GREMLIN Database
Q7LXE2 - Polysaccharide biosynthesis related protein
UniProt: Q7LXE2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 469 (429)
Sequences: 17784 (15312)
Seq/√Len: 739.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_S271_K4.2661.00
129_M132_E3.5321.00
401_R405_L3.2841.00
41_A236_Q3.2711.00
196_F200_K3.1591.00
340_S343_P3.1491.00
311_I315_I3.0741.00
342_R346_F2.8561.00
293_I315_I2.8231.00
128_D262_F2.8031.00
100_F103_Y2.6611.00
297_I301_E2.6021.00
340_S393_T2.5591.00
234_L309_E2.4581.00
323_L380_V2.4091.00
228_G231_Y2.3761.00
351_N382_S2.3421.00
296_A311_I2.2691.00
316_L369_M2.2001.00
313_V368_I2.1931.00
223_T227_L2.1851.00
64_R68_Y2.1731.00
358_T374_S2.1681.00
66_I126_G2.1561.00
207_L345_L2.1431.00
337_A340_S2.1081.00
262_F266_L2.1071.00
298_L301_E2.1051.00
347_L385_F2.0841.00
227_L231_Y2.0771.00
272_K276_I2.0411.00
219_D359_S2.0161.00
219_D235_Y2.0101.00
33_N36_F1.9851.00
156_N159_L1.9851.00
295_I298_L1.9751.00
291_I295_I1.9731.00
296_A315_I1.9651.00
263_Y271_K1.9421.00
192_F196_F1.9371.00
362_L374_S1.9141.00
413_A417_V1.9051.00
9_K131_T1.8741.00
363_I371_G1.8701.00
312_R369_M1.8621.00
77_K81_G1.8601.00
370_G374_S1.8381.00
42_I224_A1.8151.00
65_E201_E1.7941.00
297_I311_I1.7901.00
131_T135_I1.7571.00
264_K337_A1.7481.00
354_V381_I1.7441.00
285_S325_F1.7401.00
316_L376_V1.7351.00
286_F410_P1.7221.00
227_L368_I1.7131.00
191_D194_F1.7101.00
316_L373_I1.7091.00
402_E405_L1.7011.00
361_L364_P1.6821.00
367_G370_G1.6771.00
292_S318_L1.6741.00
128_D259_T1.6691.00
40_V44_Q1.6621.00
289_V322_T1.6391.00
222_T363_I1.6151.00
362_L366_I1.6061.00
313_V372_A1.6061.00
29_A237_F1.6041.00
300_V310_G1.5961.00
129_M182_K1.5811.00
159_L163_I1.5751.00
222_T359_S1.5721.00
211_A349_L1.5691.00
312_R315_I1.5691.00
290_I414_L1.5511.00
323_L383_S1.5501.00
366_I373_I1.5481.00
274_S333_F1.5391.00
374_S378_V1.5321.00
204_P345_L1.5251.00
291_I413_A1.5251.00
242_A317_L1.5131.00
300_V314_L1.5101.00
112_F115_L1.5091.00
297_I315_I1.4911.00
150_I153_L1.4811.00
316_L372_A1.4741.00
384_S388_V1.4661.00
223_T232_L1.4641.00
144_R167_G1.4621.00
219_D375_Q1.4621.00
309_E312_R1.4541.00
346_F350_L1.4511.00
238_S310_G1.4511.00
222_T360_F1.4491.00
68_Y339_K1.4451.00
414_L418_F1.4401.00
388_V392_R1.4351.00
263_Y273_M1.4251.00
26_I30_K1.4231.00
435_L439_F1.4181.00
320_A376_V1.4141.00
275_S279_R1.3961.00
123_I127_M1.3931.00
397_I400_K1.3911.00
357_L361_L1.3901.00
223_T371_G1.3831.00
34_P234_L1.3821.00
355_V359_S1.3821.00
282_A286_F1.3801.00
347_L389_Y1.3771.00
256_L277_S1.3701.00
78_G191_D1.3691.00
295_I299_V1.3651.00
25_F240_L1.3641.00
359_S363_I1.3621.00
75_V78_G1.3591.00
230_Y234_L1.3351.00
24_F145_W1.3311.00
78_G82_K1.3261.00
36_F39_K1.3171.00
