Q7LXE8 - SULSO - GREMLIN Contacts

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Q7LXE8 - dTDP-Glucose 4,6-dehydratase (RfbB-1)

UniProt:	Q7LXE8	Sequences: MKIIVVGGAGFIGSAFVRELNKRGIKPIVVDLLTYAGRKENLIGTDYDFVQADVRSEKMHDIIKEYSPDIVINFAAETHVDRSIYKPQDFVTTNVLGTVNLLEASRKFNFKYVHISTDEVYGEECGDENSPLKPSSPYSASKASADLFVKAYVRTYGISAVIVRPSNNYGPRQFPEKLIPKAIIRTLLGIHIPVYGDGKAERDWIFVEDTARIIFDVVSRAEWKGEVYNIPGGQRYNVLEILKMLEEVSGKEVKIKFVSDRPGHDRRYCMTTSMKYEVTPFKEGLRRTYEWYLNNRWWWEPLINDKFFVEDEPWLTV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	317 (283)
Sequences:	60972 (43126)
Seq/√Len:	2563.6

ECOLI - RMLB1 GALE RMLB2 GM4D YBJS HLDD FCL RMLD YFCH YEEZ QOR2 ARNA YRAR YBJT
BACSU - YTCB GALE YFNG RMLB YFHF SPSK YTBQ YWNB YHFK YESF YHEG EPSC
HALSA - Q9HSV1 Q9HSU9 Q9HRD1 Q9HSE7 Q9HML4 Q9HS50 Q9HNV3 Q9HPF1 Q9HSQ3 Q9HR86
SULSO - Q7LXE8 Q97XG1 Q97XJ9 Q97VN5 Q7LXG5 Q980W1 Q97UM3 Q7LX44 Q7LXE6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
244_M	282_K	3.193	1.00
8_G	29_V	3.065	1.00
92_T	96_L	2.701	1.00
19_E	212_R	2.682	1.00
213_I	230_I	2.601	1.00
70_I	218_V	2.398	1.00
19_E	215_F	2.393	1.00
248_V	286_R	2.392	1.00
115_I	214_I	2.373	1.00
60_H	107_K	2.349	1.00
86_K	89_D	2.318	1.00
19_E	23_R	2.223	1.00
280_P	283_E	2.222	1.00
30_V	52_A	2.188	1.00
111_K	159_S	2.157	1.00
149_V	160_A	2.097	1.00
239_L	243_K	2.081	1.00
28_I	68_P	2.062	1.00
247_E	282_K	2.057	1.00
28_I	50_V	2.016	1.00
28_I	48_D	2.003	1.00
73_N	114_H	1.972	1.00
72_I	218_V	1.970	1.00
99_V	148_F	1.958	1.00
165_P	214_I	1.945	1.00
237_N	240_E	1.939	1.00
4_I	68_P	1.938	1.00
23_R	215_F	1.931	1.00
244_M	247_E	1.930	1.00
60_H	104_A	1.882	1.00
163_V	217_V	1.874	1.00
6_V	73_N	1.847	1.00
212_R	216_D	1.837	1.00
57_E	103_E	1.834	1.00
208_E	287_R	1.803	1.00
143_A	147_L	1.766	1.00
215_F	219_S	1.735	1.00
96_L	99_V	1.715	1.00
99_V	103_E	1.708	1.00
5_V	17_V	1.708	1.00
98_T	145_A	1.701	1.00
127_D	130_S	1.678	1.00
55_R	92_T	1.673	1.00
184_I	188_L	1.661	1.00
91_V	144_S	1.640	1.00
26_K	48_D	1.635	1.00
57_E	100_N	1.629	1.00
191_H	256_K	1.617	1.00
16_F	74_F	1.599	1.00
216_D	220_R	1.598	1.00
169_Y	284_G	1.587	1.00
19_E	22_K	1.581	1.00
23_R	219_S	1.574	1.00
16_F	72_I	1.543	1.00
279_T	287_R	1.533	1.00
206_F	287_R	1.531	1.00
