GREMLIN Database
Q7LXE8 - dTDP-Glucose 4,6-dehydratase (RfbB-1)
UniProt: Q7LXE8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 317 (283)
Sequences: 60972 (43126)
Seq/√Len: 2563.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
244_M282_K3.1931.00
8_G29_V3.0651.00
92_T96_L2.7011.00
19_E212_R2.6821.00
213_I230_I2.6011.00
70_I218_V2.3981.00
19_E215_F2.3931.00
248_V286_R2.3921.00
115_I214_I2.3731.00
60_H107_K2.3491.00
86_K89_D2.3181.00
19_E23_R2.2231.00
280_P283_E2.2221.00
30_V52_A2.1881.00
111_K159_S2.1571.00
149_V160_A2.0971.00
239_L243_K2.0811.00
28_I68_P2.0621.00
247_E282_K2.0571.00
28_I50_V2.0161.00
28_I48_D2.0031.00
73_N114_H1.9721.00
72_I218_V1.9701.00
99_V148_F1.9581.00
165_P214_I1.9451.00
237_N240_E1.9391.00
4_I68_P1.9381.00
23_R215_F1.9311.00
244_M247_E1.9301.00
60_H104_A1.8821.00
163_V217_V1.8741.00
6_V73_N1.8471.00
212_R216_D1.8371.00
57_E103_E1.8341.00
208_E287_R1.8031.00
143_A147_L1.7661.00
215_F219_S1.7351.00
96_L99_V1.7151.00
99_V103_E1.7081.00
5_V17_V1.7081.00
98_T145_A1.7011.00
127_D130_S1.6781.00
55_R92_T1.6731.00
184_I188_L1.6611.00
91_V144_S1.6401.00
26_K48_D1.6351.00
57_E100_N1.6291.00
191_H256_K1.6171.00
16_F74_F1.5991.00
216_D220_R1.5981.00
169_Y284_G1.5871.00
19_E22_K1.5811.00
23_R219_S1.5741.00
16_F72_I1.5431.00
279_T287_R1.5331.00
206_F287_R1.5311.00
88_Q92_T1.5291.00
57_E60_H1.5251.00
244_M248_V1.5161.00
16_F211_A1.4911.00
111_K161_V1.4801.00
286_R290_E1.4681.00
19_E211_A1.4621.00
193_P256_K1.4611.00
201_E235_R1.4501.00
106_R156_Y1.4451.00
12_I168_N1.4301.00
33_L49_F1.4191.00
132_L143_A1.4141.00
17_V29_V1.4141.00
60_H108_F1.4121.00
71_V105_S1.3961.00
3_I25_I1.3851.00
165_P210_T1.3811.00
40_E43_I1.3621.00
147_L150_K1.3611.00
115_I165_P1.3581.00
74_F115_I1.3561.00
239_L257_F1.3311.00
8_G17_V1.3311.00
64_K108_F1.3291.00
38_R41_N1.3101.00
150_K162_I1.3031.00
114_H145_A1.3021.00
148_F151_A1.2981.00
153_V160_A1.2901.00
116_S120_V1.2731.00
283_E287_R1.2721.00
25_I219_S1.2711.00
206_F284_G1.2711.00
18_R172_R1.2631.00
240_E243_K1.2631.00
199_K237_N1.2601.00
54_V97_G1.2501.00
70_I111_K1.2341.00
63_I68_P1.2291.00
283_E286_R1.2281.00
140_A144_S1.2271.00
138_Y142_K1.2261.00
279_T283_E1.2211.00
114_H149_V1.2151.00
4_I30_V1.2141.00
82_R86_K1.2111.00
72_I214_I1.2071.00
185_R190_I1.2051.00
103_E106_R1.2031.00
19_E208_E1.2021.00
73_N98_T1.1821.00
199_K239_L1.1741.00
114_H162_I1.1701.00
102_L152_Y1.1701.00
29_V47_Y1.1681.00
94_N141_S1.1561.00
20_L215_F1.1541.00
151_A155_T1.1541.00
60_H64_K1.1481.00
163_V214_I1.1421.00
100_N103_E1.1401.00
59_M104_A1.1351.00
111_K221_A1.1301.00
246_E252_E1.1261.00
243_K246_E1.1231.00
207_V211_A1.1161.00
104_A107_K1.1141.00
96_L100_N1.1111.00
105_S112_Y1.1041.00
205_I210_T1.1001.00
191_H254_K1.0981.00
77_E93_T1.0951.00
105_S110_F1.0941.00
265_D268_Y1.0901.00
15_A208_E1.0881.00
150_K227_V1.0861.00
39_K43_I1.0831.00
63_I104_A1.0831.00
103_E107_K1.0781.00
54_V75_A1.0781.00
102_L112_Y1.0781.00
9_A31_D1.0771.00
3_I70_I1.0751.00
18_R22_K1.0751.00
113_V163_V1.0741.00
30_V62_I1.0691.00
