GREMLIN Database
Q7LXE6 - dTDP-4-dehydrorhamnose reductase (RfbD-1)
UniProt: Q7LXE6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 226 (212)
Sequences: 40920 (25675)
Seq/√Len: 1763.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_K221_L2.7571.00
158_L211_I2.7411.00
34_K38_E2.6281.00
28_E31_K2.5841.00
156_G207_K2.4941.00
145_A160_V2.3681.00
12_V150_L2.2591.00
219_L222_E2.2041.00
104_T146_I2.1871.00
144_S217_Y2.1791.00
126_T185_K2.1651.00
57_V146_I2.1561.00
209_K215_D2.0981.00
206_S210_K2.0871.00
168_Y172_L2.0531.00
128_F185_K2.0501.00
102_I149_L2.0101.00
71_K74_D1.9471.00
144_S148_E1.9361.00
14_I150_L1.9331.00
176_E221_L1.9281.00
108_F223_G1.9051.00
15_N56_H1.8651.00
173_K176_E1.8561.00
166_S169_E1.8411.00
40_V89_G1.7821.00
163_E209_K1.7391.00
72_E207_K1.7321.00
41_K92_F1.7281.00
76_P87_L1.6701.00
87_L91_T1.6501.00
119_K123_E1.6311.00
208_A212_L1.6061.00
173_K177_K1.5781.00
156_G211_I1.5711.00
147_E151_A1.5691.00
15_N40_V1.5661.00
38_E41_K1.5551.00
105_S203_L1.5531.00
168_Y186_E1.5521.00
41_K45_R1.5461.00
16_T57_V1.5391.00
133_Y164_R1.5351.00
58_S62_V1.5201.00
47_S52_A1.5131.00
33_Y88_L1.4741.00
205_Y209_K1.4691.00
56_H89_G1.4641.00
68_G74_D1.4171.00
91_T94_L1.4071.00
68_G71_K1.4061.00
46_A50_V1.3791.00
128_F187_V1.3781.00
161_A203_L1.3771.00
169_E172_L1.3531.00
104_T142_L1.3531.00
14_I146_I1.3361.00
139_A143_A1.3191.00
56_H101_V1.3171.00
120_T125_K1.3171.00
47_S54_F1.3141.00
135_S163_E1.3111.00
84_L88_L1.3091.00
30_E34_K1.3091.00
43_M54_F1.3061.00
44_V96_Y1.3001.00
13_I47_S1.2921.00
207_K211_I1.2881.00
70_Y74_D1.2851.00
36_N85_T1.2731.00
126_T183_E1.2721.00
53_Y100_L1.2721.00
148_E152_L1.2701.00
57_V104_T1.2681.00
35_I39_A1.2651.00
137_I142_L1.2611.00
71_K204_D1.2591.00
94_L101_V1.2581.00
44_V93_A1.2501.00
24_K28_E1.2481.00
45_R48_R1.2451.00
175_K181_P1.2421.00
19_M35_I1.2351.00
37_A88_L1.2351.00
164_R202_S1.2281.00
54_F93_A1.2231.00
56_H93_A1.2211.00
165_I220_D1.2091.00
164_R200_D1.1941.00
161_A205_Y1.1921.00
138_S223_G1.1851.00
172_L175_K1.1801.00
102_I146_I1.1701.00
44_V54_F1.1491.00
165_I169_E1.1481.00
33_Y37_A1.1441.00
63_F159_N1.1371.00
48_R99_S1.1361.00
218_S222_E1.1361.00
140_R218_S1.1311.00
116_Y120_T1.1311.00
73_D207_K1.1281.00
113_F117_V1.1281.00
45_R49_V1.1201.00
16_T146_I1.1181.00
138_S218_S1.1121.00
45_R96_Y1.1111.00
103_R157_L1.1091.00
133_Y200_D1.1001.00
53_Y153_R1.0831.00
94_L157_L1.0591.00
58_S90_E1.0501.00
107_V142_L1.0451.00
158_L207_K1.0431.00
205_Y216_F1.0371.00
64_D77_N1.0361.00
133_Y166_S1.0341.00
40_V93_A1.0271.00
145_A208_A1.0091.00
38_E42_H1.0081.00
33_Y85_T1.0061.00
141_K162_G1.0051.00
33_Y38_E1.0031.00
160_V208_A1.0011.00
206_S209_K0.9951.00
46_A49_V0.9941.00
62_V76_P0.9931.00
100_L149_L0.9871.00
29_R84_L0.9771.00
144_S218_S0.9721.00
149_L212_L0.9701.00
108_F138_S0.9671.00
175_K182_G0.9591.00
66_T70_Y0.9511.00
94_L97_D0.9481.00
101_V157_L0.9461.00
116_Y119_K0.9441.00
15_N43_M0.9331.00
165_I170_L0.9281.00
121_L175_K0.9271.00
19_M32_A0.9151.00
82_Y86_K0.9141.00
42_H46_A0.9101.00
84_L91_T0.9101.00
19_M31_K0.9051.00
12_V53_Y0.9041.00
148_E151_A0.9031.00
72_E208_A0.9021.00
48_R96_Y0.8951.00
218_S223_G0.8821.00
84_L95_S0.8801.00
138_S141_K0.8781.00
144_S147_E0.8761.00
67_K74_D0.8681.00
96_Y99_S0.8681.00
169_E173_K0.8631.00
89_G93_A0.8611.00
207_K210_K0.8531.00
90_E103_R0.8511.00
118_Y174_I0.8481.00
103_R159_N0.8481.00
60_D203_L0.8471.00
175_K180_L0.8471.00
31_K35_I0.8441.00
106_G134_Y0.8421.00
110_H138_S0.8321.00
