GREMLIN Database
Q7LXD0 - Microtubule binding protein, putative
UniProt: Q7LXD0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 464 (388)
Sequences: 8904 (8382)
Seq/√Len: 425.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
303_E307_M2.4141.00
280_K284_A2.0831.00
154_K158_A2.0671.00
98_K102_A2.0301.00
313_Q317_Q2.0051.00
112_K116_R1.9711.00
203_K207_S1.9311.00
175_K179_S1.9151.00
174_T177_E1.9071.00
49_K53_S1.8631.00
91_K95_S1.8581.00
105_E109_A1.8481.00
210_K214_A1.8381.00
145_I149_E1.8351.00
314_L318_N1.8221.00
124_T128_E1.8021.00
153_K156_E1.7741.00
22_E25_G1.7731.00
236_T240_E1.7621.00
63_R67_R1.7581.00
182_K186_A1.7431.00
277_R280_K1.7301.00
307_M311_E1.7301.00
56_Q60_A1.7191.00
289_V292_Q1.7131.00
28_F32_T1.7121.00
153_K157_Q1.7111.00
187_V191_I1.7041.00
217_E221_A1.6991.00
53_S56_Q1.6721.00
299_I303_E1.6701.00
229_I233_E1.6691.00
61_Q65_E1.6671.00
370_G373_G1.6621.00
306_T310_V1.6561.00
70_K74_A1.6521.00
46_S49_K1.6511.00
195_K198_D1.6461.00
166_Q170_D1.6441.00
152_T156_E1.6421.00
320_I324_R1.6351.00
35_D39_I1.6341.00
133_E137_A1.6281.00
140_K144_R1.6271.00
240_E244_Q1.6171.00
147_K151_S1.6091.00
243_V247_I1.5931.00
224_K228_R1.5871.00
167_K171_E1.5821.00
71_L74_A1.5821.00
174_T178_E1.5811.00
212_E216_Q1.5781.00
181_K184_E1.5701.00
126_K130_A1.5691.00
215_V219_I1.5651.00
90_T93_E1.5621.00
88_R91_K1.5401.00
69_A72_E1.5371.00
84_R88_R1.5361.00
83_K86_D1.5301.00
188_Q191_I1.5171.00
318_N322_E1.5001.00
239_L242_A1.4931.00
104_Q107_I1.4891.00
100_E104_Q1.4861.00
234_E238_K1.4811.00
275_E279_A1.4651.00
111_K114_D1.4651.00
231_K235_S1.4641.00
308_K312_S1.4621.00
37_K41_K1.4561.00
119_K123_S1.4531.00
256_R259_K1.4531.00
146_T149_E1.4511.00
167_K170_D1.4451.00
118_T121_E1.4291.00
33_L36_L1.4281.00
165_A168_K1.4271.00
184_E188_Q1.4231.00
201_I205_E1.4231.00
125_K128_E1.4141.00
144_R147_K1.4131.00
244_Q247_I1.4111.00
151_S154_K1.4091.00
253_H256_R1.4041.00
180_T184_E1.4031.00
60_A63_R1.4021.00
108_E112_K1.4001.00
196_K200_R1.3971.00
32_T36_L1.3961.00
225_H228_R1.3941.00
214_A217_E1.3941.00
265_Q268_V1.3901.00
132_Q135_I1.3901.00
36_L39_I1.3871.00
122_E126_K1.3641.00
258_T261_E1.3631.00
273_R277_R1.3621.00
138_Q142_D1.3561.00
329_S333_R1.3531.00
227_E231_K1.3471.00
322_E326_A1.3441.00
75_V78_L1.3421.00
230_T233_E1.3411.00
101_Q105_E1.3361.00
75_V79_V1.3361.00
40_L43_L1.3311.00
96_T100_E1.3311.00
27_S31_V1.3281.00
321_R325_K1.3261.00
74_A78_L1.3241.00
344_E348_E1.3241.00
