GREMLIN Database
Q7LXD9 - Transposase ISC1476
UniProt: Q7LXD9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 460 (349)
Sequences: 3532 (2251)
Seq/√Len: 120.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
320_H324_N5.4011.00
395_A422_N4.1121.00
375_A382_V3.5431.00
342_Y431_A3.2811.00
252_I367_L3.1981.00
368_M384_E2.8991.00
35_R377_E2.8541.00
343_L371_I2.7711.00
366_K370_S2.6371.00
327_S331_E2.6031.00
350_V359_V2.6001.00
330_I375_A2.4821.00
189_G209_E2.4691.00
367_L371_I2.4551.00
385_V427_I2.4321.00
191_L204_A2.4281.00
278_Q356_K2.3981.00
366_K369_E2.3831.00
430_K433_G2.3611.00
403_R406_R2.3301.00
392_K402_K2.2351.00
284_V303_L2.1861.00
323_R373_L2.1641.00
372_E384_E2.1571.00
67_F71_Q2.1531.00
390_T427_I2.1151.00
44_N47_Q2.1121.00
323_R370_S2.0911.00
397_H413_L2.0471.00
341_I375_A2.0401.00
397_H411_C2.0291.00
303_L307_K2.0171.00
389_N392_K2.0121.00
343_L382_V1.9961.00
82_E86_K1.9961.00
326_A370_S1.9811.00
70_R135_P1.9661.00
298_D301_L1.9621.00
65_V104_L1.9361.00
394_C413_L1.9261.00
98_V154_R1.9251.00
410_N416_K1.9001.00
394_C411_C1.8491.00
323_R326_A1.8471.00
407_G419_S1.8401.00
277_F317_R1.8331.00
396_Y415_H1.8251.00
339_S380_M1.8191.00
323_R374_K1.8071.00
66_N107_N1.8011.00
252_I321_L1.7961.00
394_C397_H1.7651.00
83_E86_K1.7571.00
409_I417_L1.7401.00
53_R94_V1.7361.00
52_R195_F1.7291.00
301_L304_L1.7281.00
245_I253_A1.7071.00
319_T366_K1.6971.00
82_E85_Y1.6771.00
425_L429_K1.6621.00
40_R201_A1.6511.00
392_K401_V1.6441.00
60_K91_K1.6331.00
322_Y366_K1.6301.00
52_R202_W1.6251.00
201_A312_K1.5961.00
36_T205_H1.5621.00
251_V254_S1.5261.00
402_K406_R1.5251.00
372_E376_Q1.5151.00
332_T338_V1.5061.00
167_L204_A1.5031.00
352_E355_N1.4961.00
178_F182_L1.4961.00
255_V259_D1.4891.00
326_A373_L1.4871.00
409_I415_H1.4871.00
408_V416_K1.4761.00
180_G183_K1.4701.00
254_S421_L1.4651.00
281_I311_F1.4511.00
287_L291_T1.4411.00
55_A202_W1.4351.00
322_Y370_S1.4331.00
243_A255_V1.4321.00
281_I307_K1.4271.00
288_A304_L1.3851.00
179_I182_L1.3831.00
51_L202_W1.3601.00
239_G339_S1.3551.00
343_L368_M1.3471.00
117_L133_V1.3391.00
343_L384_E1.3171.00
98_V156_D1.3121.00
242_V428_L1.3121.00
199_R312_K1.3121.00
291_T303_L1.3091.00
404_N407_G1.3071.00
174_M179_I1.2981.00
277_F314_L1.2941.00
312_K316_R1.2931.00
49_R53_R1.2921.00
58_S103_V1.2881.00
108_N112_S1.2841.00
65_V107_N1.2741.00
326_A374_K1.2741.00
358_T364_Y1.2731.00
327_S378_Y1.2691.00
344_G387_E1.2550.99
372_E382_V1.2420.99
106_K152_V1.2380.99
48_E52_R1.2360.99
403_R419_S1.2270.99
370_S373_L1.2170.99
62_F103_V1.2160.99
247_L364_Y1.2130.99
256_V424_A1.2070.99
96_L99_N1.2030.99
288_A303_L1.1990.99
395_A425_L1.1990.99
284_V310_L1.1830.99
284_V307_K1.1810.99
345_Y384_E1.1670.99
390_T430_K1.1620.99
295_G300_Y1.1590.99
385_V430_K1.1530.99
194_I205_H1.1480.99
113_S133_V1.1480.99
