Q7LXE7 - SULSO - GREMLIN Contacts

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Q7LXE7 - Sugar phosphate nucleotydyl transferase

UniProt:	Q7LXE7	Sequences: MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPVSQWVLEQIRDAGIRDVIIVLGDNAPTRVVEYYGDGSKFGVRITYVYQGKARGLADAVYKVKDVVSDKFLVYLGDNLVPYDLSKFSSFKGSASILLAKVNNPNRFGVAVIKDGRVVKLIEKPKEQISDLALVGVYGFTREIFDVIESLKPSWRGELEITDAIQGLIDRGREVNYEIIQGWWKDTGTPKDILEANAFLLDRYAESRIEGVVDNSTVDGKVIIEKGAVIKNSVVRGPTYIGRDTKIINSYIGPFTSIGDQSEITDSEIEYSVILDGVKIRGVTLMDSLIGNNSTVEKGGRWQKLIIGENSSVIL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	344 (315)
Sequences:	9100 (6364)
Seq/√Len:	358.6

ECOLI - GLMU GLGC RMLA1 RMLA2 GALU GALF
BACSU - GLGC GLMU GLGD RMLA GTAB YNGB RFBF YTDA
HALSA - Q9HSZ9 Q9HSZ8 Q9HS61 Q9HQQ4 Q9HSV0
SULSO - Q7LXE7 Q97XG0 Q980H9 Q97ZD1 Q7LXK9 Q980D4 Q97U06 Q97VX4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
130_K	160_D	3.273	1.00
276_I	279_S	3.112	1.00
289_D	305_D	2.973	1.00
277_I	294_T	2.972	1.00
288_G	305_D	2.896	1.00
293_I	296_S	2.874	1.00
260_K	277_I	2.800	1.00
153_K	157_Q	2.696	1.00
121_K	125_S	2.648	1.00
31_K	39_E	2.621	1.00
305_D	321_N	2.551	1.00
294_T	310_R	2.530	1.00
130_K	208_I	2.473	1.00
141_V	159_S	2.420	1.00
94_K	178_E	2.345	1.00
278_N	295_D	2.341	1.00
252_I	269_Y	2.338	1.00
309_I	312_V	2.305	1.00
179_S	200_R	2.218	1.00
261_N	278_N	2.191	1.00
286_S	302_V	2.117	1.00
3_A	46_I	2.072	1.00
254_E	272_R	2.046	1.00
141_V	149_K	2.045	1.00
149_K	156_E	2.018	1.00
267_P	284_F	1.991	1.00
35_Q	64_Y	1.986	1.00
285_T	298_I	1.982	1.00
21_G	27_K	1.967	1.00
101_F	171_R	1.955	1.00
117_F	127_L	1.955	1.00
123_S	170_T	1.942	1.00
100_K	170_T	1.921	1.00
271_G	289_D	1.885	1.00
304_L	321_N	1.882	1.00
290_Q	306_G	1.877	1.00
147_V	206_Y	1.877	1.00
48_D	76_T	1.867	1.00
275_K	292_E	1.860	1.00
295_D	311_G	1.857	1.00
298_I	303_I	1.847	1.00
3_A	41_I	1.826	1.00
122_G	205_N	1.806	1.00
306_G	322_N	1.780	1.00
251_V	268_T	1.762	1.00
218_T	239_E	1.762	1.00
272_R	289_D	1.751	1.00
259_I	262_S	1.742	1.00
307_V	323_S	1.740	1.00
128_L	206_Y	1.732	1.00
284_F	300_Y	1.716	1.00
279_S	293_I	1.713	1.00
248_D	266_G	1.710	1.00
146_R	203_E	1.705	1.00
281_I	287_I	1.670	1.00
273_D	290_Q	1.669	1.00
117_F	168_G	1.657	1.00
50_I	78_V	1.650	1.00
237_R	240_G	1.634	1.00
175_D	179_S	1.630	1.00
256_G	273_D	1.629	1.00
38_L	49_V	1.621	1.00
135_N	153_K	1.619	1.00
216_T	225_A	1.613	1.00
291_S	307_V	1.596	1.00
115_S	119_S	1.581	1.00
303_I	309_I	1.575	1.00
