GREMLIN Database
Q7LXE5 - dTDP-4-dehydrorhamnose 3,5 epimerase (RfbC-1)
UniProt: Q7LXE5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 176 (167)
Sequences: 4427 (2876)
Seq/√Len: 222.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_C166_C3.3601.00
79_K101_E3.2731.00
33_A44_P3.1751.00
124_D127_L2.7951.00
80_I129_V2.5181.00
16_K108_H2.4831.00
8_L98_T2.4061.00
6_E13_L2.3941.00
138_S141_H2.3541.00
60_L117_A2.3101.00
64_I143_R2.3061.00
70_G111_W2.2471.00
81_L99_S2.2141.00
47_V132_V2.2101.00
50_S120_F2.1941.00
37_S42_P2.1681.00
77_K104_E2.0811.00
57_V121_Q2.0771.00
54_R125_D2.0111.00
33_A37_S2.0061.00
34_T136_D1.9931.00
70_G134_H1.9761.00
8_L96_K1.9631.00
5_F16_K1.9631.00
76_P130_Y1.9071.00
77_K126_S1.8701.00
146_N168_P1.8571.00
114_P134_H1.8401.00
67_K138_S1.8201.00
77_K128_V1.7841.00
168_P171_K1.7551.00
14_L108_H1.7491.00
161_D165_Q1.7341.00
51_F128_V1.7001.00
79_K124_D1.6991.00
49_M128_V1.6321.00
103_S106_N1.6141.00
161_D164_K1.6091.00
70_G114_P1.5891.00
81_L153_P1.5831.00
9_G116_F1.5801.00
87_V117_A1.5731.00
14_L100_A1.5591.00
67_K135_N1.5381.00
62_Y143_R1.5191.00
12_V84_A1.4801.00
34_T38_K1.4781.00
79_K103_S1.4761.00
49_M74_F1.4711.00
60_L119_G1.4671.00
19_V107_H1.3851.00
122_A127_L1.3661.00
6_E10_M1.3441.00
7_D14_L1.3181.00
80_I127_L1.3031.00
43_M111_W1.2831.00
62_Y172_A1.2631.00
67_K141_H1.2491.00
26_F51_F1.2401.00
32_K35_D1.2211.00
114_P135_N1.2151.00
12_V98_T1.2061.00
57_V157_I1.2031.00
121_Q154_I1.1791.00
117_A145_I1.1381.00
83_V152_W1.1331.00
43_M114_P1.1261.00
65_T68_E1.1211.00
84_A98_T1.1021.00
51_F126_S1.1011.00
29_E32_K1.0831.00
121_Q153_P1.0751.00
167_P171_K1.0411.00
100_A110_L1.0341.00
113_P116_F1.0291.00
62_Y117_A1.0291.00
60_L85_V1.0091.00
9_G12_V0.9911.00
147_Y157_I0.9891.00
32_K136_D0.9821.00
49_M130_Y0.9801.00
26_F49_M0.9681.00
27_F50_S0.9651.00
154_I157_I0.9631.00
82_D118_H0.9631.00
23_K161_D0.9591.00
64_I141_H0.9571.00
121_Q157_I0.9521.00
65_T141_H0.9511.00
87_V145_I0.9491.00
60_L150_I0.9481.00
30_L47_V0.9431.00
35_D39_H0.9421.00
101_E123_L0.9411.00
35_D38_K0.9210.99
81_L97_Y0.9080.99
15_I35_D0.9060.99
54_R124_D0.9060.99
5_F14_L0.9050.99
68_E141_H0.8960.99
18_K35_D0.8940.99
53_V126_S0.8910.99
145_I172_A0.8900.99
142_E166_C0.8870.99
9_G98_T0.8840.99
62_Y87_V0.8830.99
100_A108_H0.8640.99
29_E69_Q0.8530.99
9_G93_T0.8520.99
29_E46_Q0.8510.99
122_A126_S0.8380.99
48_N133_T0.8350.99
37_S41_I0.8340.99
26_F107_H0.8340.99
26_F128_V0.8260.99
21_P53_V0.8220.99
45_V136_D0.8150.99
146_N166_C0.8020.99
11_G93_T0.7970.99
7_D12_V0.7960.99
15_I39_H0.7920.98
158_I161_D0.7900.98
5_F108_H0.7850.98
84_A116_F0.7820.98
76_P128_V0.7800.98
49_M76_P0.7650.98
84_A112_I0.7560.98
130_Y133_T0.7560.98
88_R116_F0.7550.98
10_M92_P0.7550.98
12_V110_L0.7540.98
102_L110_L0.7490.98