81_I86_K1.1420.99
174_M178_F1.1420.99
112_S116_S1.1380.99
70_R74_F1.1330.99
45_G48_E1.1330.99
180_G184_W1.1210.99
169_L193_I1.1160.99
326_A367_L1.1150.99
33_N212_V1.1150.99
254_S264_L1.1130.99
263_L418_H1.1110.99
111_W135_P1.1110.99
347_F387_E1.1050.99
174_M180_G1.1010.99
284_V287_L1.0980.99
326_A371_I1.0950.99
178_F183_K1.0920.99
178_F181_R1.0860.98
402_K419_S1.0830.98
328_H332_T1.0820.98
331_E378_Y1.0780.98
330_I378_Y1.0710.98
285_Q289_D1.0680.98
116_S132_H1.0660.98
393_Y430_K1.0610.98
403_R407_G1.0590.98
385_V431_A1.0550.98
109_E113_S1.0520.98
87_K90_E1.0480.98
322_Y326_A1.0410.98
82_E105_N1.0380.98
242_V432_L1.0370.98
37_N208_I1.0370.98
350_V355_N1.0310.98
280_R283_E1.0240.98
315_T319_T1.0230.98
82_E104_L1.0230.98
153_I169_L1.0190.98
421_L425_L1.0160.98
81_I84_T1.0140.98
92_Y100_A1.0110.98
281_I314_L1.0110.98
400_E409_I1.0110.98
245_I255_V1.0100.98
407_G418_H1.0090.98
417_L421_L1.0090.98
288_A307_K1.0070.98
242_V340_T1.0060.97
102_A105_N1.0000.97
114_F135_P0.9970.97
322_Y367_L0.9910.97
86_K104_L0.9790.97
242_V342_Y0.9740.97
247_L253_A0.9710.97
329_L341_I0.9660.97
69_R108_N0.9650.97
43_P51_L0.9650.97
113_S116_S0.9560.97
114_F136_P0.9540.97
285_Q307_K0.9520.97
113_S132_H0.9520.97
86_K105_N0.9510.96
395_A417_L0.9490.96
389_N430_K0.9480.96
179_I183_K0.9440.96
43_P47_Q0.9430.96
417_L425_L0.9410.96
71_Q75_H0.9380.96
70_R111_W0.9380.96
151_L154_R0.9360.96
181_R184_W0.9350.96
395_A423_G0.9330.96
161_D164_N0.9290.96
281_I289_D0.9260.96
57_L91_K0.9260.96
113_S117_L0.9230.96
48_E202_W0.9230.96
62_F110_A0.9180.96
375_A378_Y0.9140.96
263_L421_L0.9100.95
342_Y427_I0.9060.95
387_E390_T0.9040.95
157_R170_K0.9020.95
40_R203_Y0.9010.95
247_L368_M0.9010.95
400_E403_R0.9000.95
41_L204_A0.8990.95
66_N111_W0.8980.95
179_I184_W0.8980.95
236_K239_G0.8940.95
243_A256_V0.8910.95
281_I285_Q0.8830.95
330_I341_I0.8820.95
402_K409_I0.8810.95
406_R419_S0.8810.95
310_L314_L0.8790.95
254_S263_L0.8790.95
404_N419_S0.8760.94
174_M182_L0.8750.94
371_I382_V0.8720.94
393_Y426_N0.8710.94
319_T370_S0.8700.94
163_E166_K0.8700.94
166_K175_E0.8690.94
98_V102_A0.8660.94
253_A325_L0.8660.94
97_G157_R0.8660.94
161_D168_I0.8620.94
101_Q105_N0.8620.94
409_I419_S0.8570.94
374_K377_E0.8540.94
277_F310_L0.8490.93
266_K269_R0.8480.93
73_F77_G0.8460.93
192_E205_H0.8450.93
321_L325_L0.8440.93
275_F357_F0.8430.93
300_Y304_L0.8410.93
244_S428_L0.8410.93
292_R295_G0.8380.93
60_K64_E0.8370.93
174_M181_R0.8370.93
67_F138_Y0.8350.93
259_D328_H0.8350.93
375_A380_M0.8350.93
153_I156_D0.8280.93
406_R409_I0.8230.92
168_I175_E0.8210.92
246_D420_D0.8180.92
104_L108_N0.8130.92
167_L191_L0.8110.92
282_A287_L0.8110.92
68_E72_Q0.8100.92
72_Q76_E0.8100.92
98_V155_Q0.8080.92
283_E287_L0.8080.92
313_K317_R0.8070.92
98_V101_Q0.8060.92
146_K149_Q0.8060.92
152_V190_R0.8050.92