88_Q	92_T	1.529	1.00
57_E	60_H	1.525	1.00
244_M	248_V	1.516	1.00
16_F	211_A	1.491	1.00
111_K	161_V	1.480	1.00
286_R	290_E	1.468	1.00
19_E	211_A	1.462	1.00
193_P	256_K	1.461	1.00
201_E	235_R	1.450	1.00
106_R	156_Y	1.445	1.00
12_I	168_N	1.430	1.00
33_L	49_F	1.419	1.00
132_L	143_A	1.414	1.00
17_V	29_V	1.414	1.00
60_H	108_F	1.412	1.00
71_V	105_S	1.396	1.00
3_I	25_I	1.385	1.00
165_P	210_T	1.381	1.00
40_E	43_I	1.362	1.00
147_L	150_K	1.361	1.00
115_I	165_P	1.358	1.00
74_F	115_I	1.356	1.00
239_L	257_F	1.331	1.00
8_G	17_V	1.331	1.00
64_K	108_F	1.329	1.00
38_R	41_N	1.310	1.00
150_K	162_I	1.303	1.00
114_H	145_A	1.302	1.00
148_F	151_A	1.298	1.00
153_V	160_A	1.290	1.00
116_S	120_V	1.273	1.00
283_E	287_R	1.272	1.00
25_I	219_S	1.271	1.00
206_F	284_G	1.271	1.00
18_R	172_R	1.263	1.00
240_E	243_K	1.263	1.00
199_K	237_N	1.260	1.00
54_V	97_G	1.250	1.00
70_I	111_K	1.234	1.00
63_I	68_P	1.229	1.00
283_E	286_R	1.228	1.00
140_A	144_S	1.227	1.00
138_Y	142_K	1.226	1.00
279_T	283_E	1.221	1.00
114_H	149_V	1.215	1.00
4_I	30_V	1.214	1.00
82_R	86_K	1.211	1.00
72_I	214_I	1.207	1.00
185_R	190_I	1.205	1.00
103_E	106_R	1.203	1.00
19_E	208_E	1.202	1.00
73_N	98_T	1.182	1.00
199_K	239_L	1.174	1.00
114_H	162_I	1.170	1.00
102_L	152_Y	1.170	1.00
29_V	47_Y	1.168	1.00
94_N	141_S	1.156	1.00
20_L	215_F	1.154	1.00
151_A	155_T	1.154	1.00
60_H	64_K	1.148	1.00
163_V	214_I	1.142	1.00
100_N	103_E	1.140	1.00
59_M	104_A	1.135	1.00
111_K	221_A	1.130	1.00
246_E	252_E	1.126	1.00
243_K	246_E	1.123	1.00
207_V	211_A	1.116	1.00
104_A	107_K	1.114	1.00
96_L	100_N	1.111	1.00
105_S	112_Y	1.104	1.00
205_I	210_T	1.100	1.00
191_H	254_K	1.098	1.00
77_E	93_T	1.095	1.00
105_S	110_F	1.094	1.00
265_D	268_Y	1.090	1.00
15_A	208_E	1.088	1.00
150_K	227_V	1.086	1.00
39_K	43_I	1.083	1.00
63_I	104_A	1.083	1.00
103_E	107_K	1.078	1.00
54_V	75_A	1.078	1.00
102_L	112_Y	1.078	1.00
9_A	31_D	1.077	1.00
3_I	70_I	1.075	1.00
18_R	22_K	1.075	1.00
113_V	163_V	1.074	1.00
30_V	62_I	1.069	1.00
121_Y	229_N	1.068	1.00
270_M	273_S	1.064	1.00
236_Y	281_F	1.063	1.00
150_K	160_A	1.061	1.00
282_K	286_R	1.059	1.00
3_I	20_L	1.052	1.00
216_D	219_S	1.046	1.00
95_V	144_S	1.041	1.00
21_N	46_D	1.039	1.00
236_Y	240_E	1.033	1.00
203_D	233_G	1.033	1.00