123_L153_P0.7450.98
147_Y159_V0.7390.98
36_F109_M0.7330.97
14_L110_L0.7310.97
83_V150_I0.7270.97
99_S153_P0.7250.97
167_P172_A0.7250.97
14_L98_T0.7250.97
84_A110_L0.7220.97
41_I111_W0.7210.97
64_I172_A0.7200.97
10_M93_T0.7140.97
143_R167_P0.7090.97
9_G84_A0.6990.97
95_G169_L0.6980.97
75_V80_I0.6890.96
73_V129_V0.6870.96
41_I114_P0.6850.96
21_P107_H0.6840.96
111_W134_H0.6830.96
75_V127_L0.6830.96
30_L49_M0.6820.96
93_T96_K0.6790.96
15_I72_L0.6760.96
6_E11_G0.6740.96
79_K127_L0.6690.96
71_K82_D0.6670.96
29_E48_N0.6640.95
43_M134_H0.6600.95
162_K166_C0.6570.95
107_H128_V0.6560.95
14_L106_N0.6520.95
144_C167_P0.6510.95
52_S56_V0.6440.95
54_R155_K0.6410.95
62_Y145_I0.6360.94
7_D98_T0.6350.94
74_F130_Y0.6340.94
19_V28_L0.6330.94
104_E128_V0.6320.94
33_A42_P0.6270.94
23_K158_I0.6250.94
143_R172_A0.6180.93
122_A125_D0.6170.93
30_L74_F0.6130.93
85_V145_I0.6130.93
89_K92_P0.6080.93
168_P172_A0.6070.93
98_T110_L0.6070.93
27_F48_N0.6060.93
7_D100_A0.6030.93
12_V116_F0.6010.92
101_E153_P0.5990.92
32_K36_F0.5990.92
36_F41_I0.5990.92
28_L107_H0.5980.92
89_K95_G0.5970.92
60_L145_I0.5970.92
19_V26_F0.5960.92
81_L123_L0.5940.92
68_E114_P0.5940.92
137_Y142_E0.5910.92
22_D25_G0.5910.92
53_V158_I0.5900.92
80_I120_F0.5900.92
45_V135_N0.5800.91
143_R166_C0.5790.91
97_Y150_I0.5770.91
27_F131_F0.5750.91
8_L12_V0.5710.90
51_F77_K0.5680.90
74_F128_V0.5680.90
142_E162_K0.5680.90
30_L132_V0.5650.90
69_Q133_T0.5630.90
34_T37_S0.5620.90
30_L130_Y0.5610.90
54_R156_E0.5610.90
139_P165_Q0.5600.90
77_K124_D0.5590.90
64_I67_K0.5560.89
89_K172_A0.5540.89
104_E107_H0.5490.89
79_K123_L0.5480.89
111_W114_P0.5470.88
13_L111_W0.5460.88
156_E164_K0.5460.88
133_T162_K0.5430.88
16_K106_N0.5410.88
135_N141_H0.5370.88
83_V99_S0.5370.88
53_V56_V0.5330.87
13_L113_P0.5310.87
52_S58_R0.5270.87
72_L109_M0.5260.87
79_K104_E0.5250.86
65_T172_A0.5250.86
98_T101_E0.5250.86
104_E124_D0.5230.86
11_G116_F0.5200.86
18_K21_P0.5190.86
85_V117_A0.5190.86
140_Q143_R0.5180.86
73_V82_D0.5140.85
6_E39_H0.5130.85
72_L111_W0.5120.85
81_L151_E0.5110.85
57_V152_W0.5110.85
56_V158_I0.5110.85
15_I36_F0.5100.85
133_T143_R0.5100.85
79_K105_S0.5090.85
48_N162_K0.5060.84
101_E106_N0.5050.84
159_V164_K0.5040.84
65_T138_S0.5020.84
7_D110_L0.5000.84
75_V129_V0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ixkA 2 0.9943 100 0.187 Contact Map
3rykA 2 0.9602 100 0.189 Contact Map
2c0zA 2 1 100 0.189 Contact Map
1upiA 2 0.9886 100 0.19 Contact Map
1wltA 2 0.9886 100 0.192 Contact Map
1oi6A 2 0.9943 100 0.194 Contact Map
1ep0A 2 0.9886 100 0.196 Contact Map
4hn1A 3 0.983 100 0.198 Contact Map
1dzrA 2 1 100 0.201 Contact Map
5buvA 2 0.9602 100 0.23 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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