371_L374_L1.3241.00
289_V293_K1.3231.00
298_R301_K1.3231.00
103_V107_I1.3211.00
55_D58_V1.3191.00
110_Q114_D1.3161.00
320_I323_L1.3141.00
131_V135_I1.3141.00
139_K143_E1.3131.00
310_V314_L1.3091.00
345_I349_L1.3091.00
233_E237_K1.3071.00
299_I302_L1.3071.00
136_E140_K1.3051.00
200_R203_K1.3051.00
172_R175_K1.3051.00
306_T309_L1.3041.00
219_I223_K1.2981.00
159_V163_I1.2951.00
168_K172_R1.2901.00
137_A140_K1.2891.00
251_K254_D1.2871.00
345_I348_E1.2831.00
264_I268_V1.2821.00
54_V58_V1.2811.00
173_I177_E1.2781.00
237_K240_E1.2781.00
47_M51_K1.2761.00
48_D51_K1.2751.00
283_N287_Q1.2691.00
44_L48_D1.2641.00
238_K242_A1.2621.00
301_K305_V1.2541.00
198_D202_T1.2441.00
193_A196_K1.2411.00
297_E301_K1.2391.00
97_K100_E1.2391.00
42_G46_S1.2361.00
76_E79_V1.2341.00
65_E69_A1.2281.00
278_I281_L1.2271.00
129_Q133_E1.2261.00
43_L46_S1.2211.00
242_A245_E1.2211.00
348_E352_Q1.2211.00
138_Q141_H1.2191.00
211_L214_A1.2111.00
319_E322_E1.2101.00
123_S126_K1.2051.00
305_V308_K1.2051.00
161_E165_A1.2051.00
77_Q81_A1.1991.00
57_L60_A1.1981.00
130_A133_E1.1981.00
202_T206_E1.1951.00
157_Q161_E1.1911.00
189_E193_A1.1911.00
294_R298_R1.1801.00
250_Q253_H1.1771.00
110_Q113_H1.1731.00
25_G28_F1.1691.00
74_A77_Q1.1651.00
81_A85_T1.1641.00
285_V288_L1.1641.00
186_A189_E1.1621.00
38_D41_K1.1621.00
222_Q226_D1.1581.00
170_D174_T1.1581.00
82_Q86_D1.1561.00
259_K263_S1.1531.00
68_I71_L1.1521.00
276_E280_K1.1501.00
38_D42_G1.1481.00
89_I93_E1.1471.00
315_G319_E1.1461.00
209_K212_E1.1441.00
281_L285_V1.1441.00
312_S315_G1.1421.00
156_E160_Q1.1411.00
82_Q85_T1.1401.00
300_T304_E1.1391.00
252_K256_R1.1371.00
109_A112_K1.1311.00
157_Q160_Q1.1281.00
235_S238_K1.1261.00
144_R148_L1.1251.00
139_K142_D1.1221.00
39_I42_G1.1201.00
164_E168_K1.1151.00
41_K44_L1.1141.00
405_N409_H1.1131.00
86_D90_T1.1051.00
68_I72_E1.1051.00
188_Q192_E1.1051.00
160_Q164_E1.1031.00
202_T205_E1.1021.00
158_A162_L1.1011.00
121_E125_K1.0991.00
310_V313_Q1.0961.00
49_K52_S1.0951.00
221_A224_K1.0931.00
313_Q316_M1.0911.00
162_L165_A1.0911.00
244_Q248_E1.0861.00
245_E249_A1.0861.00
158_A161_E1.0821.00
195_K199_E1.0821.00
171_E174_T1.0791.00
183_L186_A1.0761.00
97_K101_Q1.0721.00
327_L330_M1.0711.00
266_K270_A1.0701.00
213_Q217_E1.0671.00
137_A141_H1.0661.00
241_Q245_E1.0651.00
249_A252_K1.0651.00
307_M310_V1.0631.00
186_A190_L1.0541.00
58_V61_Q1.0531.00
83_K87_E1.0511.00
146_T150_E1.0511.00
255_E258_T1.0381.00
22_E29_I1.0371.00
347_D351_K1.0341.00
