GREMLIN Database
Q7LXE7 - Sugar phosphate nucleotydyl transferase
UniProt: Q7LXE7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (315)
Sequences: 9100 (6364)
Seq/√Len: 358.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_K160_D3.2731.00
276_I279_S3.1121.00
289_D305_D2.9731.00
277_I294_T2.9721.00
288_G305_D2.8961.00
293_I296_S2.8741.00
260_K277_I2.8001.00
153_K157_Q2.6961.00
121_K125_S2.6481.00
31_K39_E2.6211.00
305_D321_N2.5511.00
294_T310_R2.5301.00
130_K208_I2.4731.00
141_V159_S2.4201.00
94_K178_E2.3451.00
278_N295_D2.3411.00
252_I269_Y2.3381.00
309_I312_V2.3051.00
179_S200_R2.2181.00
261_N278_N2.1911.00
286_S302_V2.1171.00
3_A46_I2.0721.00
254_E272_R2.0461.00
141_V149_K2.0451.00
149_K156_E2.0181.00
267_P284_F1.9911.00
35_Q64_Y1.9861.00
285_T298_I1.9821.00
21_G27_K1.9671.00
101_F171_R1.9551.00
117_F127_L1.9551.00
123_S170_T1.9421.00
100_K170_T1.9211.00
271_G289_D1.8851.00
304_L321_N1.8821.00
290_Q306_G1.8771.00
147_V206_Y1.8771.00
48_D76_T1.8671.00
275_K292_E1.8601.00
295_D311_G1.8571.00
298_I303_I1.8471.00
3_A41_I1.8261.00
122_G205_N1.8061.00
306_G322_N1.7801.00
251_V268_T1.7621.00
218_T239_E1.7621.00
272_R289_D1.7511.00
259_I262_S1.7421.00
307_V323_S1.7401.00
128_L206_Y1.7321.00
284_F300_Y1.7161.00
279_S293_I1.7131.00
248_D266_G1.7101.00
146_R203_E1.7051.00
281_I287_I1.6701.00
273_D290_Q1.6691.00
117_F168_G1.6571.00
50_I78_V1.6501.00
237_R240_G1.6341.00
175_D179_S1.6301.00
256_G273_D1.6291.00
38_L49_V1.6211.00
135_N153_K1.6191.00
216_T225_A1.6131.00
291_S307_V1.5961.00
115_S119_S1.5811.00
303_I309_I1.5751.00
258_V275_K1.5691.00
283_P299_E1.5661.00
282_G285_T1.5501.00
120_F207_E1.5461.00
249_G266_G1.5451.00
242_V245_S1.5411.00
308_K324_T1.5341.00
266_G283_P1.5091.00
255_K272_R1.4701.00
242_V260_K1.4651.00
84_R88_D1.4631.00
288_G302_V1.4571.00
265_R283_P1.4541.00
176_V200_R1.4301.00
176_V196_G1.4281.00
117_F125_S1.4241.00
304_L318_L1.4181.00
41_I104_Y1.4181.00
48_D74_R1.3771.00
34_S65_Y1.3641.00
124_A197_L1.3591.00
146_R205_N1.3591.00
35_Q39_E1.3531.00
186_G189_E1.3401.00
309_I314_L1.3341.00
235_E239_E1.3271.00
88_D91_Y1.3201.00
302_V318_L1.3191.00
254_E269_Y1.3091.00
220_K239_E1.3061.00
142_I161_L1.2981.00
269_Y286_S1.2931.00
57_A79_Y1.2891.00
248_D251_V1.2871.00
175_D200_R1.2621.00
142_I206_Y1.2531.00
281_I285_T1.2531.00
251_V265_R1.2481.00
141_V151_I1.2401.00
123_S203_E1.2401.00
57_A62_V1.2401.00
136_R153_K1.2391.00
254_E271_G1.2381.00
118_S168_G1.2361.00
253_I257_A1.2351.00
102_L168_G1.2321.00
268_T285_T1.2181.00
