GREMLIN Database
Q7LXE1 - Uncharacterized protein
UniProt: Q7LXE1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 239 (186)
Sequences: 539 (501)
Seq/√Len: 36.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_F88_L4.8671.00
137_I144_V4.5851.00
156_Q179_F3.9831.00
50_F54_V3.4171.00
45_A63_A2.9551.00
95_D146_K2.7051.00
94_Y140_A2.7051.00
62_V89_V2.6051.00
42_D134_K2.3931.00
71_F90_N2.3761.00
55_A85_N2.2920.99
99_V118_E2.1290.99
95_D143_R2.1190.99
46_F160_E2.0870.99
135_M144_V2.0750.99
37_M59_K2.0660.99
94_Y119_V2.0390.99
45_A74_L2.0300.99
23_T29_W1.9800.98
74_L77_N1.9670.98
92_A119_V1.9630.98
51_T86_V1.9550.98
37_M58_A1.9300.98
125_N128_G1.8670.98
43_A135_M1.8640.98
92_A98_G1.8610.98
150_W153_Y1.8430.97
64_V93_L1.8300.97
154_V179_F1.7980.97
35_K38_D1.7830.97
67_L70_A1.7410.96
41_L64_V1.7390.96
40_V54_V1.7200.96
151_L156_Q1.7180.96
78_V88_L1.6760.95
43_A137_I1.6730.95
43_A144_V1.6320.95
137_I147_S1.6100.94
123_S148_G1.5730.94
149_E153_Y1.5660.93
148_G151_L1.5660.93
40_V58_A1.5290.93
133_V148_G1.5280.93
157_I174_L1.5170.92
58_A61_V1.5010.92
161_L170_I1.4750.91
71_F75_K1.4590.91
71_F74_L1.4530.91
124_V127_L1.4460.90
127_L168_E1.4340.90
151_L154_V1.4270.90
64_V89_V1.4230.90
27_A30_D1.4210.90
38_D131_S1.4130.89
64_V147_S1.4090.89
92_A117_V1.4040.89
138_E141_E1.3840.88
120_D123_S1.3420.87
43_A93_L1.3340.86
41_L130_F1.3100.85
142_G146_K1.2590.83
132_V158_A1.2460.82
93_L122_V1.2410.82
124_V128_G1.2410.82
52_V77_N1.1930.79
90_N145_M1.1890.79
34_V38_D1.1610.78
40_V158_A1.1610.78
64_V122_V1.1380.76
34_V37_M1.1340.76
142_G147_S1.1230.75
67_L110_S1.1110.74
78_V83_L1.1040.74
72_K146_K1.1000.74
133_V150_W1.0950.73
34_V40_V1.0850.73
67_L101_L1.0780.72
16_Y27_A1.0750.72
51_T74_L1.0680.71
94_Y143_R1.0680.71
43_A147_S1.0640.71
43_A148_G1.0540.70
100_K153_Y1.0370.69
117_V123_S1.0370.69
130_F154_V1.0160.67
71_F77_N1.0160.67
136_D160_E1.0120.67
172_H176_K1.0100.67
119_V123_S1.0040.67
55_A83_L0.9990.66
55_A59_K0.9980.66
146_K173_L0.9900.65
47_I77_N0.9890.65
123_S150_W0.9870.65
38_D59_K0.9820.65
133_V156_Q0.9780.64
40_V51_T0.9600.63
34_V54_V0.9600.63
76_E122_V0.9290.60
16_Y20_Y0.9260.60
97_D120_D0.9140.59
29_W138_E0.9070.59
92_A112_I0.8980.58
19_V49_D0.8970.58
192_N195_R0.8740.56
145_M170_I0.8640.55
22_A25_I0.8610.55
82_N153_Y0.8530.54
50_F158_A0.8490.54
101_L112_I0.8470.53
73_L98_G0.8440.53
133_V160_E0.8410.53
144_V147_S0.8380.53
90_N120_D0.8280.52
42_D93_L0.8280.52
13_P22_A0.8230.51
51_T78_V0.8190.51
162_H165_E0.8180.51
146_K169_I0.8170.51
148_G154_V0.8090.50
75_K90_N0.8040.50
35_K174_L0.8000.49
120_D124_V0.7980.49
64_V137_I0.7940.49
47_I133_V0.7940.49
50_F162_H0.7900.48
14_E17_E0.7900.48
123_S179_F0.7900.48
59_K68_P0.7880.48
86_V139_G0.7870.48
23_T27_A0.7830.48
11_K46_F0.7810.48
50_F53_K0.7800.47
46_F49_D0.7700.47
168_E178_S0.7690.47
55_A140_A0.7680.46
82_N85_N0.7670.46
133_V154_V0.7660.46
45_A65_E0.7640.46
37_M61_V0.7630.46
50_F140_A0.7620.46
67_L137_I0.7610.46
61_V149_E0.7590.46
55_A77_N0.7530.45
49_D53_K0.7510.45
24_F177_R0.7500.45
94_Y98_G0.7470.45
125_N147_S0.7370.44