40_V44_V0.8281.00
60_D105_S0.8251.00
88_L91_T0.8241.00
101_V155_T0.8171.00
25_C32_A0.8091.00
163_E205_Y0.8051.00
88_L92_F0.8041.00
175_K184_V0.8041.00
148_E212_L0.7961.00
62_V90_E0.7961.00
26_E81_Y0.7921.00
132_G167_R0.7911.00
172_L176_E0.7871.00
44_V92_F0.7861.00
92_F95_S0.7851.00
209_K216_F0.7851.00
100_L153_R0.7781.00
145_A214_V0.7781.00
149_L208_A0.7771.00
102_I145_A0.7751.00
107_V137_I0.7721.00
42_H45_R0.7681.00
148_E213_S0.7671.00
69_N202_S0.7651.00
65_G79_I0.7641.00
55_I102_I0.7641.00
104_T107_V0.7571.00
31_K34_K0.7541.00
114_P170_L0.7501.00
154_K211_I0.7501.00
121_L174_I0.7491.00
65_G199_F0.7471.00
143_A147_E0.7421.00
21_D24_K0.7411.00
48_R98_D0.7381.00
124_G180_L0.7361.00
117_V121_L0.7361.00
91_T95_S0.7351.00
32_A85_T0.7341.00
100_L158_L0.7341.00
39_A42_H0.7331.00
81_Y84_L0.7281.00
69_N204_D0.7271.00
141_K144_S0.7201.00
78_P87_L0.7171.00
55_I146_I0.7161.00
102_I160_V0.6961.00
71_K206_S0.6911.00
177_K221_L0.6831.00
100_L155_T0.6791.00
119_K122_K0.6781.00
144_S214_V0.6771.00
29_R81_Y0.6771.00
30_E41_K0.6761.00
198_P201_S0.6721.00
33_Y84_L0.6701.00
127_V130_Y0.6671.00
76_P157_L0.6671.00
41_K96_Y0.6651.00
16_T104_T0.6601.00
72_E159_N0.6601.00
76_P91_T0.6601.00
120_T128_F0.6601.00
13_I52_A0.6571.00
117_V171_A0.6551.00
55_I150_L0.6551.00
205_Y214_V0.6521.00
175_K178_F0.6481.00
61_Y83_G0.6441.00
13_I54_F0.6421.00
37_A92_F0.6391.00
121_L127_V0.6391.00
165_I173_K0.6391.00
173_K220_D0.6371.00
13_I43_M0.6361.00
24_K27_V0.6361.00
118_Y178_F0.6351.00
171_A175_K0.6351.00
109_R139_A0.6331.00
170_L220_D0.6311.00
194_T197_R0.6311.00
113_F116_Y0.6301.00
135_S162_G0.6211.00
37_A85_T0.6191.00
105_S161_A0.6181.00
34_K42_H0.6091.00
114_P117_V0.6081.00
205_Y208_A0.6071.00
12_V55_I0.6061.00
118_Y122_K0.6061.00
133_Y202_S0.6051.00
93_A101_V0.6041.00
40_V56_H0.6031.00
9_R50_V0.6011.00
62_V103_R0.6001.00
127_V184_V0.6001.00
117_V127_V0.6001.00
113_F121_L0.5971.00
43_M47_S0.5961.00
37_A41_K0.5951.00
47_S50_V0.5901.00
10_P50_V0.5891.00
92_F96_Y0.5861.00
147_E150_L0.5851.00
80_N83_G0.5821.00
100_L152_L0.5791.00
110_H140_R0.5721.00
15_N54_F0.5711.00
185_K188_D0.5701.00
55_I149_L0.5691.00
12_V151_A0.5681.00
14_I147_E0.5671.00
78_P83_G0.5661.00
169_E221_L0.5661.00
158_L208_A0.5611.00
34_K45_R0.5581.00
40_V43_M0.5571.00
57_V102_I0.5471.00
129_A171_A0.5471.00
148_E214_V0.5471.00
179_N182_G0.5461.00
60_D201_S0.5411.00
105_S135_S0.5401.00
140_R144_S0.5391.00
172_L184_V0.5391.00
131_K199_F0.5351.00
184_V187_V0.5341.00
55_I100_L0.5321.00
113_F118_Y0.5291.00
95_S98_D0.5291.00
152_L211_I0.5281.00
163_E215_D0.5281.00
66_T74_D0.5241.00
59_T62_V0.5221.00
136_P170_L0.5221.00
27_V194_T0.5221.00
53_Y154_K0.5211.00
168_Y184_V0.5201.00
23_D27_V0.5191.00
220_D223_G0.5181.00
134_Y167_R0.5181.00
47_S51_E0.5181.00
136_P167_R0.5161.00
44_V47_S0.5151.00
81_Y85_T0.5151.00
121_L178_F0.5141.00
115_V119_K0.5131.00
208_A211_I0.5091.00
20_T60_D0.5051.00
100_L156_G0.5031.00
112_G115_V0.5021.00
115_V118_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ggsA 1 0.9912 100 0.286 Contact Map
1rkxA 3 0.9646 100 0.295 Contact Map
1n7hA 4 0.9912 100 0.305 Contact Map
1i24A 4 0.9867 100 0.307 Contact Map
2z1mA 4 1 100 0.315 Contact Map
1vl0A 3 0.9956 100 0.316 Contact Map
1db3A 2 0.9956 100 0.316 Contact Map
1sb8A 2 0.9912 100 0.318 Contact Map
3sxpA 3 0.9558 100 0.318 Contact Map
1rpnA 4 0.9912 100 0.318 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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