249_S	289_Y	1.031	1.00
91_V	95_V	1.027	1.00
206_F	279_T	1.027	1.00
61_D	64_K	1.025	1.00
21_N	47_Y	1.025	1.00
104_A	108_F	1.025	1.00
14_S	172_R	1.024	1.00
101_L	112_Y	1.020	1.00
106_R	158_I	1.019	1.00
91_V	96_L	1.017	1.00
248_V	289_Y	1.016	1.00
159_S	224_K	1.013	1.00
15_A	207_V	1.012	1.00
6_V	101_L	1.008	1.00
164_R	227_V	1.007	1.00
15_A	18_R	1.003	1.00
168_N	210_T	1.002	1.00
34_T	51_Q	0.999	1.00
287_R	290_E	0.989	1.00
112_Y	149_V	0.972	1.00
150_K	154_R	0.972	1.00
11_F	170_G	0.968	1.00
93_T	97_G	0.962	1.00
102_L	149_V	0.960	1.00
248_V	282_K	0.957	1.00
50_V	62_I	0.951	1.00
208_E	279_T	0.951	1.00
178_L	182_A	0.951	1.00
30_V	59_M	0.943	1.00
181_K	185_R	0.942	1.00
31_D	49_F	0.936	1.00
181_K	184_I	0.935	1.00
33_L	51_Q	0.928	1.00
269_C	272_T	0.927	1.00
146_D	164_R	0.925	1.00
201_E	237_N	0.920	1.00
212_R	215_F	0.920	1.00
15_A	19_E	0.920	1.00
11_F	207_V	0.916	1.00
71_V	101_L	0.910	1.00
100_N	104_A	0.909	1.00
235_R	267_R	0.908	1.00
58_K	61_D	0.906	1.00
246_E	253_V	0.904	1.00
161_V	217_V	0.903	1.00
246_E	251_K	0.898	1.00
74_F	214_I	0.895	1.00
163_V	230_I	0.890	1.00
126_G	130_S	0.889	1.00
57_E	107_K	0.889	1.00
63_I	71_V	0.888	1.00
144_S	147_L	0.887	1.00
216_D	274_M	0.885	1.00
240_E	244_M	0.879	1.00
98_T	149_V	0.869	1.00
77_E	89_D	0.868	1.00
198_G	239_L	0.867	1.00
164_R	229_N	0.867	1.00
16_F	20_L	0.865	1.00
234_Q	280_P	0.864	1.00
63_I	108_F	0.863	1.00
162_I	227_V	0.861	1.00
17_V	27_P	0.856	1.00
21_N	27_P	0.852	1.00
231_P	270_M	0.851	1.00
28_I	67_S	0.848	1.00
166_S	270_M	0.848	1.00
213_I	276_Y	0.839	1.00
73_N	101_L	0.838	1.00
182_A	185_R	0.838	1.00
259_S	262_P	0.833	1.00
118_D	166_S	0.833	1.00
269_C	273_S	0.832	1.00
184_I	187_L	0.832	1.00
261_R	264_H	0.831	1.00
147_L	151_A	0.831	1.00
55_R	93_T	0.824	1.00
193_P	258_V	0.820	1.00
168_N	205_I	0.816	1.00
32_L	53_D	0.813	1.00
102_L	148_F	0.812	1.00
90_F	141_S	0.811	1.00
258_V	261_R	0.811	1.00
201_E	267_R	0.806	1.00
209_D	232_G	0.801	1.00
87_P	140_A	0.799	1.00
26_K	46_D	0.795	1.00
89_D	92_T	0.792	1.00
6_V	75_A	0.791	1.00
3_I	218_V	0.790	1.00
279_T	284_G	0.788	1.00
161_V	221_A	0.785	1.00
3_I	72_I	0.784	1.00
177_K	180_P	0.783	1.00
212_R	279_T	0.779	1.00
209_D	212_R	0.778	1.00
25_I	69_D	0.772	1.00
136_S	139_S	0.770	1.00
