GREMLIN Database
Q7LXF6 - Uncharacterized protein
UniProt: Q7LXF6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 307 (254)
Sequences: 242 (233)
Seq/√Len: 14.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_Q247_N5.7421.00
237_C244_F4.4031.00
156_I221_L3.7311.00
184_A215_S3.5040.99
219_Q279_F3.4690.99
136_A166_A3.0420.98
247_N279_F2.9460.97
238_E264_H2.9310.97
219_Q249_D2.6730.95
262_E268_S2.6360.95
136_A155_A2.5960.94
190_I212_T2.3450.91
141_S264_H2.3280.90
137_A262_E2.2680.89
134_C185_C2.2460.89
186_G191_V2.1660.87
233_L253_L2.1220.86
233_L247_N2.0980.85
235_L244_F2.0730.84
235_L262_E2.0650.84
137_A140_D1.9920.82
233_L259_I1.9890.82
160_P211_Y1.9840.81
156_I185_C1.9840.81
253_L277_A1.9800.81
186_G240_C1.9680.81
184_A213_V1.9400.80
151_K231_S1.9390.80
192_T212_T1.9220.79
253_L256_F1.9210.79
259_I262_E1.8960.78
89_D94_K1.8690.77
133_D234_K1.8680.77
233_L249_D1.8380.76
144_Y279_F1.8250.75
158_A193_V1.8220.75
91_N94_K1.8180.75
129_K258_Q1.7600.73
186_G215_S1.7520.72
237_C262_E1.7330.72
256_F279_F1.7140.71
218_L252_T1.6990.70
142_A178_I1.6960.70
219_Q233_L1.6800.69
131_V153_V1.6510.68
128_D151_K1.6460.67
143_I169_N1.6090.66
181_V221_L1.6040.65
134_C262_E1.6020.65
163_A167_E1.5990.65
134_C244_F1.5990.65
193_V240_C1.5790.64
33_P37_A1.5630.63
262_E271_K1.5550.63
137_A253_L1.5050.60
253_L263_Y1.5040.60
190_I214_P1.5010.60
136_A175_F1.4740.59
235_L241_E1.4620.58
244_F282_K1.4550.58
168_E171_K1.4300.56
134_C237_C1.3980.54
121_Y184_A1.3960.54
129_K231_S1.3860.54
232_V237_C1.3840.54
232_V235_L1.3780.53
135_G139_G1.3430.51
141_S145_F1.3390.51
134_C235_L1.3270.51
236_D239_G1.3250.50
233_L279_F1.3200.50
168_E185_C1.3130.50
135_G157_E1.3020.49
131_V145_F1.3010.49
250_S254_E1.2940.49
140_D263_Y1.2810.48
163_A180_I1.2510.46
244_F259_I1.2420.46
143_I173_N1.2400.46
167_E180_I1.2310.45
163_A188_D1.2290.45
183_A216_F1.2250.45
238_E245_L1.2130.44
237_C247_N1.2100.44
235_L264_H1.2100.44
244_F262_E1.2070.44
198_G201_P1.1930.43
129_K151_K1.1900.43
234_K238_E1.1880.43
134_C137_A1.1840.43
217_S220_G1.1810.42
242_Y273_K1.1690.42
171_K218_L1.1400.40
53_N57_V1.1400.40
132_I185_C1.1360.40
259_I274_L1.1290.40
137_A268_S1.1290.40
233_L262_E1.1270.40
35_I38_L1.1240.39
111_D114_G1.1040.38
159_Y162_I1.1020.38
91_N95_I1.1020.38
160_P213_V1.0990.38
37_A42_L1.0960.38
132_I263_Y1.0830.37
262_E281_V1.0820.37
94_K279_F1.0800.37
170_V193_V1.0730.37
144_Y169_N1.0710.37
238_E241_E1.0710.37
236_D262_E1.0710.37
132_I227_V1.0640.36
273_K277_A1.0420.35
89_D98_D1.0370.35
259_I268_S1.0320.35
219_Q253_L1.0290.35
48_V278_G1.0280.34
128_D164_K1.0240.34
241_E245_L1.0240.34
60_T165_I1.0200.34
163_A182_N1.0160.34
271_K275_E1.0130.34
129_K284_T1.0130.34
141_S253_L1.0110.34
169_N173_N1.0100.34
244_F265_Y1.0090.34
252_T281_V1.0090.34
