Q7LXE1 - SULSO - GREMLIN Contacts

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Q7LXE1 - Uncharacterized protein

UniProt:	Q7LXE1	Sequences: MIFTYGKTKLKVPEGYEYVYYATFIAAEWDFLKVKDMDTVLDAGAFIGDFTVKVARKAKEVVAVEPLPWAFKLLKENVEINNLKNVVLVNKALYDVDGVKLKIVDEGTGSRIGESGVEVDSVSVNSLGKFSVVKMDIEGAEGRVMKSGEWLDYVKQIAVELHGRENIEIIPHLLRKRSFVIRFMTRGDLVRNTVRNALLHPISFIKAEARTKVVLNYFKRKYYVPALSGDEYKIVYGRR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	239 (186)
Sequences:	539 (501)
Seq/√Len:	36.7

HALSA - Q9HQP5 Q9HSW3
SULSO - Q7LXE1 Q7LXG2 Q97XG4 Q97X54 Q97XU3 Q7LXF6 Q7LXE9 Q97XT4 Q7LXF9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
71_F	88_L	4.867	1.00
137_I	144_V	4.585	1.00
156_Q	179_F	3.983	1.00
50_F	54_V	3.417	1.00
45_A	63_A	2.955	1.00
95_D	146_K	2.705	1.00
94_Y	140_A	2.705	1.00
62_V	89_V	2.605	1.00
42_D	134_K	2.393	1.00
71_F	90_N	2.376	1.00
55_A	85_N	2.292	0.99
99_V	118_E	2.129	0.99
95_D	143_R	2.119	0.99
46_F	160_E	2.087	0.99
135_M	144_V	2.075	0.99
37_M	59_K	2.066	0.99
94_Y	119_V	2.039	0.99
45_A	74_L	2.030	0.99
23_T	29_W	1.980	0.98
74_L	77_N	1.967	0.98
92_A	119_V	1.963	0.98
51_T	86_V	1.955	0.98
37_M	58_A	1.930	0.98
125_N	128_G	1.867	0.98
43_A	135_M	1.864	0.98
92_A	98_G	1.861	0.98
150_W	153_Y	1.843	0.97
64_V	93_L	1.830	0.97
154_V	179_F	1.798	0.97
35_K	38_D	1.783	0.97
67_L	70_A	1.741	0.96
41_L	64_V	1.739	0.96
40_V	54_V	1.720	0.96
151_L	156_Q	1.718	0.96
78_V	88_L	1.676	0.95
43_A	137_I	1.673	0.95
43_A	144_V	1.632	0.95
137_I	147_S	1.610	0.94
123_S	148_G	1.573	0.94
149_E	153_Y	1.566	0.93
148_G	151_L	1.566	0.93
40_V	58_A	1.529	0.93
133_V	148_G	1.528	0.93
157_I	174_L	1.517	0.92
58_A	61_V	1.501	0.92
161_L	170_I	1.475	0.91
71_F	75_K	1.459	0.91
71_F	74_L	1.453	0.91
124_V	127_L	1.446	0.90
127_L	168_E	1.434	0.90
151_L	154_V	1.427	0.90
64_V	89_V	1.423	0.90
27_A	30_D	1.421	0.90
38_D	131_S	1.413	0.89
64_V	147_S	1.409	0.89
92_A	117_V	1.404	0.89
138_E	141_E	1.384	0.88
120_D	123_S	1.342	0.87
43_A	93_L	1.334	0.86
41_L	130_F	1.310	0.85
142_G	146_K	1.259	0.83
132_V	158_A	1.246	0.82
93_L	122_V	1.241	0.82
124_V	128_G	1.241	0.82
52_V	77_N	1.193	0.79
90_N	145_M	1.189	0.79
34_V	38_D	1.161	0.78
40_V	158_A	1.161	0.78
64_V	122_V	1.138	0.76
34_V	37_M	1.134	0.76
142_G	147_S	1.123	0.75
67_L	110_S	1.111	0.74
78_V	83_L	1.104	0.74
72_K	146_K	1.100	0.74
133_V	150_W	1.095	0.73
34_V	40_V	1.085	0.73
67_L	101_L	1.078	0.72
16_Y	27_A	1.075	0.72
51_T	74_L	1.068	0.71
94_Y	143_R	1.068	0.71
43_A	147_S	1.064	0.71
43_A	148_G	1.054	0.70