33_V216_T1.2091.00
268_T281_I1.2091.00
260_K275_K1.2021.00
292_E308_K1.2001.00
298_I301_S1.1961.00
103_V169_F1.1951.00
53_L57_A1.1901.00
196_G200_R1.1901.00
291_S304_L1.1891.00
25_L64_Y1.1891.00
35_Q68_G1.1871.00
264_V268_T1.1831.00
195_Q199_D1.1811.00
288_G304_L1.1731.00
100_K168_G1.1731.00
116_K119_S1.1701.00
50_I96_V1.1681.00
88_D92_K1.1621.00
314_L317_S1.1541.00
236_S240_G1.1501.00
72_G75_I1.1441.00
179_S196_G1.1351.00
22_P60_R1.1311.00
105_L108_N1.1301.00
250_K267_P1.1111.00
248_D265_R1.1061.00
301_S314_L1.0941.00
21_G60_R1.0871.00
29_A229_L1.0811.00
212_W228_F1.0661.00
66_G77_Y1.0651.00
104_Y114_L1.0621.00
287_I291_S1.0571.00
128_L140_A1.0551.00
282_G299_E1.0431.00
90_V103_V1.0411.00
60_R63_E1.0401.00
291_S305_D1.0321.00
151_I158_I1.0281.00
59_T63_E1.0241.00
257_A276_I1.0241.00
233_Y237_R1.0231.00
254_E257_A1.0221.00
72_G76_T1.0171.00
172_E175_D1.0171.00
36_W229_L1.0141.00
91_Y94_K1.0091.00
181_K188_L1.0091.00
28_V226_N1.0061.00
54_G83_A1.0051.00
214_K228_F1.0031.00
274_T291_S0.9981.00
27_K32_P0.9951.00
133_N136_R0.9901.00
128_L161_L0.9861.00
220_K224_E0.9861.00
271_G288_G0.9831.00
241_V245_S0.9821.00
257_A274_T0.9801.00
32_P35_Q0.9801.00
300_Y316_D0.9761.00
120_F205_N0.9751.00
241_V246_T0.9671.00
218_T221_D0.9631.00
264_V270_I0.9581.00
310_R326_E0.9501.00
24_Q106_G0.9481.00
20_T267_P0.9481.00
271_G286_S0.9441.00
176_V197_L0.9441.00
139_V162_A0.9441.00
253_I259_I0.9441.00
124_A169_F0.9401.00
32_P64_Y0.9381.00
62_V79_Y0.9381.00
99_D171_R0.9351.00
303_I307_V0.9351.00
280_Y283_P0.9341.00
163_L167_Y0.9321.00
91_Y178_E0.9321.00
309_I313_T0.9291.00
87_A180_L0.9221.00
113_D116_K0.9181.00
257_A273_D0.9181.00
285_T301_S0.9171.00
276_I281_I0.9161.00
280_Y285_T0.9161.00
131_V162_A0.9141.00
133_N153_K0.9041.00
279_S282_G0.9011.00
295_D310_R0.9001.00
214_K224_E0.8991.00
83_A88_D0.8981.00
274_T289_D0.8941.00
181_K184_W0.8941.00
247_V251_V0.8931.00
147_V204_V0.8891.00
290_Q305_D0.8811.00
154_P184_W0.8801.00
169_F193_A0.8801.00
132_N160_D0.8741.00
38_L75_I0.8741.00
319_I325_V0.8731.00
99_D170_T0.8721.00
244_N261_N0.8611.00
102_L118_S0.8561.00
246_T263_V0.8551.00
34_S61_V0.8551.00
198_I204_V0.8541.00
234_A238_I0.8541.00
296_S309_I0.8521.00
5_I41_I0.8511.00
116_K120_F0.8501.00
306_G321_N0.8451.00
254_E274_T0.8451.00
11_G23_K0.8421.00
41_I46_I0.8391.00
251_V264_V0.8361.00
293_I298_I0.8361.00
145_G208_I0.8341.00
53_L62_V0.8211.00
245_S259_I0.8211.00
250_K266_G0.8201.00
151_I156_E0.8171.00
140_A147_V0.8161.00
251_V266_G0.8161.00
267_P283_P0.8131.00