361_L365_R1.3101.00
30_K305_P1.3081.00
218_G356_L1.3041.00
15_T19_L1.3031.00
231_Y368_I1.3021.00
61_I201_E1.2991.00
22_L26_I1.2951.00
41_A233_G1.2911.00
362_L365_R1.2911.00
320_A372_A1.2891.00
203_L207_L1.2891.00
222_T226_L1.2811.00
369_M372_A1.2601.00
217_Q220_R1.2601.00
435_L438_L1.2591.00
81_G85_S1.2521.00
16_T138_N1.2471.00
292_S314_L1.2301.00
158_Y161_V1.2301.00
308_T312_R1.2301.00
330_L387_L1.2241.00
343_P389_Y1.2221.00
65_E68_Y1.2181.00
204_P342_R1.2131.00
19_L23_I1.2101.00
17_N141_L1.2061.00
223_T235_Y1.2051.00
42_I232_L1.2041.00
260_A336_A1.2031.00
155_H159_L1.2011.00
333_F390_A1.1941.00
146_G150_I1.1911.00
109_P112_F1.1881.00
55_Y59_G1.1881.00
274_S330_L1.1871.00
238_S313_V1.1861.00
103_Y106_L1.1861.00
263_Y268_S1.1821.00
62_I83_F1.1751.00
164_W168_G1.1741.00
234_L310_G1.1701.00
319_L376_V1.1701.00
201_E341_L1.1691.00
98_L102_N1.1671.00
358_T362_L1.1641.00
65_E197_K1.1631.00
39_K229_S1.1611.00
143_I170_L1.1591.00
177_S181_R1.1571.00
365_R369_M1.1551.00
147_I163_I1.1481.00
211_A345_L1.1461.00
346_F349_L1.1451.00
347_L386_I1.1441.00
360_F364_P1.1441.00
29_A304_F1.1411.00
366_I370_G1.1401.00
211_A352_A1.1401.00
37_F41_A1.1381.00
208_S344_F1.1341.00
283_L439_F1.1331.00
313_V369_M1.1331.00
7_A255_V1.1311.00
136_T175_N1.1311.00
31_I152_V1.1251.00
238_S317_L1.1221.00
410_P414_L1.1191.00
237_F304_F1.1111.00
355_V378_V1.1031.00
215_S355_V1.0921.00
257_L261_S1.0921.00
391_L394_S1.0901.00
353_G357_L1.0851.00
64_R339_K1.0831.00
136_T174_L1.0831.00
176_Y180_S1.0811.00
296_A314_L1.0751.00
259_T262_F1.0731.00
300_V311_I1.0731.00
78_G81_G1.0731.00
102_N106_L1.0701.00
151_A154_S1.0661.00
85_S89_L1.0621.00
388_V391_L1.0601.00
34_P233_G1.0551.00
173_L177_S1.0521.00
349_L353_G1.0451.00
20_I145_W1.0431.00
315_I319_L1.0401.00
214_L352_A1.0391.00
326_P383_S1.0371.00
99_L103_Y1.0341.00
308_T311_I1.0331.00
84_L87_P1.0321.00
27_V31_I1.0321.00
14_I18_V1.0311.00
48_V52_T1.0311.00
263_Y266_L1.0281.00
13_V134_A1.0261.00
163_I167_G1.0251.00
355_V375_Q1.0231.00
67_S126_G1.0231.00
10_S255_V1.0221.00
96_I100_F1.0181.00
228_G232_L1.0161.00
419_V423_Y1.0121.00
354_V358_T1.0081.00
409_M413_A1.0051.00
219_D355_V1.0011.00
293_I319_L0.9931.00
289_V293_I0.9931.00
174_L178_F0.9921.00
420_D423_Y0.9901.00
220_R232_L0.9901.00
79_V83_F0.9881.00
61_I198_H0.9871.00
376_V379_T0.9861.00
162_E166_L0.9841.00
83_F198_H0.9831.00
293_I296_A0.9821.00
242_A321_T0.9811.00
404_I408_A0.9811.00
132_E178_F0.9781.00
199_F202_G0.9781.00
359_S375_Q0.9781.00
61_I65_E0.9771.00
11_L251_A0.9761.00
69_L72_K0.9751.00
40_V160_F0.9741.00
167_G171_S0.9731.00
335_I344_F0.9641.00
236_Q240_L0.9631.00
334_I389_Y0.9631.00
185_L188_P0.9601.00
369_M373_I0.9581.00
80_V123_I0.9571.00