258_V	275_K	1.569	1.00
283_P	299_E	1.566	1.00
282_G	285_T	1.550	1.00
120_F	207_E	1.546	1.00
249_G	266_G	1.545	1.00
242_V	245_S	1.541	1.00
308_K	324_T	1.534	1.00
266_G	283_P	1.509	1.00
255_K	272_R	1.470	1.00
242_V	260_K	1.465	1.00
84_R	88_D	1.463	1.00
288_G	302_V	1.457	1.00
265_R	283_P	1.454	1.00
176_V	200_R	1.430	1.00
176_V	196_G	1.428	1.00
117_F	125_S	1.424	1.00
304_L	318_L	1.418	1.00
41_I	104_Y	1.418	1.00
48_D	74_R	1.377	1.00
34_S	65_Y	1.364	1.00
124_A	197_L	1.359	1.00
146_R	205_N	1.359	1.00
35_Q	39_E	1.353	1.00
186_G	189_E	1.340	1.00
309_I	314_L	1.334	1.00
235_E	239_E	1.327	1.00
88_D	91_Y	1.320	1.00
302_V	318_L	1.319	1.00
254_E	269_Y	1.309	1.00
220_K	239_E	1.306	1.00
142_I	161_L	1.298	1.00
269_Y	286_S	1.293	1.00
57_A	79_Y	1.289	1.00
248_D	251_V	1.287	1.00
175_D	200_R	1.262	1.00
142_I	206_Y	1.253	1.00
281_I	285_T	1.253	1.00
251_V	265_R	1.248	1.00
141_V	151_I	1.240	1.00
123_S	203_E	1.240	1.00
57_A	62_V	1.240	1.00
136_R	153_K	1.239	1.00
254_E	271_G	1.238	1.00
118_S	168_G	1.236	1.00
253_I	257_A	1.235	1.00
102_L	168_G	1.232	1.00
268_T	285_T	1.218	1.00
33_V	216_T	1.209	1.00
268_T	281_I	1.209	1.00
260_K	275_K	1.202	1.00
292_E	308_K	1.200	1.00
298_I	301_S	1.196	1.00
103_V	169_F	1.195	1.00
53_L	57_A	1.190	1.00
196_G	200_R	1.190	1.00
291_S	304_L	1.189	1.00
25_L	64_Y	1.189	1.00
35_Q	68_G	1.187	1.00
264_V	268_T	1.183	1.00
195_Q	199_D	1.181	1.00
288_G	304_L	1.173	1.00
100_K	168_G	1.173	1.00
116_K	119_S	1.170	1.00
50_I	96_V	1.168	1.00
88_D	92_K	1.162	1.00
314_L	317_S	1.154	1.00
236_S	240_G	1.150	1.00
72_G	75_I	1.144	1.00
179_S	196_G	1.135	1.00
22_P	60_R	1.131	1.00
105_L	108_N	1.130	1.00
250_K	267_P	1.111	1.00
248_D	265_R	1.106	1.00
301_S	314_L	1.094	1.00
21_G	60_R	1.087	1.00
29_A	229_L	1.081	1.00
212_W	228_F	1.066	1.00
66_G	77_Y	1.065	1.00
104_Y	114_L	1.062	1.00
287_I	291_S	1.057	1.00
128_L	140_A	1.055	1.00
282_G	299_E	1.043	1.00
90_V	103_V	1.041	1.00
60_R	63_E	1.040	1.00
291_S	305_D	1.032	1.00
151_I	158_I	1.028	1.00
59_T	63_E	1.024	1.00
257_A	276_I	1.024	1.00
233_Y	237_R	1.023	1.00
254_E	257_A	1.022	1.00
72_G	76_T	1.017	1.00
172_E	175_D	1.017	1.00
36_W	229_L	1.014	1.00
91_Y	94_K	1.009	1.00
181_K	188_L	1.009	1.00
28_V	226_N	1.006	1.00
54_G	83_A	1.005	1.00
214_K	228_F	1.003	1.00
274_T	291_S	0.998	1.00
27_K	32_P	0.995	1.00
133_N	136_R	0.990	1.00
128_L	161_L	0.986	1.00
220_K	224_E	0.986	1.00
271_G	288_G	0.983	1.00
241_V	245_S	0.982	1.00
257_A	274_T	0.980	1.00
