GREMLIN Database
Q7LXF5 - Uncharacterized protein
UniProt: Q7LXF5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 184 (167)
Sequences: 45445 (37589)
Seq/√Len: 2908.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_K62_I2.9971.00
45_K49_F2.8101.00
34_V64_K2.7841.00
83_M99_S2.5791.00
21_E136_A2.5361.00
17_F51_I2.3711.00
23_I60_N2.2661.00
162_F166_H2.0811.00
11_G14_E2.0431.00
44_L47_I1.9101.00
34_V62_I1.8801.00
15_L33_I1.8671.00
17_F132_I1.8581.00
51_I55_L1.8481.00
19_V33_I1.8141.00
145_M150_Y1.7501.00
138_E141_K1.7451.00
11_G88_H1.7291.00
110_D115_K1.7251.00
141_K150_Y1.7031.00
160_D164_E1.6941.00
119_S122_S1.6851.00
123_A162_F1.6741.00
36_M76_M1.6711.00
141_K145_M1.6571.00
103_G160_D1.6341.00
9_L89_E1.6291.00
118_Y124_V1.6261.00
125_K138_E1.6051.00
21_E133_K1.5971.00
119_S162_F1.5901.00
14_E88_H1.5341.00
53_K58_E1.5241.00
20_K55_L1.5051.00
140_T144_T1.4921.00
74_F102_V1.4871.00
122_S158_K1.4771.00
171_L175_R1.4761.00
151_N156_N1.4711.00
19_V31_L1.4651.00
108_A114_P1.4371.00
119_S123_A1.4321.00
83_M104_T1.4191.00
128_E134_L1.4191.00
38_K45_K1.4161.00
67_L72_E1.3931.00
15_L84_I1.3841.00
134_L138_E1.3761.00
34_V76_M1.3711.00
28_Y140_T1.3401.00
14_E132_I1.3401.00
3_F73_L1.3341.00
169_W172_V1.3221.00
125_K141_K1.3211.00
34_V80_A1.3171.00
78_S102_V1.3121.00
131_N134_L1.2961.00
13_L51_I1.2941.00
110_D128_E1.2901.00
36_M64_K1.2871.00
172_V176_Y1.2731.00
12_V35_V1.2581.00
80_A104_T1.2571.00
22_V140_T1.2471.00
34_V79_E1.2391.00
177_Y181_M1.2221.00
127_V138_E1.1981.00
132_I136_A1.1601.00
162_F165_K1.1541.00
28_Y144_T1.1541.00
153_L158_K1.1521.00
158_K161_K1.1491.00
92_F97_L1.1421.00
150_Y153_L1.1181.00
6_L35_V1.1171.00
88_H130_Y1.1061.00
112_P115_K1.0951.00
18_I135_M1.0951.00
21_E132_I1.0941.00
72_E75_N1.0911.00
96_I114_P1.0821.00
36_M67_L1.0641.00
67_L76_M1.0491.00
103_G157_D1.0471.00
168_D171_L1.0431.00
64_K67_L1.0411.00
14_E130_Y1.0361.00
86_P135_M1.0321.00
7_I40_P1.0281.00
73_L77_V1.0151.00
51_I54_R1.0141.00
125_K155_F1.0141.00
134_L137_T1.0091.00
142_I155_F1.0051.00
14_E109_Y0.9961.00
171_L174_E0.9961.00
74_F78_S0.9921.00
120_G138_E0.9841.00
136_A140_T0.9801.00
85_Y96_I0.9771.00
23_I28_Y0.9711.00
85_Y95_A0.9651.00
38_K66_Y0.9621.00
127_V135_M0.9551.00
161_K165_K0.9441.00
5_R9_L0.9411.00
109_Y127_V0.9401.00
87_T90_D0.9361.00
175_R178_R0.9331.00
172_V175_R0.9251.00
96_I108_A0.9231.00
85_Y114_P0.9131.00
176_Y180_L0.9051.00
77_V102_V0.9021.00
156_N159_M0.9001.00
93_S114_P0.8961.00
100_I106_V0.8961.00
150_Y155_F0.8951.00
13_L88_H0.8941.00
163_I166_H0.8911.00
68_T72_E0.8841.00
50_E54_R0.8831.00
13_L17_F0.8831.00
113_G116_S0.8751.00
161_K164_E0.8731.00
14_E17_F0.8731.00
146_N149_E0.8591.00
100_I159_M0.8561.00
108_A118_Y0.8551.00
100_I162_F0.8431.00
64_K76_M0.8371.00
17_F55_L0.8301.00
