GREMLIN Database
Q7LXE3 - Partial ORF from ISC1904
UniProt: Q7LXE3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 100 (90)
Sequences: 401 (289)
Seq/√Len: 30.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_V76_K3.6991.00
50_S61_R3.4921.00
24_A40_S3.2901.00
44_S78_V2.6741.00
69_I97_T2.6461.00
39_Y80_T2.6081.00
22_L40_S2.4600.99
48_T61_R2.4100.99
62_F85_L2.2860.99
46_I68_M2.2450.99
69_I77_V1.9870.97
37_V47_T1.8580.96
19_K68_M1.8200.95
57_H91_E1.7780.94
22_L47_T1.6930.93
86_V90_L1.6340.91
37_V49_K1.6310.91
57_H86_V1.6300.91
43_T76_K1.4730.86
68_M73_E1.4670.86
69_I74_V1.4240.85
55_I88_F1.3600.82
44_S80_T1.3090.79
20_V78_V1.2920.78
59_E86_V1.2910.78
22_L44_S1.2490.76
66_L92_Y1.2160.74
62_F92_Y1.1940.72
66_L70_L1.1910.72
32_D80_T1.1750.71
21_I74_V1.1600.70
20_V75_S1.1110.67
82_P91_E1.0780.64
63_L95_H1.0650.63
21_I65_L1.0620.63
65_L74_V1.0540.63
78_V91_E1.0480.62
55_I90_L1.0450.62
67_G95_H1.0370.61
34_I38_K1.0250.60
62_F86_V1.0240.60
50_S80_T1.0230.60
17_K67_G1.0050.59
51_S59_E0.9860.57
61_R79_I0.9840.57
70_L96_T0.9780.57
86_V93_P0.9750.57
70_L92_Y0.9680.56
20_V46_I0.9510.55
18_R71_D0.9400.54
82_P94_K0.9330.53
14_I49_K0.9300.53
39_Y50_S0.9230.52
52_P56_K0.9190.52
17_K21_I0.9130.52
22_L92_Y0.9090.51
32_D35_N0.8850.49
55_I89_G0.8830.49
50_S53_F0.8770.49
28_S52_P0.8760.49
90_L93_P0.8700.48
69_I79_I0.8510.47
86_V92_Y0.8070.43
31_D54_W0.8030.43
8_V12_M0.8000.43
92_Y96_T0.7530.39
28_S88_F0.7480.39
85_L92_Y0.7470.39
34_I49_K0.7450.38
38_K41_R0.7440.38
12_M28_S0.7440.38
12_M15_I0.7400.38
69_I81_Y0.7310.37
10_R21_I0.7130.36
62_F75_S0.7100.36
48_T65_L0.7100.36
53_F63_L0.7090.36
56_K65_L0.7040.35
42_R71_D0.7020.35
81_Y93_P0.7000.35
26_V29_N0.6950.35
28_S60_K0.6920.34
52_P89_G0.6920.34
90_L94_K0.6900.34
59_E80_T0.6890.34
63_L93_P0.6840.34
28_S79_I0.6750.33
27_S88_F0.6750.33
34_I47_T0.6690.33
78_V95_H0.6680.33
36_Q84_R0.6660.33
54_W85_L0.6660.33
38_K42_R0.6580.32
51_S90_L0.6550.32
24_A66_L0.6460.31
41_R47_T0.6450.31
10_R13_G0.6450.31
11_L58_E0.6380.31
24_A80_T0.6320.30
28_S48_T0.6260.30
29_N60_K0.6240.30
19_K75_S0.6230.30
41_R45_K0.6150.29
60_K75_S0.6130.29
31_D64_K0.6120.29
19_K46_I0.6120.29
8_V11_L0.6060.29
55_I60_K0.6000.28
10_R81_Y0.5990.28
16_R21_I0.5880.27
35_N62_F0.5860.27
44_S97_T0.5860.27
22_L59_E0.5820.27
62_F69_I0.5750.27
65_L97_T0.5750.27
10_R75_S0.5670.26
75_S93_P0.5650.26
34_I37_V0.5650.26
40_S54_W0.5580.26
77_V97_T0.5440.25
42_R64_K0.5410.24
70_L94_K0.5390.24
42_R90_L0.5360.24
35_N38_K0.5360.24
35_N92_Y0.5350.24
18_R96_T0.5330.24
44_S59_E0.5270.24
58_E95_H0.5250.24
28_S35_N0.5190.23
48_T68_M0.5170.23
77_V95_H0.5060.22
19_K34_I0.5050.22
24_A47_T0.5040.22
93_P97_T0.5010.22
15_I74_V0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lhkA 2 0.84 99.7 0.561 Contact Map
3ilxA 2 0.82 99.7 0.574 Contact Map
3bvpA 4 0.83 99.6 0.606 Contact Map
3g13A 2 0.87 99.6 0.612 Contact Map
3guvA 2 0.84 99.6 0.617 Contact Map
2mhcA 1 0.88 99.6 0.617 Contact Map
4bqqA 2 0.81 99.5 0.641 Contact Map
2gm5A 4 0.77 99.5 0.645 Contact Map
3pkzA 4 0.8 99.5 0.648 Contact Map
3uj3X 2 0.79 99.4 0.657 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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