259_T263_Y0.9571.00
330_L386_I0.9561.00
44_Q48_V0.9561.00
69_L75_V0.9551.00
300_V304_F0.9531.00
320_A323_L0.9411.00
301_E308_T0.9411.00
239_A243_G0.9401.00
82_K195_L0.9391.00
103_Y107_A0.9341.00
197_K339_K0.9341.00
101_P105_K0.9331.00
226_L363_I0.9291.00
120_L176_Y0.9271.00
7_A252_L0.9261.00
130_F255_V0.9231.00
194_F197_K0.9221.00
94_F98_L0.9201.00
299_V303_F0.9191.00
200_K203_L0.9171.00
148_S163_I0.9171.00
63_T122_A0.9161.00
293_I297_I0.9151.00
25_F304_F0.9151.00
238_S314_L0.9141.00
373_I377_I0.9141.00
79_V82_K0.9111.00
140_F144_R0.9081.00
255_V258_P0.9081.00
409_M438_L0.9071.00
287_L290_I0.9061.00
68_Y72_K0.9051.00
193_A196_F0.9031.00
343_P346_F0.8981.00
45_L220_R0.8981.00
199_F203_L0.8971.00
317_L372_A0.8961.00
8_L12_S0.8961.00
178_F182_K0.8951.00
381_I385_F0.8951.00
385_F388_V0.8911.00
66_I127_M0.8911.00
7_A11_L0.8901.00
70_Y76_N0.8851.00
61_I202_G0.8851.00
165_I168_G0.8841.00
310_G313_V0.8831.00
6_N255_V0.8821.00
81_G84_L0.8811.00
6_N128_D0.8781.00
165_I169_V0.8761.00
20_I24_F0.8741.00
66_I76_N0.8721.00
34_P307_Y0.8671.00
281_L325_F0.8651.00
276_I279_R0.8641.00
32_S36_F0.8641.00
87_P91_I0.8621.00
419_V422_P0.8531.00
389_Y393_T0.8521.00
175_N179_L0.8511.00
144_R148_S0.8491.00
70_Y127_M0.8481.00
373_I376_V0.8481.00
223_T368_I0.8431.00
142_I146_G0.8431.00
332_N335_I0.8411.00
345_L349_L0.8371.00
293_I318_L0.8371.00
9_K13_V0.8371.00
26_I29_A0.8361.00
334_I344_F0.8361.00
213_F217_Q0.8341.00
10_S134_A0.8341.00
51_F55_Y0.8331.00
82_K86_F0.8321.00
237_F240_L0.8291.00
40_V157_I0.8281.00
28_T160_F0.8281.00
160_F164_W0.8261.00
294_P414_L0.8211.00
279_R283_L0.8201.00
418_F421_P0.8191.00
224_A232_L0.8191.00
344_F348_S0.8191.00
358_T361_L0.8191.00
88_F92_P0.8161.00
359_S362_L0.8071.00
64_R341_L0.8051.00
235_Y317_L0.8041.00
273_M276_I0.8031.00
283_L287_L0.7991.00
162_E165_I0.7981.00
168_G172_V0.7971.00
288_S291_I0.7971.00
83_F87_P0.7961.00
28_T148_S0.7941.00
26_I304_F0.7941.00
145_W149_I0.7931.00
290_I294_P0.7911.00
94_F97_F0.7901.00
71_A266_L0.7861.00
116_L120_L0.7851.00
226_L360_F0.7841.00
237_F307_Y0.7791.00
35_A229_S0.7781.00
249_L253_N0.7771.00
125_I133_T0.7731.00
387_L391_L0.7731.00
69_L74_E0.7731.00
11_L15_T0.7721.00
320_A379_T0.7711.00
132_E135_I0.7711.00
221_V225_Y0.7701.00
42_I45_L0.7681.00
210_S214_L0.7671.00
320_A375_Q0.7651.00
25_F29_A0.7651.00
385_F389_Y0.7641.00
208_S348_S0.7631.00
240_L244_V0.7611.00
5_K131_T0.7601.00
171_S175_N0.7591.00
389_Y392_R0.7581.00
319_L323_L0.7561.00
87_P90_A0.7561.00
217_Q221_V0.7551.00
62_I66_I0.7511.00
175_N178_F0.7501.00
411_L415_Y0.7491.00
82_K85_S0.7481.00
81_G188_P0.7471.00
436_F439_F0.7461.00
16_T142_I0.7441.00
200_K204_P0.7441.00
211_A348_S0.7431.00
356_L360_F0.7411.00
250_G254_N0.7401.00