150_E154_K1.0341.00
216_Q219_I1.0331.00
194_Q198_D1.0331.00
62_R65_E1.0331.00
185_Q189_E1.0291.00
34_A37_K1.0291.00
250_Q254_D1.0271.00
228_R231_K1.0171.00
95_S99_L1.0151.00
115_E119_K1.0121.00
381_V386_K1.0111.00
221_A225_H1.0111.00
226_D230_T1.0111.00
125_K129_Q1.0101.00
326_A329_S1.0081.00
335_G339_E1.0081.00
251_K255_E1.0081.00
317_Q321_R1.0081.00
283_N286_E1.0071.00
21_E25_G1.0041.00
95_S98_K1.0041.00
32_T35_D1.0031.00
51_K55_D0.9941.00
191_I195_K0.9921.00
208_T212_E0.9911.00
94_E98_K0.9881.00
328_G332_K0.9851.00
151_S155_L0.9841.00
190_L193_A0.9821.00
209_K213_Q0.9821.00
58_V62_R0.9821.00
25_G29_I0.9811.00
102_A105_E0.9761.00
33_L37_K0.9761.00
247_I251_K0.9711.00
381_V384_L0.9691.00
236_T239_L0.9631.00
255_E259_K0.9631.00
297_E300_T0.9631.00
181_K185_Q0.9631.00
118_T122_E0.9611.00
45_A49_K0.9591.00
23_I27_S0.9561.00
48_D52_S0.9551.00
230_T234_E0.9441.00
67_R70_K0.9431.00
340_K343_I0.9411.00
134_L138_Q0.9411.00
66_E70_K0.9401.00
159_V162_L0.9391.00
76_E80_E0.9331.00
287_Q291_A0.9271.00
285_V289_V0.9241.00
57_L61_Q0.9221.00
237_K241_Q0.9191.00
192_E196_K0.9161.00
96_T99_L0.9161.00
164_E167_K0.9131.00
134_L137_A0.9121.00
145_I148_L0.9101.00
135_I139_K0.9081.00
178_E181_K0.9041.00
229_I236_T0.9031.00
279_A282_E0.9001.00
300_T303_E0.8991.00
72_E76_E0.8981.00
166_Q169_H0.8921.00
326_A331_G0.8901.00
324_R328_G0.8901.00
104_Q108_E0.8891.00
216_Q220_E0.8861.00
155_L158_A0.8861.00
47_M50_L0.8861.00
73_N77_Q0.8841.00
334_W338_F0.8831.00
87_E91_K0.8831.00
233_E236_T0.8821.00
333_R336_R0.8811.00
398_Y410_K0.8811.00
109_A113_H0.8811.00
52_S56_Q0.8801.00
288_L292_Q0.8791.00
359_Y362_K0.8761.00
81_A84_R0.8751.00
160_Q163_I0.8751.00
92_L95_S0.8741.00
220_E224_K0.8741.00
27_S30_N0.8711.00
142_D146_T0.8681.00
331_G335_G0.8651.00
208_T211_L0.8651.00
194_Q197_H0.8631.00
64_A67_R0.8621.00
205_E208_T0.8591.00
254_D258_T0.8571.00
272_R275_E0.8541.00
319_E324_R0.8541.00
328_G331_G0.8531.00
372_F376_G0.8511.00
24_L28_F0.8511.00
243_V246_L0.8501.00
272_R276_E0.8491.00
264_I267_L0.8471.00
114_D118_T0.8461.00
229_I232_L0.8431.00
50_L53_S0.8421.00
127_L130_A0.8411.00
386_K389_K0.8411.00
304_E308_K0.8411.00
152_T155_L0.8411.00
249_A253_H0.8401.00
206_E210_K0.8361.00
26_I30_N0.8351.00
34_A38_D0.8341.00
193_A197_H0.8331.00
163_I167_K0.8331.00
346_V350_A0.8291.00
296_D300_T0.8281.00
22_E26_I0.8271.00
93_E97_K0.8271.00
263_S266_K0.8241.00
53_S57_L0.8241.00
207_S210_K0.8191.00
332_K336_R0.8191.00
248_E252_K0.8181.00
