GREMLIN Database
Q7LXE9 - Uncharacterized protein
UniProt: Q7LXE9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 301 (236)
Sequences: 295 (286)
Seq/√Len: 18.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
220_A248_D5.1051.00
238_C245_I4.5441.00
259_N280_F4.4311.00
143_L222_L3.6361.00
174_T216_T3.1760.99
172_A216_T3.1460.99
175_N244_A3.0250.99
175_N247_R2.9210.99
123_A153_G2.9190.99
174_T241_C2.8990.99
234_L259_N2.8660.99
150_Y168_L2.8190.98
150_Y170_P2.7820.98
128_S265_H2.7410.98
129_S166_V2.7110.98
172_A214_V2.6590.98
147_P212_I2.6020.97
118_V140_V2.5660.97
147_P170_P2.4560.96
220_A250_P2.4550.96
174_T180_V2.4370.96
220_A280_F2.3970.96
236_M245_I2.3670.95
143_L173_L2.2620.94
124_S127_D2.2420.94
263_E284_Y2.2160.93
121_V173_L2.1820.93
179_Y213_K2.1690.93
220_A254_L2.1060.91
73_K78_N2.0010.89
123_A142_A1.9890.89
251_A255_N1.9720.88
118_V136_G1.9420.88
105_Y110_Y1.9400.88
239_E242_E1.8800.86
128_S132_F1.8500.85
131_F156_N1.8340.84
116_G138_E1.7680.82
238_C265_H1.7630.82
120_D235_K1.7590.82
131_F280_F1.6980.79
121_V245_I1.6960.79
124_S263_E1.6510.77
177_E221_S1.6480.77
110_Y132_F1.6370.77
254_L259_N1.6060.75
217_T221_S1.5900.75
150_Y153_G1.5720.74
171_Y217_T1.5520.73
239_E265_H1.5510.73
133_A140_V1.5370.72
238_C241_C1.5350.72
181_D213_K1.5310.72
177_E217_T1.5180.71
116_G136_G1.5140.71
263_E269_Q1.5080.71
237_D263_E1.4810.69
122_G126_A1.4750.69
248_D280_F1.4500.67
220_A259_N1.4470.67
257_I280_F1.4370.67
263_E275_L1.4120.65
121_V238_C1.3780.63
141_I222_L1.3280.60
130_I156_N1.3230.60
238_C242_E1.3090.59
157_I168_L1.2960.58
156_N159_I1.2870.58
262_L269_Q1.2780.57
248_D259_N1.2550.56
236_M263_E1.2420.55
187_D270_D1.2360.55
146_F149_S1.2340.55
154_K168_L1.2300.54
118_V138_E1.2190.54
260_I269_Q1.2150.53
234_L280_F1.1940.52
260_I263_E1.1820.51
172_A184_I1.1740.51
150_Y154_K1.1720.51
110_Y265_H1.1640.50
182_F212_I1.1530.50
124_S254_L1.1290.48
178_G217_T1.1170.47
124_S264_F1.1160.47
265_H272_P1.1160.47
174_T178_G1.1100.47
264_F269_Q1.1070.47
234_L250_P1.1000.46
121_V263_E1.0980.46
138_E232_Y1.0850.45
153_G182_F1.0800.45
122_G144_E1.0580.44
179_Y215_P1.0280.42
254_L269_Q1.0270.42
92_T150_Y1.0260.42
122_G240_G1.0260.42
238_C258_E1.0090.41
56_I276_R1.0050.40
218_T221_S1.0050.40
254_L264_F0.9950.40
119_I233_L0.9830.39
137_A258_E0.9810.39
150_Y177_E0.9720.39
146_F192_N0.9720.39
136_G152_L0.9690.38
43_K48_N0.9650.38
169_L222_L0.9600.38
78_N82_L0.9600.38
128_S264_F0.9560.38
118_V132_F0.9510.37
244_A247_R0.9430.37
143_L278_A0.9430.37
169_L224_Q0.9370.36
263_E272_P0.9340.36
262_L280_F0.9300.36
223_I252_E0.9250.36
157_I162_L0.9210.36