108_A126_F0.8261.00
16_P52_V0.8171.00
14_E135_M0.8171.00
96_I117_V0.8161.00
10_K95_A0.8091.00
84_I139_V0.8071.00
15_L86_P0.8061.00
169_W173_V0.8041.00
152_S157_D0.8031.00
52_V63_Y0.7941.00
19_V60_N0.7901.00
104_T156_N0.7851.00
118_Y126_F0.7821.00
146_N151_N0.7801.00
157_D161_K0.7771.00
20_K24_T0.7761.00
13_L47_I0.7761.00
125_K142_I0.7761.00
49_F53_K0.7751.00
46_A49_F0.7691.00
22_V139_V0.7581.00
111_I114_P0.7431.00
107_V127_V0.7411.00
10_K90_D0.7401.00
22_V143_L0.7371.00
13_L44_L0.7301.00
121_L141_K0.7261.00
137_T141_K0.7251.00
105_P156_N0.7231.00
20_K23_I0.7211.00
156_N160_D0.7181.00
83_M95_A0.7141.00
22_V31_L0.7131.00
145_M151_N0.7121.00
76_M79_E0.7081.00
3_F77_V0.7061.00
155_F158_K0.7031.00
93_S96_I0.6991.00
46_A50_E0.6991.00
76_M80_A0.6931.00
22_V136_A0.6891.00
100_I123_A0.6851.00
52_V57_L0.6791.00
110_D126_F0.6771.00
47_I51_I0.6711.00
99_S104_T0.6661.00
18_I136_A0.6651.00
90_D93_S0.6641.00
23_I29_K0.6621.00
77_V104_T0.6591.00
10_K87_T0.6581.00
109_Y135_M0.6561.00
123_A159_M0.6551.00
82_C139_V0.6551.00
82_C142_I0.6541.00
75_N79_E0.6521.00
125_K150_Y0.6501.00
39_F45_K0.6491.00
31_L143_L0.6461.00
168_D172_V0.6451.00
39_F44_L0.6441.00
20_K57_L0.6361.00
174_E178_R0.6341.00
173_V177_Y0.6331.00
8_P13_L0.6321.00
29_K144_T0.6311.00
32_K60_N0.6241.00
85_Y93_S0.6231.00
96_I106_V0.6221.00
67_L73_L0.6221.00
6_L45_K0.6201.00
120_G123_A0.6131.00
47_I50_E0.6121.00
52_V61_I0.6061.00
142_I151_N0.6061.00
44_L48_F0.6051.00
12_V44_L0.6001.00
111_I129_E0.6001.00
128_E131_N0.5971.00
28_Y31_L0.5951.00
109_Y129_E0.5911.00
107_V138_E0.5911.00
17_F20_K0.5881.00
155_F159_M0.5841.00
146_N152_S0.5801.00
115_K126_F0.5781.00
21_E24_T0.5781.00
18_I132_I0.5721.00
105_P142_I0.5701.00
97_L117_V0.5661.00
17_F21_E0.5591.00
133_K136_A0.5581.00
118_Y123_A0.5571.00
145_M149_E0.5491.00
120_G125_K0.5431.00
50_E53_K0.5431.00
81_R151_N0.5421.00
75_N78_S0.5411.00
149_E153_L0.5411.00
152_S156_N0.5411.00
8_P44_L0.5391.00
176_Y179_D0.5381.00
93_S97_L0.5381.00
97_L163_I0.5351.00
107_V142_I0.5311.00
52_V55_L0.5301.00
3_F36_M0.5291.00
87_T95_A0.5281.00
18_I139_V0.5261.00
100_I156_N0.5251.00
137_T140_T0.5211.00
83_M106_V0.5141.00
19_V22_V0.5131.00
133_K137_T0.5091.00
8_P88_H0.5081.00
123_A158_K0.5041.00
141_K144_T0.5001.00
31_L81_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n9wA 1 0.9293 100 0.11 Contact Map
2r60A 1 0.9674 100 0.148 Contact Map
2x6qA 1 0.9511 100 0.151 Contact Map
3oy2A 2 0.962 100 0.171 Contact Map
3c48A 2 0.9348 100 0.178 Contact Map
1rzuA 1 0.9239 100 0.187 Contact Map
3s28A 4 0.9674 100 0.189 Contact Map
3froA 3 0.9402 100 0.191 Contact Map
2jjmA 4 0.9348 100 0.193 Contact Map
4rbnA 3 0.9674 100 0.195 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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