147_K150_E0.8181.00
182_K185_Q0.8171.00
172_R176_L0.8161.00
107_I111_K0.8151.00
327_L331_G0.8151.00
262_E266_K0.8141.00
241_Q244_Q0.8131.00
333_R337_D0.8131.00
285_V292_Q0.8111.00
90_T94_E0.8061.00
401_K405_N0.8051.00
231_K234_E0.8051.00
121_E124_T0.8041.00
390_V393_I0.8021.00
354_G358_K0.8021.00
383_L386_K0.8001.00
344_E347_D0.7981.00
222_Q225_H0.7951.00
128_E131_V0.7941.00
282_E286_E0.7921.00
286_E289_V0.7891.00
140_K143_E0.7851.00
223_K227_E0.7831.00
376_G380_D0.7831.00
284_A287_Q0.7821.00
218_L221_A0.7801.00
334_W337_D0.7791.00
305_V309_L0.7781.00
179_S182_K0.7781.00
391_Y395_I0.7771.00
228_R232_L0.7721.00
43_L47_M0.7711.00
265_Q269_D0.7681.00
116_R119_K0.7671.00
39_I43_L0.7651.00
374_L379_Y0.7631.00
238_K241_Q0.7631.00
368_D374_L0.7631.00
171_E175_K0.7611.00
288_L291_A0.7561.00
319_E323_L0.7551.00
227_E230_T0.7551.00
113_H116_R0.7541.00
179_S183_L0.7531.00
141_H144_R0.7501.00
124_T127_L0.7491.00
350_A353_E0.7471.00
89_I92_L0.7441.00
88_R92_L0.7441.00
71_L75_V0.7431.00
143_E147_K0.7371.00
382_D386_K0.7371.00
154_K157_Q0.7351.00
111_K115_E0.7341.00
384_L389_K0.7321.00
217_E220_E0.7301.00
150_E153_K0.7291.00
353_E356_D0.7291.00
316_M320_I0.7251.00
54_V57_L0.7221.00
390_V396_K0.7211.00
93_E96_T0.7201.00
390_V401_K0.7201.00
248_E251_K0.7181.00
31_V34_A0.7161.00
106_L109_A0.7131.00
302_L305_V0.7121.00
131_V134_L0.7121.00
213_Q216_Q0.7121.00
41_K45_A0.7111.00
299_I306_T0.7101.00
197_H200_R0.7091.00
46_S50_L0.7011.00
301_K304_E0.7011.00
304_E307_M0.7001.00
321_R324_R0.7001.00
232_L235_S0.6991.00
376_G379_Y0.6981.00
165_A169_H0.6921.00
311_E314_L0.6921.00
128_E132_Q0.6911.00
389_K396_K0.6901.00
94_E97_K0.6891.00
101_Q104_Q0.6891.00
356_D362_K0.6891.00
69_A73_N0.6881.00
143_E146_T0.6851.00
192_E195_K0.6801.00
77_Q80_E0.6781.00
224_K227_E0.6771.00
271_Q275_E0.6761.00
384_L391_Y0.6751.00
279_A283_N0.6741.00
30_N34_A0.6711.00
393_I400_E0.6711.00
382_D397_S0.6661.00
388_T396_K0.6661.00
262_E265_Q0.6641.00
70_K73_N0.6641.00
103_V106_L0.6641.00
278_I282_E0.6580.99
401_K404_V0.6570.99
291_A295_T0.6570.99
201_I204_L0.6550.99
55_D59_D0.6550.99
257_I261_E0.6540.99
404_V408_A0.6520.99
175_K178_E0.6520.99
345_I350_A0.6490.99
392_L411_F0.6420.99
79_V83_K0.6420.99
311_E315_G0.6410.99
257_I260_L0.6400.99
87_E90_T0.6390.99
314_L317_Q0.6390.99
162_L166_Q0.6370.99
169_H172_R0.6350.99
271_Q274_A0.6330.99
356_D361_N0.6320.99
403_D406_W0.6300.99
316_M319_E0.6290.99
108_E111_K0.6270.99
390_V395_I0.6260.99