144_S	148_F	0.768	1.00
106_R	157_G	0.765	1.00
212_R	276_Y	0.762	1.00
216_D	276_Y	0.754	1.00
77_E	90_F	0.754	1.00
56_S	59_M	0.754	1.00
125_C	130_S	0.753	1.00
38_R	43_I	0.751	1.00
91_V	141_S	0.750	1.00
272_T	278_V	0.747	1.00
59_M	100_N	0.744	1.00
244_M	281_F	0.741	1.00
122_G	133_K	0.739	1.00
165_P	168_N	0.737	1.00
243_K	247_E	0.736	1.00
89_D	93_T	0.735	1.00
248_V	290_E	0.735	1.00
172_R	175_P	0.731	1.00
98_T	102_L	0.729	1.00
152_Y	156_Y	0.725	1.00
267_R	270_M	0.725	1.00
116_S	146_D	0.724	1.00
265_D	270_M	0.723	1.00
137_P	140_A	0.721	1.00
166_S	231_P	0.720	1.00
103_E	152_Y	0.715	1.00
248_V	285_L	0.714	1.00
256_K	259_S	0.714	1.00
206_F	209_D	0.709	1.00
217_V	274_M	0.708	1.00
71_V	112_Y	0.707	1.00
235_R	269_C	0.706	1.00
169_Y	206_F	0.705	1.00
106_R	152_Y	0.704	1.00
57_E	104_A	0.702	1.00
255_I	258_V	0.698	1.00
16_F	214_I	0.696	1.00
160_A	225_G	0.695	1.00
246_E	249_S	0.694	1.00
97_G	100_N	0.693	1.00
211_A	215_F	0.691	1.00
140_A	147_L	0.691	1.00
216_D	275_K	0.690	1.00
63_I	105_S	0.688	1.00
186_T	246_E	0.686	1.00
25_I	70_I	0.683	1.00
171_P	287_R	0.679	1.00
183_I	187_L	0.676	1.00
15_A	211_A	0.674	1.00
260_D	263_G	0.672	1.00
39_K	51_Q	0.671	1.00
145_A	149_V	0.670	1.00
177_K	181_K	0.669	1.00
14_S	18_R	0.669	1.00
236_Y	244_M	0.665	1.00
83_S	90_F	0.661	1.00
39_K	42_L	0.660	1.00
257_F	263_G	0.658	1.00
189_G	251_K	0.657	1.00
266_R	269_C	0.655	1.00
84_I	137_P	0.653	1.00
91_V	140_A	0.652	1.00
38_R	42_L	0.651	1.00
242_L	246_E	0.650	1.00
70_I	113_V	0.648	1.00
53_D	56_S	0.648	1.00
20_L	218_V	0.647	1.00
127_D	271_T	0.643	1.00
257_F	260_D	0.636	1.00
134_P	139_S	0.632	1.00
209_D	279_T	0.632	1.00
120_V	132_L	0.631	1.00
33_L	38_R	0.627	1.00
185_R	188_L	0.626	1.00
87_P	137_P	0.626	1.00
113_V	218_V	0.622	1.00
162_I	225_G	0.622	1.00
113_V	214_I	0.620	1.00
12_I	210_T	0.618	1.00
236_Y	241_I	0.617	1.00
105_S	108_F	0.610	1.00
31_D	35_Y	0.605	1.00
241_I	281_F	0.603	1.00
159_S	222_E	0.603	1.00
151_A	154_R	0.600	1.00
119_E	139_S	0.600	1.00
256_K	260_D	0.599	1.00
171_P	206_F	0.598	1.00
120_V	146_D	0.595	1.00
266_R	272_T	0.594	1.00
23_R	212_R	0.591	1.00
29_V	49_F	0.590	1.00
182_A	186_T	0.590	1.00
99_V	144_S	0.588	1.00
152_Y	158_I	0.587	1.00
215_F	218_V	0.587	1.00
23_R	216_D	0.586	1.00