279_S295_D0.8111.00
42_R74_R0.8091.00
296_S299_E0.8081.00
42_R68_G0.8081.00
34_S51_I0.8071.00
251_V283_P0.8061.00
307_V321_N0.8041.00
242_V246_T0.8041.00
54_G88_D0.8021.00
53_L77_Y0.7941.00
59_T62_V0.7941.00
180_L193_A0.7921.00
138_G152_E0.7821.00
56_N60_R0.7801.00
175_D178_E0.7731.00
294_T299_E0.7691.00
320_G323_S0.7671.00
220_K235_E0.7661.00
76_T96_V0.7661.00
126_I147_V0.7621.00
126_I140_A0.7601.00
73_V77_Y0.7601.00
237_R247_V0.7581.00
257_A289_D0.7581.00
72_G78_V0.7551.00
247_V264_V0.7541.00
129_A162_A0.7541.00
62_V77_Y0.7531.00
37_V104_Y0.7521.00
161_L208_I0.7471.00
252_I255_K0.7471.00
13_R23_K0.7471.00
243_D251_V0.7471.00
35_Q65_Y0.7461.00
4_V101_F0.7451.00
227_A230_L0.7431.00
311_G315_M0.7421.00
4_V50_I0.7411.00
44_A114_L0.7411.00
32_P36_W0.7361.00
311_G324_T0.7361.00
100_K121_K0.7351.00
6_L105_L0.7331.00
248_D268_T0.7321.00
156_E159_S0.7301.00
244_N247_V0.7291.00
246_T261_N0.7291.00
29_A226_N0.7281.00
248_D283_P0.7281.00
129_A213_W0.7241.00
310_R313_T0.7241.00
23_K107_D0.7230.99
25_L60_R0.7230.99
185_R189_E0.7200.99
73_V76_T0.7190.99
143_K148_V0.7170.99
121_K168_G0.7160.99
294_T297_E0.7140.99
51_I65_Y0.7140.99
319_I323_S0.7110.99
242_V258_V0.7060.99
228_F231_D0.7030.99
22_P56_N0.7010.99
121_K170_T0.6970.99
301_S317_S0.6970.99
29_A36_W0.6970.99
307_V319_I0.6960.99
256_G272_R0.6940.99
124_A204_V0.6940.99
173_I197_L0.6920.99
196_G199_D0.6900.99
311_G326_E0.6900.99
259_I264_V0.6890.99
141_V148_V0.6870.99
128_L147_V0.6860.99
292_E310_R0.6770.99
307_V320_G0.6770.99
231_D235_E0.6750.99
5_I38_L0.6740.99
307_V310_R0.6700.99
49_V73_V0.6700.99
40_Q44_A0.6680.99
50_I97_V0.6670.99
305_D322_N0.6630.99
282_G287_I0.6630.99
42_R49_V0.6600.99
285_T299_E0.6560.99
149_K195_Q0.6490.99
28_V33_V0.6490.99
257_A272_R0.6480.99
242_V250_K0.6480.99
176_V193_A0.6480.99
39_E43_D0.6460.99
38_L65_Y0.6390.99
93_V96_V0.6380.99
127_L166_V0.6380.99
180_L196_G0.6370.99
291_S321_N0.6360.99
311_G316_D0.6330.99
78_V81_G0.6290.99
312_V315_M0.6280.99
214_K225_A0.6260.99
105_L165_G0.6260.99
304_L320_G0.6250.99
287_I290_Q0.6250.99
224_E227_A0.6240.99
131_V160_D0.6200.98
233_Y236_S0.6200.98
79_Y82_K0.6190.98
72_G79_Y0.6190.98
84_R188_L0.6180.98
180_L191_T0.6180.98
286_S289_D0.6170.98
253_I256_G0.6160.98
280_Y297_E0.6140.98
187_E192_D0.6120.98
46_I118_S0.6120.98
243_D250_K0.6100.98
164_V213_W0.6080.98
254_E289_D0.6070.98
47_R74_R0.6040.98
169_F173_I0.6030.98
125_S168_G0.6030.98
24_Q61_V0.6020.98
276_I287_I0.6010.98
318_L321_N0.6010.98
102_L114_L0.6000.98
107_D215_D0.6000.98