32_P	35_Q	0.980	1.00
300_Y	316_D	0.976	1.00
120_F	205_N	0.975	1.00
241_V	246_T	0.967	1.00
218_T	221_D	0.963	1.00
264_V	270_I	0.958	1.00
310_R	326_E	0.950	1.00
24_Q	106_G	0.948	1.00
20_T	267_P	0.948	1.00
271_G	286_S	0.944	1.00
176_V	197_L	0.944	1.00
139_V	162_A	0.944	1.00
253_I	259_I	0.944	1.00
124_A	169_F	0.940	1.00
32_P	64_Y	0.938	1.00
62_V	79_Y	0.938	1.00
99_D	171_R	0.935	1.00
303_I	307_V	0.935	1.00
280_Y	283_P	0.934	1.00
163_L	167_Y	0.932	1.00
91_Y	178_E	0.932	1.00
309_I	313_T	0.929	1.00
87_A	180_L	0.922	1.00
113_D	116_K	0.918	1.00
257_A	273_D	0.918	1.00
285_T	301_S	0.917	1.00
276_I	281_I	0.916	1.00
280_Y	285_T	0.916	1.00
131_V	162_A	0.914	1.00
133_N	153_K	0.904	1.00
279_S	282_G	0.901	1.00
295_D	310_R	0.900	1.00
214_K	224_E	0.899	1.00
83_A	88_D	0.898	1.00
274_T	289_D	0.894	1.00
181_K	184_W	0.894	1.00
247_V	251_V	0.893	1.00
147_V	204_V	0.889	1.00
290_Q	305_D	0.881	1.00
154_P	184_W	0.880	1.00
169_F	193_A	0.880	1.00
132_N	160_D	0.874	1.00
38_L	75_I	0.874	1.00
319_I	325_V	0.873	1.00
99_D	170_T	0.872	1.00
244_N	261_N	0.861	1.00
102_L	118_S	0.856	1.00
246_T	263_V	0.855	1.00
34_S	61_V	0.855	1.00
198_I	204_V	0.854	1.00
234_A	238_I	0.854	1.00
296_S	309_I	0.852	1.00
5_I	41_I	0.851	1.00
116_K	120_F	0.850	1.00
306_G	321_N	0.845	1.00
254_E	274_T	0.845	1.00
11_G	23_K	0.842	1.00
41_I	46_I	0.839	1.00
251_V	264_V	0.836	1.00
293_I	298_I	0.836	1.00
145_G	208_I	0.834	1.00
53_L	62_V	0.821	1.00
245_S	259_I	0.821	1.00
250_K	266_G	0.820	1.00
151_I	156_E	0.817	1.00
140_A	147_V	0.816	1.00
251_V	266_G	0.816	1.00
267_P	283_P	0.813	1.00
279_S	295_D	0.811	1.00
42_R	74_R	0.809	1.00
296_S	299_E	0.808	1.00
42_R	68_G	0.808	1.00
34_S	51_I	0.807	1.00
251_V	283_P	0.806	1.00
307_V	321_N	0.804	1.00
242_V	246_T	0.804	1.00
54_G	88_D	0.802	1.00
53_L	77_Y	0.794	1.00
59_T	62_V	0.794	1.00
180_L	193_A	0.792	1.00
138_G	152_E	0.782	1.00
56_N	60_R	0.780	1.00
175_D	178_E	0.773	1.00
294_T	299_E	0.769	1.00
320_G	323_S	0.767	1.00
220_K	235_E	0.766	1.00
76_T	96_V	0.766	1.00
126_I	147_V	0.762	1.00
126_I	140_A	0.760	1.00
73_V	77_Y	0.760	1.00
237_R	247_V	0.758	1.00
257_A	289_D	0.758	1.00
72_G	78_V	0.755	1.00
247_V	264_V	0.754	1.00
129_A	162_A	0.754	1.00
62_V	77_Y	0.753	1.00
37_V	104_Y	0.752	1.00
161_L	208_I	0.747	1.00
252_I	255_K	0.747	1.00
13_R	23_K	0.747	1.00
243_D	251_V	0.747	1.00
35_Q	65_Y	0.746	1.00
4_V	101_F	0.745	1.00
227_A	230_L	0.743	1.00
311_G	315_M	0.742	1.00
4_V	50_I	0.741	1.00
44_A	114_L	0.741	1.00