153_V	158_I	0.586	1.00
64_K	67_S	0.582	1.00
148_F	152_Y	0.580	1.00
5_V	20_L	0.578	1.00
141_S	145_A	0.578	1.00
4_I	63_I	0.575	1.00
203_D	235_R	0.574	1.00
140_A	151_A	0.572	1.00
183_I	289_Y	0.572	1.00
95_V	99_V	0.572	1.00
15_A	172_R	0.572	1.00
268_Y	271_T	0.571	1.00
32_L	35_Y	0.570	1.00
44_G	47_Y	0.570	1.00
267_R	271_T	0.570	1.00
76_A	94_N	0.570	1.00
17_V	21_N	0.569	1.00
81_D	84_I	0.568	1.00
4_I	62_I	0.567	1.00
9_A	33_L	0.566	1.00
265_D	269_C	0.563	1.00
146_D	162_I	0.562	1.00
185_R	189_G	0.561	1.00
234_Q	282_K	0.560	1.00
259_S	263_G	0.559	1.00
180_P	183_I	0.555	1.00
114_H	117_T	0.553	1.00
4_I	71_V	0.551	1.00
73_N	112_Y	0.551	1.00
67_S	108_F	0.550	1.00
163_V	213_I	0.549	1.00
200_A	238_V	0.549	1.00
220_R	228_Y	0.548	1.00
137_P	141_S	0.548	1.00
151_A	156_Y	0.546	1.00
134_P	143_A	0.546	1.00
87_P	91_V	0.545	1.00
102_L	106_R	0.545	1.00
11_F	15_A	0.545	1.00
4_I	52_A	0.542	1.00
210_T	214_I	0.542	1.00
161_V	228_Y	0.541	1.00
180_P	184_I	0.540	1.00
132_L	147_L	0.537	1.00
18_R	21_N	0.537	1.00
28_I	62_I	0.529	1.00
98_T	114_H	0.527	1.00
113_V	217_V	0.526	1.00
99_V	151_A	0.524	1.00
18_R	208_E	0.522	1.00
138_Y	141_S	0.522	1.00
153_V	225_G	0.520	1.00
210_T	230_I	0.519	1.00
171_P	208_E	0.518	1.00
116_S	164_R	0.517	1.00
63_I	101_L	0.515	1.00
124_E	130_S	0.513	1.00
16_F	115_I	0.513	1.00
233_G	272_T	0.512	1.00
240_E	282_K	0.511	1.00
54_V	59_M	0.510	1.00
183_I	245_L	0.509	1.00
258_V	264_H	0.509	1.00
21_N	45_T	0.507	1.00
21_N	44_G	0.506	1.00
190_I	193_P	0.505	1.00
146_D	150_K	0.505	1.00
77_E	94_N	0.504	1.00
149_V	162_I	0.504	1.00
161_V	220_R	0.504	1.00
15_A	171_P	0.503	1.00
111_K	114_H	0.502	1.00
258_V	262_P	0.501	1.00
52_A	62_I	0.500	1.00
203_D	232_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1sb8A	2	0.9306	100	0.243	Contact Map
3rufA	2	0.9274	100	0.25	Contact Map
1orrA	3	0.9306	100	0.251	Contact Map
1oc2A	2	0.9874	100	0.252	Contact Map
3m2pA	2	0.9022	100	0.257	Contact Map
2c20A	2	0.9432	100	0.258	Contact Map
2q1sA	2	0.9527	100	0.259	Contact Map
1rpnA	4	0.9369	100	0.259	Contact Map
2hunA	2	0.9779	100	0.26	Contact Map
4egbA	5	0.9211	100	0.262	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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