254_L257_I0.9210.36
113_S118_V0.9140.35
156_N263_E0.9100.35
260_I272_P0.9000.34
174_T219_L0.8930.34
40_L51_F0.8910.34
123_A233_L0.8900.34
234_L248_D0.8880.34
103_E110_Y0.8880.34
44_L219_L0.8780.33
130_I160_N0.8780.33
69_G225_K0.8740.33
238_C262_L0.8740.33
111_G279_G0.8710.33
245_I260_I0.8660.32
132_F265_H0.8620.32
79_N246_L0.8600.32
121_V236_M0.8580.32
262_L282_V0.8580.32
171_Y215_P0.8550.32
126_A248_D0.8540.32
118_V257_I0.8540.32
145_P236_M0.8480.31
177_E215_P0.8470.31
272_P276_R0.8470.31
255_N258_E0.8440.31
243_Y274_I0.8430.31
114_F230_R0.8380.31
75_A78_N0.8320.31
266_D272_P0.8310.31
264_F284_Y0.8240.30
92_T278_A0.8240.30
73_K79_N0.8230.30
74_E139_K0.8140.30
234_L260_I0.8130.30
156_N160_N0.8070.29
263_E273_D0.8060.29
140_V160_N0.7970.29
234_L266_D0.7930.29
127_D264_F0.7810.28
68_K113_S0.7760.28
99_G103_E0.7710.27
140_V235_K0.7710.27
106_E110_Y0.7710.27
50_I215_P0.7620.27
140_V261_I0.7610.27
119_I173_L0.7600.27
250_P259_N0.7590.27
245_I283_N0.7590.27
88_L166_V0.7560.27
146_F174_T0.7530.27
107_C110_Y0.7510.26
222_L275_L0.7480.26
63_L135_N0.7470.26
219_L251_A0.7410.26
270_D275_L0.7400.26
182_F241_C0.7400.26
140_V271_L0.7360.26
232_Y254_L0.7360.26
133_A166_V0.7350.26
155_Y158_K0.7350.26
126_A240_G0.7330.26
245_I262_L0.7300.25
245_I263_E0.7280.25
238_C271_L0.7270.25
236_M242_E0.7260.25
136_G140_V0.7250.25
192_N267_Y0.7220.25
125_N142_A0.7210.25
172_A219_L0.7200.25
232_Y282_V0.7170.25
236_M262_L0.7130.25
41_E52_L0.7120.25
162_L168_L0.7110.25
70_W228_I0.7090.24
215_P244_A0.7090.24
127_D236_M0.7070.24
263_E282_V0.7060.24
127_D132_F0.7060.24
233_L260_I0.7050.24
154_K256_K0.7020.24
242_E265_H0.7010.24
97_D106_E0.7000.24
119_I228_I0.7000.24
124_S232_Y0.6950.24
214_V225_K0.6920.24
74_E119_I0.6900.24
238_C248_D0.6890.24
219_L253_V0.6880.24
142_A145_P0.6860.23
84_K157_I0.6780.23
70_W78_N0.6770.23
129_S257_I0.6750.23
101_I110_Y0.6750.23
129_S160_N0.6740.23
261_I272_P0.6740.23
124_S149_S0.6730.23
45_K63_L0.6700.23
79_N82_L0.6700.23
145_P235_K0.6640.22
153_G238_C0.6620.22
59_L162_L0.6610.22
120_D144_E0.6610.22
254_L261_I0.6590.22
123_A190_N0.6540.22
144_E237_D0.6540.22
73_K82_L0.6520.22
219_L271_L0.6510.22
180_V216_T0.6500.22
236_M260_I0.6500.22
68_K80_A0.6500.22
254_L275_L0.6480.22
261_I265_H0.6480.22
263_E268_P0.6440.22
67_K76_D0.6430.22
116_G225_K0.6430.22
120_D123_A0.6420.22
40_L44_L0.6420.22
50_I164_N0.6390.21
110_Y239_E0.6380.21
137_A253_V0.6370.21
265_H271_L0.6330.21
95_G279_G0.6310.21
126_A144_E0.6300.21
256_K281_N0.6280.21
64_S158_K0.6270.21
237_D271_L0.6260.21
164_N184_I0.6260.21
210_Q284_Y0.6240.21
72_V77_E0.6230.21
102_D230_R0.6220.21