121_Y229_N1.0681.00
270_M273_S1.0641.00
236_Y281_F1.0631.00
150_K160_A1.0611.00
282_K286_R1.0591.00
3_I20_L1.0521.00
216_D219_S1.0461.00
95_V144_S1.0411.00
21_N46_D1.0391.00
236_Y240_E1.0331.00
203_D233_G1.0331.00
249_S289_Y1.0311.00
91_V95_V1.0271.00
206_F279_T1.0271.00
61_D64_K1.0251.00
21_N47_Y1.0251.00
104_A108_F1.0251.00
14_S172_R1.0241.00
101_L112_Y1.0201.00
106_R158_I1.0191.00
91_V96_L1.0171.00
248_V289_Y1.0161.00
159_S224_K1.0131.00
15_A207_V1.0121.00
6_V101_L1.0081.00
164_R227_V1.0071.00
15_A18_R1.0031.00
168_N210_T1.0021.00
34_T51_Q0.9991.00
287_R290_E0.9891.00
112_Y149_V0.9721.00
150_K154_R0.9721.00
11_F170_G0.9681.00
93_T97_G0.9621.00
102_L149_V0.9601.00
248_V282_K0.9571.00
50_V62_I0.9511.00
208_E279_T0.9511.00
178_L182_A0.9511.00
30_V59_M0.9431.00
181_K185_R0.9421.00
31_D49_F0.9361.00
181_K184_I0.9351.00
33_L51_Q0.9281.00
269_C272_T0.9271.00
146_D164_R0.9251.00
201_E237_N0.9201.00
212_R215_F0.9201.00
15_A19_E0.9201.00
11_F207_V0.9161.00
71_V101_L0.9101.00
100_N104_A0.9091.00
235_R267_R0.9081.00
58_K61_D0.9061.00
246_E253_V0.9041.00
161_V217_V0.9031.00
246_E251_K0.8981.00
74_F214_I0.8951.00
163_V230_I0.8901.00
126_G130_S0.8891.00
57_E107_K0.8891.00
63_I71_V0.8881.00
144_S147_L0.8871.00
216_D274_M0.8851.00
240_E244_M0.8791.00
98_T149_V0.8691.00
77_E89_D0.8681.00
198_G239_L0.8671.00
164_R229_N0.8671.00
16_F20_L0.8651.00
234_Q280_P0.8641.00
63_I108_F0.8631.00
162_I227_V0.8611.00
17_V27_P0.8561.00
21_N27_P0.8521.00
231_P270_M0.8511.00
28_I67_S0.8481.00
166_S270_M0.8481.00
213_I276_Y0.8391.00
73_N101_L0.8381.00
182_A185_R0.8381.00
259_S262_P0.8331.00
118_D166_S0.8331.00
269_C273_S0.8321.00
184_I187_L0.8321.00
261_R264_H0.8311.00
147_L151_A0.8311.00
55_R93_T0.8241.00
193_P258_V0.8201.00
168_N205_I0.8161.00
32_L53_D0.8131.00
102_L148_F0.8121.00
90_F141_S0.8111.00
258_V261_R0.8111.00
201_E267_R0.8061.00
209_D232_G0.8011.00
87_P140_A0.7991.00
26_K46_D0.7951.00
89_D92_T0.7921.00
6_V75_A0.7911.00
3_I218_V0.7901.00
279_T284_G0.7881.00
161_V221_A0.7851.00
3_I72_I0.7841.00
177_K180_P0.7831.00
212_R279_T0.7791.00
209_D212_R0.7781.00
25_I69_D0.7721.00
136_S139_S0.7701.00
144_S148_F0.7681.00
106_R157_G0.7651.00
212_R276_Y0.7621.00
216_D276_Y0.7541.00
77_E90_F0.7541.00
56_S59_M0.7541.00
125_C130_S0.7531.00
38_R43_I0.7511.00
91_V141_S0.7501.00
272_T278_V0.7471.00
59_M100_N0.7441.00
244_M281_F0.7411.00
122_G133_K0.7391.00
165_P168_N0.7371.00
243_K247_E0.7361.00
89_D93_T0.7351.00
248_V290_E0.7351.00
172_R175_P0.7311.00
98_T102_L0.7291.00
152_Y156_Y0.7251.00
267_R270_M0.7251.00
116_S146_D0.7241.00
265_D270_M0.7231.00
137_P140_A0.7211.00
166_S231_P0.7201.00
103_E152_Y0.7151.00
248_V285_L0.7141.00
256_K259_S0.7141.00
206_F209_D0.7091.00
217_V274_M0.7081.00
71_V112_Y0.7071.00
235_R269_C0.7061.00
169_Y206_F0.7051.00
106_R152_Y0.7041.00
57_E104_A0.7021.00
255_I258_V0.6981.00
16_F214_I0.6961.00
160_A225_G0.6951.00
246_E249_S0.6941.00
97_G100_N0.6931.00
211_A215_F0.6911.00
140_A147_L0.6911.00
216_D275_K0.6901.00
63_I105_S0.6881.00