251_V265_Y0.8040.91
69_R85_Y0.8010.91
330_I380_M0.8010.91
400_E406_R0.8010.91
102_A154_R0.7980.91
395_A415_H0.7970.91
117_L132_H0.7970.91
176_I180_G0.7910.91
399_V412_P0.7890.91
186_G208_I0.7880.91
80_N86_K0.7820.90
288_A291_T0.7820.90
251_V263_L0.7800.90
430_K434_V0.7780.90
345_Y387_E0.7720.90
153_I157_R0.7700.90
299_A302_E0.7680.90
111_W114_F0.7680.90
97_G156_D0.7660.89
408_V417_L0.7650.89
392_K400_E0.7650.89
193_I204_A0.7630.89
265_Y268_V0.7610.89
354_G358_T0.7590.89
98_V157_R0.7590.89
57_L92_Y0.7580.89
56_N59_A0.7580.89
369_E372_E0.7530.89
149_Q152_V0.7520.89
78_K84_T0.7510.88
152_V192_E0.7510.88
332_T339_S0.7490.88
327_S374_K0.7490.88
291_T296_E0.7480.88
249_I361_M0.7480.88
301_L305_R0.7480.88
365_R369_E0.7430.88
282_A285_Q0.7420.88
157_R160_V0.7410.88
393_Y400_E0.7380.88
345_Y368_M0.7380.88
169_L172_F0.7370.88
36_T194_I0.7350.87
38_V194_I0.7330.87
39_V204_A0.7330.87
62_F107_N0.7320.87
355_N359_V0.7310.87
348_N387_E0.7290.87
253_A367_L0.7290.87
175_E180_G0.7270.87
190_R207_P0.7240.87
95_I98_V0.7240.87
280_R284_V0.7220.86
56_N60_K0.7190.86
61_L103_V0.7190.86
289_D303_L0.7180.86
187_K209_E0.7170.86
256_V421_L0.7150.86
340_T381_K0.7120.86
80_N83_E0.7110.86
286_S289_D0.7100.86
243_A338_V0.7100.86
102_A152_V0.7100.86
349_I358_T0.7090.85
238_K241_K0.7090.85
243_A341_I0.7080.85
370_S374_K0.7040.85
393_Y409_I0.7010.85
423_G426_N0.7000.85
57_L95_I0.7000.85
346_P387_E0.7000.85
177_D180_G0.7000.85
156_D159_K0.6980.85
244_S256_V0.6980.85
159_K168_I0.6980.85
80_N84_T0.6960.84
195_F202_W0.6960.84
34_R207_P0.6950.84
117_L134_S0.6950.84
409_I412_P0.6930.84
97_G154_R0.6920.84
76_E79_V0.6900.84
106_K192_E0.6890.84
51_L55_A0.6890.84
274_Y277_F0.6880.84
34_R189_G0.6830.83
54_L151_L0.6820.83
392_K403_R0.6810.83
103_V107_N0.6800.83
322_Y363_S0.6790.83
151_L155_Q0.6750.83
291_T299_A0.6710.82
153_I158_Y0.6700.82
95_I100_A0.6690.82
56_N91_K0.6680.82
73_F114_F0.6680.82
387_E430_K0.6660.82
383_F431_A0.6660.82
38_V319_T0.6650.82
368_M372_E0.6640.82
53_R57_L0.6630.81
236_K380_M0.6630.81
402_K407_G0.6630.81
246_D391_S0.6620.81
151_L157_R0.6620.81
69_R111_W0.6610.81
80_N85_Y0.6610.81
427_I430_K0.6580.81
73_F76_E0.6570.81
331_E340_T0.6560.81
296_E299_A0.6560.81
111_W115_F0.6540.81
300_Y303_L0.6530.80
421_L424_A0.6530.80
99_N151_L0.6510.80
282_A290_R0.6490.80
54_L95_I0.6490.80
201_A316_R0.6470.80
64_E91_K0.6460.80
240_N339_S0.6420.79
73_F111_W0.6390.79
54_L96_L0.6330.78
249_I357_F0.6320.78
340_T383_F0.6300.78
168_I172_F0.6290.78
395_A429_K0.6270.78
401_V406_R0.6270.78
96_L153_I0.6260.78
275_F356_K0.6250.77
41_L193_I0.6250.77
282_A307_K0.6250.77
36_T207_P0.6250.77
250_N263_L0.6240.77
393_Y398_D0.6240.77
396_Y417_L0.6240.77
102_A106_K0.6240.77
168_I171_D0.6230.77
292_R296_E0.6190.77
274_Y356_K0.6180.77
244_S342_Y0.6180.77