154_K258_E0.6180.21
194_V216_T0.6180.21
90_I142_A0.6170.20
260_I275_L0.6150.20
40_L45_K0.6120.20
113_S132_F0.6110.20
135_N166_V0.6070.20
150_Y222_L0.6070.20
232_Y263_E0.6030.20
123_A231_V0.6020.20
220_A234_L0.6020.20
127_D265_H0.6010.20
147_P157_I0.6000.20
128_S138_E0.6000.20
128_S236_M0.5990.20
124_S269_Q0.5980.20
164_N172_A0.5980.20
265_H285_E0.5970.20
258_E287_K0.5950.20
66_L134_T0.5930.20
276_R279_G0.5920.19
262_L281_N0.5920.19
194_V213_K0.5910.19
106_E253_V0.5900.19
271_L277_K0.5890.19
176_Y219_L0.5890.19
122_G237_D0.5850.19
264_F276_R0.5820.19
132_F231_V0.5760.19
124_S138_E0.5740.19
264_F272_P0.5730.19
144_E240_G0.5710.19
132_F211_K0.5700.19
67_K141_I0.5690.19
103_E106_E0.5690.19
62_L78_N0.5680.19
238_C263_E0.5680.19
75_A79_N0.5670.19
145_P172_A0.5670.19
245_I272_P0.5670.19
222_L226_Y0.5640.18
145_P277_K0.5630.18
137_A143_L0.5610.18
237_D265_H0.5580.18
50_I246_L0.5570.18
159_I286_N0.5570.18
262_L275_L0.5570.18
260_I287_K0.5560.18
173_L222_L0.5540.18
233_L259_N0.5530.18
77_E80_A0.5530.18
182_F207_K0.5530.18
174_T182_F0.5520.18
92_T143_L0.5510.18
147_P215_P0.5480.18
141_I171_Y0.5460.18
135_N279_G0.5450.18
44_L48_N0.5440.18
62_L66_L0.5440.18
238_C268_P0.5440.18
236_M269_Q0.5400.18
153_G168_L0.5390.17
143_L247_R0.5380.17
140_V237_D0.5340.17
137_A241_C0.5320.17
139_K167_I0.5310.17
269_Q286_N0.5270.17
151_E154_K0.5270.17
125_N287_K0.5270.17
142_A153_G0.5260.17
234_L245_I0.5250.17
61_A227_N0.5240.17
242_E245_I0.5220.17
187_D190_N0.5220.17
128_S133_A0.5210.17
43_K49_R0.5210.17
261_I264_F0.5200.17
268_P280_F0.5200.17
119_I168_L0.5200.17
123_A168_L0.5190.17
52_L85_E0.5180.17
58_D121_V0.5180.17
66_L217_T0.5180.17
125_N160_N0.5180.17
220_A238_C0.5170.17
139_K157_I0.5150.17
123_A162_L0.5130.17
63_L277_K0.5110.16
118_V271_L0.5110.16
88_L115_K0.5110.16
85_E155_Y0.5100.16
164_N280_F0.5090.16
71_K74_E0.5070.16
91_R246_L0.5070.16
161_N172_A0.5060.16
48_N53_K0.5060.16
59_L147_P0.5060.16
179_Y277_K0.5050.16
106_E164_N0.5050.16
157_I207_K0.5030.16
59_L221_S0.5030.16
45_K50_I0.5010.16
261_I271_L0.5010.16
118_V287_K0.5000.16
90_I155_Y0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2py6A 4 0.8571 100 0.504 Contact Map
3gnlA 1 0.5216 96.2 0.891 Contact Map
3kr9A 1 0.515 96.1 0.891 Contact Map
3lecA 2 0.5249 95.8 0.894 Contact Map
3k6rA 1 0.7807 95.3 0.898 Contact Map
3lpmA 2 0.598 95.2 0.899 Contact Map
4lwoB 2 0.6412 93.9 0.905 Contact Map
4qdjA 1 0.6744 93.9 0.905 Contact Map
1wy7A 1 0.6113 93.7 0.906 Contact Map
2yxdA 4 0.5714 93.6 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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