100_K	153_Y	1.037	0.69
117_V	123_S	1.037	0.69
130_F	154_V	1.016	0.67
71_F	77_N	1.016	0.67
136_D	160_E	1.012	0.67
172_H	176_K	1.010	0.67
119_V	123_S	1.004	0.67
55_A	83_L	0.999	0.66
55_A	59_K	0.998	0.66
146_K	173_L	0.990	0.65
47_I	77_N	0.989	0.65
123_S	150_W	0.987	0.65
38_D	59_K	0.982	0.65
133_V	156_Q	0.978	0.64
40_V	51_T	0.960	0.63
34_V	54_V	0.960	0.63
76_E	122_V	0.929	0.60
16_Y	20_Y	0.926	0.60
97_D	120_D	0.914	0.59
29_W	138_E	0.907	0.59
92_A	112_I	0.898	0.58
19_V	49_D	0.897	0.58
192_N	195_R	0.874	0.56
145_M	170_I	0.864	0.55
22_A	25_I	0.861	0.55
82_N	153_Y	0.853	0.54
50_F	158_A	0.849	0.54
101_L	112_I	0.847	0.53
73_L	98_G	0.844	0.53
133_V	160_E	0.841	0.53
144_V	147_S	0.838	0.53
90_N	120_D	0.828	0.52
42_D	93_L	0.828	0.52
13_P	22_A	0.823	0.51
51_T	78_V	0.819	0.51
162_H	165_E	0.818	0.51
146_K	169_I	0.817	0.51
148_G	154_V	0.809	0.50
75_K	90_N	0.804	0.50
35_K	174_L	0.800	0.49
120_D	124_V	0.798	0.49
64_V	137_I	0.794	0.49
47_I	133_V	0.794	0.49
50_F	162_H	0.790	0.48
14_E	17_E	0.790	0.48
123_S	179_F	0.790	0.48
59_K	68_P	0.788	0.48
86_V	139_G	0.787	0.48
23_T	27_A	0.783	0.48
11_K	46_F	0.781	0.48
50_F	53_K	0.780	0.47
46_F	49_D	0.770	0.47
168_E	178_S	0.769	0.47
55_A	140_A	0.768	0.46
82_N	85_N	0.767	0.46
133_V	154_V	0.766	0.46
45_A	65_E	0.764	0.46
37_M	61_V	0.763	0.46
50_F	140_A	0.762	0.46
67_L	137_I	0.761	0.46
61_V	149_E	0.759	0.46
55_A	77_N	0.753	0.45
49_D	53_K	0.751	0.45
24_F	177_R	0.750	0.45
94_Y	98_G	0.747	0.45
125_N	147_S	0.737	0.44
62_V	112_I	0.736	0.44
140_A	144_V	0.734	0.43
123_S	147_S	0.734	0.43
140_A	162_H	0.732	0.43
23_T	46_F	0.732	0.43
111_R	114_E	0.730	0.43
29_W	158_A	0.728	0.43
111_R	115_S	0.726	0.43
41_L	60_E	0.726	0.43
133_V	157_I	0.725	0.43
84_K	101_L	0.723	0.43
11_K	28_E	0.721	0.42
91_K	120_D	0.719	0.42
18_Y	30_D	0.712	0.42
47_I	160_E	0.710	0.41
40_V	61_V	0.707	0.41
161_L	186_R	0.705	0.41
25_I	29_W	0.704	0.41
106_E	145_M	0.701	0.41
85_N	92_A	0.695	0.40
88_L	155_K	0.685	0.39
172_H	187_G	0.684	0.39
19_V	30_D	0.677	0.39
122_V	157_I	0.676	0.39
52_V	81_N	0.676	0.39
133_V	178_S	0.676	0.39
144_V	160_E	0.675	0.38
84_K	146_K	0.672	0.38
142_G	173_L	0.671	0.38
24_F	133_V	0.669	0.38
138_E	160_E	0.664	0.38
74_L	78_V	0.663	0.37
121_S	124_V	0.662	0.37
97_D	101_L	0.659	0.37
107_G	110_S	0.659	0.37
122_V	127_L	0.656	0.37
76_E	97_D	0.655	0.37
37_M	55_A	0.655	0.37
77_N	192_N	0.653	0.37
40_V	50_F	0.651	0.36
32_L	37_M	0.650	0.36
69_W	176_K	0.649	0.36
23_T	50_F	0.645	0.36
147_S	150_W	0.645	0.36
186_R	190_V	0.644	0.36