62_V112_I0.7360.44
140_A144_V0.7340.43
123_S147_S0.7340.43
140_A162_H0.7320.43
23_T46_F0.7320.43
111_R114_E0.7300.43
29_W158_A0.7280.43
111_R115_S0.7260.43
41_L60_E0.7260.43
133_V157_I0.7250.43
84_K101_L0.7230.43
11_K28_E0.7210.42
91_K120_D0.7190.42
18_Y30_D0.7120.42
47_I160_E0.7100.41
40_V61_V0.7070.41
161_L186_R0.7050.41
25_I29_W0.7040.41
106_E145_M0.7010.41
85_N92_A0.6950.40
88_L155_K0.6850.39
172_H187_G0.6840.39
19_V30_D0.6770.39
122_V157_I0.6760.39
52_V81_N0.6760.39
133_V178_S0.6760.39
144_V160_E0.6750.38
84_K146_K0.6720.38
142_G173_L0.6710.38
24_F133_V0.6690.38
138_E160_E0.6640.38
74_L78_V0.6630.37
121_S124_V0.6620.37
97_D101_L0.6590.37
107_G110_S0.6590.37
122_V127_L0.6560.37
76_E97_D0.6550.37
37_M55_A0.6550.37
77_N192_N0.6530.37
40_V50_F0.6510.36
32_L37_M0.6500.36
69_W176_K0.6490.36
23_T50_F0.6450.36
147_S150_W0.6450.36
186_R190_V0.6440.36
67_L159_V0.6410.36
164_R167_I0.6370.35
110_S179_F0.6350.35
44_G48_G0.6350.35
87_V112_I0.6330.35
23_T28_E0.6310.35
162_H181_I0.6310.35
93_L148_G0.6260.34
104_V189_L0.6220.34
193_T196_N0.6190.34
19_V111_R0.6190.34
50_F184_M0.6180.34
93_L144_V0.6180.34
122_V148_G0.6130.33
57_K92_A0.6090.33
97_D112_I0.6080.33
38_D58_A0.6080.33
161_L171_P0.6070.33
150_W156_Q0.6040.33
157_I173_L0.6030.33
16_Y43_A0.6030.33
33_K132_V0.6030.33
21_Y92_A0.6030.33
18_Y22_A0.5970.32
98_G119_V0.5970.32
160_E178_S0.5950.32
155_K180_V0.5950.32
97_D181_I0.5940.32
109_G116_G0.5940.32
64_V94_Y0.5890.32
144_V169_I0.5890.32
121_S147_S0.5880.32
38_D161_L0.5850.31
16_Y28_E0.5840.31
12_V81_N0.5790.31
64_V144_V0.5790.31
22_A29_W0.5770.31
66_P90_N0.5750.31
91_K95_D0.5750.31
80_I124_V0.5740.30
44_G65_E0.5730.30
29_W47_I0.5730.30
31_F110_S0.5700.30
22_A28_E0.5700.30
189_L194_V0.5680.30
94_Y166_N0.5660.30
132_V156_Q0.5650.30
81_N139_G0.5650.30
20_Y29_W0.5640.30
78_V86_V0.5580.29
141_E160_E0.5550.29
89_V98_G0.5540.29
156_Q178_S0.5540.29
66_P107_G0.5530.29
80_I194_V0.5530.29
113_G139_G0.5520.29
41_L127_L0.5520.29
68_P77_N0.5510.29
184_M187_G0.5490.29
109_G142_G0.5480.29
93_L120_D0.5470.28
48_G65_E0.5460.28
143_R170_I0.5460.28
47_I63_A0.5450.28
53_K151_L0.5430.28
77_N119_V0.5410.28
50_F66_P0.5390.28
83_L112_I0.5330.28
17_E147_S0.5280.27
108_T112_I0.5280.27
11_K16_Y0.5280.27
174_L182_R0.5280.27
173_L177_R0.5260.27
70_A137_I0.5260.27
145_M173_L0.5240.27
106_E109_G0.5220.27
67_L183_F0.5190.27
64_V151_L0.5160.26
137_I140_A0.5160.26
148_G166_N0.5140.26
16_Y23_T0.5070.26
29_W162_H0.5050.26
118_E127_L0.5030.25
43_A64_V0.5030.25
116_G175_R0.5020.25
92_A156_Q0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2py6A 4 0.7699 100 0.507 Contact Map
3a27A 1 0.7531 98.7 0.811 Contact Map
3k6rA 1 0.749 98.7 0.814 Contact Map
2jjqA 1 0.6946 98.6 0.822 Contact Map
3v97A 1 0.7866 98.4 0.83 Contact Map
2yx1A 2 0.7238 98.3 0.833 Contact Map
1uwvA 1 0.7573 98.3 0.833 Contact Map
2yxdA 4 0.7364 98.2 0.84 Contact Map
2b78A 1 0.7992 98.1 0.842 Contact Map
1yzhA 1 0.8285 98.1 0.845 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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