186_T246_E0.6861.00
25_I70_I0.6831.00
171_P287_R0.6791.00
183_I187_L0.6761.00
15_A211_A0.6741.00
260_D263_G0.6721.00
39_K51_Q0.6711.00
145_A149_V0.6701.00
177_K181_K0.6691.00
14_S18_R0.6691.00
236_Y244_M0.6651.00
83_S90_F0.6611.00
39_K42_L0.6601.00
257_F263_G0.6581.00
189_G251_K0.6571.00
266_R269_C0.6551.00
84_I137_P0.6531.00
91_V140_A0.6521.00
38_R42_L0.6511.00
242_L246_E0.6501.00
70_I113_V0.6481.00
53_D56_S0.6481.00
20_L218_V0.6471.00
127_D271_T0.6431.00
257_F260_D0.6361.00
134_P139_S0.6321.00
209_D279_T0.6321.00
120_V132_L0.6311.00
33_L38_R0.6271.00
185_R188_L0.6261.00
87_P137_P0.6261.00
113_V218_V0.6221.00
162_I225_G0.6221.00
113_V214_I0.6201.00
12_I210_T0.6181.00
236_Y241_I0.6171.00
105_S108_F0.6101.00
31_D35_Y0.6051.00
241_I281_F0.6031.00
159_S222_E0.6031.00
151_A154_R0.6001.00
119_E139_S0.6001.00
256_K260_D0.5991.00
171_P206_F0.5981.00
120_V146_D0.5951.00
266_R272_T0.5941.00
23_R212_R0.5911.00
29_V49_F0.5901.00
182_A186_T0.5901.00
99_V144_S0.5881.00
152_Y158_I0.5871.00
215_F218_V0.5871.00
23_R216_D0.5861.00
153_V158_I0.5861.00
64_K67_S0.5821.00
148_F152_Y0.5801.00
5_V20_L0.5781.00
141_S145_A0.5781.00
4_I63_I0.5751.00
203_D235_R0.5741.00
140_A151_A0.5721.00
183_I289_Y0.5721.00
95_V99_V0.5721.00
15_A172_R0.5721.00
268_Y271_T0.5711.00
32_L35_Y0.5701.00
44_G47_Y0.5701.00
267_R271_T0.5701.00
76_A94_N0.5701.00
17_V21_N0.5691.00
81_D84_I0.5681.00
4_I62_I0.5671.00
9_A33_L0.5661.00
265_D269_C0.5631.00
146_D162_I0.5621.00
185_R189_G0.5611.00
234_Q282_K0.5601.00
259_S263_G0.5591.00
180_P183_I0.5551.00
114_H117_T0.5531.00
4_I71_V0.5511.00
73_N112_Y0.5511.00
67_S108_F0.5501.00
163_V213_I0.5491.00
200_A238_V0.5491.00
220_R228_Y0.5481.00
137_P141_S0.5481.00
151_A156_Y0.5461.00
134_P143_A0.5461.00
87_P91_V0.5451.00
102_L106_R0.5451.00
11_F15_A0.5451.00
4_I52_A0.5421.00
210_T214_I0.5421.00
161_V228_Y0.5411.00
180_P184_I0.5401.00
132_L147_L0.5371.00
18_R21_N0.5371.00
28_I62_I0.5291.00
98_T114_H0.5271.00
113_V217_V0.5261.00
99_V151_A0.5241.00
18_R208_E0.5221.00
138_Y141_S0.5221.00
153_V225_G0.5201.00
210_T230_I0.5191.00
171_P208_E0.5181.00
116_S164_R0.5171.00
63_I101_L0.5151.00
124_E130_S0.5131.00
16_F115_I0.5131.00
233_G272_T0.5121.00
240_E282_K0.5111.00
54_V59_M0.5101.00
183_I245_L0.5091.00
258_V264_H0.5091.00
21_N45_T0.5071.00
21_N44_G0.5061.00
190_I193_P0.5051.00
146_D150_K0.5051.00
77_E94_N0.5041.00
149_V162_I0.5041.00
161_V220_R0.5041.00
15_A171_P0.5031.00
111_K114_H0.5021.00
258_V262_P0.5011.00
52_A62_I0.5001.00
203_D232_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sb8A 2 0.9306 100 0.243 Contact Map
3rufA 2 0.9274 100 0.25 Contact Map
1orrA 3 0.9306 100 0.251 Contact Map
1oc2A 2 0.9874 100 0.252 Contact Map
3m2pA 2 0.9022 100 0.257 Contact Map
2c20A 2 0.9432 100 0.258 Contact Map
2q1sA 2 0.9527 100 0.259 Contact Map
1rpnA 4 0.9369 100 0.259 Contact Map
2hunA 2 0.9779 100 0.26 Contact Map
4egbA 5 0.9211 100 0.262 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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