32_P	36_W	0.736	1.00
311_G	324_T	0.736	1.00
100_K	121_K	0.735	1.00
6_L	105_L	0.733	1.00
248_D	268_T	0.732	1.00
156_E	159_S	0.730	1.00
244_N	247_V	0.729	1.00
246_T	261_N	0.729	1.00
29_A	226_N	0.728	1.00
248_D	283_P	0.728	1.00
129_A	213_W	0.724	1.00
310_R	313_T	0.724	1.00
23_K	107_D	0.723	0.99
25_L	60_R	0.723	0.99
185_R	189_E	0.720	0.99
73_V	76_T	0.719	0.99
143_K	148_V	0.717	0.99
121_K	168_G	0.716	0.99
294_T	297_E	0.714	0.99
51_I	65_Y	0.714	0.99
319_I	323_S	0.711	0.99
242_V	258_V	0.706	0.99
228_F	231_D	0.703	0.99
22_P	56_N	0.701	0.99
121_K	170_T	0.697	0.99
301_S	317_S	0.697	0.99
29_A	36_W	0.697	0.99
307_V	319_I	0.696	0.99
256_G	272_R	0.694	0.99
124_A	204_V	0.694	0.99
173_I	197_L	0.692	0.99
196_G	199_D	0.690	0.99
311_G	326_E	0.690	0.99
259_I	264_V	0.689	0.99
141_V	148_V	0.687	0.99
128_L	147_V	0.686	0.99
292_E	310_R	0.677	0.99
307_V	320_G	0.677	0.99
231_D	235_E	0.675	0.99
5_I	38_L	0.674	0.99
307_V	310_R	0.670	0.99
49_V	73_V	0.670	0.99
40_Q	44_A	0.668	0.99
50_I	97_V	0.667	0.99
305_D	322_N	0.663	0.99
282_G	287_I	0.663	0.99
42_R	49_V	0.660	0.99
285_T	299_E	0.656	0.99
149_K	195_Q	0.649	0.99
28_V	33_V	0.649	0.99
257_A	272_R	0.648	0.99
242_V	250_K	0.648	0.99
176_V	193_A	0.648	0.99
39_E	43_D	0.646	0.99
38_L	65_Y	0.639	0.99
93_V	96_V	0.638	0.99
127_L	166_V	0.638	0.99
180_L	196_G	0.637	0.99
291_S	321_N	0.636	0.99
311_G	316_D	0.633	0.99
78_V	81_G	0.629	0.99
312_V	315_M	0.628	0.99
214_K	225_A	0.626	0.99
105_L	165_G	0.626	0.99
304_L	320_G	0.625	0.99
287_I	290_Q	0.625	0.99
224_E	227_A	0.624	0.99
131_V	160_D	0.620	0.98
233_Y	236_S	0.620	0.98
79_Y	82_K	0.619	0.98
72_G	79_Y	0.619	0.98
84_R	188_L	0.618	0.98
180_L	191_T	0.618	0.98
286_S	289_D	0.617	0.98
253_I	256_G	0.616	0.98
280_Y	297_E	0.614	0.98
187_E	192_D	0.612	0.98
46_I	118_S	0.612	0.98
243_D	250_K	0.610	0.98
164_V	213_W	0.608	0.98
254_E	289_D	0.607	0.98
47_R	74_R	0.604	0.98
169_F	173_I	0.603	0.98
125_S	168_G	0.603	0.98
24_Q	61_V	0.602	0.98
276_I	287_I	0.601	0.98
318_L	321_N	0.601	0.98
102_L	114_L	0.600	0.98
107_D	215_D	0.600	0.98
15_R	19_H	0.600	0.98
50_I	76_T	0.600	0.98
314_L	319_I	0.599	0.98
51_I	75_I	0.596	0.98
9_G	23_K	0.596	0.98
7_H	51_I	0.592	0.98
304_L	307_V	0.591	0.98
279_S	283_P	0.589	0.98
62_V	66_G	0.587	0.98
274_T	277_I	0.586	0.98
94_K	97_V	0.586	0.98
74_R	77_Y	0.586	0.98
52_V	89_A	0.585	0.98
124_A	194_I	0.585	0.98
183_S	187_E	0.585	0.98
50_I	93_V	0.583	0.98
40_Q	114_L	0.583	0.98
270_I	274_T	0.583	0.98
6_L	52_V	0.582	0.98