37_F237_F0.7391.00
347_L351_N0.7361.00
140_F171_S0.7341.00
227_L363_I0.7331.00
289_V318_L0.7321.00
38_G233_G0.7311.00
257_L332_N0.7291.00
80_V83_F0.7281.00
290_I410_P0.7261.00
34_P230_Y0.7261.00
350_L385_F0.7241.00
27_V149_I0.7201.00
205_L341_L0.7181.00
100_F104_V0.7181.00
217_Q243_G0.7161.00
136_T171_S0.7151.00
273_M277_S0.7141.00
220_R236_Q0.7131.00
296_A318_L0.7131.00
76_N79_V0.7131.00
332_N336_A0.7091.00
48_V51_F0.7081.00
319_L322_T0.7061.00
241_V304_F0.7041.00
215_S352_A0.7001.00
68_Y265_A0.7001.00
16_T20_I0.7001.00
380_V384_S0.6991.00
330_L383_S0.6991.00
287_L413_A0.6991.00
407_T410_P0.6981.00
68_Y197_K0.6981.00
124_M179_L0.6971.00
12_S16_T0.6971.00
187_L190_L0.6941.00
111_L115_L0.6941.00
119_V122_A0.6921.00
147_I150_I0.6921.00
277_S329_S0.6901.00
33_N307_Y0.6881.00
359_S371_G0.6881.00
63_T67_S0.6861.00
201_E205_L0.6811.00
36_F157_I0.6771.00
358_T377_I0.6761.00
405_L409_M0.6731.00
109_P114_Y0.6731.00
4_I8_L0.6731.00
269_D337_A0.6731.00
412_I415_Y0.6721.00
159_L162_E0.6711.00
413_A416_E0.6711.00
281_L329_S0.6701.00
227_L367_G0.6701.00
97_F105_K0.6701.00
75_V194_F0.6701.00
117_N172_V0.6691.00
219_D239_A0.6691.00
233_G236_Q0.6671.00
345_L348_S0.6651.00
110_Y168_G0.6641.00
204_P341_L0.6631.00
205_L335_I0.6621.00
410_P413_A0.6621.00
376_V380_V0.6621.00
109_P165_I0.6621.00
4_I7_A0.6611.00
21_A25_F0.6611.00
408_A411_L0.6601.00
98_L101_P0.6601.00
35_A39_K0.6581.00
240_L243_G0.6581.00
336_A339_K0.6581.00
86_F195_L0.6581.00
121_V125_I0.6571.00
330_L390_A0.6561.00
63_T126_G0.6561.00
141_L144_R0.6561.00
408_A412_I0.6551.00
172_V176_Y0.6551.00
324_P379_T0.6541.00
37_F233_G0.6531.00
158_Y162_E0.6531.00
290_I293_I0.6521.00
350_L353_G0.6501.00
402_E406_L0.6481.00
343_P347_L0.6481.00
144_R163_I0.6471.00
287_L410_P0.6471.00
218_G222_T0.6461.00
301_E311_I0.6461.00
259_T273_M0.6451.00
375_Q379_T0.6441.00
307_Y310_G0.6441.00
99_L102_N0.6411.00
13_V138_N0.6351.00
257_L336_A0.6321.00
17_N21_A0.6301.00
354_V357_L0.6291.00
57_I202_G0.6291.00
333_F337_A0.6281.00
28_T32_S0.6281.00
287_L291_I0.6251.00
248_V251_A0.6241.00
324_P328_N0.6231.00
125_I130_F0.6211.00
116_L172_V0.6211.00
8_L15_T0.6201.00
231_Y234_L0.6191.00
424_L429_L0.6171.00
284_I288_S0.6161.00
364_P371_G0.6151.00
406_L409_M0.6151.00
157_I161_V0.6131.00
226_L364_P0.6111.00
331_T335_I0.6081.00
195_L199_F0.6081.00
327_I383_S0.6081.00
28_T37_F0.6071.00
297_I308_T0.6071.00
82_K87_P0.6061.00
382_S386_I0.6061.00
211_A215_S0.6061.00
331_T344_F0.6051.00
147_I166_L0.6051.00
136_T178_F0.6021.00
424_L428_L0.6021.00
233_G237_F0.6011.00
231_Y235_Y0.6001.00
242_A245_P0.5991.00
113_L172_V0.5981.00
78_G194_F0.5951.00
415_Y418_F0.5951.00
318_L321_T0.5951.00
212_N216_S0.5941.00
349_L352_A0.5931.00