15_R19_H0.6000.98
50_I76_T0.6000.98
314_L319_I0.5990.98
51_I75_I0.5960.98
9_G23_K0.5960.98
7_H51_I0.5920.98
304_L307_V0.5910.98
279_S283_P0.5890.98
62_V66_G0.5870.98
274_T277_I0.5860.98
94_K97_V0.5860.98
74_R77_Y0.5860.98
52_V89_A0.5850.98
124_A194_I0.5850.98
183_S187_E0.5850.98
50_I93_V0.5830.98
40_Q114_L0.5830.98
270_I274_T0.5830.98
6_L52_V0.5820.98
99_D172_E0.5810.98
131_V134_P0.5810.98
36_W39_E0.5810.98
122_G203_E0.5790.98
268_T282_G0.5770.98
148_V198_I0.5740.97
126_I204_V0.5720.97
40_Q43_D0.5700.97
146_R198_I0.5680.97
65_Y75_I0.5680.97
265_R268_T0.5670.97
209_I213_W0.5660.97
308_K311_G0.5650.97
76_T79_Y0.5630.97
116_K207_E0.5630.97
88_D188_L0.5610.97
54_G57_A0.5610.97
128_L208_I0.5600.97
241_V256_G0.5560.97
157_Q160_D0.5550.97
53_L61_V0.5540.97
136_R221_D0.5520.97
183_S192_D0.5520.97
242_V247_V0.5520.97
29_A233_Y0.5500.97
183_S186_G0.5500.97
161_L206_Y0.5500.97
309_I325_V0.5490.97
9_G13_R0.5480.97
226_N230_L0.5460.97
130_K161_L0.5420.96
274_T288_G0.5420.96
42_R73_V0.5410.96
33_V37_V0.5400.96
176_V179_S0.5390.96
228_F232_R0.5380.96
312_V324_T0.5370.96
78_V82_K0.5370.96
243_D246_T0.5350.96
282_G297_E0.5330.96
91_Y177_I0.5330.96
75_I78_V0.5330.96
322_N326_E0.5320.96
310_R314_L0.5320.96
241_V244_N0.5320.96
274_T305_D0.5290.96
5_I37_V0.5290.96
221_D224_E0.5280.96
31_K36_W0.5280.96
63_E66_G0.5270.96
4_V90_V0.5260.96
177_I180_L0.5250.96
229_L233_Y0.5240.96
292_E296_S0.5240.96
310_R324_T0.5230.96
8_G52_V0.5230.96
274_T290_Q0.5220.96
177_I193_A0.5210.96
287_I293_I0.5190.95
295_D299_E0.5190.95
104_Y166_V0.5180.95
187_E191_T0.5170.95
244_N251_V0.5170.95
308_K312_V0.5160.95
82_K88_D0.5150.95
244_N262_S0.5140.95
298_I314_L0.5120.95
150_L191_T0.5120.95
317_S320_G0.5120.95
3_A44_A0.5120.95
125_S207_E0.5090.95
39_E42_R0.5090.95
176_V180_L0.5080.95
180_L188_L0.5070.95
236_S239_E0.5060.95
6_L89_A0.5040.95
224_E228_F0.5040.95
257_A260_K0.5040.95
140_A161_L0.5030.95
262_S276_I0.5010.95
93_V97_V0.5010.95
72_G82_K0.5010.95
296_S312_V0.5000.94
65_Y77_Y0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ggoA 3 0.9535 100 0.374 Contact Map
3brkX 2 0.9448 100 0.381 Contact Map
1yp2A 4 0.968 100 0.384 Contact Map
4g3qA 3 0.9884 100 0.416 Contact Map
1hm9A 3 0.968 100 0.424 Contact Map
4fceA 3 0.9593 100 0.426 Contact Map
2v0hA 3 0.9738 100 0.43 Contact Map
2icyA 1 0.8547 100 0.504 Contact Map
2i5kA 5 0.8634 100 0.527 Contact Map
3jukA 3 0.6715 100 0.527 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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