120_L123_S0.6250.99
142_D145_I0.6240.99
161_E164_E0.6230.99
92_L96_T0.6220.99
349_L352_Q0.6200.99
132_Q136_E0.6200.99
219_I222_Q0.6200.99
136_E139_K0.6200.99
29_I33_L0.6170.99
292_Q296_D0.6160.99
59_D62_R0.6140.99
129_Q132_Q0.6130.99
36_L40_L0.6120.99
199_E203_K0.6080.99
234_E237_K0.6040.99
29_I32_T0.6040.99
214_A218_L0.6030.99
246_L249_A0.6030.99
367_D370_G0.6010.99
51_K54_V0.6000.99
330_M334_W0.5980.99
359_Y380_D0.5970.99
177_E181_K0.5960.99
187_V190_L0.5950.99
99_L103_V0.5950.99
177_E180_T0.5930.99
105_E108_E0.5920.99
212_E215_V0.5920.99
85_T88_R0.5910.99
116_R120_L0.5900.99
280_K283_N0.5890.99
235_S239_L0.5880.99
409_H412_N0.5840.99
45_A48_D0.5840.99
295_T299_I0.5830.99
25_G30_N0.5830.99
266_K269_D0.5830.99
197_H201_I0.5810.99
258_T262_E0.5810.99
346_V349_L0.5790.99
178_E182_K0.5770.99
204_L207_S0.5760.99
196_K199_E0.5750.99
396_K400_E0.5750.99
173_I176_L0.5720.99
327_L334_W0.5710.99
141_H145_I0.5710.99
180_T183_L0.5690.98
323_L327_L0.5670.98
99_L102_A0.5670.98
50_L54_V0.5650.98
339_E343_I0.5630.98
203_K206_E0.5630.98
389_K395_I0.5620.98
385_I390_V0.5610.98
401_K406_W0.5590.98
290_E294_R0.5590.98
359_Y363_F0.5580.98
191_I194_Q0.5550.98
269_D273_R0.5540.98
117_I121_E0.5540.98
26_I29_I0.5540.98
309_L313_Q0.5530.98
381_V385_I0.5510.98
78_L82_Q0.5510.98
149_E153_K0.5510.98
384_L408_A0.5490.98
84_R87_E0.5470.98
388_T393_I0.5450.98
148_L151_S0.5420.98
252_K255_E0.5410.98
31_V35_D0.5380.98
242_A246_L0.5380.98
392_L395_I0.5380.98
302_L306_T0.5370.98
184_E187_V0.5340.98
59_D63_R0.5340.98
204_L208_T0.5320.98
68_I75_V0.5310.98
393_I403_D0.5290.98
395_I400_E0.5240.97
117_I120_L0.5220.97
326_A330_M0.5180.97
318_N321_R0.5180.97
67_R71_L0.5140.97
377_V380_D0.5130.97
317_Q320_I0.5130.97
388_T395_I0.5120.97
72_E75_V0.5090.97
347_D350_A0.5080.97
345_I351_K0.5060.97
200_R204_L0.5050.97
371_L375_K0.5050.97
63_R66_E0.5040.97
128_E135_I0.5030.97
348_E351_K0.5000.97
404_V407_A0.5000.97
355_L358_K0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i84S 2 0.2435 99.7 0.546 Contact Map
1c1gA 2 0.6121 99.5 0.618 Contact Map
4uxvA 1 0.9289 97.9 0.789 Contact Map
2dfsA 2 0.3405 96.7 0.828 Contact Map
4linA 5 0.5194 96.5 0.833 Contact Map
2v71A 3 0.3448 96.4 0.834 Contact Map
3o0zA 2 0.3448 96.3 0.836 Contact Map
4rsiB 1 0.5603 95.8 0.842 Contact Map
4iloA 3 0.4806 95.6 0.845 Contact Map
3na7A 1 0.5 95.1 0.85 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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