111_D134_C0.9920.33
160_P182_N0.9870.32
186_G227_V0.9850.32
231_S262_E0.9830.32
262_E274_L0.9790.32
33_P40_S0.9790.32
264_H270_L0.9730.32
149_G153_V0.9680.32
170_V175_F0.9640.31
140_D261_M0.9640.31
249_D279_F0.9630.31
39_K43_R0.9630.31
166_A247_N0.9610.31
237_C241_E0.9590.31
213_V255_Y0.9490.31
188_D217_S0.9430.30
202_T209_N0.9420.30
216_F245_L0.9420.30
268_S271_K0.9370.30
242_Y279_F0.9320.30
237_C240_C0.9220.29
205_M279_F0.9210.29
60_T69_Y0.9130.29
177_N184_A0.9120.29
170_V206_S0.9120.29
89_D95_I0.9080.29
131_V231_S0.9070.29
154_I182_N0.9010.28
167_E171_K0.9000.28
133_D241_E0.8880.28
175_F178_I0.8860.28
184_A218_L0.8810.28
131_V149_G0.8790.27
185_C221_L0.8780.27
135_G239_G0.8770.27
261_M268_S0.8760.27
257_D280_K0.8740.27
205_M209_N0.8650.27
150_A237_C0.8640.27
134_C266_G0.8630.27
236_D264_H0.8540.26
188_D220_G0.8490.26
122_Q218_L0.8480.26
217_S280_K0.8470.26
54_G254_E0.8410.26
87_D154_I0.8410.26
183_A214_P0.8400.26
147_L242_Y0.8400.26
235_L268_S0.8390.26
152_R179_Q0.8350.26
169_N172_L0.8330.25
87_D214_P0.8310.25
149_G184_A0.8280.25
140_D145_F0.8230.25
139_G157_E0.8230.25
138_I286_P0.8190.25
156_I181_V0.8170.25
163_A171_K0.8080.24
148_K256_F0.8030.24
135_G234_K0.8020.24
219_Q237_C0.7980.24
133_D157_E0.7940.24
232_V260_I0.7920.24
133_D139_G0.7910.24
34_L41_L0.7900.24
133_D238_E0.7890.24
263_Y268_S0.7880.24
121_Y264_H0.7880.24
237_C249_D0.7880.24
147_L166_A0.7860.24
46_P177_N0.7860.24
164_K167_E0.7780.23
264_H271_K0.7690.23
257_D274_L0.7660.23
132_I221_L0.7650.23
146_S153_V0.7620.23
40_S44_H0.7620.23
264_H268_S0.7590.22
175_F196_R0.7580.22
258_Q285_K0.7540.22
141_S263_Y0.7530.22
253_L262_E0.7530.22
94_K253_L0.7510.22
40_S55_E0.7460.22
253_L258_Q0.7460.22
142_A173_N0.7440.22
135_G236_D0.7440.22
115_V121_Y0.7410.22
64_Y222_I0.7400.22
245_L273_K0.7360.22
91_N98_D0.7350.22
237_C264_H0.7310.21
182_N188_D0.7300.21
166_A237_C0.7280.21
131_V241_E0.7260.21
241_E264_H0.7240.21
186_G189_G0.7210.21
137_A141_S0.7190.21
94_K167_E0.7190.21
271_K274_L0.7130.21
142_A285_K0.7130.21
137_A263_Y0.7130.21
134_C192_T0.7080.21
33_P38_L0.7070.21
157_E163_A0.7060.20
184_A262_E0.7060.20
56_K100_N0.7050.20
158_A184_A0.7050.20
145_F264_H0.7000.20
35_I40_S0.6940.20
72_F95_I0.6930.20
185_C217_S0.6930.20
207_S251_S0.6900.20
159_Y186_G0.6890.20
77_R218_L0.6840.20
252_T271_K0.6830.20
183_A193_V0.6790.20
120_E168_E0.6760.19
90_E93_I0.6750.19
219_Q245_L0.6750.19
177_N242_Y0.6710.19
66_I107_Y0.6700.19
140_D235_L0.6670.19
150_A153_V0.6660.19
32_N42_L0.6650.19
146_S241_E0.6620.19
195_P211_Y0.6620.19
89_D96_I0.6620.19
192_T201_P0.6590.19
121_Y238_E0.6580.19
155_A165_I0.6580.19
263_Y271_K0.6530.19
131_V256_F0.6510.19
132_I180_I0.6510.19
114_G283_V0.6500.19
219_Q256_F0.6490.19
55_E87_D0.6490.19
50_E254_E0.6480.18
138_I186_G0.6460.18