99_D	172_E	0.581	0.98
131_V	134_P	0.581	0.98
36_W	39_E	0.581	0.98
122_G	203_E	0.579	0.98
268_T	282_G	0.577	0.98
148_V	198_I	0.574	0.97
126_I	204_V	0.572	0.97
40_Q	43_D	0.570	0.97
146_R	198_I	0.568	0.97
65_Y	75_I	0.568	0.97
265_R	268_T	0.567	0.97
209_I	213_W	0.566	0.97
308_K	311_G	0.565	0.97
76_T	79_Y	0.563	0.97
116_K	207_E	0.563	0.97
88_D	188_L	0.561	0.97
54_G	57_A	0.561	0.97
128_L	208_I	0.560	0.97
241_V	256_G	0.556	0.97
157_Q	160_D	0.555	0.97
53_L	61_V	0.554	0.97
136_R	221_D	0.552	0.97
183_S	192_D	0.552	0.97
242_V	247_V	0.552	0.97
29_A	233_Y	0.550	0.97
183_S	186_G	0.550	0.97
161_L	206_Y	0.550	0.97
309_I	325_V	0.549	0.97
9_G	13_R	0.548	0.97
226_N	230_L	0.546	0.97
130_K	161_L	0.542	0.96
274_T	288_G	0.542	0.96
42_R	73_V	0.541	0.96
33_V	37_V	0.540	0.96
176_V	179_S	0.539	0.96
228_F	232_R	0.538	0.96
312_V	324_T	0.537	0.96
78_V	82_K	0.537	0.96
243_D	246_T	0.535	0.96
282_G	297_E	0.533	0.96
91_Y	177_I	0.533	0.96
75_I	78_V	0.533	0.96
322_N	326_E	0.532	0.96
310_R	314_L	0.532	0.96
241_V	244_N	0.532	0.96
274_T	305_D	0.529	0.96
5_I	37_V	0.529	0.96
221_D	224_E	0.528	0.96
31_K	36_W	0.528	0.96
63_E	66_G	0.527	0.96
4_V	90_V	0.526	0.96
177_I	180_L	0.525	0.96
229_L	233_Y	0.524	0.96
292_E	296_S	0.524	0.96
310_R	324_T	0.523	0.96
8_G	52_V	0.523	0.96
274_T	290_Q	0.522	0.96
177_I	193_A	0.521	0.96
287_I	293_I	0.519	0.95
295_D	299_E	0.519	0.95
104_Y	166_V	0.518	0.95
187_E	191_T	0.517	0.95
244_N	251_V	0.517	0.95
308_K	312_V	0.516	0.95
82_K	88_D	0.515	0.95
244_N	262_S	0.514	0.95
298_I	314_L	0.512	0.95
150_L	191_T	0.512	0.95
317_S	320_G	0.512	0.95
3_A	44_A	0.512	0.95
125_S	207_E	0.509	0.95
39_E	42_R	0.509	0.95
176_V	180_L	0.508	0.95
180_L	188_L	0.507	0.95
236_S	239_E	0.506	0.95
6_L	89_A	0.504	0.95
224_E	228_F	0.504	0.95
257_A	260_K	0.504	0.95
140_A	161_L	0.503	0.95
262_S	276_I	0.501	0.95
93_V	97_V	0.501	0.95
72_G	82_K	0.501	0.95
296_S	312_V	0.500	0.94
65_Y	77_Y	0.500	0.94

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ggoA	3	0.9535	100	0.374	Contact Map
3brkX	2	0.9448	100	0.381	Contact Map
1yp2A	4	0.968	100	0.384	Contact Map
4g3qA	3	0.9884	100	0.416	Contact Map
1hm9A	3	0.968	100	0.424	Contact Map
4fceA	3	0.9593	100	0.426	Contact Map
2v0hA	3	0.9738	100	0.43	Contact Map
2icyA	1	0.8547	100	0.504	Contact Map
2i5kA	5	0.8634	100	0.527	Contact Map
3jukA	3	0.6715	100	0.527	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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