289_D307_K0.6180.77
352_E359_V0.6180.77
396_Y425_L0.6160.76
431_A435_I0.6150.76
408_V418_H0.6150.76
280_R310_L0.6130.76
287_L290_R0.6110.76
316_R319_T0.6100.76
259_D264_L0.6080.76
389_N393_Y0.6080.76
425_L428_L0.6070.75
386_V389_N0.6060.75
104_L107_N0.6060.75
110_A136_P0.6040.75
250_N254_S0.6040.75
306_E309_R0.6040.75
158_Y170_K0.6030.75
274_Y278_Q0.6030.75
275_F278_Q0.6030.75
50_K54_L0.6010.75
325_L328_H0.6010.75
292_R300_Y0.6010.75
255_V258_N0.6000.75
274_Y314_L0.5970.74
90_E93_K0.5950.74
327_S370_S0.5950.74
43_P176_I0.5940.74
253_A329_L0.5930.74
390_T393_Y0.5920.74
175_E184_W0.5920.74
341_I371_I0.5910.73
107_N111_W0.5890.73
169_L191_L0.5850.73
285_Q311_F0.5850.73
252_I326_A0.5850.73
105_N154_R0.5840.73
285_Q288_A0.5840.73
68_E71_Q0.5830.72
304_L308_R0.5830.72
61_L100_A0.5830.72
429_K434_V0.5830.72
177_D182_L0.5810.72
311_F318_L0.5790.72
79_V84_T0.5790.72
150_I153_I0.5770.72
203_Y312_K0.5760.72
60_K89_Y0.5750.71
249_I350_V0.5740.71
277_F313_K0.5740.71
252_I322_Y0.5720.71
404_N408_V0.5690.71
194_I198_T0.5690.71
54_L99_N0.5670.70
353_K357_F0.5660.70
418_H423_G0.5660.70
348_N351_Q0.5650.70
78_K81_I0.5630.70
114_F117_L0.5600.69
115_F136_P0.5590.69
293_N300_Y0.5570.69
348_N352_E0.5570.69
51_L151_L0.5560.69
389_N409_I0.5540.69
252_I371_I0.5530.69
175_E179_I0.5520.68
417_L422_N0.5490.68
64_E68_E0.5480.68
98_V153_I0.5470.68
97_G153_I0.5460.68
286_S290_R0.5460.68
359_V391_S0.5460.68
154_R157_R0.5440.67
346_P349_I0.5440.67
349_I364_Y0.5420.67
68_E85_Y0.5400.67
325_L367_L0.5400.67
284_V306_E0.5390.67
38_V203_Y0.5390.67
245_I329_L0.5390.67
38_V198_T0.5390.67
176_I179_I0.5370.66
152_V156_D0.5340.66
342_Y430_K0.5340.66
53_R95_I0.5310.65
101_Q104_L0.5300.65
208_I331_E0.5240.64
348_N358_T0.5240.64
182_L186_G0.5230.64
73_F115_F0.5230.64
422_N426_N0.5220.64
324_N327_S0.5190.64
373_L377_E0.5170.63
57_L60_K0.5160.63
274_Y317_R0.5160.63
81_I85_Y0.5160.63
253_A264_L0.5150.63
79_V108_N0.5150.63
285_Q293_N0.5150.63
54_L58_S0.5150.63
412_P419_S0.5140.63
249_I268_V0.5120.63
51_L193_I0.5120.63
388_Y392_K0.5110.62
403_R409_I0.5100.62
58_S95_I0.5090.62
116_S133_V0.5090.62
55_A151_L0.5080.62
147_R150_I0.5070.62
69_R72_Q0.5060.62
253_A343_L0.5050.62
241_K339_S0.5040.61
177_D184_W0.5040.61
269_R317_R0.5040.61
314_L318_L0.5010.61
189_G207_P0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.2826 95.7 0.934 Contact Map
1iv0A 1 0.2109 94.3 0.939 Contact Map
1vhxA 2 0.2978 94.2 0.939 Contact Map
4ep4A 2 0.3391 75.6 0.955 Contact Map
1qypA 1 0.0935 71.9 0.956 Contact Map
4aybP 1 0.087 66.7 0.958 Contact Map
2k4xA 1 0.1152 53.9 0.961 Contact Map
1hjrA 2 0.3348 51.1 0.962 Contact Map
1ffkW 1 0.1522 50.9 0.962 Contact Map
3j20Y 1 0.1043 41.8 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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