43_R47_F0.6440.18
33_P36_V0.6430.18
40_S43_R0.6390.18
97_Y282_K0.6360.18
155_A166_A0.6340.18
145_F232_V0.6330.18
72_F102_I0.6330.18
32_N35_I0.6320.18
219_Q257_D0.6320.18
143_I276_K0.6310.18
39_K101_E0.6310.18
112_I145_F0.6280.18
247_N282_K0.6240.18
76_A251_S0.6230.18
231_S257_D0.6220.18
137_A144_Y0.6210.18
39_K42_L0.6210.18
37_A40_S0.6210.18
186_G193_V0.6210.18
119_E187_T0.6200.18
135_G238_E0.6180.17
33_P39_K0.6170.17
185_C266_G0.6170.17
137_A162_I0.6160.17
141_S163_A0.6150.17
233_L241_E0.6140.17
194_N251_S0.6120.17
209_N283_V0.6100.17
231_S244_F0.6100.17
262_E278_G0.6090.17
51_L54_G0.6070.17
264_H284_T0.6060.17
48_V83_I0.6060.17
235_L263_Y0.6050.17
80_G216_F0.6010.17
85_I121_Y0.6000.17
92_T279_F0.5990.17
140_D262_E0.5990.17
140_D151_K0.5960.17
235_L245_L0.5960.17
163_A166_A0.5950.17
136_A185_C0.5940.17
93_I173_N0.5930.17
135_G241_E0.5920.17
119_E269_H0.5910.17
159_Y193_V0.5890.17
177_N229_K0.5890.17
190_I254_E0.5890.17
35_I42_L0.5880.17
247_N273_K0.5830.16
201_P218_L0.5820.16
36_V51_L0.5820.16
50_E65_K0.5780.16
188_D221_L0.5760.16
175_F210_G0.5750.16
233_L256_F0.5730.16
161_K217_S0.5700.16
166_A230_G0.5700.16
218_L233_L0.5690.16
70_Y171_K0.5670.16
169_N279_F0.5650.16
59_V187_T0.5650.16
52_K184_A0.5630.16
43_R50_E0.5600.16
184_A260_I0.5600.16
36_V42_L0.5600.16
89_D93_I0.5580.16
37_A44_H0.5550.16
219_Q282_K0.5550.16
32_N43_R0.5530.16
90_E105_K0.5510.15
142_A151_K0.5510.15
253_L268_S0.5470.15
186_G223_K0.5460.15
128_D131_V0.5450.15
103_I216_F0.5440.15
146_S178_I0.5440.15
230_G249_D0.5440.15
249_D252_T0.5420.15
238_E263_Y0.5410.15
155_A275_E0.5350.15
147_L190_I0.5340.15
83_I213_V0.5340.15
117_I227_V0.5330.15
173_N189_G0.5310.15
253_L264_H0.5290.15
81_K99_T0.5280.15
158_A182_N0.5260.15
137_A235_L0.5250.15
141_S151_K0.5250.15
154_I251_S0.5250.15
184_A230_G0.5250.15
264_H281_V0.5240.15
184_A236_D0.5230.15
186_G190_I0.5230.15
149_G158_A0.5230.15
183_A246_L0.5220.15
169_N262_E0.5200.15
59_V83_I0.5160.14
97_Y131_V0.5150.14
71_A79_K0.5100.14
66_I92_T0.5100.14
140_D264_H0.5090.14
188_D216_F0.5080.14
152_R261_M0.5080.14
232_V279_F0.5070.14
247_N256_F0.5060.14
169_N174_N0.5050.14
93_I128_D0.5050.14
268_S279_F0.5030.14
204_L270_L0.5030.14
34_L38_L0.5030.14
52_K169_N0.5010.14
120_E260_I0.5000.14
58_L163_A0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2py6A 4 0.8958 100 0.547 Contact Map
3opnA 1 0.5309 97.6 0.877 Contact Map
3kr9A 1 0.5244 97.1 0.887 Contact Map
3lecA 2 0.5342 96.9 0.89 Contact Map
3p2eA 1 0.57 96.8 0.89 Contact Map
3evzA 1 0.6156 96.8 0.891 Contact Map
3k6rA 1 0.7752 96.8 0.891 Contact Map
3eeyA 3 0.5603 96.7 0.892 Contact Map
3mtiA 2 0.5505 96.7 0.892 Contact Map
3gnlA 1 0.5309 96.7 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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