.00
31_P	53_H	0.651	1.00
105_D	162_S	0.648	1.00
35_I	55_K	0.648	1.00
104_Y	194_P	0.643	1.00
48_F	51_T	0.642	1.00
112_A	199_F	0.640	1.00
79_I	162_S	0.640	1.00
69_S	174_K	0.638	1.00
227_E	230_L	0.638	1.00
81_F	111_N	0.636	1.00
98_I	160_V	0.634	1.00
10_A	38_K	0.634	1.00
8_V	85_D	0.632	1.00
137_S	141_R	0.632	1.00
113_Q	158_S	0.631	1.00
7_I	75_S	0.626	1.00
3_R	32_T	0.624	1.00
228_D	232_F	0.624	1.00
8_V	83_L	0.624	1.00
14_K	43_Y	0.622	1.00
17_I	45_I	0.621	1.00
4_S	29_L	0.616	1.00
170_V	173_L	0.615	1.00
150_F	194_P	0.613	1.00
27_N	89_F	0.612	1.00
13_R	64_L	0.607	1.00
14_K	45_I	0.606	1.00
232_F	236_F	0.605	1.00
109_Y	198_D	0.605	1.00
20_A	85_D	0.603	1.00
14_K	17_I	0.602	1.00
82_F	172_L	0.601	1.00
156_G	172_L	0.601	1.00
3_R	29_L	0.600	1.00
7_I	82_F	0.598	1.00
41_K	45_I	0.596	1.00
110_H	154_F	0.596	1.00
112_A	201_K	0.594	1.00
142_R	145_E	0.594	1.00
138_I	141_R	0.593	1.00
17_I	48_F	0.591	1.00
106_I	109_Y	0.587	1.00
213_S	216_E	0.587	1.00
230_L	234_Q	0.586	1.00
69_S	172_L	0.586	1.00
24_V	36_V	0.585	1.00
27_N	95_R	0.584	1.00
141_R	145_E	0.584	1.00
59_T	67_K	0.584	1.00
4_S	101_F	0.583	1.00
198_D	202_L	0.582	1.00
124_N	127_T	0.579	1.00
234_Q	238_S	0.579	1.00
80_L	166_A	0.579	1.00
89_F	203_T	0.578	1.00
166_A	171_D	0.577	1.00
3_R	98_I	0.577	1.00
40_F	60_D	0.576	1.00
32_T	76_S	0.574	1.00
137_S	140_T	0.573	1.00
139_D	144_K	0.572	1.00
136_T	139_D	0.571	1.00
192_N	195_I	0.571	1.00
17_I	85_D	0.570	1.00
198_D	201_K	0.565	1.00
259_I	263_E	0.565	1.00
165_L	169_C	0.564	1.00
20_A	86_D	0.563	1.00
13_R	20_A	0.563	1.00
21_I	54_V	0.562	1.00
16_F	20_A	0.561	1.00
27_N	94_I	0.560	1.00
81_F	158_S	0.557	1.00
12_R	45_I	0.556	1.00
235_I	238_S	0.556	1.00
16_F	208_I	0.556	1.00
190_E	235_I	0.554	1.00
20_A	88_L	0.552	1.00
39_N	84_D	0.552	1.00
134_Y	137_S	0.550	1.00
14_K	18_K	0.547	1.00
248_S	251_Q	0.545	1.00
30_K	53_H	0.544	1.00
84_D	180_V	0.543	1.00
9_T	64_L	0.542	1.00
7_I	80_L	0.541	1.00
165_L	192_N	0.541	1.00
19_D	22_E	0.540	1.00
100_K	106_I	0.539	1.00
11_H	39_N	0.538	1.00
182_T	186_F	0.537	1.00
142_R	146_L	0.537	1.00
209_M	212_N	0.537	1.00
233_K	237_S	0.536	1.00
221_L	224_M	0.534	1.00
87_D	203_T	0.533	1.00
14_K	47_S	0.533	1.00
244_F	248_S	0.533	1.00
224_M	231_Y	0.531	1.00
21_I	49_L	0.531	1.00
25_M	32_T	0.530	1.00
3_R	33_E	0.530	1.00
165_L	191_N	0.529	1.00
155_N	158_S	0.529	1.00
163_R	166_A	0.525	1.00
101_F	162_S	0.521	1.00
137_S	142_R	0.521	1.00
81_F	97_V	0.521	1.00
265_S	269_A	0.520	1.00
49_L	54_V	0.520	1.00
37_V	57_I	0.520	1.00
234_Q	237_S	0.516	1.00
49_L	58_Y	0.516	1.00
260_S	263_E	0.514	1.00
155_N	182_T	0.514	1.00
269_A	272_S	0.514	1.00
92_D	202_L	0.512	1.00
246_E	249_I	0.509	1.00
108_F	159_I	0.509	1.00
173_L	187_C	0.508	1.00
8_V	21_I	0.508	1.00
265_S	268_D	0.507	1.00
135_Y	138_I	0.505	1.00
12_R	43_Y	0.505	1.00
183_F	186_F	0.504	1.00
208_I	214_N	0.504	1.00
37_V	74_Q	0.503	1.00
102_S	162_S	0.503	1.00
243_D	247_M	0.503	1.00
226_Y	231_Y	0.502	1.00
161_I	184_L	0.502	1.00
154_F	182_T	0.501	1.00
99_Y	102_S	0.501	1.00
208_I	212_N	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bcvA	2	0.5514	100	0.306	Contact Map
3l7iA	4	0.0561	100	0.328	Contact Map
1qg8A	1	0.676	100	0.352	Contact Map
2z86A	2	0.7664	100	0.352	Contact Map
1xhbA	1	0.9564	100	0.367	Contact Map
2d7iA	1	0.9751	100	0.38	Contact Map
5ajoA	1	0.9938	100	0.39	Contact Map
4fixA	3	0.9844	100	0.422	Contact Map
4p02A	1	0.9875	100	0.466	Contact Map
2nxvA	4	0.704	100	0.467	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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