67_L	159_V	0.641	0.36
164_R	167_I	0.637	0.35
110_S	179_F	0.635	0.35
44_G	48_G	0.635	0.35
87_V	112_I	0.633	0.35
23_T	28_E	0.631	0.35
162_H	181_I	0.631	0.35
93_L	148_G	0.626	0.34
104_V	189_L	0.622	0.34
193_T	196_N	0.619	0.34
19_V	111_R	0.619	0.34
50_F	184_M	0.618	0.34
93_L	144_V	0.618	0.34
122_V	148_G	0.613	0.33
57_K	92_A	0.609	0.33
97_D	112_I	0.608	0.33
38_D	58_A	0.608	0.33
161_L	171_P	0.607	0.33
150_W	156_Q	0.604	0.33
157_I	173_L	0.603	0.33
16_Y	43_A	0.603	0.33
33_K	132_V	0.603	0.33
21_Y	92_A	0.603	0.33
18_Y	22_A	0.597	0.32
98_G	119_V	0.597	0.32
160_E	178_S	0.595	0.32
155_K	180_V	0.595	0.32
97_D	181_I	0.594	0.32
109_G	116_G	0.594	0.32
64_V	94_Y	0.589	0.32
144_V	169_I	0.589	0.32
121_S	147_S	0.588	0.32
38_D	161_L	0.585	0.31
16_Y	28_E	0.584	0.31
12_V	81_N	0.579	0.31
64_V	144_V	0.579	0.31
22_A	29_W	0.577	0.31
66_P	90_N	0.575	0.31
91_K	95_D	0.575	0.31
80_I	124_V	0.574	0.30
44_G	65_E	0.573	0.30
29_W	47_I	0.573	0.30
31_F	110_S	0.570	0.30
22_A	28_E	0.570	0.30
189_L	194_V	0.568	0.30
94_Y	166_N	0.566	0.30
132_V	156_Q	0.565	0.30
81_N	139_G	0.565	0.30
20_Y	29_W	0.564	0.30
78_V	86_V	0.558	0.29
141_E	160_E	0.555	0.29
89_V	98_G	0.554	0.29
156_Q	178_S	0.554	0.29
66_P	107_G	0.553	0.29
80_I	194_V	0.553	0.29
113_G	139_G	0.552	0.29
41_L	127_L	0.552	0.29
68_P	77_N	0.551	0.29
184_M	187_G	0.549	0.29
109_G	142_G	0.548	0.29
93_L	120_D	0.547	0.28
48_G	65_E	0.546	0.28
143_R	170_I	0.546	0.28
47_I	63_A	0.545	0.28
53_K	151_L	0.543	0.28
77_N	119_V	0.541	0.28
50_F	66_P	0.539	0.28
83_L	112_I	0.533	0.28
17_E	147_S	0.528	0.27
108_T	112_I	0.528	0.27
11_K	16_Y	0.528	0.27
174_L	182_R	0.528	0.27
173_L	177_R	0.526	0.27
70_A	137_I	0.526	0.27
145_M	173_L	0.524	0.27
106_E	109_G	0.522	0.27
67_L	183_F	0.519	0.27
64_V	151_L	0.516	0.26
137_I	140_A	0.516	0.26
148_G	166_N	0.514	0.26
16_Y	23_T	0.507	0.26
29_W	162_H	0.505	0.26
118_E	127_L	0.503	0.25
43_A	64_V	0.503	0.25
116_G	175_R	0.502	0.25
92_A	156_Q	0.500	0.25

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2py6A	4	0.7699	100	0.507	Contact Map
3a27A	1	0.7531	98.7	0.811	Contact Map
3k6rA	1	0.749	98.7	0.814	Contact Map
2jjqA	1	0.6946	98.6	0.822	Contact Map
3v97A	1	0.7866	98.4	0.83	Contact Map
2yx1A	2	0.7238	98.3	0.833	Contact Map
1uwvA	1	0.7573	98.3	0.833	Contact Map
2yxdA	4	0.7364	98.2	0.84	Contact Map
2b78A	1	0.7992	98.1	0.842	Contact Map
1yzhA	1	0.8285	98.1	0.845	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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