200_K342_R0.5931.00
42_I220_R0.5931.00
209_S213_F0.5931.00
85_S88_F0.5921.00
235_Y239_A0.5921.00
47_E51_F0.5921.00
197_K201_E0.5911.00
26_I303_F0.5911.00
220_R239_A0.5911.00
341_L344_F0.5901.00
334_I390_A0.5891.00
95_L99_L0.5871.00
406_L410_P0.5831.00
40_V161_V0.5821.00
276_I280_V0.5811.00
294_P297_I0.5811.00
279_R402_E0.5811.00
379_T383_S0.5801.00
58_P83_F0.5801.00
354_V378_V0.5791.00
286_F322_T0.5781.00
298_L302_R0.5771.00
45_L49_V0.5761.00
135_I139_L0.5751.00
412_I438_L0.5751.00
208_S212_N0.5751.00
282_A322_T0.5731.00
177_S180_S0.5731.00
355_V358_T0.5731.00
32_S157_I0.5721.00
172_V175_N0.5711.00
82_K192_F0.5701.00
267_G271_K0.5671.00
351_N378_V0.5641.00
267_G270_E0.5641.00
10_S14_I0.5631.00
141_L145_W0.5631.00
294_P417_V0.5611.00
379_T382_S0.5611.00
198_H202_G0.5581.00
117_N121_V0.5571.00
323_L376_V0.5561.00
18_V21_A0.5561.00
372_A376_V0.5551.00
256_L260_A0.5531.00
35_A230_Y0.5521.00
46_L221_V0.5511.00
240_L304_F0.5491.00
314_L318_L0.5471.00
42_I225_Y0.5451.00
214_L218_G0.5451.00
409_M412_I0.5451.00
252_L256_L0.5451.00
231_Y309_E0.5441.00
16_T19_L0.5411.00
46_L50_T0.5411.00
260_A333_F0.5401.00
88_F91_I0.5391.00
362_L370_G0.5391.00
55_Y87_P0.5381.00
113_L169_V0.5381.00
104_V108_I0.5381.00
130_F133_T0.5371.00
417_V420_D0.5361.00
137_G141_L0.5351.00
164_W167_G0.5341.00
67_S261_S0.5331.00
337_A393_T0.5331.00
120_L123_I0.5311.00
344_F386_I0.5311.00
73_K76_N0.5301.00
127_M131_T0.5261.00
149_I153_L0.5261.00
412_I416_E0.5251.00
166_L170_L0.5241.00
272_K275_S0.5231.00
10_S130_F0.5231.00
375_Q378_V0.5231.00
70_Y73_K0.5231.00
149_I152_V0.5221.00
139_L174_L0.5221.00
69_L194_F0.5221.00
42_I221_V0.5201.00
18_V247_M0.5201.00
190_L195_L0.5191.00
110_Y114_Y0.5171.00
280_V284_I0.5161.00
215_S378_V0.5151.00
258_P262_F0.5151.00
281_L285_S0.5141.00
49_V213_F0.5141.00
136_T140_F0.5141.00
316_L319_L0.5141.00
266_L269_D0.5131.00
25_F37_F0.5121.00
144_R147_I0.5101.00
383_S387_L0.5091.00
286_F290_I0.5091.00
301_E304_F0.5091.00
264_K267_G0.5091.00
340_S389_Y0.5081.00
38_G228_G0.5081.00
76_N127_M0.5071.00
65_E69_L0.5071.00
327_I386_I0.5051.00
15_T18_V0.5041.00
44_Q164_W0.5031.00
401_R404_I0.5031.00
286_F407_T0.5031.00
260_A274_S0.5021.00
64_R336_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.8486 100 0.428 Contact Map
3w4tA 1 0.8401 100 0.429 Contact Map
4humA 1 0.8614 100 0.432 Contact Map
3mktA 1 0.855 100 0.439 Contact Map
1pw4A 1 0.7676 25.1 0.95 Contact Map
2cfqA 1 0.7996 23.2 0.951 Contact Map
4n7wA 2 0.3902 20.1 0.952 Contact Map
3zuxA 1 0.3753 14.2 0.955 Contact Map
3o7qA 1 0.4158 13.4 0.956 Contact Map
3wdoA 1 0.8081 13.2 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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